HIF2α activation and mitochondrial deficit due to iron chelation cause retinal atrophy by Yang Kong, Pei‐Kang Liu, Yao Li, Nicholas D Nolan, Peter M J Quinn, Chun‐Wei Hsu, Laura A Jenny, Jin Zhao, Xuan Cui, Ya‐Ju Chang, Katherine J Wert, Janet R Sparrow, Nan‐Kai Wang, Stephen H Tsang

“…Moreover, suppressing hyperactivity of HIF2α and preserving mitochondrial dysfunction by α‐ketoglutarate (AKG) protects the RPE against lesions both in vitro and in vivo. …”
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Palladium-Based Nanocomposites Remodel Osteoporotic Microenvironment by Bone-Targeted Hydrogen Enrichment and Zincum Repletion by Lubing Liu, Huiying Liu, Xiaoya Lu, Zhengshuai Yin, Wei Zhang, Jing Ye, Yingying Xu, Zhenzhen Weng, Jun Luo, Xiaolei Wang

“…This mechanism disrupts the vicious cycle of autophagic dysfunction–ROS accumulation–macrophage inflammation. …”
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The Interplay between Liver and Adipose Tissue in the Onset of Liver Diseases: Exploring the Role of Vitamin Deficiency by Ivan Tattoli, Aimee Rachel Mathew, Antonella Verrienti, Lucia Pallotta, Carola Severi, Fausto Andreola, Virve Cavallucci, Mauro Giorgi, Mara Massimi, Lapo Bencini, Marco Fidaleo

“…The exact mechanisms remain elusive; however, the crucial involvement of specific vitamins in metabolic functions, alongside the reclassification of liver disease as metabolic dysfunction-associated steatotic liver disease (MASLD), has prompted researchers to investigate the potential cause-effect dynamics between vitamin deficiency and liver disease. …”
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Fructose metabolism and its roles in metabolic diseases, inflammatory diseases, and cancer by Zhenhong Li, Xinzou Fan, Fan Gao, Shengguang Pan, Xiao Ma, Hao Cheng, Hiroko Nakatsukasa, Wei Zhang, Dunfang Zhang

“…The role of fructose in metabolic diseases, including metabolic dysfunction-associated fatty liver disease, hyperinsulinemia, and hyperuricemia, is also highlighted. …”
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Therapeutic intervention with anti-TNF alleviates colonic and hepatic toxicity induced by perfluorooctanoic acid (PFOA)Mendeley Data by Wei Li, Yongjing Qian, Xiaojing Cai, Yu He, Xiannan Meng, Ling Zhang

“…Furthermore, anti-TNF therapy effectively mitigates hepatic inflammation, liver dysfunction, lipid metabolism disturbances, NLRP3 inflammasome activation, and apoptosis in the liver triggered by PFOA. …”
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Physical Activity vs. Pharmacotherapy in PCOS Treatment: A relief of Clinical Evidence on Exercise and Metformine Efficacy by Magdalena Bartold, Janina Pohrybieniuk, Marta Piotraszewska, Maria Grys, Filip Kochański, Karolina Wołk, Magda Skudzińska, Aleksandra Jaskulska, Dominika Błonka, Jan Pietrzak

“…Summary Managing polycystic ovary syndrome (PCOS) effectively involves both exercise and medication. Regular aerobic activity improves insulin sensitivity and reproductive health, while metformin addresses insulin resistance and metabolic issues. …”
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Advancements in mitochondrial-targeted nanotherapeutics: overcoming biological obstacles and optimizing drug delivery by Yang Li, Yang Li, Xiao-meng Li, Li-si Wei, Jun-feng Ye

“…Mitochondria, critical for cellular energy and health, when dysfunctional, contribute to cancer, neurodegenerative diseases, and metabolic disorders. …”
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D‐Aspartate treatment attenuates myelin damage and stimulates myelin repair by Valeria de Rosa, Agnese Secondo, Anna Pannaccione, Roselia Ciccone, Luigi Formisano, Natascia Guida, Roberta Crispino, Annalisa Fico, Roman Polishchuk, Antimo D'Aniello, Lucio Annunziato, Francesca Boscia

“…D‐Aspartate promoting effects on OPC maturation involved the activation of glutamate transporters, AMPA and NMDA receptors, and the Na+/Ca2+ exchanger NCX3. …”
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Increased BNIP3-mediated mitophagy attenuates GDAP1 loss of function - implications for Charcot-Marie-Tooth disease 4A by Li Zhang, Alireza Pouya, Janina Kopetzky, Sara Bitar, Christina Wolf, Federica Dal Bello, David Gomez-Zepeda, Stefan Tenzer, Axel Methner

“…Neural expression of human BNIP3 reduced the detrimental effects of Gdap1 knockdown on eclosion and climbing ability in adult flies, while simultaneous knockdown of both genes was detrimental. …”
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Mitochondria‐Targeted ROS Scavenging Natural Enzyme Cascade Nanogels for Periodontitis Treatment via Hypoxia Alleviation and Immunomodulation by Yanfen Zheng, Liuzhou Mao, Qi Wang, Haohua Hu, Bahriman Xarpidin, Zheng Luo, Yun‐Long Wu

“…Although antioxidants can reduce ROS and inflammation, most lack specificity and have a short residence time, limiting their effectiveness. Since mitochondria are the primary source of ROS, targeting mitochondrial ROS is a promising strategy for periodontitis treatment. …”
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YAP/Smad3 promotes pathological extracellular matrix microenviroment‐induced bladder smooth muscle proliferation in bladder fibrosis progression by Xing‐Peng Di, Xi Jin, Jian‐Zhong Ai, Li‐Yuan Xiang, Xiao‐Shuai Gao, Kai‐Wen Xiao, Hong Li, De‐Yi Luo, Kun‐Jie Wang

“…Patients suffer from bladder dysfunction caused by bladder fibrosis. Moreover, the interactive mechanisms between ECM and bladder fibrosis are still obscure. …”
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An Insulin Upstream Open Reading Frame (INSU) Is Present in Skeletal Muscle Satellite Cells: Changes with Age by Qing-Rong Liu, Min Zhu, Faatin Salekin, Brianah M. McCoy, Vernon Kennedy, Jane Tian, Caio H. Mazucanti, Chee W. Chia, Josephine M. Egan

“…Insulin resistance, stem cell dysfunction, and muscle fiber dystrophy are all age-related events in skeletal muscle (SKM). …”
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Moschcowitz Syndrome – A Rare Conundrum with Acute Pancreatitis – Case Report and Narrative Review of Literature by Debashish Mishra, Ashraf Talat Mohammed Abdelrahman, Abeesh Padmanabha Pillai, Sajid Syed, Mudhasir Ahmad, Sahithi Surapaneni, Mathew Vadukoot Lazar, Yogesh Yadav, Priyanka Gupta, Rakesh Kumar Gupta, Sekhar Warier, Rafeek Puthukudikandyl kader, Devendra Shetty, Baiju Faizal Puthenkote

“… Introduction: Moschcowitz syndrome or Thrombotic Thrombocytopenic Purpura (TTP) is a thrombogenic condition due to deficiency or dysfunction of A disintegrin and metalloproteinase with a thrombospondin type 1 motif member 13 (ADAMTS13), which causes a myriad of clinical presentations. …”
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NLRP3 inflammasome inhibits mitophagy during the progression of temporal lobe epilepsy by Mengqian Wu, Cong Yu, Fuli Wen, Yunfei Li, Xu Zhang, Yinzhou Wang, Xiaoqian Chen, Xingyong Chen

“…Abstract Epilepsy is a neurological disorder involving mitochondrial dysfunction and neuroinflammation. This study examines the relationship between NLRP3 inflammasome activation and mitophagy in the temporal lobe epilepsy, which has not been reported before. …”
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<i>Codium fragile</i> Extract Ameliorates Respiratory Function by Controlling Allergic Inflammation in Ovalbumin-Induced Bronchial Disorders in Mice by Hyo Lim Lee, Yeong Hyeon Ju, In Young Kim, Hye Ji Choi, Yu Mi Heo, Hwa Rang Na, Ho Jin Heo

“…This study investigated the effect of <i>Codium fragile</i> (WCF) water extract in reducing allergic inflammation in ovalbumin (OVA)-induced mice. …”
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The role of exosomes in the mechanisms of inflammation development in patients with cardiovascular pathology and the contribution to therapeutic potential of stem cells by P. F. Muzychenko, Zh. M. Minchenko, T. I. Havrylenko, V. A. Cherniak, S. V. Demidov, N. O. Ryzhkova, O. A. Pidhaina

“…Studies show the indirect effect of exosomes on the immune response activation, coordination of cellular senescence processes and antigen presentation. …”
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Transcriptomic time course of skeletal muscle disuse and rehabilitation in middle‐aged adults by Zachary D. Von Ruff, Sean P. Kilroe, Erik D. Marchant, Emily J. Arentson‐Lantz, Steven Widen, Jill Thompson, Alejandro Villasante‐Tezanos, Elena Volpi, Doug Paddon‐Jones, Blake B. Rasmussen

“…Abstract Disuse drives rapid muscle atrophy and metabolic dysfunction. This study aimed to characterize phenotypic and transcriptomic skeletal muscle changes in middle‐aged individuals during disuse and rehabilitation. …”
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Autoinflammatory diseases. Part 3: NLRP and NLRC inflammasomopathies. Biologic therapies for inflammasomopathies by O.V. Shvaratska, T.A. Bordii, M.V. Kalichevska, O.V. Klymenko, O.M. Taran, O.V. Klimova, Ya.V. Vilenskyi, T.K. Mavropulo

“…Autoinflammation is currently considered a distinct category of immune dysfunction along with autoimmunity/allergy and immunodeficiency. …”
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Unveiling the gut’s plastic predicament: How micro- and nano-plastics drive distinct toxicological pathways in Enchytraeus crypticus by Xing Li, Hao Qiu, Wenxing Li, Cornelis A.M. Van Gestel, Chao Jin, Erkai He

“…Exposure in a simulated soil matrix spiked with MPs and NPs differently reshaped the gut microenvironment of the worms due to their distinct gastrointestinal fate, thereby inducing different adverse effects via distinct molecular signaling pathways. …”
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ACE2 shedding exacerbates sepsis-induced gut leak via loss of microbial metabolite 5-methoxytryptophan by Jiacheng Gong, Haoyang Lu, Yuhan Li, Qihan Xu, Yuanyuan Ma, Anni Lou, Wanfu Cui, Weihua Song, Peng Qu, Zhuoer Chen, Linghao Quan, Xi Liu, Ying Meng, Xu Li

“…Abstract Background Sepsis, a critical organ dysfunction resulting from an aberrant host response to infection, remains a leading cause of mortality in ICU patients. …”
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