Sexual Dimorphism in Cardiometabolic Diseases: From Development to Senescence and Therapeutic Approaches by Thea Chevalley, Marion Dübi, Laurent Fumeaux, Maria Serena Merli, Alexandre Sarre, Natacha Schaer, Umberto Simeoni, Catherine Yzydorczyk

“…Although lifestyle choices in adulthood play a crucial role in the development of these conditions, it is well established that events occurring early in life can have an important effect. Recent research on cardiometabolic diseases has highlighted the influence of sexual dimorphism on risk factors, underlying mechanisms, and response to therapies. …”
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Calcium Channel Blocker Lacidipine Promotes Antitumor Immunity by Reprogramming Tryptophan Metabolism by Yuwen Sheng, Chong Qiao, Zhonghui Zhang, Xiaoke Shi, Linhan Yang, Ruiying Xi, Jialing Yu, Wanli Liu, Guolin Zhang, Fei Wang

“…Abstract Dysfunction of calcium channels is involved in the development and progression of some cancers. …”
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Self‐Healing COCu‐Tac Hydrogel Enhances iNSCs Transplantation for Spinal Cord Injury by Promoting Mitophagy via the FKBP52/AKT Pathway by Zhenming Tian, Han‐Jian Hu, Chun Cheung Chan, Tian Hu, Chaoyang Cai, Hong Li, Limin Rong, Gang‐Biao Jiang, Bin Liu

“…However, challenges such as graft rejection and dysfunction caused by mitochondrial damage persist after transplantation, presenting formidable barriers. …”
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Cholinergic neurotransmission in the anterior cingulate cortex is associated with cognitive performance in healthy older adults: Baseline characteristics of the Improving Neurologi... by Ana de Figueiredo Pelegrino, Mouna Attarha, Paule-Joanne Toussaint, Lydia Ouellet, Sarah-Jane Grant, Thomas Van Vleet, Etienne de Villers-Sidani

“…Aging is associated with dysfunction in the cholinergic system, including degeneration of basal forebrain cholinergic terminals that innervate the cortex, which directly contributes to age- and disease-related cognitive decline. …”
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Study on the Toxicological Impacts of Intraperitoneal Microcystin-LR Injection on GIFT Tilapia (<i>Oreochromis niloticus</i>) Through Multi-Omics Analysis by Haizheng Wu, Haojun Zhu, Quanjie Li, Jiancao Gao, Jinliang Du, Liping Cao, Yi Sun, Gangchun Xu

“…This study employed multi-omics analysis to systematically evaluate the toxic effects of intraperitoneal injection of MC-LR on GIFT tilapia. …”
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Statin therapy associated Lactobacillus intestinalis attenuates pancreatic fibrosis through remodeling intestinal homeostasis by Yuhang Sui, Tao Zhang, Suwen Ou, Guanqun Li, Liwei Liu, Tianqi Lu, Can Zhang, Yukai Cao, Rui Bai, Haoxin Zhou, Xinbo Zhao, Yue Yuan, Gang Wang, Hua Chen, Rui Kong, Bei Sun, Le Li

“…Statins alter gut microbiota and exert anti-inflammatory effects, but its role in CP has not been fully elucidated. …”
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Injectable glycyrrhizic acid-based hydrogel with Immunoregulatory and angiogenic properties for diabetic wound healing by Haisheng Wu, Zichao Xue, Zhigang Wang, Jiacai Mei, Mingzhe Shao, Jian Zhang, Haiyang Hu, Ye Pan

“…The resulting AGA/SFMA@DFO hydrogel effectively modulates macrophage polarization and enhances vascular regeneration under inflammatory conditions. …”
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UCP2 inhibition eliminates pancreatic β cell autoinflammation in T2DM with islet-mitochondrial sequential targeting nanomedicines by Zerun Liu, Wensheng Chen, Jinping Zhang, Ting Huang, Ying Hong, Tianjiao Zhao, Min Liu, Qiaohui Chen, Yongqi Yang, Shuya Wang, Jue Wang, Xiaohong Ying, Yiming Li, Qiong Huang, Kelong Ai

“…Abstract Pancreatic β-cell dysfunction and mass loss are core pathologies of type 2 diabetes mellitus (T2DM), which are closely related to intense autoinflammation. …”
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The Role of Oxidative Stress in Skin Disorders Associated with Alcohol Dependency and Antioxidant Therapies by Joanna Wróblewska, Anna Długosz, Damian Czarnecki, Wioletta Tomaszewicz, Błażej Błaszak, Joanna Szulc, Weronika Wróblewska

“…Antioxidants may offer protective and regenerative effects by scavenging free radicals, modulating inflammatory responses, and enhancing skin barrier function. …”
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The role of HMOX1-mediated ferroptosis in blue light-induced damage to retinal pigment epithelium by Chunyi Ji, Yiqi Wang, Yahan Ju, Siwei Liu, Xirui Chen, Jiajing Wang, Na Sun, Zhimin Tang, Ping Gu, Jing Ji

“…In mice, treatment with ZnPP effectively rescued RPE degeneration and visual function. …”
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L-Ascorbic Acid (LAA) Supplementation as a Potential Treatment for Skin Aging: Regulation of Adipose Tissue Mesenchymal Stem Cells (AT-MSCs) Protein Secretion by Komang Ardi Wahyuningsih, I. Gede Eka Wiratnaya, I. Wayan Weta, I. Gde Raka Widiana, Wimpie I. Pangkahila, Ida Ayu Ika Wahyuniari, I. Made Muliarta, Veronika Maria Sidharta, Assyafiya Salwa

“…Skin aging is mostly caused by the accumulation of reactive oxygen species (ROS) that lead to cellular dysfunction. One promising therapy for skin aging is the secretome product of adipose tissue mesenchymal stem cells (AT-MSCs). …”
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Prospects of finerenone use in Russian population of patients with chronic kidney disease and type 2 diabetes. Resolution of multidisciplinary. Advisory board by M. V. Shestakova, V. A. Dobronravov, A. S. Ametov, M. B. Antsiferov, M. M. Batyushin, I. N. Bobkova, G. R. Galstyan, T. Y. Demidova, V. V. Klimontov, A. M. Mkrtumyan, N. A. Petunina, E. I. Prokopenko, N. V. Chebotareva, M. S. Shamkhalova

“…According to the results of recent clinical studies, the cardio- and renoprotective effects of finerenone were apparent throughout a wide range of CKD C1-C4 in T2D patients, regardless of the severity of kidney dysfunction, the level of HbA1c and other drug therapy. …”
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Priming Mesenchymal Stem Cells with Endothelial Growth Medium Boosts Stem Cell Therapy for Systemic Arterial Hypertension by Lucas Felipe de Oliveira, Thalles Ramos Almeida, Marcus Paulo Ribeiro Machado, Marilia Beatriz Cuba, Angélica Cristina Alves, Marcos Vinícius da Silva, Virmondes Rodrigues Júnior, Valdo José Dias da Silva

“…The central aim of this study was to evaluate whether priming of MSCs with endothelial growth medium (EGM-2) increases their therapeutic effects in spontaneously hypertensive rats (SHRs). …”
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Precise genetic control of ATOH1 enhances maturation of regenerated hair cells in the mature mouse utricle by Tian Wang, Tian Yang, Amanda Kedaigle, Gabriela Pregernig, Ryan McCarthy, Ben Holmes, Xudong Wu, Lars Becker, Ning Pan, Kathy So, Leon Chen, Jun He, Ahmad Mahmoudi, Soumya Negi, Monika Kowalczyk, Tyler Gibson, Noah Druckenbrod, Alan G. Cheng, Joseph Burns

“…In mammals, hair cell loss causes vestibular dysfunction as spontaneous regeneration is nearly absent. …”
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Mediastinal ectopic thyroid tissue as diferential diagnostic problem: A case report by Stojanoski Stefan, Bjelović Milorad, Ilinčić Branislava, Vučković Dejan, Kozić Duško, Medić Stojanoska Milica

“…Clinically, it can manifest with thyroid gland dysfunction or with symptoms and signs caused by a compressive effect on the surrounding structures, but in most cases it is an asymptomatic condition and incidental finding. …”
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Clinical Case-control Study of Postoperative Ocular Microbiota Colonization Using Microbial Analysis in Patients Undergoing Blepharoplasty by Hejia Zhao, PhD, Yanjun Chen, MD, Huamin Mao, MD, Junpu Ye, MD, Min Fu, MD, Jinhao Qiu, MD, Yunhan Zhang, BS, Er Pan, MD, Ke Xiong, MD

“…Subgroup analysis based on age and sex in the surgical group revealed no significant effects of these factors on microbial composition and abundance. …”
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Comparative evaluation of visceral and renal protection methods during thoracoabdominal aortic repair (Experience of Russian Surgery Research Center named after B.V. Petrovsky) by E. Yu. Chepurnyak, Yu. V. Belov, E. R. Charchyan, A. A. Eremenko, L. S. Lokshin, B. A. Аkselrod, O. V. Dymova, K. A. Zinoviev, A. V. Panov

“…The objective: to compare the effectiveness of visceral and renal protection methods during thoracoabdominal aortic (TAA) repair: left atrial-femoral bypass (LAFB) and cardiopulmonary bypass (CPB) in conjunction with selective perfusion (SP) of these organs.Subjects: 81 patients who underwent TAA repair were enrolled in retrospective analysis: LAFB was used in 29 patients (Group 1), CPB and SP ‒ in 52 patients (Group 2).Results. …”
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The Interplay of Iron and Lipid Homeostasis in Non-Alcoholic Fatty Liver Disease by Clinton J. Kidman, Cyril D.S. Mamotte, Keea R. Inder-Smith, Mark J. Tobin, Mark J. Hackett, Ross M. Graham

“…Both iron deficiency and overload have been demonstrated as being involved with metabolic dysfunction; hence, tight regulation of iron absorption is essential to maintain health. …”
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Inhibition of HDAC3 induces neuroprotection by activating the Npas4 signaling pathway following surgical brain injury in rats by Haiping Gu, Yating Gong, Muyao Wu, Mengying Shi, Jiejie Yu, Hongfei Zhu, Ya-ming Sun, Baoqi Dang

“…RGFP966 application can significantly improve brain edema and neurological dysfunction 24 hr after SBI, enhance autophagy, and reduce inflammation. …”
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Stearoyl-CoA desaturase 1 deficiency drives saturated lipid accumulation and increases liver and plasma acylcarnitines by Mugagga Kalyesubula, Helaina Von Bank, Jessica W. Davidson, Maggie S. Burhans, Madelaine M. Becker, Ahmed Aljohani, Judith Simcox, James M. Ntambi

“…Elevated SCD1 expression and its products are associated with obesity, metabolic dysfunction-associated steatotic liver disease, insulin resistance, and cancer. …”
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