Exhaustion of Activated CD8 T Cells Predicts Disease Progression in Primary HIV-1 Infection. by Matthias Hoffmann, Nikos Pantazis, Genevieve E Martin, Stephen Hickling, Jacob Hurst, Jodi Meyerowitz, Christian B Willberg, Nicola Robinson, Helen Brown, Martin Fisher, Sabine Kinloch, Abdel Babiker, Jonathan Weber, Nneka Nwokolo, Julie Fox, Sarah Fidler, Rodney Phillips, John Frater, SPARTAC and CHERUB Investigators

“…In Cox models, progression to the trial endpoint was most marked for PD-1/CD38 co-expressing cells, with evidence for a stronger effect within 12 weeks from confirmed diagnosis of PHI. …”
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Nicotinamide mononucleotide combined with PJ-34 protects microglial cells from lipopolysaccharide-induced mitochondrial impairment through NMNAT3-PARP1 axis by Jia Li, Xiao-Yu Cheng, Rui-Xia Ma, Bin Zou, Yue Zhang, Miao-Miao Wu, Yao Yao, Juan Li

“…Abstract Lipopolysaccharide (LPS) is known to induce cell injury and mitochondrial dysfunction, which are pivotal in neuroinflammation and related disorders. …”
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Outlook for the Use of Neurodevelopmental Therapy in Children with Perinatal Central Nervous System Damage: a Review by Maya A. Khan, Elena V. Kostenko, Natalya A. Mikitchenko, Maria G. Degtyareva, Zareta Kh. Shungarova

“…There was a decrease in the manifestations of oral motor dysfunction, salivation, and improved chewing when using this method. …”
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Alterations of the interactome of Bcl-2 proteins in breast cancer at the transcriptional, mutational and structural level. by Simon Mathis Kønig, Vendela Rissler, Thilde Terkelsen, Matteo Lambrughi, Elena Papaleo

“…Their dysfunction enables cancer cells to evade cell death. …”
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HIF-1α alleviates ferroptosis in ulcerative colitis by regulation of GPX4 by Weitao Hu, Yanliang Cai, Daxing Cai, Zongchi Chen, Siying Huang, Su Zhang, Huie Zhuang, Taiyong Fang, Xiaoqing Chen

“…This study aimed to explore the potential effect of hypoxia inducible factor-1α (HIF-1α) on ferroptosis in intestinal epithelial cells (IECs) in UC. …”
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Purslane oleracea polysaccharides alleviate male reproductive damage caused by acrylonitrile by improving gut microbiota dysbiosis and metabolic disorder by Weihua Li, Hongbing Li, Jing Wu, Chenggang Jia, Yanli Lei

“…Integrative analyses revealed a strong association between gut microbiota imbalance, metabolic alterations, and reproductive dysfunction, highlighting the protective role of POP in mitigating ACN-induced adverse effects. …”
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Metformin hydrochloride improves hepatic glucolipid metabolism in diabetes progression through SIRT5-mediated ECHA desuccinylation by Liang Tang, Qing Sun, Jinling Luo, Suying Peng

“…In vitro, DMBG mitigated PA-induced alterations in glucose consumption and mitochondrial dysfunction in HepG2 cells, an effect that was abrogated upon SIRT5 knockdown. …”
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The protective properties of resveratrol against glycerol-induced acute kidney injury in rats by Mohammadreza Baghishani, Soghra Mehri, Tahereh Aminifard, Amirhossein Jafarian, Hossein Hosseinzadeh

“…Resveratrol (RSV) is a polyphenol compound with anti-inflammatory and antioxidant effects and it is found in various plants. This research evaluated the protective effects of RSV in rhabdomyolysis-induced AKI in rat kidneys.Materials and Methods: Thirty-six male Wistar rats were randomly assigned to six groups (n=6): 1) control (normal saline), 2) glycerol only (10 ml/kg, intramuscular), 3, 4, and 5) glycerol +RSV (5, 10, and 25 mg/kg, intraperitoneal injection) and 6) RSV (25 mg/kg). …”
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Precision targeting in acupuncture: a pilot and feasibility study protocol of ultrasound-guided approach for non-specific low back pain by Zihan Liu, Tianying Chang, Jili Fu, Hui Chi, Xiaodan Wang, Lisha Wang, Wenqi Cui, Yingzi Cui, Zhibin Cong

“…As its secondary objective, the treatment effectiveness will be assessed by observing the changes in the patient’s pain level and low back dysfunction before and after treatment. …”
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Develop a prognostic and drug therapy efficacy prediction model for hepatocellular carcinoma based on telomere maintenance-associated genes by Jian-Hao Zheng, Ding Shi, Yun-Jie Chen, Jian-Ping Liu, Zheng Zhou

“…Immune profiling indicated notable disparities in immune infiltration among these groups, with high-risk patients displaying elevated Tumor Immune Dysfunction and Exclusion (TIDE) scores, suggesting potential immune evasion.ConclusionIn short, our prognosis model based on TMGs effectively categorized HCC patients using risk scores, enabling dependable prognostic forecasts and identification of potential therapeutic targets for personalized treatment in HCC management. …”
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Non-Adrenergic Vasopressors in Patients with or at Risk for Vasodilatory Shock. A Systematic Review and Meta-Analysis of Randomized Trials. by Alessandro Belletti, Mario Musu, Simona Silvetti, Omar Saleh, Laura Pasin, Fabrizio Monaco, Ludhmila A Hajjar, Evgeny Fominskiy, Gabriele Finco, Alberto Zangrillo, Giovanni Landoni

“…Catecholamines side effects such as increased myocardial oxygen consumption and development of arrhythmias are well known. …”
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From genes to therapy: a lipid Metabolism-Related genetic risk model predicts HCC outcomes and enhances immunotherapy by Lei Xu, Ting Xiao, Tengfei Chao, Huihua Xiong, Wei Yao

“…The immune signature associated with the risk model was also evaluated by the CIBERSORT algorithm, tumor immune dysfunction and exclusion algorithm, and single sample gene set enrichment analysis. …”
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A Scoping Review on Cognition in Myelodysplastic Syndromes: Advances and Challenges by Anna Tsiakiri, Konstantinos Frigkas, Pinelopi Vlotinou, Menelaos Papoutselis, Foteini Christidi, Efstratios Karavasilis, Ioannis Kotsianidis, Nikolaos Kourkoutsakis, Konstantinos Vadikolias, Konstantinos Liapis

“…These impairments are linked to systemic inflammation, neurotoxic treatment effects, and the psychological burden of chronic disease. …”
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HEART AND VESSEL REMODELING IN DIFFERENT AGE GROUPS OF PATIENTS WITH ARTERIAL HYPERTENSION by V. N. Kandilova

“…It is known that each of the factors (arterial hypertension (AH) and age) has a negative effect on the remodeling of both the heart and vessels, while their combined effect has not been sufficiently studied. …”
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Modulation of Rage and CD147 in Cerebral Amyloid Angiopathy <i>in vitro</i> by A. I. Mosiagina, E. B. Boytsova, E. D. Khilazheva, E. A. Teplyashina, A. V. Morgun, A. B. Salmina

“…In the study of Alzheimer’s disease (AD), the cause-and-effect relationship between neurodegenerative changes and the accompanying amyloid angiopathy is becoming increasingly important. …”
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The role and regulatory mechanism of miR-122-5p in the process of pilon fracture healing by Yang Zhang, Yingnan Li, Min Zhou, Lichang Yang

“…The overexpression of miR-122-5p enhanced the proliferation ability of osteoblasts, inhibited cell apoptosis, and upregulated the expressions of ALP, OCN, and RUNX2; knockdown of miR-122-5p elicits opposite effect. PDCD4 is a direct target of miR-122-5p. The osteoblast dysfunction induced by miR-122-5p inhibitors can be reversed by down-regulating PDCD4. …”
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Higher Circulating Lymphocytes and the Incidence of Pre-eclampsia and Eclampsia by Qiuping Zhao, Rongmei Liu, Hui Chen, Xiaomo Yang, Jiajia Dong, Minfu Bai, MingYang Yu, Zeying Feng, Dingyuan Zeng

“…Excessive immune activation contributes to the onset of early dysfunction of the maternal-fetal interface, and it is closely linked to the development of pre-eclampsia. …”
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<i>Lactiplantibacillus plantarum</i> 1008 Promotes Reproductive Function and Cognitive Activity in Aged Male Mice with High-Fat-Diet-Induced Obesity by Altering Metabolic Parameter... by Chin-Yu Liu, Tsung-Yu Tsai, Te-Hua Liu, Ting-Chia Chang, Yi-Wen Chen, Chih-Wei Tsao

“…Moreover, LP1008 exerted antioxidant, anti-inflammatory and anti-apoptotic effects in aged, obese male mice. LP1008 reversed diet-induced obesity, age-related reproductive dysfunction and pathological damage by increasing testosterone levels and altering the gut microbiome through the regulation of mediators involved in oxidative stress, apoptosis and inflammation.…”
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The prolyl 4-hydroxylase inhibitor GSK360A decreases post-stroke brain injury and sensory, motor, and cognitive behavioral deficits. by Jin Zhou, Jie Li, Daniel M Rosenbaum, Jian Zhuang, Carrie Poon, Pu Qin, Katrina Rivera, John Lepore, Robert N Willette, Erding Hu, Frank C Barone

“…Thus, our goal was to investigate the effect of pre-stroke surgery brain protection using a verified GSK360A PHD inhibition paradigm on post-stroke surgery outcomes. …”
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Exosome circ-CBLB promotes M1 macrophage polarization in rheumatoid arthritis through the TLR3/TRAF3 signaling axis by Mengyu Zhang, Lei Wan, Xiaojun Zhang, Siyu Wang, Feng Li, Dawei Yan

“…This inflammation leads to the degradation of joint cartilage and bone, resulting in joint dysfunction and deformity. Early symptoms of RA are often subtle, complicating timely diagnosis. …”
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