Genetic Causality of Hypothyroidism and Adverse Pregnancy Outcomes: A Combined Mendelian Randomisation Study and Bioinformatics Analysis by Feng Z, Dang C, Xu Z, Zhang Y

“…Heterogeneity tests, multiplicity tests and leave-one-out sensitivity analyses did not reveal any heterogeneity or multiplicity effects in the estimated effects of these three exposure factors on the risk of ovarian dysfunction.Conclusion: Our research establishes genetically the causal relationship between pregnancy-related hypertension, hypothyroidism, and poor fetal growth—a relationship that could be linked to endosomal and cellular transport.Keywords: hypothyroidism, adverse pregnancy outcomes, Mendelian randomization, integrated bioinformatics…”
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How to treat not causing harm? by Ekaterina V. Kulchavenya

“…Difficulty selecting drug therapy for patients with intercurrent diseases is demonstrated, selection of drugs exerting the narrowest spectrum of undesirable effects in cases of compulsory polypharmacy is substantiated. …”
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Uncovering mechanism of hepatotoxicity diseases caused by tetrahydrocannabinol based on novel network toxicology and experimental verification by Tiantian Zou, Ruilin Zhang, Liping Hu, Genmeng Yang, Xuanyu Chen, Mengqing Wang, Tiantian Cheng, Shengjie Nie, Linlin Liu, Shijun Hong

“…THC exposure significantly altered the expression patterns of 10 critical target genes: ERBB2, GPX1, MAPK14, NR1H4, SOD1, CXCR2, PPARG, EGFR, TYMS and KDR. The hepatotoxic effects of THC appear to arise from the synergistic interplay of multiple pathways and the coordinated dysfunction of various gene products. …”
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Neck Exercises Versus Myofascial Release for Chronic Tension-Type Headache and Posture: A Randomized Controlled Trial Protocol by Mobina Ahmadi, Mohammadreza Pourahmadi, Mansoureh Togha, Reza Salehi

“…Conclusion: This study compares the effectiveness of a top-down versus a bottom-up physiotherapy approach in CTTH patients with FHP. …”
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Bridging the Gap Between hiPSC-CMs Cardiotoxicity Assessment and Clinical LVEF Decline Risk: A Case Study of 21 Tyrosine Kinase Inhibitors by Zhijie Wan, Chenyu Wang, Shizheng Luo, Jinwei Zhu, Hua He, Kun Hao

“…These adverse effects often lead to treatment discontinuation, severely impacting patient outcomes. …”
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Taurine, alpha lipoic acid and vitamin B6 ameliorate the reduced developmental competence of immature mouse oocytes exposed to methylglyoxal by Saba Mokhtari, Amir Hossein Mahdavi, Farnoosh Jafarpour, Mohsen Rahimi Andani, Maurizio Dattilo, Mohammad Hossein Nasr-Esfahani

“…Previous studies have shown that hydrogen sulfide, a gasotransmitter with anti-AGEs effects, is produced in a process influenced by vitamin B6. …”
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HPA system in anxiety disorder patients treated with cognitive behavioural therapy: A review by Jennifer Lange, Angelika Erhardt-Lehmann

“…To conclude, cortisol seems to be a promising candidate to depict several aspects of AD-related disease status and CBT effects, however, additional prospective studies are needed to evaluate the mode of applications of this marker in the clinical routine.…”
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ACTIVITY OF NITRO-OXIDATIVE PROCESSES IN PREGNANT WOMEN WITH IDIOPATHIC ARTERIAL HYPOTENSION by Leonid Markin, Olena Popovych, Alla Popovych

“…Significant increase in peroxynitrite is one of the causes of endothelial dysfunction. In pregnant women with IAH due to the low content of H2S - its vasoconstrictive effects are prevalent, which may indicate an indirect interaction between both of these systems of vasoregulation.…”
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Characteristics of the Autonomic Nervous System State in Patients with Systemic Lupus Erythematosus with the Different Activity Degree According to the Indices of Heart Rate Variab... by Abrahamovych U.

“…The state of the autonomic NS in patients with SLE with varying degrees of activity is characterized by a decrease in the total activity of vegetative effects on the heart rhythm due to the reduction of sympathetic and parasympathetic effects, as well as the humoral component. …”
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CGKRK-targeted lipid nanoparticles enhance in vivo rosiglitazone delivery to the placenta to ameliorate murine preeclampsia by Ke Li, Xiaoyan Jia, Dawei Guo, Haiming Wang, Haonan Shui, Hongbo Qi, Hua Zhang

“…Summary: Placenta-targeting nano-drugs have emerged as a safe and effective treatment option for preeclampsia (PE). Downregulation of peroxisome proliferator-activated receptor γ (PPARγ) induces dysfunctional placental trophoblasts and facilitates placental reactive oxygen species, which weakens the PGC1α/UCP2 oxidative stress pathway, causing PE symptoms. …”
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Viral mitochondriopathy in COVID-19 by Tsung-Hsien Chen, Tien-Hsin Jeng, Ming-Yang Lee, Hsiang-Chen Wang, Kun-Feng Tsai, Chu-Kuang Chou

“…These changes drive both acute COVID-19 and its longer-term effects, known as “long COVID”. This review examines new findings on the mechanisms by which SARS-CoV-2 affects mitochondria and for the impact on chronic immunity, long-term health risks, and potential treatments.…”
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Hydrogen inhalation in rehabilitation program of the medical staff recovered from COVID-19 by L. V. Shogenova, Thi Tuet Truong, N. O. Kryukova, K. A. Yusupkhodzhaeva, D. D. Pozdnyakova, T. G. Kim, A. V. Chernyak, Е. N. Kalmanova, O. S. Medvedev, T. A. Kuropatkina, S. D. Varfolomeev, A. M. Ryabokon, O. А. Svitich, M. P. Kostinov, Ibaraki Kunio, Maehara Hiroki, A. G. Chuchalin

“…Inhalation therapy with H(H2O)m in the rehabilitation program of COVID-19 survivors during the recovery period is a safe and highly effective method. Manifestations of silent hypoxemia and endothelial dysfunction decreased, while exercise tolerance increased. …”
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CDC7 Inhibition Potentiates Antitumor Efficacy of PARP Inhibitor in Advanced Ovarian Cancer by Shini Liu, Peng Deng, Zhaoliang Yu, Jing Han Hong, Jiuping Gao, Yulin Huang, Rong Xiao, Jiaxin Yin, Xian Zeng, Yichen Sun, Peili Wang, Ruizi Geng, Jason Yongsheng Chan, Peiyong Guan, Qiang Yu, Bin‐Tean Teh, Qingping Jiang, Xiaojun Xia, Ying Xiong, Jianfeng Chen, Yongliang Huo, Jing Tan

“…Collectively, this study presents an effective treatment strategy for patients with advanced OV by combining CDC7 inhibitors (CDC7i) and PARPi, offering a promising therapeutic approach for patients with limited response to PARPi.…”
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Longitudinal profiling of host response and oropharyngeal respiratory microbiome reveals dynamic alterations during recovery from community-acquired pneumonia by Lizhe Hong, Lijun Suo, Kang Chang, Hongyun Cao, Jiahui Luan, Fuxin Zhang, Xiaofeng Yu, Xiaohui Zou, Bo Liu, Bin Cao

“…We observed CAP patients mounted rapid, effective, and moderate immune responses against infection. …”
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β‐Glucuronidase‐Expressing Lactobacillus reuteri Triggers Irinotecan Enterotoxicity Through Depleting the Regenerative Epithelial Stem/Progenitor Pool by Bei Yue, Ruiyang Gao, Ling Zhao, Donghui Liu, Cheng Lv, Ziyi Wang, Fangbin Ai, Beibei Zhang, Zhilun Yu, Xiaolong Geng, Hao Wang, Kang Wang, Kaixian Chen, Chenghai Liu, Zhengtao Wang, Wei Dou

“…CPT11‐treated mice exhibited significant colon shortening, inflammatory infiltration, intestinal barrier dysfunction, and ISC impairment, which correlated with gut dysbiosis, enrichment of GUS‐expressing bacteria, and intraluminal SN38 accumulation. …”
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Antioxidant Supplementation in Childhood Obesity: A Path to Improved Metabolic Health? by Ancuta Lupu, Cristina Maria Mihai, Felicia Dragan, Irina Tarnita, Mirabela Alecsa, Tatiana Chisnoiu, Ionela Daniela Morariu, Magdalena Cuciureanu, Alin Horatiu Nedelcu, Delia Lidia Salaru, Emil Anton, Ciprian Danielescu, Silvia Fotea, Gabriela Stoleriu, Omer Faruk Beser, Vasile Valeriu Lupu

“…Childhood obesity is linked to heightened oxidative stress, a key driver of endothelial dysfunction, inflammation, and metabolic complications. …”
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Nonobese mice with nonalcoholic steatohepatitis fed on a choline‐deficient, l‐amino acid‐defined, high‐fat diet exhibit alterations in signaling pathways by Noriko Suzuki‐Kemuriyama, Akari Abe, Sae Nakane, Kinuko Uno, Shuji Ogawa, Atsushi Watanabe, Ryuhei Sano, Megumi Yuki, Katsuhiro Miyajima, Dai Nakae

“…Here, we analyzed the effects of dietary methionine content on NASH induced in mice fed on a choline‐deficient, methionine‐lowered, l‐amino acid‐defined high‐fat diet (CDAHFD). …”
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The impact of garlic use on human health. A review of its therapeutic potential and application in athletes by Michał Borawski, Aleksandra Ciuła, Anna Jakubiak, Joanna Miśkiewicz, Klaudia Mularczyk, grzegorz Karaban, Magdalena Kupis, Tadeusz Kuźnieców, Patrycja Znamirowska, Monika Paszkowska

“…The review explores the effects of garlic on hypertension, lipid metabolism, atherosclerosis, retinopathy, physical performance, organ perfusion, and the risk of developing certain malignancies — particularly gastric and prostate cancers. …”
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Presymptomatic targeted circuit manipulation for ameliorating Huntington’s disease pathogenesis by Ebenezer C. Ikefuama, Ashley N. Slaviero, Alexander D. Silvagnoli, Emmanuel L. Crespo, Raegan Schalau, Madison Gott, Maya O. Tree, Gary L. Dunbar, Julien Rossignol, Ute Hochgeschwender

“…Here, we investigated the effect of presymptomatic cell-type specific manipulation of activity of pyramidal neurons and parvalbumin interneurons in the M1 motor cortex on disease progression in the R6/2 HD mouse model. …”
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SST neurons in the periaqueductal gray regulate urination and bladder function by Junan Yan, Ziyan Gao, Xianping Li, Jun Li, Chunhui Yuan, Shanshan Liang, Jun Li, Guoxian Deng, Lingxuan Yin, Shutong Pang, Wei Shao, Xiaowen Xia, He Zhu, Jiwei Yao

“…Moreover, activation of l/vlPAG SST+ neurons projecting to the pontine micturition center (PMC) elicited urination and bladder contraction, effects that were absent following pelvic nerve transection. …”
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