Secondary prevention of preeclampsia by Muhammad Ilham Aldika Akbar, Muhammad Ilham Aldika Akbar, Roudhona Rosaudyn, Khanisyah Erza Gumilar, Khanisyah Erza Gumilar, Renuka Shanmugalingam, Gustaaf Dekker, Gustaaf Dekker

“…Low molecular weight heparins (LMWH), have pleiotropic effects, besides their anticoagulant effects, LMWH have significant anti-inflammatory effects, and have a potential restricted use in patients with history of prior severe placental vasculopathy with or without the maternal preeclamptic syndrome. …”
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Dimethyl Itaconate Alleviates Escherichia coli‐Induced Endometritis Through the Guanosine‐CXCL14 Axis via Increasing the Abundance of norank_f_Muribaculaceae by Yuhang He, Jiapei Cai, Xufeng Xie, Xinyu Zhang, Linkai Qu, Jiuxi Liu, Yongguo Cao

“…Abstract Endometritis, a prevalent reproductive system disease with high incidence, leads to reproductive dysfunction in humans and animals, causing huge economic losses. …”
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Panaxatriol saponins exert anti-renal fibrosis by suppressing TNF-α mediated inflammation and TGF-β1/Smad3 signaling pathway by Si Yi, Feiyan Li, Xin Ma, Yao Xu, Weijing Lai, Hongxi Chen, Junming Fan, Nan Mao, Sichong Ren

“…Western blotting, quantitative real-time PCR (qRT-PCR), and immunohistochemistry were utilized to validate the involvement of specific signaling pathways in PTS-mediated anti-fibrotic effects. Our data demonstrated that PTS alleviated renal dysfunction and provided protective effects against renal fibrosis, primarily through the TNF-α and TGF-β1 signaling pathways. …”
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Evaluation of predictive value and changes of 99mTc-MIBI clearance and myocardial perfusion in patients with heart failure and indications for cardiac resynchronization therapy by A. I. Mishkina, T. A. Atabekov, A. S. Platonov, S. I. Sazonova, R. E. Batalov, K. V. Zavadovsky

“…To study the significance of 99mTc-MIBI washout rate as a scintigraphic marker of mitochondrial dysfunction in predicting the effectiveness of cardiac resynchronization therapy (CRT), and to evaluate the long-term effect of CRT on 99mTc-MIBI clearance and myocardial perfusion.Material and methods. …”
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Study Protocol: Evaluating the Impact of Diabetic Medications on Semen Quality: A Comparative Analysis of Diabetic Patients and Nondiabetic Controls with Correlation to Fertility P... by Lakhan P. Padwal, Akash More, Namrata Choudhary, Ganesh L. Kalasakar

“…Understanding these effects can lead to personalized treatment approaches that reduce the negative impact on male fertility. …”
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Anticancer Mechanisms of Ginsenoside Compound K: A Review by Yu-Po Lee, Hui-Ting Chan, Tzu-Hsuan Li, Lichieh (Julie) Chu, Sheau-Long Lee, Yu-Quan Chang, Robert YL Wang

“…This modification is focused on identifying methodologies that can effectively target cancerous cells while minimizing damage to normal cells. …”
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The contribution of childhood trauma to irritability symptoms by Lana Ruvolo Grasser, Ruiyu Yang, Melissa A. Brotman, Jillian Lee Wiggins

“…We hypothesized unique effects of threat versus deprivation on irritability. …”
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Phytobiotics in poultry: revolutionizing broiler chicken nutrition with plant-derived gut health enhancers by Uchechukwu Edna Obianwuna, Xinyu Chang, Vivian U. Oleforuh-Okoleh, Patience N. Onu, Haijun Zhang, Kai Qiu, Shugeng Wu

“…The review emphasizes the importance of continued research to refine phytobiotic formulations, explore synergistic effects, and incorporate advanced technologies such as AI-driven methods and precision nutrition to tailor feeding strategies more effectively. …”
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The immediate alteration of cerebellar Glx/GABA and cerebello-thalamo-cortical connectivity in patients with schizophrenia after cerebellar TMS by Chenyang Yao, Youjin Zhao, Qian Zhang, Ziyuan Zhao, Kai Ai, Bo Zhang, Su Lui

“…Abstract Cerebellar dysfunction is a key aspect of schizophrenia, with the cerebello-thalamo-cortical (CTC) hyperconnectivity serving as a neural signature. …”
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High glucose inhibits proliferation, migration, and osteogenic differentiation of human placenta-derived mesenchymal stem cells by Supawadee Duangprom, Pakpoom Kheolamai, Chairat Tantrawatpan, Sirikul Manochantr

“…Abstract Chronic hyperglycemia is recognized as an important contributor to chronic inflammation, oxidative stress, and organ dysfunction that causes serious complications in diabetes and aging. …”
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Vascular endothelial overexpression of human CYP2J2 (Tie2-CYP2J2 Tr) modulates cardiac oxylipin profiles and enhances coronary reactive hyperemia in mice. by Ahmad Hanif, Matthew L Edin, Darryl C Zeldin, Christophe Morisseau, John R Falck, Mohammed A Nayeem

“…EETs and HETEs often have opposite biologic effects; EETs are vasodilatory and protect against ischemia/reperfusion injury, while ω-terminal HETEs are vasoconstrictive and cause vascular dysfunction. …”
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Investigating endocannabinoid system and subjective responses to exercise in cancer patients: Rationale and future research directionsKey Points by Abha Gourshettiwar, Judith Lacey, Shelley Kay, Justine Stehn, Mitchell Low, Birinder S. Cheema

“…However, most cancer patients remain insufficiently active due in part to subjectively reported treatment-related side effects (and late effects) including fatigue, pain, appetite dysregulation, insomnia, cognitive impairment, depression, anxiety, low self-efficacy, and poor motivation. …”
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Hepatic Nuclear Factor Erythroid 2 Related Factor 1 Activity Promotes Host Defense in Endotoxemia and Bacterial SepsisSummary by Michael J. Trites, Lei Li, Uche Njoku, May G. Akl, Aidan Hydomako, Scott B. Widenmaier

“…Background & Aims: Sepsis and endotoxemia cause mortality by inducing organ dysfunction and damage. Liver defends against such insults by mediating metabolic adaptations that promote stress and damage control. …”
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Decreased calcineurin immunoreactivity in the postmortem brain of a patient with schizophrenia who had been prescribed the calcineurin inhibitor, tacrolimus, for leukemia by Wada A, Kunii Y, Matsumoto J, Hino M, Nagaoka A, Niwa S, Yabe H

“…Thus, tacrolimus may introduce side effects such as cognitive dysfunction and extrapyramidal symptoms. …”
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Long-Term Exercise Mitigates Energy Expenditure and Inflammatory Responses Induced by Sleep Deprivation in Mice by Tian-Shu Zheng, Xin-Ran Gao, Chen Gu, Yu-Ning Ru, Rui-Ping Xu, Yu-Hang Yang, De-Hua Wang

“…However, whether exercise can mitigate the adverse effects of unavoidable SD remains unclear. <b>Methods</b>: To explore the protective effects of exercise against SD-induced gut microbiota and metabolic dysfunction, mice were randomly assigned to four groups: control (CTR), exercise (EXE), SD, and exercise + SD (EXE + SD). …”
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Chrysophanol-mediated trx-1 activation attenuates renal fibrosis through inhibition of the JNK/Cx43 signaling pathway by Neng Bao, Jin Wang, Qiyu Yue, Fang Cao, Xuejing Gu, Kejian Wen, Wei Kong, Mingjia Gu

“…In the cell model, the regulatory effect of chrysophanol on the Trx-1/JNK/Cx43 pathway was evaluated using western blotting and flow cytometry.Results Chrysophanol treatment significantly ameliorated renal dysfunction and histopathological damage in the UUO mouse model, accompanied by a reduction in serum oxidative stress markers. …”
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Psilocybin and Motor Function: A Triple‐Blind, Dose‐Finding Study in Healthy Participants by Chiranth Bhagavan, Richard Kanaan, Olivia Carter, Glenn Nielsen, David Berlowitz, Sara Issak, Sabine Braat, Sophie Zaloumis, Zachary Attard, Georgina Oliver, Deanne Mayne, David McKernon, Greg Roebuck, James Rucker, Matthew Butler, Alexander Bryson

“…Moreover, there is a theoretical rationale for using psychedelics to promote motor retraining in certain neuropsychiatric conditions associated with motor dysfunction. This protocol paper outlines the first study to investigate the feasibility and safety of performing movement tasks during the acute effects of psilocybin in healthy participants. …”
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Mitigating Increased Cardiovascular Risk in Patients with Obstructive Sleep Apnea Using GLP-1 Receptor Agonists and SGLT2 Inhibitors: Hype or Hope? by Paschalis Karakasis, Marios Sagris, Dimitrios Patoulias, Theocharis Koufakis, Panagiotis Theofilis, Aleksandra Klisic, Nikolaos Fragakis, Mohamed El Tanani, Manfredi Rizzo

“…These agents, originally developed for T2D management, have demonstrated pleiotropic effects, including significant weight loss, blood pressure reduction, and amelioration of endothelial dysfunction and arterial stiffness, along with anti-inflammatory benefits, which may be particularly beneficial in OSA. …”
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Baicalin reduces sunitinib-induced cardiotoxicity in renal carcinoma PDX model by inhibiting myocardial injury, apoptosis and fibrosis by Zefu Yang, Zefu Yang, Jianping Wan, Xinjin Zhang, Jiaqi Mei, Hua Hao, Sibo Liu, Yun Yi, Meixiu Jiang, Yuanqiao He, Yuanqiao He, Yuanqiao He

“…Moreover, BA effectively protected SU-induced cardiac dysfunction by decreasing injury, apoptosis, and fibrosis. …”
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FGF21 protects against HFpEF by improving cardiac mitochondrial bioenergetics in mice by Ke Zhang, Jing Gan, Baile Wang, Wei Lei, Dong Zhen, Jie Yang, Ningrui Wang, Congcong Wen, Xiaotang Gao, Xiaokun Li, Aimin Xu, Xinguang Liu, Yulin Li, Fan Wu, Zhuofeng Lin

“…Global or adipose FGF21 deficiency exacerbates cardiac diastolic dysfunction and damage in high-fat diet (HFD) plus N[w]-nitro-L-arginine methyl ester (L-NAME)-induced HFpEF mice, whereas these effects are notably reversed by FGF21 replenishment. …”
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