Gene Expression Changes as Biomarkers of Immunosenescence in Bulgarian Individuals of Active Age by Dragomira Nikolova, Yana Todorova, Zora Hammoudeh, Blaga Rukova, Radoslava Emilova, Milena Aleksova, Vesselina Koleva, Maria Nikolova

“…On the other hand, we identified markers of possible protective effects against oxidative stress and tumorigenesis. …”
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The impact of pathological factors on the structure and function of erythrocyte membranes: from the molecular level to clinical consequences by D.А. Liadov

“…Pathological changes in erythrocyte membranes are critical in microcirculatory dysfunction, chronic hypoxia, and systemic disease progression. …”
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Exploratory Ultrasound Analysis of the Diaphragm and Respiratory Capacity in Women with Primary Dysmenorrhea: A Cross-Sectional Observational Study by Rebeca del Prado-Álvarez, María García-Arrabé, Ángel González-de-la-Flor, Marta de la Plaza San Frutos, Jaime Almazán-Polo, Cecilia Estrada-Barranco

“…These findings suggest a potential compensatory mechanical adaptation rather than global respiratory dysfunction. Further longitudinal studies with larger sample sizes are needed to explore the clinical significance of these findings.…”
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Data-driven cluster analysis on the association of aging, obesity and insulin resistance with new-onset diabetes in Chinese adults: a multicenter retrospective cohort study by Yazhi Wang, Mingkang Zhang, Peng Wang

“…BackgroundType 2 diabetes mellitus (T2DM) is an endocrine and metabolic disorder that can lead to multi-organ damage and dysfunction, imposing significant financial burden on national healthcare systems. …”
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Validation of the PEACE score for predicting abnormal echocardiographic findings in pulmonary embolism patients by Kazım Ersin Altınsoy

“…Specifically, in predicting right ventricular dysfunction, the PEACE Score achieved an AUC of 0.85 (95% CI: 0.77–0.93, p < 0.001). …”
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Relationship between the acromiohumeral distance and muscle function of deltoid and infraspinatus in patients with rotator cuff tears by Ryuta Oishi, Kyosuke Hoshikawa, Nariyuki Mura, Tomohiro Uno, Michiaki Takagi

“…AHD narrowing suggests that the effect of the infraspinatus muscle dysfunction is more significant than structural failure caused by an infraspinatus tendon tear.…”
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Pelvic floor structural changes during the first singleton pregnancy and the risk factors of stress urinary incontinence by Chuanqing Sun, Hongyu Yang, Keting Li, Ping He

“…Abstract Background Pelvic floor dysfunction (PFD) usually occurs due to issues with the pelvic floor muscle and fascia tissue. …”
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Obesity reprograms the normal pancreas and pancreatic cancer microbiome in mice and humans by Raquel Santana da Cruz, Shravanthy Suguru, Sara P. C. Paiva, Ijeoma Nwugwo, Bhaskar Kallakury, Benjamin A. Weinberg, Katherine L. Cook, Sonia de Assis

“…Obesity (and underlying metabolic dysfunction) is estimated to account for up to 50% of all PDACs. …”
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The Dual Role and Therapeutic Implications of the Wnt/&amp;beta;-Catenin Pathway in Diabetic Kidney Disease by Adeerjiang Y, Gan XX, Li WT, Li QT, Jiang YQ, Zhu X, Hu CM, Wang PX, Jiang S

“…However, clinical translation faces challenges such as pathway redundancy, off-target effects, and the need for precise dosing to balance protective and injurious outcomes. …”
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The implications of frailty in older adults with epilepsy by Syeda Amrah Hashmi, Seerat Sachdeva, Udeept Sindhu, Carolyn Tsai, Kalyanchakradhar Bonda, Mark Keezer, Ifrah Zawar, Vineet Punia

“…Mechanistically, frailty develops through complex interactions among molecular and cellular damage, including genomic instability, mitochondrial dysfunction, and hormonal changes. These contribute to systemic muscle mass, bone density, and organ function decline. …”
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Nebivolol Exerts Hepatoprotective Activity During CLP-Induced Sepsis by Modulating Oxidative Stress, Liver Regeneration, and AKT/MAPK Pathways in Rats by Rahma Tharwat Sabra, Amany Abdlrehim Bekhit, Nourhan Tharwat Sabra, Nadia Ahmed Abd El-Moeze, Moustafa Fathy

“…Sepsis is a potentially catastrophic organ dysfunction arising from an infection-induced immunologic reaction leading to severe inflammation, progression of septic shock, and damage to body organs. …”
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Association between timing of operative interventions and mortality in emergency general surgery by Katherine M Reitz, Joshua B Brown, Matthew D Neal, David S Silver, Liling Lu, Jamison Beiriger, Yekaterina Khamzina, Andrew B Peitzman

“…We assessed the association between operative timing quintiles and in-hospital mortality using a mixed-effect hierarchical multivariable model, adjusting for patient demographics, comorbidities, organ dysfunction, and clustering at the hospital level.Results A total of 1199 patients were included. …”
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Compatibility of pulse–pulse intervals with R–R intervals in assessing cardiac autonomic function and its relation to risks of atherosclerosis by Cheuk-Kwan Sun, Cyuan-Cin Liu, Wei-Min Liu, Hsien-Tsai Wu, Ruay-Ming Huang, An-Bang Liu

“…Conclusion: PPI may be an alternative parameter for effectively assessing cardiac autonomic function in nonoverweight healthy individuals. …”
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The sphingosine‐1‐phosphate signaling pathway (sphingosine‐1‐phosphate and its receptor, sphingosine kinase) and epilepsy by Lin Wang, Qingxia Kong, Xinyi Leng, Howan Leung, Yang Li

“…Epilepsy often coexists with cardiovascular disease, cognitive dysfunction, depression, etc., which seriously affects the patient's quality of life. …”
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Dystrophinopathy in the paravertebral muscle of adolescent idiopathic scoliosis: a prospective case-control study in China by Junyu Li, Danfeng Zheng, Zekun Li, Jiaxi Li, Zexi Yang, Xiang Zhang, Yingshuang Zhang, Miao Yu

“…Therefore, dystrophin dysfunction may be relevant to AIS occurrence and development.…”
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The role of epigenetic modifications in the formation of heterogeneous phenotypes in diabetes mellitus (a literature review) by O.V. Zinych, A.A. Shuprovych, O.M. Trofymenko, K.P. Komisarenko

“…This review article provides a summary and update on the role of epigenetic mechanisms in predisposition and progression of diabetes, analyzes the data concerning the cause-and-effect relationship between epigenetic changes and the emergence of distinct metabolic phenotypes. …”
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Systemic treatment type is not associated with abnormal post-treatment noninvasive liver stiffness measurement in psoriasis by Yue Xiao, Jingya Gao, Yiyi Wang, Dan Hao, Wei Yan, Dingke Wen, Siyi Zeng, Shiqi Yang, Yingyu Shi, Wei Li

“…BackgroundPsoriasis is commonly associated with metabolic dysfunction-associated steatotic liver disease, raising concerns about the hepatic effects of systemic treatments on psoriasis and its comorbid conditions. …”
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Relationship between lymphocyte-related parameters and the prognosis of patients with lupus nephritis by Wenyi Qi, Rong Zhu, Xue Bai, Ping Luo, Manyu Luo

“…BackgroundThe occurrence of lupus nephritis is primarily caused by the dysfunction of the autoimmune system, leading to the deposition of immune complexes (ICs) in the kidneys and associated inflammatory responses. …”
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Tibetan golden acupuncture inhibits JNK/caspase-3 signaling pathway to alleviate neuronal apoptosis in cerebral ischemia-reperfusion injury by Yaru Liu, Yixilamu, Guilin Jin, Mingke Feng, Chunhua, Dawa

“…Conclusions: GA can restore neurological dysfunction and inhibit hippocampal neuronal apoptosis in CI/RI mice, at least partially through inhibition of the JNK/Caspase-3 signaling pathway and regulation of apoptosis signals.…”
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Moderate pyridoxal phosphate deficiency enhances neuronal excitability and promotes calcium dysregulation by Valerie Girgis, Ashlyn Tharington, Jadyn Trivett, Sylvia Fitting, Rick B. Meeker, Clio Rubinos

“…Chronic ADP treatment led to compensatory changes in neural activity, suggesting potential differences between acute and chronic pyridoxine deficiency.ConclusionThis study demonstrates that even a modest reduction in PLP activity induces transient neuronal hyperexcitability, which may enhance the pathological effects of disease, injury, and inflammation. These findings highlight the importance of pyridoxine in maintaining neural stability and suggest that low pyridoxine levels could contribute to neurological dysfunction. …”
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