Multi-omics reveals the mechanism of vagus nerve stimulation in the treatment of chronic congestive heart failure by Yuchi Hu, Songyuan Dai, Liling Chen, Xuejuan Ma, Hao Li, Yanan Lu, Chuanxin Li, Xinyun Chen, Hongning Li, Yanzhou Lu, Yimei Huang, Lulu Zhao, Baotong Hua, Ling Zhao

“…In this study, models of CHF and VNS were established prior to performing echocardiography, H&E staining, and flow cytometry to evaluate the effects of VNS on pathological damage associated with CHF and myocardial mitochondrial dysfunction. …”
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Accumulation of advanced oxidative protein products exacerbate satellite glial cells activation and neuropathic pain by Chen Tu, Shi-Cheng Wang, Meng-Xuan Dai, Si-Qi Lai, Zhi-Wei Huang, Yong-Peng Yu, Yun-Biao Chen, Ji-Huan Zeng, Liang Wang, Zhao-Ming Zhong

“…The RAGE inhibitor FPS-ZM1 effectively inhibited AOPPs-induced SGC activation. …”
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The Hidden Dangers: E-Cigarettes, Heated Tobacco, and Their Impact on Oxidative Stress and Atherosclerosis—A Systematic Review and Narrative Synthesis of the Evidence by Arianna Magna, Nausica Polisena, Ludovica Polisena, Chiara Bagnato, Elena Pacella, Roberto Carnevale, Cristina Nocella, Lorenzo Loffredo

“…Furthermore, the chemicals found in electronic cigarette liquids may exacerbate inflammation and cause endothelial dysfunction. Furthermore, through a systematic review, we analyzed the effects of chronic exposure to electronic and heated tobacco cigarettes on endothelial function, as assessed by brachial flow-mediated dilation (FMD). …”
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Immunotherapy against tau fragment diminishes AD pathology, improving synaptic function and cognition by Jie Xiang, Zhengjiang Qian, Ye Xi, Yanuo Wei, Guangxing Wang, Xia Liu, Zhi-Hao Wang, Zhentao Zhang, Shengxi Wu, Keqiang Ye

“…We conducted chronic intraperitoneal administration of the antibody to evaluate its effects on tau aggregation, synaptic integrity, and cognitive function. …”
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Intrinsic factors behind long COVID: exploring the role of nucleocapsid protein in thrombosis by Ahmed Eltayeb, Muhamed Adilović, Maryam Golzardi, Altijana Hromić-Jahjefendić, Alberto Rubio-Casillas, Vladimir N. Uversky, Elrashdy M. Redwan

“…While NPs from other coronaviruses, such as SARS-CoV and MERS-CoV, are known to increase inflammation and cause acute lung injury, the specific effects of the SARS-CoV-2 NP on host cells remain largely unexplored. …”
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Meta-Analysis of Tai Chi Chuan in Treating Lumbar Spondylosis and Back Pain by Fushun Zhang, Junfang Zhao, Nan Jiang, Qiao Zhai, Juanjuan Hu, Jing Zhang

“…Background. The effectiveness of Tai Chi Chuan in treating various ailments has been well reported; however, its effect on back pain and lumbar spondylosis remains unclear. …”
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Thermosensitive hydrogel composite with si-Cx43 nanoparticles and anti-VEGF agent for synergistic treatment of diabetic retinopathy by Lihui Wen, Mengxin Gan, Siying Xiong, Li Dai, Wen Chen, Wen Shi

“…In vitro studies evaluated the cytotoxicity, anti-angiogenic effects, and permeability regulation in hyperglycemic retinal cells under hyperglycemic conditions. …”
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Hyperuricemia, gout and comorbidity by N. A. Shostak, N. G. Pravdyuk, T. K. Loginova, G. N. Lazarenko

“…Current data indicate the presence of pro-inflammatory, pro-oxidant and vasoconstrictive effects of uric acid, which may contribute to the development of cardiometabolic disorders. …”
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TRADITIONAL AND CASCADE PLASMAPHERESIS IN ANTIBODY TITERS’ REDUCTION IN RENAL TRANSPLANT RECIPIENTS by A.V. Vatazin, A.B. Zulkarnayev, R.O. Kantarija, M. Krstich

“…DFPF can safely and effectively reduce the high titers of antibodies that are responsible for humoral rejection of renal allograft. …”
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Maternal cardiovascular adaptation to pregnancy in obese pregnant women by Deesha Patel, Martina Avesani, Mark R. Johnson, Giovanni Di Salvo, Makrina D. Savvidou

“…However, little is known about the effect of obesity on maternal cardiac function. The aim of this study was to investigate the effect of obesity on the maternal cardiovascular system. …”
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Right ventricular function in athletes engaged in endurance exercise using speckle tracking echocardiography: a meta-analysis by Chenzan Guo, Hebin Zhang, Cunxin Yang, Peipei Hu, Hui Ma, Ying Ma, Feng Gao

“…Abstract Background Long-term endurance training is associated with structural, functional, and biochemical markers of cardiac dysfunction in highly trained athletes. Many studies have focused on structural changes in the right ventricle (RV) and few have examined functional adaptation of the right ventricle. …”
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Sexual function and pelvic floor function five years after hysterectomy by Catharina Forsgren, Ulrika Johannesson

“…Abstract Introduction The effects of benign hysterectomy on sexual function and pelvic floor remain uncertain. …”
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Genetic and therapeutic for oral lichen planus and diabetes mellitus: a comprehensive study by Manman Yao, Yueting Lu, Tiejun Liu, Hongyue Shang, Hualin Lu, Bo Dong, Yanzhi Xu

“…It also aims to identify potential pharmacological and herbal treatments that effectively address both OLP and the metabolic dysfunctions associated with DM. …”
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Comparison of peritoneal dialysis and hemodialysis on sleep and life quality in patients with refractory congestive heart failure by YIN Dong-yang, ZHANG Qing-yan, SUN Cheng, XU Peng-fei, SHAO Qiu-yuan, JIANG Chun-ming, ZHANG Miao

“…Objective To investigate the effect of peritoneal dialysis(PD)and hemodialysis(HD)on sleep and life quality in patients with refractory congestive heart failure(RCHF).Methods The clinical data and follow-up material of PD patients(31)or HD ones(17)in Nanjing Drum Tower Hospital Affiliated to Nanjing University Medical School from January 1,2010 to December 31,2017,were analyzed retrospectively.Clinical and laboratory examination data before and 6 months after dialysis,the MOS item short from health survey(SF-36)results,and Pittsburgh sleep quality index( PSQI)were collected for analysis.Through self-contrast of the indices before and after treatment,effects of the two treatment ways on life quality in these patients were compared.Results After six months treatment,both PD and HD effectively improved NYHA classification and B-type natriuretic peptide levels(both P<0.01)with no significant difference between the two treatment ways(P>0.05).Neither PD nor HD significantly improved left ventricular ejection fraction after 6-month dialysis(P>0.05).Except hypnotic drugs and daytime dysfunction,other sleep quality indices were improved significantly the HD patients(P<0.05).In the PD patients,except hypnotic drugs,other 6 sleep quality indices were improved significantly(P<0.05).Total PSQI scores were increased for both HD and PD ways(P<0.05)with no difference between HD and PD(P>0.05).Other 7 life quality indices except emotional function were significantly improved in the HD patients(P<0.01),while all the eight life quality indices were improved in the PD patients(P<0.01).After treatment of 6 months,except physical function other life quality indices for the PD patients were better than those for the HD patients(all P<0.05).Logistic regression analysis showed that PD was associated with better emotional function and physical function than HD(P<0.05).Conclusions Both PD and HD can both improve clinical symptoms and sleep quality in RCHF patients as assessed by NYHA classification and B-type natriuretic peptide levels.However,improvement of life quality for PD was better than that for HD.…”
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Differential regulation of innate immune cytokine production through pharmacological activation of Nuclear Factor-Erythroid-2-Related Factor 2 (NRF2) in burn patient immune cells a... by Timothy K Eitas, Wesley H Stepp, Lucas Sjeklocha, Clayton V Long, Caitlin Riley, James Callahan, Yolanda Sanchez, Peter Gough, Laquanda Knowlin, David van Duin, Shiara Ortiz-Pujols, Samuel W Jones, Robert Maile, Zhi Hong, Scott Berger, Bruce A Cairns

“…Burn patients suffer from immunological dysfunction for which there are currently no successful interventions. …”
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Omega-3 Fatty Acids and Exercise in Obesity Management: Independent and Synergistic Benefits in Metabolism and Knowledge Gaps by Viviana Sandoval, Álvaro Vergara-Nieto, Amanda Bentes, Saulo Silva, Carolina Núñez, Sergio Martínez-Huenchullán

“…Specifically, MICT improves body fat distribution and mitochondrial efficiency, whereas HIIT has notable effects on metabolic adaptability and insulin signaling. …”
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Mitochondrial functional impairment in ARL3‐mutation related rod‐cone dystrophy by Xiaoli Zhang, Shun Yao, Lujia Zhang, Beisi Zhang, Mingzhu Yang, Qingge Guo, Jin Xu, Zhongfeng Wang, Bo Lei, Xiuxiu Jin

“…Conversely, ARL3C118F primarily influenced cell apoptosis with minimal effects on mitochondrial function in ARPE‐19 cells. …”
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Preservation of sexual function with blue laser vaporization in the treatment of benign prostatic hyperplasia: a prospective study by Zun-Jie Hu, Fei Liu, Bing-Hui Li, Yan Hu, Qiao Huang, Cong Zhu, Xian-Tao Zeng, Yong-Wei Zhao

“…We evaluated the treatment’s effectiveness and its impact on preserving sexual function using standardized questionnaires. …”
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Rumex japonicus Houtt. alleviates dextran sulfate sodium-induced colitis by protecting tight junctions in mice by Hee-Young Kim, Hyongjun Jeon, Chang Hwan Bae, Yukyoung Lee, Hyungwoo Kim, Seungtae Kim

“…According to recent studies, plants of the genus Rumex have beneficial functionalities such as anti-microbial, antioxidative, and anti-inflammatory effects. Inflammatory bowel disease, including Crohn's disease and ulcerative colitis, is a chronic inflammatory disease characterized by an abnormal immune response and epithelial barrier dysfunction. …”
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Efficacy and safety of clarithromycin for patients with sepsis or septic shock: a systematic review and meta-analysis by Pengyue Zhao, Renqi Yao, Jiaqi Yang, Wei Wen, Yongming Yao, Xiaohui Du

“…The pooled results confirmed that clarithromycin had no beneficial effect on progression to multiple organ dysfunction syndrome (RR: 1.51; 95% CI: 1.02–2.25; P = 0.04; I2 = 0%), 28-day mortality (RR: 1.09; 95% CI: 0.87–1.36; P = 0.46; I2 = 0%), and 90-day mortality (RR: 0.86; 95% CI: 0.71–1.03; P = 0.10; I2 = 81%) in patients with sepsis or septic shock. …”
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