Tim-3 pathway dysregulation and targeting in sepsis-induced immunosuppression by Jialiu Luo, Cong Zhang, Deng Chen, Teding Chang, Shunyao Chen, Zhiqiang Lin, Chengla Yi, Zhao-Hui Tang

“…There are four different ligands for Tim-3, and accumulating evidence indicates that Tim-3 and its ligands play a crucial role in regulating immune cell dysfunction during sepsis. Anti-Tim-3 antibodies have been applied in the field of cancer immunotherapy and have achieved positive therapeutic effects in some clinical trials. …”
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Flavonoids from Polypodium hastatum as neuroprotective agents attenuate cerebral ischemia/reperfusion injury in vitro and in vivo via activating Nrf2 by Huankai Yao, Ruiqing Wu, Dan Du, Fengwei Ai, Feng Yang, Yan Li, Suhua Qi

“…Further investigations have disclosed AAKR attenuated oxidative stress, mitochondrial dysfunction and following apoptosis resulting from OGD/R. …”
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Poisoning from <i>Alocasia × amazonica</i> Roots: A Case Report by Stanila Stoeva-Grigorova, Stela Dragomanova, Maya Radeva-Ilieva, Gabriela Kehayova, Simeonka Dimitrova, Simeon Marinov, Petko Marinov, Marieta Yovcheva, Diana Ivanova, Snezha Zlateva

“…These superficial and mucosal lesions resolved without the development of adhesions. Systemic effects comprised impaired consciousness indicative of encephalopathy, early metabolic acidosis, pulmonary edema with acute respiratory insufficiency, mild liver dysfunction, and hematuria. …”
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Lipid metabolism-mediated fertility decline in male mice exposed to Fluorene-9-bisphenol: An integrated DNA methylation and transcriptomics analysis by Danni Jiang, Yang Yang, Xiaojuan Han, Qianni Li, Yingxiu Ma, Jun Jiao, Lan Chao

“…Here, a BHPF-exposed mouse model was established to evaluate the effect of BHPF on male fertility. The results showed that BHPF exposure induced reproductive dysfunction, including testis damage, spermatogenesis impairment, steroid hormone disruption and sperm quality degradation. …”
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Resveratrol Protects against Sepsis-Associated Encephalopathy and Inhibits the NLRP3/IL-1β Axis in Microglia by Da-ming Sui, Qun Xie, Wen-jing Yi, Sahil Gupta, Xi-ya Yu, Jin-bao Li, Jun Wang, Jia-feng Wang, Xiao-ming Deng

“…Sepsis-associated encephalopathy (SAE) is characterized as brain dysfunction associated with sepsis. In this study we sought to investigate the effects of resveratrol in mice with SAE, as well as its effects in NLRP3 inflammasome and IL-1β, which were critical in the pathogenesis of SAE. …”
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Approach to Hyperthyroidism by Raisa Chowdhury, Sena Turkdogan, Jennifer A. Silver, Jessica Hier, Stuart Bursey, Danah Quttaineh, Mark Khoury, Lamiae Himdi

“…Management strategies include beta-blockers for symptomatic relief, though side effects such as bradycardia and fatigue may occur. …”
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Sex and regional differences in gene expression across the striatum in psychosis by Megan S. Perez, RuoFei Yin, Madeline R. Scott, Wei Zong, Marianne L. Seney, Xiangning Xue, Mariah A. Hildebrand, Vaishnavi G. Shankar, Jill R. Glausier, David A. Lewis, George C. Tseng, Kyle D. Ketchesin, Colleen A. McClung

“…Overall, we identified regional and sex differences in gene expression across the human striatum that may underlie sex-specific striatal dysfunction and symptomatology in psychosis.…”
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Investigating the efficacy of melatonin, topical sodium citrate, and multivitamin with zinc as a potential treatment for postinfectious loss of smell by Ellen Cristine Duarte Garcia, Letícia Ribeiro Rosa, Ana Caroline Rodrigues dos Santos, Gabrieli Kaori Alves Ishimatsu, Natália Medeiros Dias Lopes, Marco Aurélio Fornazieri

“…Objectives: Upper respiratory tract infections, including COVID-19, are associated with olfactory dysfunction and there is a need for novel therapeutic approaches. …”
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A Phosphatidyl Conjugated Telomerase-Dependent Telomere-Targeting Nucleoside Demonstrates Colorectal Cancer Direct Killing and Immune Signaling by Merve Yilmaz, Sibel Goksen, Ilgen Mender, Gunes Esendagli, Sefik Evren Erdener, Alessandra Ahmed, Ates Kutay Tenekeci, Larisa L. Birichevskaya, Sergei M. Gryaznov, Jerry W. Shay, Z. Gunnur Dikmen

“…In mouse colorectal cancer models, diC6-THIO demonstrated strong anticancer effects alone and in combination with PD1/PD-L1 inhibitors. …”
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Intestinal Epithelial-Derived Exosomes Under Cold Stimulation Promote Adipose Thermogenesis by Xue Han, Tiange Feng, Yaxu Yang, Ziming Zhu, Fangyu Shao, Lijun Sun, Yue Yin, Weizhen Zhang

“…In vitro, Cold IEC-Exo directly stimulated thermogenesis in primary adipocytes by elevating oxygen consumption rate, proton leak, and fatty acid uptake, with no effect on glucose uptake. Small RNA sequencing identified miR-674-3p as a key mediator enriched in Cold IEC-Exo. miR-674-3p mimicry replicated Cold IEC-Exo effects, augmenting <i>Ucp1</i> expression, mitochondrial uncoupling, and fatty acid utilization in adipocytes. …”
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Radiofrequency Electromagnetic and Pulsed Magnetic Fields Protected the Kidney Against Lipopolysaccharide-Induced Acute Systemic Inflammation, Oxidative Stress, and Apoptosis by Re... by Çağrı Balci, Mustafa S. Özcan, Halil Aşci, Pınar Karabacak, Oya Kuruşçu, Rümeysa Taner, Özlem Özmen, Muhammet Y. Tepebaşi, İlter İlhan, Selçuk Çömlekçi

“…<i>Background/Objectives</i>: Sepsis-associated acute kidney injury caused by lipopolysaccharide (LPS) is related to hypoxia, amplification of the inflammatory response, oxidative stress, mitochondrial dysfunction, and apoptosis. This study aims to explore the protective effects of a radiofrequency electromagnetic field (RF-EMF) and a pulsed magnetic field (PMF) on acute kidney injury in rats. …”
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Cell biobank as a necessary infrastructure for the development and implementation of mesenchymal stem cell-based therapy in the treatment of anthracycline-induced cardiotoxicity. L... by L. Yu. Grivtsova, O. E. Popovkina, N. N. Dukhova, O. A. Politiko, V. V. Yuzhakov, L. A. Lepekhina, S. Sh. Kalsina, S. A. Ivanov, A. D. Kaprin

“…Although modern pharmacological treatment of various cardiomyopathies can slow the development of myocardial dysfunction, they have limited effectiveness in patients with end-stage disease. …”
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Feasibility of Xenogeneic Mitochondrial Transplantation in Neuronal Systems: An Exploratory Study by Eriko Nakamura, Tomoaki Aoki, Cyrus E. Kuschner, Yusuke Endo, Jacob S. Kazmi, Tai Yin, Ryosuke Takegawa, Lance B. Becker, Kei Hayashida

“…Mitochondrial transplantation (MTx) has emerged as a potential therapeutic approach for diseases associated with mitochondrial dysfunction, yet its scalability and cross-species feasibility remain underexplored. …”
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Nootkatone Alleviates Type 2 Diabetes in db/db Mice Through AMPK Activation and ERK Inhibition: An Integrated In Vitro and In Vivo Study by Yingjie Li, Linlin Zheng, Mimi Chen, Ruodi Li, Yansu Yu, Lu Qiao, Jialu Liu, Xiaopo Zhang, Yong Zhang, Yuxin Zhang, Wei Zheng

“…Collectively, our findings suggest that Nok exerts anti-diabetic effects via dual modulation of AMPK activation and MAPK inhibition, effectively restoring metabolic homeostasis and mitigating inflammation in T2DM. …”
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TAK-653 Reverses Core Depressive Symptoms in Chronic Stress-Induced Monkey Model by Ling Li, Zhiting Zhang, Xinhe Liu, Mengni Zhou, Shenglin Wen, Ji Dai

“…Recent research has identified dysfunction within the glutamate system as a crucial element influencing both the onset and management of depressive symptoms. …”
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Zearalenone Exposure Damages Skeletal Muscle Through Oxidative Stress and Is Alleviated by Glutathione, Nicotinamide Mononucleotide, and Melatonin by Dandan Li, Wei Fu, Jiyue Zhang, Yaqiu Lin, Xianrong Xiong, Jian Li, Yan Xiong

“…Here, we analyzed the toxic effect of ZEN on muscle and the mitigation of antioxidants (GSH, NMN, and melatonin) for this toxicity. …”
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Altered connection properties of the left dorsolateral superior frontal gyrus in de novo drug-naïve insomnia disorder by Hui Wang, Xianjun Ma, Xingru Xu, Qian Ning, Benyu Qiao, Bofeng Yang, Na Sun, Dong Xu, Xin Tang

“…Receiver operating characteristic analysis showed that the weighted DC of the left dorsolateral SFG effectively differentiates between ID and HC, exhibiting high sensitivity and specificity.ConclusionThis study offers new insights into brain dysfunction and the pathophysiology of ID through voxel-based DC measurements. …”
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EHDPP induces proliferation inhibition and apoptosis to spermatocyte: Insights from transcriptomic and metabolomic profiles by Ying Wang, An-Liang Guo, Yang Xu, Xiaoyan Xu, Lin Yang, Yang Yang, Lan Chao

“…Finally, we found that excessive ROS production caused DNA damage and mitochondrial dysfunction; NAC supplement reversed the side effects of EHDPP such as DNA damage, proliferation inhibition, apoptosis and decline in sperm motility. …”
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CTRP3 attenuates myocardial lipotoxicity via suppression of lipid accumulation, inflammation, apoptosis, and mitochondrial oxidative stress by Qingpeng Wang, Jiangyang Chi, Chen Wang, Yanhong Yuan, Rui Tian, Yun Yang, Xinzhong Chen

“…Nevertheless, its cardioprotective potential against myocardial lipotoxicity remains poorly understood.ObjectiveA comprehensive approach combining in vivo high-fat diet (HFD) murine models and in vitro palmitic acid-induced cardiomyocyte injury systems was employed.Methodsthis study used animal and cellular experiments to verify the function of CTRP3.ResultsHFD feeding induced significant lipid droplet deposition in cardiomyocytes, concomitant with enhanced inflammatory responses, elevated apoptotic activity, and exacerbated oxidative stress, ultimately leading to cardiac dysfunction. Both cardiac-specific CTRP3 overexpression and exogenous recombinant CTRP3 (rCTRP3) administration demonstrated remarkable cardioprotective effects, manifested through: (1) Significant attenuation of intramyocardial lipid accumulation (p &lt; 0.05) (2) Suppression inflammatory pathways (3) Inhibition of mitochondrial-dependent apoptosis (4) Enhancement of antioxidant defense systems. …”
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Exploring the link between dietary inflammatory index and NAFLD through a structural equation modeling approach by Azam Doustmohammadian, Farhad Zamani, James R. Hébert, Maziar Moradi-Lakeh, Sepideh Esfandyiari, Bahareh Amirkalali, Nima Motamed, Mansooreh Maadi, Sherry Price, Esmaeel Gholizadeh, Hossein Ajdarkosh

“…Abstract Nonalcoholic fatty liver disease (NAFLD) or metabolic dysfunction–associated steatotic liver disease (MASLD) is a significant global public health dilemma with wide-ranging social and economic implications. …”
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