Incretin-based therapies for the treatment of obesity-related diseases by Irene Caruso, Angelo Cignarelli, Gian Pio Sorice, Sebastio Perrini, Francesco Giorgino

“…., heart failure) and metabolic diseases (i.e. type 2 diabetes [T2D], metabolic dysfunction-associated steatotic liver disease [MASLD]). …”
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Annona squamosa (custard apple) leaves extract mitigates abemaciclib-induced liver injury (AILI) in male rats by Lashin S. Ali, Gamal Mohamed, Ahmed A. El-Mansy, Khaled S. El-Bayoumi, Mohammed Y. Sobhey, Abd El-Fattah B. M. El-Beltagy, Reham A. Ghanem

“…This study aims to assess the hepatotoxic effects of abemaciclib on male rats and the potential mitigative role of Annona squamosa leaf extract (ALE) against these effects. …”
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Рhotopic Negative Response for Testing the Function of Inner Retina: Registration Requirements and Comparison in the Eyes with Natural Pupil Width and in Conditions of Drug Mydrias... by V. I. Kotelin, M. O. Kirillova, M. V. Zueva, I. V. Tsapenko, A. N. Zhuravleva, O. A. Kiseleva, A. M. Bessmertny

“…Purpose: To evaluate the possibility of registration of the photopic negative response (PhNR) without pupil dilatation in healthy individuals to determine the dysfunction of neurons of the inner retina.Methods: 12 healthy persons (23 eyes) aged 24 to 40 years were examined. …”
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The Role of Ferritin in Assessing COVID-19 Severity by Yu. S. Polushin, I. V. Shlyk, E. G. Gavrilova, E. V. Parshin, A. M. Ginzburg

“…Ferritin is one of the biomarkers requiring special attention; its blood level increases significantly especially in the severe course of COVID-19. Information on the effect of hyperferritinemia on the disease outcome is very contradictory as are the ideas about the causes of its development.The objective: to study the effect of hyperferritinemia on the disease outcome and analyse the possible causes of its development in severe COVID-19.Subjects and Methods. …”
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Adipose Stromal Cell Heterogeneity and Trafficking: Implications for Breast Cancer Metastasis and Obesity by Caroline R. McCauley, Tamara R. Fischer, Nicole M. Cullen, Mackenzie L. Hawes, Khudeja Salim, Devon R. Roeming, Jordan F. Wright, Olivia M. Mayer, Van T. Hoang, Elizabeth C. Martin, Matthew E. Burow, Bruce A. Bunnell

“…This review analyzes ASC migration, the role of ASCs in breast cancer progression and immune modulation, and breast cancer-driven ASC dysfunction to further the understanding of ASCs for future clinical applications.…”
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Mathematics teaching for sustainable development: Challenges and successes by Motshidisi masilo

“…Effective instructional practices must focus on including learners’ cultural and social realities through democratic dialogue. …”
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Mindful Eating Approaches to Cardiometabolic Risk Factors: Systematic Review and Meta-Analysis of Intervention Studies by Paola Iaccarino Idelson, Lanfranco D’Elia, Pasquale Strazzullo

“…Mindful eating was as effective as other recognized types of interventions regarding the clinical outcomes examined, but in many cases, they were more effective in terms of factors which may lead to improvement over a longer period. …”
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Targeting the PI3K-AKT pathway to alleviate 6PPDQ-induced cognitive impairment associated with metabolic syndrome by Leisheng Wang, Yifei Fu, Shiwei Xu, Enhong Chen, Shuo Zhang, Dongjie Yang, Youzhao He, Yuanlong Gu, Yong Mao, Fenglai Yuan, Hao Hu

“…Transcriptomic and Western blot analyses suggest that 6PPDQ disrupts insulin signaling through inhibition of the PI3K-AKT pathway, leading to metabolic and cognitive dysfunction. Notably, treatment with the PI3K-AKT agonist SC79 partially alleviated these effects. …”
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Salidroside enhances 5-fluorouracil sensitivity against hepatocellular carcinoma via YIPF5-induced mitophagy by Sumin Sun, Haili Hu, Feiyu Li, Feiyu Li, Sheng Huan, Long Chen, Jiahui Chen, Peihua Sun, Xiaoqing Dong, Xiaoqing Dong

“…One of our key findings in this endeavour was the potent anti-HCC effect of the natural product Salidroside (Sal) when co-administered with 5-FU. …”
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Time‐restricted feeding mitigates Alzheimer's disease‐associated cognitive impairments via a B. pseudolongum‐propionic acid‐FFAR3 axis by Yihang Zhao, Mengzhen Jia, Chen Ding, Bingkun Bao, Hangqi Li, Jiabin Ma, Weixuan Dong, Rui Gao, Xuhui Chen, Jiao Chen, Xiaoshuang Dai, Yuanqiang Zou, Jun Hu, Lin Shi, Xuebo Liu, Zhigang Liu

“…Experiments in 5xFAD mice corroborated the gut microbiota‐dependent effect of TRF on mitigating cognitive dysfunction, amyloid‐beta deposition, and neuroinflammation. …”
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TNF-α-NF-κB activation through pathological α-Synuclein disrupts the BBB and exacerbates axonopathy by Min-Tae Jeon, Sinnead Anne Cogill, Kyu-Sung Kim, Yongjin Kim, Hyerin Kim, Chung-Yeol Lee, Suji Kim, Suhyeon Son, Jeongyeon Kim, Jaehyeok Lee, Inyeong Park, Mookyung Cheon, Do-Geun Kim

“…Summary: Dysfunction of the blood-brain barrier (BBB) is recognized as a key factor in the progression of neurodegenerative diseases (NDs), but the detailed mechanisms behind its pathogenesis and impact on neurodegeneration remain elusive. …”
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A Novel Mutation Located in the N‐Terminal Domain of MYO15A Caused Sensorineural Hearing Loss by Yanli Wang, Zengping Liu, Yong Li, Zhipeng Nie, Baicheng Xu, Yiming Zhu, Shihong Duan, Xingjian Chen, Huan Tan, Jiong Dang, Minxin Guan, Yufen Guo

“…Results Results showed that this homozygous MYO15A mutation (PVS1 + PM2 + PP1 + PP3), which is located in the N‐terminal domain, displayed significant differences in the morphology and function of hair cell‐like cells between the proband and the normal control, although it had no effect on the totipotency of iPSCs. Conclusion Our study demonstrates that the novel variant c.2482C>T in the MYO15A gene may cause inner ear hair cell dysfunction and audiological disorders in this family.…”
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Diabetic nephropathy: Pathophysiology and potential therapeutic role of plant extracts by Mehak Naseer Mir, Ishfaq Ahmad Malik, Rayees Ahmad Naik, Sonalika Singh, Aabid Rashid Hurra, Zahid Ahmad Wani, Rakhmat Shah, Yaqoob Lone

“…This review underscores the importance of multifaceted therapeutic strategies targeting both metabolic dysregulation and oxidative stress to effectively prevent and manage diabetic nephropathy.…”
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LCN2 induces neuronal loss and facilitates sepsis-associated cognitive impairments by Cuiping Guo, Wensheng Li, Yi Liu, Abdoul Razak Mahaman Yacoubou, Jianzhi Wang, Rong Liu, Shusheng Li, Xiaochuan Wang

“…Interestingly, the recombinant LCN2 protein exhibited similar effects on synaptic dysfunction and cognitive deficits in C57 mice. …”
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Structural Insights into Isovaleryl-Coenzyme A Dehydrogenase: Mechanisms of Substrate Specificity and Implications of Isovaleric Acidemia-Associated Mutations by Kaide Ju, Fang Bai, Youwei Xu, Qingao Li, Gengchen Su, Ye Jin, Houzao Chen, Shuyang Zhang, Xiaodong Luan

“…Additionally, we investigated the impact of various disease-associated hotspot mutations derived from different regions, demonstrating their effects on enzyme stability and activity. Notably, mutations such as A314V, S281G/F382V, and E411K resulted in substantial loss of function, while others exhibited milder effects, which is consistent with our structural analyses. …”
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The combination of hydrogels and rutin-loaded black phosphorus nanosheets treats rheumatoid arthritis by Jing Hou, Shujiang Yin, Runqing Jiao, Wen Chen, Wenjuan Wang, Han Zhang, Zhiyong Liu, Zhenyang Chen, Xing Tian

“…The fluctuating nature of RA often necessitates long-term oral administration of treatment drugs, which can unfortunately lead to adverse effects such as gastrointestinal discomfort and hepatic and renal dysfunction. …”
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Machine learning analysis of ARVC informed by sodium channel protein-based interactome networks by Yanan Zhu, Hui Zhang, Xuan Zhao, Xin Wang, Lina Xing, Sijie Yao, Xiao Jin, Tingting Li, Ting Dai, Xinyue Ding, Zhen Qi, Zongjun Liu

“…BackgroundArrhythmogenic right ventricular cardiomyopathy (ARVC) is an inherited cardiac disorder characterized by sodium channel dysfunction. However, the clinical management of ARVC remains challenging. …”
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Resveratrol attenuates hepatic oxidative stress and preserves gut mucosal integrity in high-fat diet-fed rats by modulating antioxidant and anti-inflammatory pathways by Tahmina Yasmin, Sreelakshmi N. Menon, Ajay Pandey, Shahnaz Siddiqua, Syed Abdul Kuddus, Md. Mizanur Rahman, Ferdous Khan, Nazia Hoque, Md. Sohel Rana, Nusrat Subhan, Emran Habibi, Fatemeh Ramezani, Satyajit D. Sarker, Lutfun Nahar, Md. Ashraful Alam, Raquibul Hasan

“…Abstract This study evaluated the protective effects of resveratrol against high-fat diet (HFD)-induced hepatic dysfunction and intestinal mucus layer depletion with a focus on antioxidant and anti-inflammatory mechanisms. …”
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Long-term dental follow-up in hematological stem cells transplantation children by Luiz Alberto Valente Júnior, Paulo Sérgio da Silva Santos, Fabio Luiz Coracin, Alexandre Viana Frascino, Marcelo Fava, Vicente Odone Filho

“…Temporomandibular joint dysfunction was found to be more prevalent in the patients who was diagnosed with graft-versus-host disease. …”
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Transoral robotic salivary surgery for hilar\parenchymal submandibular stones by Pasquale Capaccio, Pasquale Capaccio, Matteo Lazzeroni, Sara Torretta, Sara Torretta, Lorenzo Salvatore Solimeno, Valentina Cristofaro, Michele Proh, Giovanni Cammaroto, Giuseppe Meccariello, Claudio Vicini, Lorenzo Pignataro, Lorenzo Pignataro

“…In addition, the mean stone size in cases failing TORSS was smaller than that documented in successfully treated patients (7.8 ± 1.8 vs. 9.8 ± 2.4 mm). No major untoward effects were observed (transitory lingual nerve dysfunction in 3 patients undergoing Xi Da Vinci surgery). …”
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