A novel photosensitizer DTPP-mediated photodynamic therapy induces oxidative stress and apoptosis through mitochondrial pathways in LA795 cells by Liqing Zheng, Ze Li, Ruibo Wang, Jing Wang, Bochao Liu, Yiying Wang, Shihao Qin, Junying Yang, Jianhua Liu

“…Objective: Investigation of the effects of 5–5- (4-N, N-diacetoxylphenyl)-10,15,20- tetraphenylporphyrin (DTPP)-mediated photodynamic therapy (PDT) on oxidative stress and mitochondrial apoptosis in LA795 lung cancer cells. …”
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Circulating mitochondrial DNA promotes M2 polarization of tumor associated macrophages and HCC resistance to sorafenib by Qi Yang, Mengmeng Cui, Jiaxin Wang, Yuan Zhao, Weitao Yin, Ziqian Liao, Yixuan Liang, Zhixiong Jiang, Yujia Li, Jinrong Guo, Lixia Qi, Jiaxing Chen, Jing Zhao, Dengke Bao, Zhi-Xiang Xu

“…Sorafenib induced mitochondrial dysfunction and promoted the release of mtDNA into extracellular matrix of HCC. …”
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Long-term renal outcomes in COVID-19 survivors: a cohort study by S. Naderi, K. Samadi, A. A. Zeraati, N. Mahdavifar, A. Kaffash, M. Akbari, Z. Jalambadani

“…COVID-19 has been associated with both acute and chronic extrapulmonary complications, including renal dysfunction. Understanding the long-term effects of COVID-19 on renal function is essential for managing recovery in affected individuals.Objective. …”
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Comparative efficacy and safety of statins for osteoporosis: a study protocol for a systematic review and network meta-analysis by Wei Zhu, Nan Xiang, Guangwen Zhou, Mengxin Xiong, Yaojun Xue, Ali Deng, Zhangkui Tan

“…Other studies have further indicated that the therapeutic effect of OP in statin-treated patients is dose dependent. …”
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Machine learning insights on activities of daily living disorders in Chinese older adults by Huanting Zhang, Wenhao Zhou, Jianan He, Xingyou Liu, Jie Shen

“…Additionally, a robust predictive model was developed using longitudinal data from 13,220 individuals, improving the accuracy of ADL disorder risk predictions. 3) The meaning of the finding is that incorporating behavioral interventions into community care strategies can effectively enhance the well-being of older adults by minimizing their risk of ADL dysfunction.…”
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Application of a novel sliding ⁃ traction head holder in craniovertebral junction abnormalities surgery by WU Kun, ZHANG Fan, FAN Tao

“…Demonstrating significant therapeutic effects in the surgical treatment of patients with congenital basilar invagination.…”
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Extra-aural disorders in patients with acoustic trauma who were in the zone of the antiterrorist operation. by T. A. Shidlovs’ka, L. G. Petruk

“…Usage of such survey results allows to prove targeted and timely treatment of patients with acoustic trauma and to provide its effectiveness. The findings deepen our knowledge about the role of cerebral circulation and brain activity in the development of sensoneural hearing impairment in acoustic trauma in real combat conditions.…”
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Quantitative relationship between hippocampal injury and mechanical load and body weight in closed head injury of male rats using quadratic orthogonal regression by Peng Wang, Xuewei Song, Qiushi Wang, Jinlong Qiu, Xiyan Zhu, Tianming Yu, Hongyi Xiang, Hui Zhao

“…Abstract Memory dysfunction, a common symptom following closed head impact injuries, suggests deficits in hippocampal function. …”
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Neurological and organ health risks associated with pesticide mixture exposure in banana farm workers in Moungo Division, Cameroon by Vidal Jules Kamga Nanhah, Leonel Javeres Mbah Ntepe, Boris Ronald Tonou Tchuente, Pauline Vervaine Hagbe, David Goda, Yannick Dudric Enonguene Ekedjoum, Fils Armand Ella, Guy Roussel Takuissu Nguemto, Damaris Enyegue Mandob, Judith Laure Ngondi

“…This study aimed to evaluate chronic pesticide exposure effects on liver, renal, and neurological function among banana workers in the Moungo Division, Cameroon. …”
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Soy-based purified ingredient diet affects mouse gut permeability and the microbiome in fragile X mice by Cara J. Westmark, Cara J. Westmark

“…Although fragile X messenger ribonucleoprotein is ubiquitously expressed, there is a dearth of knowledge regarding its role outside of the brain including effects on gut dysfunction in fragile X. The aim of this study was to generate novel data on gastrointestinal barrier function and the gut microbiome in response to Fmr1 genotype, sex and diet in mice.MethodsFmr1KO male mice and littermate controls in an FVB background were maintained on two purified ingredient diets (AIN-93G with casein protein versus soy protein isolate) versus two standard chows (Teklad 2019 with wheat, corn and yeast protein versus Purina 5015 with wheat, soy, corn, yeast and whey protein sources). …”
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SPTBN1 overexpression ameliorates atherosclerosis by inhibiting oxidative stress and inflammation via regulating the TRIM37/TRAF2/NF-κB pathway by Senyan Wu, Xiaoni Tan, Guobing Cheng

“…This study aimed to elucidate the roles of SPTBN1 in endothelial dysfunction during AS progression. Methods SPTBN1 levels in the plasma samples of AS patients and aortic tissues of AS mouse model were tested. …”
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Male Akita diabetic mice develop underactive bladder independent of NLRP3 that can be prevented with blood glucose control by Austin J. Livingston, J. Todd Purves, Michael R. Odom, Huixia Jin, Francis M. Hughes, Jr.

“…Aim:: Diabetic bladder dysfunction (DBD) is the most common diabetic complication. …”
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Lack of Evidence for the Efficacy of Antifungal Medications to Treat Atopic Dermatitis: A Systematic Review by Luis F. Andrade, Teresa Ju, Parsa Abdi, Michael R. Anderson, Elise Edwards, Nicole Khalil, Olivia Burke, Daniella Jaguan, Jonathan I. Silverberg

“…ABSTRACT Background Atopic dermatitis (AD) is characterised by immune dysregulation and skin‐barrier dysfunction, which can predispose to microbial dysbiosis and skin infections. …”
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Dexmedetomidine improves septic acute kidney injury by inhibiting inflammation and oxidative stress through the activation of the Pink1/Park2 autophagy pathway by Qiuxia Liao, Zhi Feng, Hairong Lin, Ye Zhou, Xinxin Lin, Xiao Lin, Huichang Zhuo

“…Dexmedetomidine—an α2 adrenergic agonist widely used as a sedative—exerts protective effects in SAKI. However, its correlation with autophagy remains unclear. …”
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In vitro and in vivo characterization of wild type BMP9 and a non-osteogenic variant in models of pulmonary arterial hypertension. by Tobias G Schips, Karl W Kavalkovich, Lai-Ming Yung, Salam Ibrahim, Makhosi Edmondson, Zhigang Hong, Chin-Hu Huang, Simon Hinke, Xinkang Wang, Andrea R Nawrocki, Annmarie Winkis, Jinquan Luo, Iman Farasat, Brian Geist, Yang Wang, Russell Bialecki, Jey R Jeyaseelan, David R Bauman

“…Endothelial dysfunction and the resulting vascular remodeling are hallmarks of pulmonary hypertension, a debilitating disease of high arterial pressure in the lungs and the right side of the heart. …”
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Rebamipide (Mucosta®), a clinically approved drug, alleviates neuroinflammation and dopaminergic neurodegeneration in a Parkinson’s disease model by Hye-Sun Lim, Jinyoung Park, Eunjeong Kim, Wonhwa Lee, Hwi-Yeol Yun, Seung Hoon Lee, Gunhyuk Park

“…Abstract Background Parkinson’s disease (PD) is characterized by dopaminergic neuron loss, neuroinflammation, and motor dysfunction. PD is a multifactorial disease, with neuroinflammation driven by NLRP3 inflammasome activation representing an important component of its pathological progression. …”
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Impact of chronic opioid on cognitive function and spermatogenesis in rat: An experimental study by Hamid Norioun, Seyed Jamal Moshtaghian, Firoozeh Alavian, Maryam Khombi Shooshtari, Golnaz Alipour, Saeedeh Ghiasvand

“…Abstract Background: Opioid analgesics like morphine and methadone are widely used for managing severe pain; however, concerns over their potential misuse and adverse effects on the brain and reproductive system are significant. …”
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The Anti-Inflammatory Potential of Tricyclic Antidepressants (TCAs): A Novel Therapeutic Approach to Atherosclerosis Pathophysiology by Majid Eslami, Marzieh Monemi, Mohammad Ali Nazari, Mohammad Hossein Azami, Parand Shariat Rad, Valentyn Oksenych, Ramtin Naderian

“…By inhibiting the NLRP3 inflammasome and suppressing pathways including JAK/STAT, MAPK, and PI3K, these effects are produced, improving endothelial function and reducing oxidative stress. …”
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Assessment of infusion therapy impact on the dynamics of endothelin-1 in patients with acute ischemic stroke by A. I. Semenenko, N. O. Semenenko, Н. I. Hrebtii, S. L. Malуk, R. Ya. Bodnar, O. M. Hinhuliak

“…Intensive therapy with HAES-LX-5 % and HES 130 had a better depressing effect on an increase in EN-1 level than other solutions.…”
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System-wide targeted analysis of oxylipins and lipoproteins in chronic peripheral neuropathic pain—an explorative study by Mika Jönsson, Emmanuel Bäckryd, Stefan Ljunggren, Nina Ottosson, Amaia Jauregi-Miguel, Sara I. Liin, Antonio Checa, Craig E. Wheelock, Bijar Ghafouri

“…Neuroinflammation and oxidative dysfunction, and their reciprocal interplay, are critically involved in the pathophysiology of chronic neuropathic pain (NeuP). …”
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