Aerobic exercise ameliorates atherosclerosis-induced cognitive impairment via hippocampal IL-33/NF-κB signaling modulation by Jianwei Peng, Zaoshang Chang, Jinyun Wang, Zijie Liao, Yunjie Yang, Lianwei Mu, Shen Wang, Junhao Huang, Jingbo Xia, Min Hu

“…Atherosclerosis (AS), a common cardiovascular condition, is often linked to cognitive dysfunction. This study investigates how aerobic exercise affects cognitive impairments caused by AS in ApoE−/− mice. …”
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Structural studies of the IFNλ4 receptor complex using cryoEM enabled by protein engineering by William S. Grubbe, Bixia Zhang, Aileen Kauffman, Fabian Byléhn, Kasia Padoł, Hae-Gwang Jung, Seung Bum Park, Jessica M. Priest, Engin Özkan, Juan J. de Pablo, T. Jake Liang, Minglei Zhao, Juan L. Mendoza

“…While genetic and cellular studies revealed the detrimental effects of IFNλ4 expression, extensive structural and functional characterization has been limited by the inability to express and purify the protein, complicating explanations of its paradoxical behavior. …”
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Cognitive predictors and genetic moderators of employment outcomes in people with schizophrenia by Rachael Keir Blackman, Dwight Dickinson, Michael D. Gregory, Bhaskar S. Kolachana, Daniel P. Eisenberg, Karen F. Berman

“…Additionally, polygenic risk for schizophrenia moderated the effect of working memory cognitive scores on the prediction of future employment. …”
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The MYC/TXNIP axis mediates NCL-Suppressed CD8+T cell immune response in lung adenocarcinoma by Dan Xiao, Tanxiu Chen, Xinlin Yu, Ying Song, Yigang Liu, Wei Yan

“…Results NCL was associated with T cell dysfunction and glucose metabolism. NCL silencing enhanced CD8+ T cell glucose metabolism, cytotoxicity, and infiltration, while NCL overexpression had the opposite effect. …”
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Tracking spasticity dynamics in hemiparetic stroke survivors following cyproheptadine administration: a pilot study using controlled varying tendon indentation depths by Sungjin Bae, Sungjin Bae, Matthieu K. Chardon, Elliot J. Roth, Elliot J. Roth, William Z. Rymer, William Z. Rymer, Nina L. Suresh, Nina L. Suresh

“…Spasticity, a significant health concern among stroke survivors, is characterized by increased muscle tone due to upper motor neuron dysfunction. Conventional clinical assessments, such as the Modified Ashworth Scale (MAS), often lack the sensitivity to accurately monitor treatment. …”
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The Impact of Infectious Diseases on Clinical Characteristics and Immunological Correlations in Pediatric Henoch–Schönlein Purpura: A Five-Year Retrospective Study by Sînziana Oprițescu, Gabriela Viorela Nițescu, Mihaela Golumbeanu, Dora Boghițoiu, Elena Iuliana Ioniță, Diana-Andreea Ușurelu, Cristian Lucaci, Adriana Negoiță, Elena Moroșan

“…Furthermore, this retrospective study considered other factors, such as demographic characteristics (sex, area/environment, and age), and their effect on the pediatric population diagnosed with HSP. …”
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Polysulfur-based bulking of dynamin-related protein 1 prevents ischemic sulfide catabolism and heart failure in mice by Akiyuki Nishimura, Seiryo Ogata, Xiaokang Tang, Kowit Hengphasatporn, Keitaro Umezawa, Makoto Sanbo, Masumi Hirabayashi, Yuri Kato, Yuko Ibuki, Yoshito Kumagai, Kenta Kobayashi, Yasunari Kanda, Yasuteru Urano, Yasuteru Shigeta, Takaaki Akaike, Motohiro Nishida

“…Disruption of Cys644 S-glutathionylation nullifies the cardioprotective effect of GSSG against heart failure after myocardial infarction. …”
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WDJ-S4, a standardized herbal formula, promotes gastrointestinal motility via modulation of the acetylcholine pathway in a loperamide-induced functional dyspepsia mice by Seung-Ju Hwang, Chang-Seob Seo, Dong-Cheol Baek, Tae-Wook Woo, Jing-Hua Wang, Jin-Seok Lee, Yu-Jin Choi, Ji-Yeon Gu, Dong-Seon Kim, Chang-Gue Son

“…C-kit level and smooth muscle contraction-related genes were elevated by WDJ-S4 in both the gastric antrum and jejunum.Conclusion Overall, WDJ-S4 can effectively promote GI motility. The efficacy is associated with modulation of acetylcholine pathway and the interstitial cells of Cajal (ICCs) activation. …”
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Reassessing the roles of oxidative DNA base lesion 8-oxoGua and repair enzyme OGG1 in tumorigenesis by Jing Wang, Chunshuang Li, Jinling Han, Yaoyao Xue, Xu Zheng, Ruoxi Wang, Zsolt Radak, Yusaku Nakabeppu, Istvan Boldogh, Xueqing Ba

“…Thus, in addition to the potential mutagenicity, 8-oxoGua may contribute to tumor development and progression through the altered gene expression stemming from its epigenetic effects.…”
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CARDIAC RESYNCHRONIZATION THERAPY WITH OR WITHOUT AN IMPLANTABLE CARDIOVERTER DEFIBRILLATOR IN DIFFERENT GROUPS OF HEART FAILURE PATIENTS by Perisic Zoran, Kostic Tomislav, Ilic Stevan, Koracevic Goran, Djindjic Boris, Milic Dragan, Vladimir Mitov, Salinger Martinovic Sonja, Stanojevic Dragana, Golubovic Mladjan

“…Implantable cardioverter-defibrillators and cardiac resynchronization therapy have been shown to improve survival, decrease hospital readmissions and mortality, and improve functional status and quality of life in patients with heart failure and left ventricular systolic dysfunction. Aim of the study was to examine the effects of different CRT devices in carefully selected heart failure patients during 1 year.Material and methods. …”
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Comparative pharmacokinetics and pharmacodynamics of two formulations of agalsidase beta (agalsidase Biosidus) and Fabrazyme® by intravenous infusion in healthy male volunteers by Viridiana Berstein, Eduardo M. Pirotzky, Hernán D. Taconelli, M. Gabriela Gobbi, Lara Beider, Natali D. Salgueiro, Laila Dome, Roberto A. Diez, Hugo Sotelo, Sabrina Coppola

“…Fabry disease is a rare X-linked lysosomal condition that leads to the accumulation of glycosphingolipids in various tissues, causing cellular dysfunction, tissue remodeling, progressive fibrosis, and organ failure. …”
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Redo inferior pubectomy for failed anastomotic urethroplasty in pelvic fracture urethral injury by Lin Wang, Wenxiong Song, Xufeng Peng, Rong Lyu, Jijian Wang, Chongrui Jin, Chao Feng, Xiangguo Lyu, Yinglong Sa, Yidong Liu

“…Objectives. To assess the effect of redo inferior pubectomy on the management of complicated pelvic fracture urethral injury (PFUI) in patients with a history of failed anastomotic urethroplasty. …”
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Nitroxyl Hybrids with Curcumin and Stilbene Scaffolds Display Potent Antioxidant Activity, Remodel the Amyloid Beta Oligomer, and Reverse Amyloid Beta-Induced Cytotoxicity by Madhu S. Budamagunta, Hidetoshi Mori, Joshua Silk, Ryan R. Slez, Balázs Bognár, Ulises Ruiz Mendiola, Tamás Kálai, Izumi Maezawa, John C. Voss

“…The disorder and heterogeneity of low-molecular-weight amyloid-beta oligomers (AβOs) underlie their participation in multiple modes of cellular dysfunction associated with the etiology of Alzheimer’s disease (AD). …”
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Organelles Ca2+ redistribution contributes to cadmium-induced EMT of renal cancer cells through p-cPLA2-mediated arachidonic acid release by Jie Gu, Jiacheng Ruan, Chuanzhi Guo, Zehua Li, Huilin Fu, Yimin Xie, Hebing Xie, Xun Gong, Haifeng Shi

“…Previous studies have suggested that Cd2+-altered the AA metabolism associates with renal dysfunction. However, the role and mechanism of Cd2+-regulated AA source in promoting RCC progression are still unclear. …”
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Knockout of Bmal1 in dopaminergic neurons induces ADHD-like symptoms via hyperactive dopamine signaling in male mice by Yichun Zhang, Xin Li, Yong Liu, Xiangyu Li, Dengfeng Liu, Qingyun Han, Xiran Liu, Xuyi Wang, Jia-Da Li, Suixin Deng

“…While dopaminergic dysfunction is strongly associated with mental illnesses, the mechanistic connection between circadian clock genes and dopamine signaling remains elusive. …”
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Reducing Systemic Inflammation in IUGR-Born Neonatal Lambs via Daily Oral ω-3 PUFA Supplement Improved Skeletal Muscle Glucose Metabolism, Glucose-Stimulated Insulin Secretion, and... by Melanie R. White, Rachel L. Gibbs, Pablo C. Grijalva, Zena M. Hicks, Haley N. Beer, Eileen S. Marks-Nelson, Dustin T. Yates

“…Conversely, ω-3 PUFA had little effect on IUGR-induced changes in lipid flux and hematology parameters, did not resolve greater muscle TNFR1, and further reduced muscle β2-adrenoceptor content. …”
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Midregional Proadrenomedullin (MRproADM) Serum Levels in Critically Ill Patients Are Associated with Short-Term and Overall Mortality during a Two-Year Follow-Up by Lukas Buendgens, Eray Yagmur, Axel Ginsberg, Ralf Weiskirchen, Theresa Wirtz, Samira Abu Jhaisha, Albrecht Eisert, Tom Luedde, Christian Trautwein, Frank Tacke, Alexander Koch

“…Adrenomedullin (ADM) is a peptide with pleiotropic effects in systemic inflammation. Its more stable precursor protein midregional proadrenomedullin (MRproADM) can be measured more reliably compared to ADM. …”
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Biomimetic integration of functionally controlled modular tissue building blocks for engineering 3D vascularized adipose tissue by Sangmin Lee, Jeongbok Lee, Hyunseok Kwon, Heungsoo Shin

“…In this study, we propose a novel approach to reconstruct vascularized adipose tissues in vitro by effectively coupling adipogenesis and vasculogenesis. …”
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Lipidomic and transcriptomic profiling reveal alterations in the coexistence of gestational diabetes mellitus and preeclampsia impacting maternal and neonatal outcomes by Chenxiao Zhang, Yanli Huang, Xixian Mai, Lu Liu, Yan Li, Fei Zheng, Judan Cao, Chen Zou, Changshan Wang, Jinjun Ran, Hui Zhang, Xiaonan Wang

“…Our findings indicate that PE and PG groups exhibit more pronounced lipidomic alterations, which are associated with adverse neonatal outcomes, while GDM and PG groups show more significant transcriptomic changes related to maternal neuronal and immune dysfunction, potentially increasing the risk of postpartum depression (PD). …”
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Association between sarcopenic obesity and cardiovascular diseases: the role of systemic inflammation indices by Yuhong Luo, Yuhong Luo, Chen Xin, Chen Xin, Yuhua Liu, Yuhua Liu, Yan Xu, Yan Xu, Guixin Liu, Guixin Liu, Binru Han, Binru Han

“…Adjusted multivariate analysis examined the association between SO and cardiovascular multimorbidities. The moderating effects of AISI and SIRI were analyzed using the Johnson–Neyman method and SPSS Process Macro.ResultsThis cross-sectional study included 1,010 participants aged ≥50 years. …”
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