Multi-organ frailty is enhanced by periodontitis-induced inflammaging by Yoshitaka Kase, Satoru Morikawa, Yuji Okano, Tatsuya Hosoi, Takazumi Yasui, Yoko Taki-Miyashita, Mitsutaka Yakabe, Maraku Goto, Kazuyuki Ishihara, Sumito Ogawa, Taneaki Nakagawa, Hideyuki Okano

“…We developed mouse models with varying severity and duration of periodontitis to examine its effects. Methods We generated mouse models with mild and severe periodontitis, categorizing the disease duration into 3-month and 5-month periods for analysis. …”
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Human spinal cord activation during filling and emptying of the bladder by Kofi A. Agyeman, Darrin J. Lee, Aidin Abedi, Sofia Sakellaridi, Evgeniy I. Kreydin, Jonathan Russin, Yu Tung Lo, Kevin Wu, Wooseong Choi, Sumant Iyer, V. Reggie Edgerton, Charles Y. Liu, Vassilios N. Christopoulos

“…Understanding how the spinal cord represents bladder pressure can provide valuable insights into the neural mechanisms underlying bladder control and contribute to developing better therapies for bladder dysfunction. However, measuring neural activity in the human spinal cord is notoriously challenging due to its small size and the surrounding bony and fascial enclosures, limiting the effectiveness of traditional neuroimaging techniques. …”
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Cocaine perturbs neurodevelopment and increases neuroinflammation in a prenatal cerebral organoid model by Jessica L. Davis, Ciaran Kennedy, Ciara L. McMahon, Louise Keegan, Shane Clerkin, Niall J. Treacy, Alan E. Hoban, Yazeed Kelly, Dermot F. Brougham, John Crean, Keith J. Murphy

“…Abstract Prenatal exposure to cocaine causes abnormalities in foetal brain development, which are linked to later development of anxiety, depression and cognitive dysfunction. Previous studies in rodent models have indicated that prenatal cocaine exposure affects proliferation, differentiation and connectivity of neural cell types. …”
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Identifying common pathways for doxorubicin and carfilzomib-induced cardiotoxicities: transcriptomic and epigenetic profiling by Conagh Kelly, Dylan J. Kiltschewskij, Angeline J.W. Leong, Tatt Jhong Haw, Amanda J. Croft, Lohis Balachandran, Dongqing Chen, Danielle R. Bond, Heather J. Lee, Murray J. Cairns, Aaron L. Sverdlov, Doan T. M. Ngo

“…Given this common cardiotoxic effect of these chemotherapies, we aimed to investigate differential and common mechanism(s) associated with Doxorubicin and Carfilzomib-induced cardiac dysfunction. …”
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Comprehensive review of adverse reactions and toxicology in ASO-based therapies for Duchenne Muscular Dystrophy: From FDA-approved drugs to peptide-conjugated ASO by Umme Sabrina Haque, Melissa Kohut, Toshifumi Yokota

“…This results in the absence or dysfunction of the dystrophin protein, leading to muscle weakness, loss of ambulation, respiratory issues, and cardiac complications, often leading to premature death. …”
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NMDA receptor antagonists mitigate COVID-19-induced neuroinflammation and improve survival in a mouse model by Emily R. Prantzalos, Jane P. Chesser, Judy Songrady Logan, Kristen A. McLaurin, Charles D. Anderson, Jon D. Gabbard, William E. Severson, Kenneth E. Palmer, Bobbi Jo Mullins, Linda Dwoskin, Jill R. Turner

“…Interestingly, older adults with neurological dysfunction maintained on N-methyl-d-aspartate receptor (NMDAR) antagonists, such as memantine, had reduced incidence and severity of COVID-19. …”
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Treatment of wrist stiffness through posture orthosis and active exercise: A case report by Paolo Boccolari, Mario Lando, Lucia Zingarello, Leonardo Monzani Vecchi, Roberto Tedeschi, Danilo Donati

“…Introduction: Wrist fractures, particularly the distal radius, can result in significant stiffness and hand dysfunction if not mobilized early. The variable immobilization period post-fracture depends on fracture type, location, stability, and surgical intervention. …”
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Metabolomes of mitochondrial diseases and inclusion body myositis patients: treatment targets and biomarkers by Jana Buzkova, Joni Nikkanen, Sofia Ahola, Anna H Hakonen, Ksenia Sevastianova, Topi Hovinen, Hannele Yki‐Järvinen, Kirsi H Pietiläinen, Tuula Lönnqvist, Vidya Velagapudi, Christopher J Carroll, Anu Suomalainen

“…Inclusion body myositis (IBM), a sporadic inflammatory muscle disease, also shows mitochondrial dysfunction. We investigated whether primary and secondary MDs modify metabolism to reveal pathogenic pathways and biomarkers. …”
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PPARδ Activation Rescues Pancreatic β-Cell Line INS-1E from Palmitate-Induced Endoplasmic Reticulum Stress through Enhanced Fatty Acid Oxidation by Mingming Cao, Yuzhen Tong, Qingguo Lv, Xiang Chen, Yang Long, Li Jiang, Jun Wan, Yuwei Zhang, Fang Zhang, Nanwei Tong

“…Finally, we show that PPARδ could protect pancreatic β cells from palmitate-induced cell death and dysfunction of insulin secretion. Our work elucidates the protective effect of PPARδ on the fatty-acid-induced toxicity of pancreatic β cells.…”
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C-type natriuretic peptide attenuates enhanced glycolysis and de novo pyrimidine synthesis in pericytes of patients with pulmonary arterial hypertension by Minhee Noh, Ankita Mitra, Lisa Krebes, Werner Schmitz, Jan Dudek, Stuti Agarwal, Christoph Maack, Paula Arias-Loza, Takahiro Higuchi, Ivan Aleksic, Vinicio A. de Jesus Perez, Michaela Kuhn, Swati Dabral

“…Abstract Metabolic reprogramming of vascular cells plays a crucial role in Pulmonary Arterial Hypertension (PAH), marked by a shift from oxidative phosphorylation to glycolysis (Warburg effect), altered purine biosynthesis, impaired glutaminolysis and fatty acid oxidation, driving endothelial and smooth muscle cell hyperproliferation. …”
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The Role of Coenzyme Q10 in Modern Medicine: Insights into Energy Metabolism and Antioxidant Therapy by Mateusz Górski, Adrianna Załęska, Mateusz Bychowski, Julia Kwaśna, Izabela Kaźmierczyk, Kacper Lenart, Michał Homza, Natalia Zakrzewska, Szymon Bednarek, Joanna Kulicka

“… Background: Coenzyme Q10 (CoQ10), a key component of mitochondrial energy production and a potent antioxidant, plays an essential role in addressing oxidative stress and mitochondrial dysfunction. Its applications span cardiovascular health, infectious diseases, neurological conditions, reproductive health, and fatigue management. …”
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Female glucagon receptor knockout mice are prone to steatosis but resistant to weight gain when fed a MASH‐promoting GAN diet and a high‐fat diet by Katrine D. Galsgaard, Emilie Elmelund, Jenna E. Hunt, Mark M. Smits, Trisha J. Grevengoed, Christina Christoffersen, Nils J. Færgeman, Jesper Havelund, Nicolai J. Wewer Albrechtsen, Jens J. Holst

“…Thus, glucagon provides a switch from hepatic glucose and lipid storage towards lipid and amino acid breakdown fueling glucose production during fasting. However, the effects of genetic deletion of the glucagon receptor on lipid metabolism are unclear. …”
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Fucoidan from Fucus vesiculosus alleviates MetALD via promoting HIF-1α ubiquitination to suppress peripheral monocyte infiltration by Lei Li, Jialiang Luo, Di Wang, Yuan Chang, Chaohui Duan, Daming Zuo

“…Our findings reveal a previously unrecognized mechanism by which fucoidan exerts its anti-inflammatory effects via targeting the PHD2–HIF-1α axis, offering a promising therapeutic strategy for MetALD.…”
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Excessive expression of progranulin leads to neurotoxicity rather than neuroprotection by Shinya Kusakari, Hiroaki Suzuki, Mikiro Nawa, Katsuko Sudo, Rio Yamazaki, Tamami Miyagi, Tomoko Ohara, Masaaki Matsuoka, Kohsuke Kanekura

“…However, the mechanisms underlying the neuroprotective effects of PGRN remain unclear. To investigate the neuroprotective mechanisms of PGRN in vivo, we generated human PGRN transgenic (Tg) mice using the CAG promoter. …”
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Mechanisms of Neurosyphilis-Induced Dementia: Insights into Pathophysiology by Aya Fadel, Hussain Hussain, Robert J. Hernandez, Amanda Marie Clichy Silva, Amir Agustin Estil-las, Mohammad Hamad, Zahraa F. Saadoon, Lamia Naseer, William C. Sultan, Carla Sultan, Taylor Schnepp, Arumugam R. Jayakumar

“…<i>Treponema pallidum</i> triggers an inflammatory cascade, resulting in neuronal injury and synaptic dysfunction. Abnormal protein accumulations, including TAR DNA-binding protein 43 (TDP-43) and tau, contribute to neuronal loss and cognitive decline. …”
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Cirrhotic cardiomyopathy: a systematic review and meta-analysis of prevalence across various diagnostic approaches by Mohammed Ewid, Suliman Alsagaby, Abdulsalam Al-Ruqi, Odi Al-Shamikh, Abdulelah Aljohani, Mariam Safwan Bourgleh, Moaz Safwana

“…BACKGROUND: Cirrhotic cardiomyopathy (CCM) is a cardiac dysfunction associated with liver cirrhosis, yet no consensus exists on standardized diagnostic criteria. …”
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Harnessing electroacupuncture: a promising strategy against sleep deprivation-exacerbated post-cardiac arrest brain injury by Wenchao Fu, Cong Hu, Can Ma, Shihua Lv, Xianzhang Zeng, Tingting Li, Jiahui Chen, Xiao Han, Xin Tan, Xuefei Li, Wenzhi Li

“…EA treatment significantly attenuated these effects, restoring EAAT2 levels, mitigating calcium overload, and enhancing synaptic integrity. …”
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Selective targeting of genes regulated by zinc finger proteins in endometriosis and endometrioid adenocarcinoma by zinc niflumato complex with neocuproine by Ivana Špaková, Lukáš Smolko, Gabriela Sabolová, Zuzana Badovská, Katarína Kalinová, Corina Madreiter-Sokolowski, Wolfgang F. Graier, Mária Mareková, Janka Vašková, Miroslava Rabajdová

“…In addition, [Zn(neo)(nif)2] affects ROS production and Ca2+ level, possibly pointing to mitochondrial dysfunction as a potential cause for the described apoptosis.…”
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Subclinical rejection and allograft survival in kidney transplantation: protocol for a systematic review and meta-analysis by Takayuki Yamada, Michele Molinari, Arjun Lalit Kalaria, Michele Klein-Fedyshin, Shota Obata, Massiel Cruz-Peralta, Bryce Parrish, Amaan Z Rahman, Rajil B Mehta

“…We will employ a random effects model. We will evaluate heterogeneity using the I2 variable. …”
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Cth/Mpst double ablation results in early onset fatty liver disease in lean mice by Antonia Katsouda, Maria Markou, Dimitrios Valakos, Ioannis Theodorou, Andreas Papapetropoulos

“…Metabolic dysfunction-associated fatty liver disease (MAFLD), a condition that stems from hepatic lipid accumulation in the absence of liver damage and overt inflammation, has become the most common hepatic disorder worldwide. …”
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