Clinical efficacy of a fixed-dose combination of amlodipine/indapamide/perindopril in patients with hypertension and multiple risk factors by A. A. Pirozhenko, A. S. Ryabtsev, S. V. Shlyk, N. V. Drobotya, V. V. Kaltykova

“…The results of echocardiography indicated left ventricular (LV) hypertrophy (LVH) by left ventricular mass index (LVMI), left ventricular posterior wall thickness (LVPWT), interventricular septum (IVS) and its diastolic dysfunction by E/A, while an increase in CAVI and biological vascular age reflected an increase in arterial stiffness. …”
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Healthy longevity-associated protein improves cardiac function in murine models of cardiomyopathy with preserved ejection fraction by Valeria Vincenza Alvino, Sadie Slater, Yan Qiu, Monica Cattaneo, Khaled Abdelsattar Kassem Mohammed, Seamus Gate, Vealmurugan Sekar, Annibale Alessandro Puca, Paolo Madeddu

“…There is no therapy to prevent heart dysfunction in aging and diabetic individuals. In previous studies, a single administration of the longevity-associated variant (LAV) of the human BPIFB4 gene halted heart decline in older and type 2 diabetic mice. …”
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A model-based spectral directional approach reveals the long-term impact of COVID-19 on cardiorespiratory control and baroreflex by Beatrice Cairo, Francesca Gelpi, Vlasta Bari, Martina Anguissola, Pavandeep Singh, Beatrice De Maria, Marco Ranucci, Alberto Porta

“…Abstract Background Coronavirus disease 19 (COVID-19) patients might develop sequelae after apparent resolution of the infection. Autonomic dysfunction and baroreflex failure have been frequently reported. …”
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Nonlinear association between visceral fat metabolism score and heart failure: insights from LightGBM modeling and SHAP-Driven feature interpretation in NHANES by Ningyi Cheng, Yukun Chen, Lei Jin, Liangwan Chen

“…Correlations validated METS-VF as a composite index of visceral adiposity and metabolic dysfunction (waist circumference r = 0.43, high-density lipoprotein cholesterol r = − 0.38, all P < 0.001). …”
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Outcomes following I-131 treatment with cumulative dose exceeding or equal to 600 mCi in differentiated thyroid carcinoma patients by Chalermrat Kaewput, Pawana Pusuwan

“…Our study suggests that the decision to administer further treatments should be made on an individual basis because beneficial effects may be controversial.…”
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Meconium aspiration syndrome: do we know? by Murat Yurdakök

“…Thirdly, an alternative route for the presence of MSAF in the presence of fetal hypoxia is reduced clearance of defecated meconium due to impaired fetal swallowing or unidentified placental dysfunction in addition to or instead of an increase in its passage. …”
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ZIP7 contributes to the pathogenesis of diabetic cardiomyopathy by suppressing mitophagy in mouse hearts by Ningzhi Yang, Rui Zhang, Hualu Zhang, Yonghao Yu, Zhelong Xu

“…Finally, ZIP7 cKO prevented cardiac dysfunction and fibrosis caused by T2DM. Conclusions ZIP7 upregulation mediates the inhibition of mitophagy by T2DM in mouse hearts by suppressing the PINK1/Parkin pathway. …”
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High-dose thiamine supplementation ameliorates obesity induced by a high-fat and high-fructose diet in mice by reshaping gut microbiota by Yu Xia, Yu Xia, Lulu Wang, Yanyan Qiu, Weihong Ge, Weihong Ge, Weihong Ge

“…Therefore, in the present study, the effects of high-dose thiamine supplementation on HFFD-induced obesity and gut microbiota dysbiosis were investigated.MethodsHFFD-fed mice were supplemented with high-dose thiamine for eight weeks. …”
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What does not Kill You Makes You Stronger: An Online Survey into Healthcare Providers’ Mental Health during Corona Pandemic by Amrita Chakraborti, Suvajit Pal

“…Clarification needed on reported hypersomnia and effect of lockdown activities on mental health.…”
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Barriers to and Facilitators of Implementing Team-Based Extracorporeal Membrane Oxygenation Simulation Study: Exploratory Analysis by Joan Brown, Sophia De-Oliveira, Christopher Mitchell, Rachel Carmen Cesar, Li Ding, Melissa Fix, Daniel Stemen, Krisda Yacharn, Se Fum Wong, Anahat Dhillon

“… Abstract IntroductionExtracorporeal membrane oxygenation (ECMO) is a critical tool in the care of severe cardiorespiratory dysfunction. Simulation training for ECMO has become standard practice. …”
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Inhaled Nitric Oxide as an Adjunct to Thrombolytic Therapy in a Patient with Submassive Pulmonary Embolism and Severe Hypoxemia by Omesh Toolsie, Umut Gomceli, Gilda Diaz-Fuentes

“…We present a patient with hypoxemia and right ventricular dysfunction due to submassive acute pulmonary emboli where iNO was used as a bridge to thrombolysis. …”
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Comparison of Radiographic Reconstruction and Clinical Improvement between Artificial Cervical Disc Replacement and Anterior Cervical Discectomy and Fusion by Yuxiang Chen, Yue Li, Yong Hai, Peng Yin, Yuzeng Liu, Jincai Yang, Qingjun Su

“…This study aimed to evaluate the effectiveness of ACDR on the treatment of CDDD on the aspect of radiographic reconstruction and clinical improvement compared with anterior cervical discectomy and fusion (ACDF). …”
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Combining ROC Curves to Improve Diagnostic Values for Vitamin D3 and Chloride Co-Transporters in Connection to Epilepsy and Sleep Problems, Comorbidities in Autism Spectrum Disorde... by Afaf El-Ansary, Altaf Alabdali, Abir Ben Bacha, Mona Alonazi, Laila Y. Al-Ayadhi

“…The study of GABAergic dysfunction could explain the substantial comorbidity with epilepsy or increased susceptibility to seizures observed in people with autism. …”
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Identifying the role of Phytomolecules in  the management of liver diseases by modulating NRF2 pathway: A Scoping Review Protocol [version 2; peer review: 2 approved] by Richard Lobo, Krishnadas Nandakumar, Priyobrat Rajkhowa, Ajay Mili

“…Oxidative stress is a critical factor in the pathogenesis and progression of various liver diseases, contributing to cellular damage and dysfunction. The Liver is particularly vulnerable to the harmful effects of reactive oxygen species when the balance between their production and the body’s antioxidant defense mechanisms is disrupted. …”
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Levothyroxine therapy and its impact on serum lipids: Addressing dyslipidemia in hypothyroidism by Rohit Kumar Gupta, Rajeev Verma, Manisha Verma, Anirudh Mukherjee, Pramod Kumar, Mahendra Kumar Meena, Manu Sharma

“…Levothyroxine also effectively normalized TSH levels in both subclinical (8.6 ± 0.8 μU/mL to 2.9 ± 1.33 μU/mL) and overt hypothyroidism (45.1 ± 30.4 μU/mL to 3.5 ± 1.1 μU/mL), demonstrating its efficacy in managing thyroid function and associated dyslipidemia. …”
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Ginger (Zingiber officinale) dietary supplementation in mice regulates liver antioxidant defense systems in a dose- and age-dependent by Maima Matin, Kamil Wysocki, Jarosław Olav Horbańczuk, Luciana Rossi, Atanas G. Atanasov, Atanas G. Atanasov

“…IntroductionOxidative stress and impaired antioxidant defenses contribute significantly to liver dysfunction, particularly with aging. This study evaluated the dose- and age-dependent effects of dietary ginger (Zingiber officinale) supplementation on liver antioxidant defense systems in mice.MethodsMale Swiss Webster mice aged 3, 6, and 12 months (n = 48 per age group) received standard feed or feed supplemented with either 0.6% or 1.8% dried ginger powder for 3 months. …”
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Problems of using phenol (hydroxybenzene) and parabens as pharmaceutical stabilizers: analysis using machine learning methods by I. Yu. Torshin, O. A. Gromova

“…Thirdly, teratogenic and other toxic effects on the embryo and pregnancy were demonstrated not only in experimental studies (neurotoxicity and teratogenesis in animal models), but also in clinical observations (metabolic disorders in a pregnant woman, including the metabolism of purines and fatty acids beta-oxidation, hyperactivity and/or excess body weight in children, asthma, thyroid dysfunction, etc.).Conclusion. …”
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Iron Homeostasis as a Mediator Linking Central Obesity with MASLD and Primary Liver Cancer: A Two-Step Mendelian Randomization Study by Yuping Zeng, Xia Wang, Shenlin Liao, Chuan Li, Jie Chen, He He

“…<b>Objectives</b>: This study aimed to explore the mediating effects of iron homeostasis biomarkers linking central obesity with metabolic dysfunction-associated steatotic liver disease (MASLD) and primary liver cancer (PLC) via Mendelian randomization (MR) analysis. …”
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The Impact of Immune Checkpoint Inhibitors on Fertility Preservation and Pregnancy Outcomes by Agata Prokopiuk, Adrianna Tabeau, Agnieszka Pawlik, Patryk Dudek, Klaudia Łuczak, Wiktoria Ulicka, Justyna Pięta, Hanna Sitarek, Joanna Prus, Marcel Chudzikowski

“…Immune checkpoint inhibitors may cause endocrine-related adverse effects, such as hypophysitis, thyroid dysfunction, and adrenal insufficiency, which can disrupt gonadal function. …”
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CARDIORENAL RELATIONS AND QUALITY OF LIFE IN ELDERLY PATIENTS WITH CHRONIC HEART FAILURE IN LONG TERM THERAPY WITH CARVEDILOL AND BISOPROLOL by M. A. Statsenko, I. A. Sporova, S. V. Belenkova, N. N. Shilina

“…It had priority in reduction of myocardial sympathetic overactivity and nephroprotective action. This effect can be clinically valuable in complex long term therapy of elderly patients with CHF and renal dysfunction.…”
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