Scutellarin prevents obesity-induced renal fibrosis via reduced activation of AP-1 by Haoan Yi, Yibing Jiang, Wei Li, Ling Shen, Wei Zhang, Shude Li, Yushan Xu, Fei Li

“…This study investigates the effect of Scutellarin (SCU) on obesity-induced renal fibrosis. …”
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Yellow Wine Polyphenolic Compounds protect against myocardial ischemia-reperfusion injury in rats by activating Nrf2 nuclear translocation to regulate the balance of mitochondrial... by Lili Xu, Jiedong Zhou, Haifei Lou, Haodi Gu, Haixia Xu, Zuoquan Zhong, Hui Lin, Chengjian Jiang

“…Its mechanisms are closely related to oxidative stress and mitochondrial dysfunction. Yellow Wine Polyphenolic Compounds, a dietary polyphenol with significant antioxidant effects, have been shown to offer protection in various cardiovascular diseases. …”
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Comprehensive analysis of histophysiology, transcriptomics and metabolomics in goslings exposed to gossypol acetate: unraveling hepatotoxic mechanisms by Jun Yu, Jun Yu, Haiming Yang, Jian Wang, Zixin Huang, Shi Chen, Hongchang Zhao, Jun Wang, Zhiyue Wang

“…Although the general toxicity of free gossypol is well-known, its specific effects on the liver—the primary site where it accumulates—are less thoroughly studied, particularly at the molecular level. …”
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Three hospitalized non-critical COVID-19 subphenotypes and change in intubation or death over time: A latent class analysis with external and longitudinal validation. by William S Stringer, Amy S Labar, Joshua D Geleris, Evan V Sholle, David A Berlin, Claire M McGroder, Matthew J Cummings, Max R O'Donnell, Haoyang Yi, Xuehan Yang, Ying Wei, Edward J Schenck, Matthew R Baldwin

“…Our machine learning model can facilitate heterogeneity-of-treatment effect analyses of clinical trials of adults hospitalized with non-critical COVID-19.…”
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A Hydrolyzed Soybean Protein Enhances Oxidative Stress Resistance in <i>C. elegans</i> and Modulates Gut–Immune Axis in BALB/c Mice by Jun Liu, Yansheng Zhao, Fei Leng, Xiang Xiao, Weibo Jiang, Shuntang Guo

“…In immunocompromised mice, 20% HSP alleviated CTX-induced immune dysfunction by increasing peripheral white blood cells and lymphocytes, attenuating thymic atrophy, and reducing hepatic oxidative stress via MDA inhibition. …”
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Cell Homeostasis or Cell Death—The Balancing Act Between Autophagy and Apoptosis Caused by Steatosis-Induced Endoplasmic Reticulum (ER) Stress by Anna Stilkerich, Gerda Schicht, Lena Seidemann, René Hänsel, Adrian Friebel, Stefan Hoehme, Daniel Seehofer, Georg Damm

“…Metabolic-dysfunction-associated steatotic liver disease (MASLD) is a prevalent liver condition with potential progression to cirrhosis and impaired regeneration post-resection. …”
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INFLUENCE OF SINGLE NUCLEOTIDE POLYMORPHISMS OF THE KISS1 GENE ON THE DEVELOPMENT OF ANOVULATORY INFERTILITY IN WOMEN by Анна Николаевна Лысова, Елена Петровна Шатунова, Елена Григорьевна Зарубина

“…The relevance of the problem is associated with the increasing prevalence of anovulatory infertility in women and the need to improve the effectiveness of its treatment. Objective – to study the effect of single nucleotide polymorphisms of the KISS1 gene on the level of sex hormones, regulatory peptins and the development of anovulatory infertility in women. …”
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Skeletal muscle-derived musclin attenuates glycolysis, oxidative stress, and pulmonary hypertension through the NPR3/AKT/mTORC1 pathway by Sun Xiongshan, Wang Jia, Xiao Yi, Li De, Wang Qiang, Guo Wei, Yang Yongjian

“…Musclin is an exercise-responsive myokine that exerts protective effects on cardiovascular diseases. The current study aims to explore the role of musclin in the development of PH. …”
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Mangiferin Alleviates Renal Interstitial Fibrosis in Streptozotocin-Induced Diabetic Mice through Regulating the PTEN/PI3K/Akt Signaling Pathway by Yanyan Song, Wei Liu, Ke Tang, Junting Zang, Dong Li, Hang Gao

“…Mangiferin has shown positive effect on the prevention or treatment of diabetes and its complications. …”
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Liraglutide Attenuates Atorvastatin-Induced Hepatotoxicity by Restoring GLP-1R Expression and Activating Nrf2 and Autophagy Pathways in Wistar Rats by Engy A. Elsiad, Hayat A. Abd El Aal, Hesham A. Salem, Mohammed F. El-Yamany, Mostafa A. Rabie

“…Nonetheless, the potential protective effects of liraglutide (LIRA), a GLP-1R agonist, against atorvastatin (ATO)-induced liver dysfunction have not been fully elucidated. …”
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Impact of respiratory training combined with electrical phrenic nerve stimulation on pulmonary and trunk function in individuals who have recently experienced a stroke by Yan-Fang Sui, Zhen-Hua Song, Jing-Qin Shi, Shan-Shan Wang, Bin-Bin Li, Liang-Qian Tong

“…ObjectiveThis study aims to explore the effects of combining phrenic nerve electrical stimulation with respiratory training on pulmonary and trunk function in post-stroke individuals. …”
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Optimizing cardiometabolic risk in people living with human immunodeficiency virus: A deep dive into an important risk enhancer by Elizabeth A. Kobe, Aarti Thakkar, Sarina Matai, Esra Akkaya, Neha J. Pagidipati, Robert W. McGarrah, Gerald S. Bloomfield, Nishant P. Shah

“…Effective antiretroviral therapy (ART) is now nearly ubiquitous. …”
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HIV as a Cause of Immune Activation and Immunosenescence by T. Sokoya, H. C. Steel, M. Nieuwoudt, T. M. Rossouw

“…At present, the most effective strategy appears to be early antiretroviral treatment initiation. …”
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Successful Diagnosis of Sengers Syndrome Using a Comprehensive Genomic Analysis by Kohta Nakamura, Yukiko Yatsuka, Sachie Naito, Akira Hasegawa, Takeya Kasukawa, Atsushi Kondo, Yoshihito Kishita, Yohei Sugiyama, Takanori Onuki, Tomohiro Ebihara, Tomoko Tsuruoka, Takuya Fushimi, Akira Ohtake, Kei Murayama, Atsuko Imai‐Okazaki, Yasushi Okazaki

“…ABSTRACT Background Sengers syndrome is an autosomal recessive mitochondrial DNA depletion syndrome characterized by hypertrophic cardiomyopathy, congenital cataracts, skeletal myopathy, exercise intolerance, and lactic acidosis. Dysfunction of acylglycerol kinase (AGK) is responsible for the disease, and several AGK gene variants have been reported. …”
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Formulated citrus peel extract gold lotion improves cognitive and functional recovery from traumatic brain injury (TBI) in rats by Cheng Guang, Yue Zhiwei, Wang Liwen, Miyauchi Yutaka, Suzawa Michiko, Li Shiming, Ho Chi‐Tang, Zhao Hui, Chen Naiyao

“…In this study, we explored whether the formatted citrus peel extract gold lotion (GL) could have a therapeutic effect on rats suffered TBI. TBI rat model was prepared by the electric Cortical Contusion Impactor (eCCI) device. …”
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Gut microbiota‐CRAMP axis shapes intestinal barrier function and immune responses in dietary gluten‐induced enteropathy by Zhengnan Ren, Li‐Long Pan, Yiwen Huang, Hongbing Chen, Yu Liu, He Liu, Xing Tu, Yanyan Liu, Binbin Li, Xiaoliang Dong, Xiaohua Pan, Hanfei Li, Yu V Fu, Birgitta Agerberth, Julien Diana, Jia Sun

“…Exogenous CRAMP corrected gliadin‐triggered epithelial dysfunction and promoted regulatory immune responses at the intestinal mucosa. …”
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Identification of a TIGIT-expressing CD8+ T cell subset as a potential prognostic biomarker in colorectal cancer by Shouli Cao, Meidan Wang, Weiqiang Sun, Zhibin Ma, Kun Yang, Ting Li, Ting Li, Xuedan Zhu, Yang Pei, Mingyue Pan, Liqun Wang, Liqun Wang, Honglin Ding

“…TIGIT is an inhibitory immune checkpoint receptor on T cells and NK cells that mediates immunosuppressive effects by binding to ligands on malignant or antigen-presenting cells. …”
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CAPG enhances adipogenesis and inflammatory cytokine expression in adipocytes by Luyao Zhang, Botao Sang, Sainan Li, Ying Li, Dachuan Guo, Qi-Nan Ma, Xiangfei Liu, Xiaoshuo Li, Beidong Chen, Deping Liu

“…ELISA and qPCR results further demonstrated that Capg knockdown effectively attenuated inflammatory responses in adipocytes. …”
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ROS-scavenging hydrogen nanotherapy simultaneously targets inflammation and pain in rheumatoid arthritis by Qiong Wu, Jian Zhang, Yu Nan, Shixin Zhang, Yuyang He, Kexin Ye, Xiaowen Ruan, Sai Kishore Ravi, Hushan Wang, Fangfang Chen

“…Furthermore, hydrogen therapy could effectively restrain the release of inflammatory factors and central sensitization by alleviating mitochondrial dysfunction in peripheral neurons and inhibit NF-κB pathway. …”
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Advances in research on biomaterials and stem cell/exosome-based strategies in the treatment of traumatic brain injury by Wenya Chi, Yingying He, Shuisheng Chen, Lingyi Guo, Yan Yuan, Rongjie Li, Ruiyao Liu, Dairan Zhou, Jianzhong Du, Tao Xu, Yuan Yu

“…Bioscaffolds can mimic the extracellular matrix environment, regulate cellular interactions, and increase the effectiveness of local treatments following surgical interventions. …”
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