Exploring Liraglutide’s mechanism in reducing renal fibrosis: the Fsp1-CoQ10-NAD(P)H pathway by Qi Chen, Ji-Xian Song, Zhi Zhang, Ji-Ren An, Yu-Jing Gou, Miao Tan, Yashuo Zhao

“…First, LIRA ameliorated renal dysfunction and fibrosis in db/db mice. Second, LIRA inhibited lipid peroxidation by up-regulating T-SOD, GSH-Px, and GSH activities as well as down-regulating the levels of 8-OHDG, MDA, LPO, 4-HNE, 12-Lox, and NOX4 in db/db mice. …”
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Astrocytes carrying LRRK2 G2019S exhibit increased levels of clusterin chaperone via miR-22-5p and reduced ability to take up α-synuclein fibrils by Alice Filippini, Giulia Carini, Alessandro Barbon, Massimo Gennarelli, Isabella Russo

“…Abstract Accumulating evidence highlights that dysfunction of astrocyte biology might contribute to Parkinson’s disease (PD) onset and progression. …”
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The Possibilities of Thromboelastography in Assessing Safety of Neuraxial Blocks in Gestational Thrombocytopenia (Clinical Study) by E. N. Plakhotina, T. N. Belousova, N. B. Kuzina, A. N. Kuzovlev, E. V. Bryantsev

“…Unlike other types of thrombocytopenia, it is not accompanied by dysfunction of the cellular component of hemostasis. …”
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Burden of knee osteoarthritis in China and globally from 1992 to 2021, and projections to 2030: a systematic analysis from the Global Burden of Disease Study 2021 by Yueming Lv, Liang Sui, Hao Lv, Jiacheng Zheng, Huichao Feng, Fujie Jing

“…BackgroundKnee osteoarthritis (KOA) is primarily characterized by joint pain and dysfunction, and KOA has increasingly emerged as a public health concern in China and globally. …”
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Association between lifestyle factors and liver function parameters in the middle-aged and older population by Lin Ye Sun, Ting Yu Lu, Ya Li Jin, Wei Sen Zhang, Lin Xu

“…We therefore explored the synergistic effects of various lifestyle factors on liver function. …”
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Blimp-1 orchestrates macrophage polarization and metabolic homeostasis via purine biosynthesis in sepsis by Wenjuan Peng, Qiushi Qin, Rui Li, Yujia Liu, Lan Li, Yue Zhang, Liuluan Zhu

“…In vitro studies with BMDM further suggested that the purine biosynthesis and Ornithine cycle metabolic regulation is involved in Blimp-1’s effects on M2 macrophage polarization, and mediates Blimp-1’s impact on septic mice. …”
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Spectrum of Kidney Biopsy Findings Associated With Methamphetamine Use by Hae Yoon Grace Choung, Cynthia C. Nast, Mark Haas, Mercury Lin, Michifumi Yamashita, Jean Hou

“…However, there are few reports and series examining the toxic kidney effects of METH, and associated histopathological changes are not well-described. …”
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Compound probiotics alleviate hyperuricemia-induced renal injury via restoring gut microbiota and metabolism by Ping Liu, Ping Hu, Meiping Jin, Weiqian Sun, Jiajun Wu, Yuyan Tang, Danye Shi, Ting Xie, Yijing Tong, Lusheng Huang, Dongliang Zhang, Hui Zheng, Xudong Xu, Haidong He

“…Gut microbiota composition and metabolite profiles were evaluated using 16 S rRNA gene sequencing and non-targeted metabolomics of fecal samples.Our findings demonstrate that the compound probioticS effectively attenuated hyperuricemia-associated renal dysfunction and interstitial fibrosis. …”
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Bio-inspired natural fibers-derived e-skin equipped with intelligent drug-release system for advanced robustly-integrated melanoma therapy by Xinhua Liu, Yifan Fei, Boqiang Cui, Xing Chen, Jiamin Zhang, Ouyang Yue, Zhongxue Bai, Ling Wen, Huie Jiang

“…Notably, pH-responsive Cu2⁺ liberation from CuS-NPs facilitates intelligent functional switching: bactericidal activity at tumor microenvironment pH (5.0–6.0) and pro-regenerative effects under physiological pH (7.4) for wound healing. …”
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Recent Advances in the Therapeutic Potential of Cannabinoids Against Gliomas: A Systematic Review (2022–2025) by Farideh A. Javid, Andrej Belancic, Man Ki Kwok, Yun Wah Lam

“…Combination therapies, particularly cannabidiol with temozolomide or radiotherapy, exhibited additive or synergistic anti‐tumor effects, although variability between glioma subtypes suggests the need for personalized approaches. …”
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A systematic review and meta-analysis of efruxifermin’s efficacy in improving liver fibrosis in patients with NASH/MASH by Shuzhai Li, Wangyuan Zou, Yingying Zhou, Wenjie Li, Wei Liao, Tao Li, Zhiming Zhang

“…Background & AimsEfruxifermin is a potential treatment for non-alcoholic steatohepatitis (NASH, now termed metabolic dysfunction-associated steatohepatitis, MASH). This study aimed to analyze the effectiveness of efruxifermin in improving liver fibrosis in patients with MASH.MethodsSystematic searches of PubMed, Cochrane Library, and Embase databases were conducted. …”
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Macrotroponin interference and association with cardiotoxicity in patients receiving cardiotoxic breast cancer therapy: a pilot study by Andrea Soosaipillai, Inbar Nardi-Agmon, Davor Brinc, Anselmo Fabros, Peter A. Kavsak, Paaladinesh Thavendiranathan, Ashley Di Meo

“…Abstract Background Cancer therapy-related cardiac dysfunction (CTRCD) is an important adverse effect in patients receiving potential cardiotoxic cancer therapies. …”
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Determination of Factors Affecting Sleep Quality in Postoperative Patients and Improvement of Correctible Causes by Ayşegül Özgök, Gökçe Selçuk Sert, Dilek Öztürk Kazancı

“…Subjective Sleep Quality, Sleep Latency, Sleep Duration, Habitual Sleep Efficiency, Sleep Disorder, Sleeping Drug Use, and Daytime Dysfunction. Each component is evaluated over 0-3 points. …”
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Blockade of HSP70 Improves Vascular Function in a Mouse Model of Type 2 Diabetes by Valentina Ochoa Mendoza, Amanda Almeida de Oliveira, Kenia Pedrosa Nunes

“…In diabetes, blood vessels often show impaired contractility, contributing to vascular dysfunction. However, HSP70’s specific role in T2D-related vascular contraction remains unclear. …”
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The DRP1 receptor FIS1 is critical to the expansion of triple-negative breast cancer tumor-initiating cells by Tetiana Katrii, Tanya Freywald, Malkon G. Estrada, Amr El Zawily, Behzad Toosi, Frederick S. Vizeacoumar, Franco J. Vizeacoumar, Andrew Freywald, Scot C. Leary

“…Remarkably, we found that this phenotypic effect occurred in the absence of significant changes in ROS production, mitochondrial membrane potential and oxidative phosphorylation complex abundance even though FIS1-deficient TICs harbored a more reticular mitochondrial network. …”
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Case Report: The window that closed too soon: lessons from a late CLN2 diagnosis and death of a 9-year-old boy by Anna Bryzik, Dawid Larysz, Patrycja Larysz, Julia Izabela Karpierz, Justyna Paprocka

“…A class of progressive, autosomal recessive neurodegenerative diseases known as neuronal ceroid lipofuscinoses (NCLs) are brought on by lysosomal protein or enzyme dysfunction. This leads to the pathological buildup of autofluorescent ceroid-lipofuscin in neurons and other tissues. …”
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<i>Cicer arietinum</i> Extract Suppresses Lung Sepsis Induced by Cecal Ligation and Puncture in Rats by Amer Al Ali, Mohammed H. Abu-Alghayth, Khaled I. Ghaleb, Sara Ibrahim

“…Sepsis is characterized by multiple organ dysfunction, which is now accepted to be due to oxidative damage. …”
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Ilex Guayusa Tea Improves Glycaemia and Autonomic Modulation in Female Streptozotocin-Induced Diabetic Rats by Tafne Coelho Mello, Danielle da Silva Dias, Nathalia Bernardes, Amanda Aparecida do Araujo, Camila Paixão dos Santos, Susana Llesuy, Kátia De Angelis, Filipe F. Stoyell-Conti

“…Thus, this study evaluated the effects of Ilex guayusa tea on cardiovascular, autonomic, metabolic, and oxidative stress parameters in diabetic rats, as well as its antioxidant and phytochemical properties. …”
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Potential diagnostic and therapeutic gene in chronic low back pain through pyroptosis modulation: A silico study based on the dataset analysis by Jintao Guo, Tao Sun

“…Our aim in this research was to look into the effects of genes associated with pyroptosis in cLBP, with the goal of describing possible markers for diagnosis and targets for treatment. …”
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Significance of catestatin in the pathogenesis of heart failure with preserved ejection fraction in patients with non-obstructive coronary artery disease by E. V. Grakova, K. V. Kopieva, A. M. Gusakova, A. V. Smorgon, A. N. Maltseva, A. V. Mochula, A. V. Svarovskaya, K. V. Zavadovsky

“…In patients with non-obstructive coronary artery disease (CAD), to evaluate the pathophysiological significance and diagnostic effectiveness of catestatin in detecting heart failure with preserved ejection fraction (HFpEF), as well as to assess the relationship of the levels of this biomarker with heart rate variability (HRV) parameters and the severity of diastolic dysfunction.Material and methods. …”
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