Free fatty acid-induced DDX3 inhibits autophagy via miR-141 upregulation in diet-induced MASLD mice model system by Md. Musa Hossain, Amit K. Mishra, Ajay K. Yadav, Md. Ismail, Teja Naveen Sata, Amrendra K. Sah, Arnab Banik, Gopal Sharma, Senthil K. Venugopal

“…Introduction and Objectives: Metabolic dysfunction-associated steatotic liver disease (MASLD) is one of the primary causes of chronic liver disease and may lead to liver cirrhosis and hepatocellular carcinoma. …”
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Electrophysiological and Behavioral Markers of Hyperdopaminergia in DAT-KO Rats by Zoia Fesenko, Maria Ptukha, Marcelo M. da Silva, Raquel S. Marques de Carvalho, Vassiliy Tsytsarev, Raul R. Gainetdinov, Jean Faber, Anna B. Volnova

“…<b>Background/Objectives:</b> Dopamine dysfunction (DA) is a hallmark of many neurological disorders. …”
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Rosuvastatin mitigates blood–brain barrier disruption in sepsis-associated encephalopathy by restoring occludin levels by Qin Shen, Qian Yu, Taojiang Chen, Lijuan Zhang

“…Importantly, silencing KLF2 abrogated Rosuvastatin's protective effects on endothelial permeability and occludin expression. …”
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Protein C and protein S deficiency associated cerebral venous thrombosis: one case report by HUANG Zhan, ZHU Ming-fang, MENG Qi, TAN Lei-lei, ZHANG Jie-wen, HUANG Yue

“…Conclusions PCD and PSD are critical etiological factors for CVT. NOACs effectively improve venous reflux and avoid warfarin-related coagulation dysfunction, representing a preferred therapeutic option. …”
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AT1‐AA Is Produced in Offspring in Response to Placental Ischemia and Is Lowered by B‐Cell Depletion Without Compromising Overall Offspring Health by Nathan Campbell, Evangeline Deer, Dylan Solise, Denise C. Cornelius, Ty Turner, Lorena M. Amaral, Owen Herrock, Ariel Jordan, Shivani Shukla, Tarek Ibrahim, Babbette LaMarca

“…Background Preeclampsia, new‐onset hypertension during pregnancy alongside other organ dysfunction, is the leading cause of mortality for the mother and low birth weight for the baby. …”
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Recombinant human urinary trypsin inhibitor improves the immunological function of splenic dendritic cells in mice with acute lung injury by Tong Wang, Wenna Liu, Jun Li, Yongli Wan, Hang Su, Anlong Qi

“…Recombinant human urinary trypsin inhibitor (rhUTI), a serine protease inhibitor compounded by genetic engineering technology, is expected to replace UTI, which has been reported to protect multiple organs against inflammation- and/or injury-induced dysfunction. The aim of the present study was to investigate the immunomodulatory effects of rhUTI on splenic dendritic cells (DCs) in LPS-induced ALI mice. …”
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Targeting hypoxia-inducible factor-1 in a hypoxidative stress model protects retinal pigment epithelium cells from cell death and metabolic dysregulation by Annika Schubert, Maria Eduarda Lobo Barbosa da Silva, Tabea Ambrock, Orbel Terosian, Anna Malyshkina, Claudia Padberg, Safa Larafa, Johann Matschke, Joachim Fandrey, Yoshiyuki Henning

“…Abstract Oxidative stress and hypoxia lead to dysfunction of retinal pigment epithelium (RPE) cells and are hallmarks of diseases such as age-related macular degeneration (AMD), the most common blinding disease in the elderly population. …”
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Postinfarction Hearts Are Protected by Premature Senescent Cardiomyocytes Via GATA4‐Dependent CCN1 Secretion by Sumei Cui, Li Xue, Feihong Yang, Shuai Dai, Ziqi Han, Kai Liu, Baoshan Liu, Qiuhuan Yuan, Zhaoqiang Cui, Yun Zhang, Feng Xu, Yuguo Chen

“…In vivo, a tail vein injection of AAV9‐Gata4‐shRNA significantly attenuated senescence‐related secretory phenotype secretion and aggravated postinfarction heart dysfunction. Furthermore, among activated senescence‐related secretory phenotype factors, CCN1 administration reduced myofibroblast viability in vitro and rescued the deleterious effect of AAV9‐Gata4‐shRNA in vivo. …”
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Reversible posterior leucoencephalopathy syndrome associated with bone marrow transplantation Leucoencefalopatia posterior reversível associada a transplante de medula óssea by Hélio A.G. Teive, Ivar V. Brandi, Carlos H.F. Camargo, Marco A. Bittencourt, Carmem M. Bonfim, Maria L. Friedrich, Carlos R. de Medeiros, Lineu C. Werneck, Ricardo Pasquini

“…The mechanism by which immunosuppressive agents can cause this syndrome is not clear, but it is probably related with cytotoxic effects of these agents on the vascular endothelium. …”
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Efficiency validation for application of medical and psychological rehabilitation and digitalpsychophysiological therapy in regulation of atherosclerosis development at the level o... by A. V. Gertsev, Yu. N. Zakrevskii, V. N. Ischuk

“…Risk factors for cardiovascular diseases at the initial stages of atherosclerosis formation cause endothelial dysfunction and trigger a cascade of immune inflammation in coronary vessels, which is based on shifting immune response towards activation of lymphocytes, with predominance of cellular immune reactions. …”
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Genetic and functional analyses of SHANK2 mutations suggest a multiple hit model of autism spectrum disorders. by Claire S Leblond, Jutta Heinrich, Richard Delorme, Christian Proepper, Catalina Betancur, Guillaume Huguet, Marina Konyukh, Pauline Chaste, Elodie Ey, Maria Rastam, Henrik Anckarsäter, Gudrun Nygren, I Carina Gillberg, Jonas Melke, Roberto Toro, Beatrice Regnault, Fabien Fauchereau, Oriane Mercati, Nathalie Lemière, David Skuse, Martin Poot, Richard Holt, Anthony P Monaco, Irma Järvelä, Katri Kantojärvi, Raija Vanhala, Sarah Curran, David A Collier, Patrick Bolton, Andreas Chiocchetti, Sabine M Klauck, Fritz Poustka, Christine M Freitag, Regina Waltes, Marnie Kopp, Eftichia Duketis, Elena Bacchelli, Fiorella Minopoli, Liliana Ruta, Agatino Battaglia, Luigi Mazzone, Elena Maestrini, Ana F Sequeira, Barbara Oliveira, Astrid Vicente, Guiomar Oliveira, Dalila Pinto, Stephen W Scherer, Diana Zelenika, Marc Delepine, Mark Lathrop, Dominique Bonneau, Vincent Guinchat, Françoise Devillard, Brigitte Assouline, Marie-Christine Mouren, Marion Leboyer, Christopher Gillberg, Tobias M Boeckers, Thomas Bourgeron

“…While many rare variants in synaptic proteins have been identified in patients with ASD, little is known about their effects at the synapse and their interactions with other genetic variations. …”
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Predicting postoperative trauma-induced coagulopathy in patients with severe injuries by machine learning by Xiaohui Du, Wei Wang, Bo Xu, Jiang Zheng, Victor W. Xia, Yi Guo, Shuai Feng, Qingxiang Mao, Hong Fu

“…Patients who develop TIC usually have a poor prognosis, characterised by increased organ dysfunction, susceptibility to sepsis, and high mortality. …”
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Computational modeling of fear and stress responses: validation using consolidated fear and stress protocols by Brunna Carolinne Rocha Silva Furriel, Brunna Carolinne Rocha Silva Furriel, Brunna Carolinne Rocha Silva Furriel, Geovanne Pereira Furriel, Mauro Cunha Xavier Pinto, Rodrigo Pinto Lemos

“…Dysfunction in fear and stress responses is intrinsically linked to various neurological diseases, including anxiety disorders, depression, and Post-Traumatic Stress Disorder. …”
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Early detection of cognitive impairment in the general population through a digital tool targeting the prospective memory. A pilot study by Olimpia Pino, Elisa Bertoni, Paolo Diletto, Luca Ferrari, Mauro Gaspari, Annalisa Pelosi

“…Objective Based on Prospective Memory (PM), we developed a digitalized tool (Chrono) aimed at the detection of cognitive dysfunction. It incorporated event-based tasks signaled by focal/non-focal cues.Method The validation group consisted of 67 individuals ([Formula: see text] = 61.24; range 50–74 years) assigned, according to MoCA’s cut-off, to Probable impaired (n = 25) vs. …”
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<i>Patrinia scabiosaefolia</i> L. Modulates the Intestinal Microecology to Treat DSS-Induced Ulcerative Colitis: UHPLC-OE-MS/MS, Network Pharmacology, and Experimental Validation by Longfei Zhang, Xiaoxiao Liu, Mingze Xu, Xinyi Cheng, Ning Li, Haiyan Xu, Yining Feng, Tianzhu Guan, Lixia Xiao

“…GO enrichment analysis suggested that PS may alleviate UC-related renal dysfunction by modulating immune responses, inflammation, and cell signaling pathways. …”
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Comparing cognitive impairment using MACFIMS in patients with multiple sclerosis and healthy controls: a systematic review and meta-analysis by Amirreza Nasirzadeh, Mohammad Mohammadi, Melika Arab Bafrani, Aynaz Mohammadi, Hossein Bakhtiari-Dovvombaygi

“…Conclusions The MACFIMS effectively discriminates between pwMS patients and HCs, demonstrating its validity as a comprehensive cognitive assessment tool for MS. …”
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Biochemical and Histological Study of Rat Liver Injury Induced by carbon tetrachloride (CCl4) by Ansam Awad Ali

“… :        The liver is a vital organ that plays a key role in the detoxification of endogenous and exogenous, current study aimed to evaluate the toxic effect of carbon tetrachloride (CCl4) on the liver structure substances, Thirty-four male Sprague Dawley rats at the age of (8-10 weeks) were used. …”
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EXAMINATION INDICES OF THE STATE OF THE VEGETATIVE NERVOUS SYSTEM IN CASE OF PERIODONTAL DISEASES IN THE PATIENTS WITH AFFECTED CERVICAL INTERVERTEBRAL DISCS by V. M. Kulygina, T.O. Tepla

“…At present the evaluation of vegetative dysfunction manifestations according to A. Vein and determination of its regulatory mechanisms according to Kerdo and Hildebrant has become widespread. …”
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Structure-Function Relationship of the Ryanodine Receptor Cluster Network in Sinoatrial Node Cells by Alexander V. Maltsev, Valeria Ventura Subirachs, Oliver Monfredi, Magdalena Juhaszova, Pooja Ajay Warrier, Shardul Rakshit, Syevda Tagirova, Anna V. Maltsev, Michael D. Stern, Edward G. Lakatta, Victor A. Maltsev

“…However, these heterogeneities reduce the effect of β-adrenergic stimulation in terms of its <i>relative change</i> in AP firing rate. …”
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Remote photobiomodulation ameliorates behavioral and neuropathological outcomes in a rat model of repeated closed head injury by Chongyun Wu, Meng Li, Zhe Chen, Shu Feng, Qianting Deng, Rui Duan, Timon Cheng-Yi Liu, Luodan Yang

“…Results demonstrated that remote PBM significantly improved depressive-like behaviors, motor dysfunction, and social interaction impairment while enhancing grip strength and reducing neuronal damage, apoptosis, and degeneration induced by rCHI. …”
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