Jet lag-induced circadian disruption elevates glioma risk by altering molecular profiles in distinct brain regions by Yong Zhang, Wanling Zheng, Rufei Dai, Tianyi Ma, Zonghan Li, Jicheng Li, Jiawei Shen

“…Clock gene mutations amplified these effects, particularly in Bmal1 −/− mice, indicating core clock components as critical modulators of neural oncogenesis. …”
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Comparative evaluation of anesthesia methods for reconstructive carotid surgery by M. I. Neymark, V. V. Shmelyov, Z. A. Titova, S. A. Khaustova, B. A. Shadymov

“…However, more pronounced postoperative cognitive dysfunction was noted when this method of anesthesia was used.Conclusion. …”
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Clinical and neuroimaging aspects of formal thought disorder in schizophrenia: a brief narrative review by O. A. Levada, O. S. Troian

“…Treatment strategies for FTD should include effects on astroglial and microglial dysfunction.…”
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Structured prenatal yoga on endothelial function in high-risk preeclampsia of pregnant women focusing on ET-1/NO ratio by Hamimatus Zainiyah, Bambang Purwanto, Ernawati Ernawati, Raden Argarini, Mukhoirotin Mukhoirotin

“… Introduction: Endothelial dysfunction, marked by a high ET-1/NO ratio, plays a key role in preeclampsia. …”
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Transobturator tape surgery experience: Urodynamic evaluation of 220 patients in a single tertiary center in Turkey by Inal Hasan Ali, Inal Zeynep Ozturk

“…Nevertheless, additional studies are needed to corroborate our findings and determine the long-term effects.…”
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Enhancing quality of life through physical exercise in a patient with triple lumbar disc herniation: A longitudinal case study by Kristina Randow de Almeida, Marko Kapeleti, Vuk Stevanović, Vladimir Mrdaković, Marija Macura

“…It alters functional movement patterns and causes improper compensatory body positioning, leading to muscle dysfunction. Physical exercise is a key treatment for chronic cases. …”
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Phosphodiesterase 10A as a Therapeutic Target in Neuropsychopharmacology: A Review by A. R. Dorotenko, I. M. Sukhanov, G. V. Iskarevskii, A. S. Ulitina, A. A. Savchenko, M. А. Tur

“…The commercial success of selective PDE5 inhibitors for erectile dysfunction and PDE4 inhibitors for respiratory and skin diseases has drawn the close attention of pharmaceutical companies to other PDEs as well. …”
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Impacts of CACNB4 overexpression on dendritic spine density in both sexes and relevance to schizophrenia by Emily M. Parker, Nathan L. Kindja, Rebecca A. DeGiosio, Ryan B. Salisbury, Josh M. Krivinko, Claire E. J. Cheetham, Matthew L. MacDonald, Weijia Fan, Bin Cheng, Robert A. Sweet

“…Genetic studies strongly implicate calcium signaling dysfunction in the etiology of neurodevelopmental disorders including schizophrenia. …”
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Combined Surgical Tactics with Step-up Approach in the Treatment of Infected Acute Pancreatitis by I. A. Kryvoruchko, V. V. Boyko, K. Yu. Parkhomenko, A. G. Drozdova, S. A. Andreieshchev

“…In the regression analysis, only the presence of multiple organ dysfunction before (AUC = 0.867) and after surgery (AUC = 0.930) significantly affected postoperative mortality, but the effect of the prevalence of pancreatic necrosis (AUC = 0.693) on mortality was limited. …”
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Rare Case of Lumbosacral Conjoint Root Diagnosed as Sequestered Disc by MRI: A Case Report by Akram Awadallah

“…Sensation was intact, and there was no loss of sphincters control or bladder dysfunction. A standard plain lumbosacral MRI was performed. …”
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Causal relationship between immune cells and risk of heart failure: evidence from a Mendelian randomization study by Wenjing Cao, Zefu Yang, Liumei Mo, Zhenhao Liu, Jiawei Wang, Zhenhong Zhang, Kui Wang, Wei Pan

“…BackgroundHeart failure (HF) is a clinical syndrome resulting from structural damage or dysfunction of the heart. Previous investigations have highlighted the critical involvement of immune cells in the progression of heart failure, with distinct roles attributed to different types of immune cells. …”
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Visceral adiposity index in patients with coronary artery disease, obesity and type 2 diabetes by A. A. Khorlampenko, V. N. Karetnikova, A. M. Kochergina, Yu. S. Ignatova, E. V. Belik, O. V. Gruzdeva, N. K. Brel, A. N. Kokov, O. L. Barbarash

“…The obtained correlations between VAI and clinical and metabolic parameters confirm the practicability of using it to determine adipose tissue dysfunction in patients with/without CMD. The effect of increased VAI on the cardiovascular risk in high-risk patients requires further study.…”
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Systematic review of thyroid function in NKX2-1-related disorders: Treatment and follow-up. by Beatriz Carmona-Hidalgo, Estefanía Herrera-Ramos, Rocío Rodríguez-López, Laia Nou-Fontanet, José C Moreno, Juan Antonio Blasco-Amaro, Juliane Léger, Juan Darío Ortigoza-Escobar, NKX2-1-Related Disorders Guideline Working Group

“…<h4>Background</h4>NKX2-1, a crucial transcription factor in thyroid, lung, and brain development, is associated with rare disorders featuring thyroid dysfunction, neurological abnormalities, and respiratory symptoms. …”
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Quercetin prevents rats from type 1 diabetic liver damage by inhibiting TGF-ꞵ/apelin gene expression by Gholampour Firouzeh, Abbasi Susan, Karimi Zeinab

“…The current survey aimed to evaluate the ameliorative effect of quercetin (Q) on liver functional disorders and tissue damage developed by diabetes mellitus in rats. …”
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APPLICATION OF PHOSPHODIESTERASE TYPE 5 INHIBITORS SILDENAFIL IN PATIENTS WITH PULMONARY HYPERTENSION by T. V. Martynyuk, Z. H. Dadacheva, V. M. Paramonov, O. A. Arkhipova, S. N. Nakonechnikov, I. Ye. Chazova

“…The key component of the pathogenesis of pulmonary hypertension (PH) is endothelial dysfunction with imbalance between vasodilators and vasoconstrictors and activation of the blood coagulation system. …”
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Impact of rituximab therapy on endothelial function and other markers of atherosclerosisin patients with active rheumatoid arthritis by Aleksandr Vital'evich Volkov, O G Lineva, K Kh Kuzikyants, G V Lukina, E L Nasonov, Aleksandr Vitalyevich Volkov, O G Lineva, K Kh Kuzikyants, G V Lukina, E L Nasonov

“…Endothelial dysfunction plays a key role in the pathogenesis of atherosclerosis. …”
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Adaptation of mitochondrial bioenergetics to coenzyme Q deficiency in human endothelial cells after chronic exposure to bisphosphonates by Adrianna Budzinska, Lukasz Galganski, Krzysztof Wojcicki, Wieslawa Jarmuszkiewicz

“…Abstract Nitrogen-containing bisphosphonates (N-BPs), widely used in bone disease therapy, inhibit the mevalonate pathway, which affects coenzyme Q (CoQ) biosynthesis and may compromise mitochondrial function, particularly in endothelial cells where oxidative stress and mitochondrial dysfunction contribute to cardiovascular disease. This study examined the effects of chronic six-day exposure of human endothelial cells to N-BPs on mitochondrial bioenergetic functions, focusing on drug-induced mitochondrial CoQ (mtCoQ) deficiency. …”
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Polyethylene glycol versus lactulose in the treatment of hepatic encephalopathy: a systematic review and meta-analysis by Gilles Jadd Hoilat, Mohamad Fekredeen Ayas, Judie Noemie Hoilat, Ahmed Abu-Zaid, Ceren Durer, Seren Durer, Talal Adhami, Savio John

“…Background Hepatic encephalopathy (HE) is defined as brain dysfunction that occurs because of acute liver failure or liver cirrhosis and is associated with significant morbidity and mortality. …”
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Levels of Serum 25(OH)VD3, HIF-1α, VEGF, vWf, and IGF-1 and Their Correlation in Type 2 Diabetes Patients with Different Urine Albumin Creatinine Ratio by Ying Shao, Chuan Lv, Qin Yuan, Qiuyue Wang

“…Serum 25(OH)VD3 may have protective effects on DKD partly by inhibiting inflammation, abnormal angiogenesis, and vascular endothelial dysfunction.…”
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A humanized yeast-based toolkit for monitoring phosphatidylinositol 3-kinase activity at both single cell and population levels by Julia María Coronas-Serna, Teresa Fernández-Acero, María Molina, Víctor J. Cid

“…Phosphatidylinositol 3-kinase (PI3K) is a key regulator of phosphoinositide-dependent signaling in mammalian cells and its dysfunction is related to multiple syndromes, including cancer. …”
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