Repair of infarcted myocardium by skeletal muscle-derived mesenchymal stromal cells delivered by a bioprinted collagen patch by Rose Guesdon, Serena Santoro, Audrey Cras, Etienne Pagin, Didier Serteyn, Justine Ceusters, Fabien Guillemot, Albert Hagège, Philippe Menasché

“…This study assessed the effects of another under-investigated cell source: the skeletal muscle whose autologous MSC feature the clinically appealing advantage of being retrievable by a minimally invasive microbiopsy. …”
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Massive Activation of GABA_A Receptors: Rundown, Ionic and Neurodegenerative Consequences by Sergey A. Menzikov, Danila M. Zaichenko, Aleksey A. Moskovtsev, Sergey G. Morozov, Aslan A. Kubatiev

“…Massive activation can also induce the rundown effect of the receptor function. This rundown effect partly involves phosphorylation, Ca²⁺ and the processes of receptor desensitization. …”
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Andrographolide Inhibits Nuclear Factor-κB Activation through JNK-Akt-p65 Signaling Cascade in Tumor Necrosis Factor-α-Stimulated Vascular Smooth Muscle Cells by Yu-Ying Chen, Ming-Jen Hsu, Cheng-Ying Hsieh, Lin-Wen Lee, Zhih-Cherng Chen, Joen-Rong Sheu

“…Critical vascular inflammation leads to vascular dysfunction and cardiovascular diseases, including abdominal aortic aneurysms, hypertension, and atherosclerosis. …”
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TDP-43 overexpression in the hypothalamus drives neuropathology, dysregulates metabolism and impairs behavior in mice by Sofia Bergh, Nicolas Casadei, Sanaz Gabery, Oskar Simonsson, João M. N. Duarte, Deniz Kirik, Huu Phuc Nguyen, Åsa Petersén

“…Taken together, AAV-vector mediated TDP-43 overexpression in the hypothalamus leads to neuropathology with the development of metabolic dysfunction and apathy-like behavior. These results indicate that TDP-43 can exert direct pathological effects in the hypothalamus, which may contribute to the development of the non-motor phenotype in TDP-43 proteinopathies.…”
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The study of miR-130a expression and its mechanism of action in peripheral blood endothelial progenitor cells (EPCs) in type 2 diabetes mellitus (T2DM) by Yawei Cai, Yao Zhu, Ning Xu, Tongen Chen

“…In this study, we aim to investigate the potential involvement of the TGFβ1/miR-130a/IL-18 axis underlying the dysfunction of endothelial progenitor cells (EPCs) in T2DM patients. …”
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A nonsense mutation in mouse Tardbp affects TDP43 alternative splicing activity and causes limb-clasping and body tone defects. by Thomas Ricketts, Philip McGoldrick, Pietro Fratta, Pietro Fratta, Hugo M de Oliveira, Rosie Kent, Vinaya Phatak, Sebastian Brandner, Gonzalo Blanco, Linda Greensmith, Abraham Acevedo-Arozena, Elizabeth M C Fisher

“…Attempts to model TDP43 dysfunction in mice have used knockouts or transgenic overexpressors, which have revealed the difficulties of manipulating TDP43, whose level is tightly controlled by auto-regulation. …”
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INNOVATIVE ASPECTS OF OPEN INGUINAL HERNIA SURGERY: REDUCING COMPLICATIONS AND PREVENTING RECURRENCES by К. Рахманов, О. Хужамов, С. Давлатов, Б. Хамдамов, С. Янченко, Н. Абдуллаєва, З. Джалілова

“…The present study is aimed at improving the effectiveness of treatment, reducing the frequency of relapses and complications, as well as improving long-term treatment outcomes. …”
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The Use of Antioxidants for Cardiovascular Protection in Fetal Growth Restriction: A Systematic Review by Charmaine R. Rock, Suzanne L. Miller, Beth J. Allison

“…This systematic review aimed to determine whether antenatal antioxidant intervention can effectively protect the developing cardiovascular system in FGR. …”
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Assessment Of The Impact Of Alcohol Intake On Cognition – A Cohort Study by Deekshitha Alla

“…Besides these socioeconomic effects, alcoholism also results in various degrees of physiological aberrations that lead to abnormalities in cognitive and behavioral functions. …”
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Inotropes and Vasopressors Use in Critical Care and Perioperative Medicine: Evidence-Based Approach (Review) by A. Belletti, M. L. Azzolini, L. Baldetti, G. Landoni, A. Franco, A. Zangrillo

“…Norepinephrine has been traditionally considered contraindicated in patients with ventricular dysfunction, but recent trials suggested hemodynamic effects similar to epinephrine in patients with cardiogenic shock. …”
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Lipopolysaccharide-Induced Transcriptional Changes in LBP-Deficient Rat and Its Possible Implications for Liver Dysregulation during Sepsis by Zhixiang He, Zichen Song, Leilei Meng, Wenhui Cheng, Fan Huang, Mao Zheng, Wenhui Xu, Rong Xiao, Haoshu Fang, Yaling Zhu

“…Sepsis is an organ dysfunction caused by the dysregulated inflammatory response to infection. …”
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MicroRNA-15a, microRNA-15b and microRNA-16 inhibit the human dopamine D1 receptor expression in four cell lines by targeting 3′UTR –12 bp to + 154 bp by Xue Wu, Feng-ling Xu, Xi Xia, Bao-jie Wang, Jun Yao

“…Background The abnormal expression Dopamine D1 receptor (DRD1) gives rise to the dysfunction of dopaminergic neurotransmitter and may be associated with the occurrence of schizophrenia. …”
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The relationship between proteinuria and coronary risk: a systematic review and meta-analysis. by Vlado Perkovic, Christine Verdon, Toshiharu Ninomiya, Federica Barzi, Alan Cass, Anushka Patel, Meg Jardine, Martin Gallagher, Fiona Turnbull, John Chalmers, Jonathan Craig, Rachel Huxley

“…These estimates were combined using a random-effects model. Sensitivity analyses were conducted to examine possible sources of heterogeneity in effect size. …”
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Lumbopelvic Stability and Trunk Muscle Contractility of Individuals with Chronic Ankle Instability by Ryan S McCann, Kelly Johnson, Ashley M B Suttmiller

“…# Background Chronic ankle instability (CAI) results in hip neuromuscular impairments that can perpetuate dysfunction through reduced lumbopelvic stability and subsequent malpositioning of the lower body during functional movement. …”
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Creative use of Clear Aligners with Tongue Spikes for Open Bite Correction: A Case Report by Ricardo Alexandre Laske, Rosilene Andrea Machado, Gil Guilherme Gasparello, Thiago Martrtins Meira, Orlando Motohiro Tanaka

“…This case report demonstrates the effectiveness of using clear aligners with sharpened tongue spurs to address orthodontic relapse, misalignment, and AOB in an adult female patient. …”
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THYROID STATUS AND ITS CORRELATION WITH THE FUNCTIONAL ACTIVITY OF IMMUNOCYTES by V. V. Zdor, E. V. Markelova, B. I. Geltser

“…These effects may involve either primary activation of mast cells by thyroid hormones, or secondary changes of thyroid status. …”
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Japan Diabetes Complications Study: Revisiting one of the first large‐scale clinical studies in East Asians with diabetes by Hirohito Sone, Chika Horikawa, Sachiko Tanaka‐Mizuno, Ryo Kawasaki, Kazuya Fujihara, Tatsumi Moriya, Atsushi Araki, Shiro Tanaka, Yasuo Akanuma

“…It aimed to evaluate the effects of intensive lifestyle interventions on diabetic complications. …”
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A high-fat diet exacerbates arsenic toxicity in various organs. A systematic review of toxicity and mechanism by Hoda Vahedi, Fateme Pourmotahari, Ali Akbar Oroojan, Amin Rasekhian, Soheila Alboghobeish

“…Interestingly, this combination also caused reduced weight gain despite increased insulin resistance and β-cell dysfunction. Modulation of hepatic autophagy pathways emerged as a possible mechanism linking arsenic toxicity to metabolic dysregulation. …”
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IVF/ICSI treatment for patients with diminished ovarian reserve with or without Kuntai capsule pretreatment: a retrospective cohort study stratified by a controlled ovarian stimula... by Xiaoju Wan, Min Yu, Xingwu Wu, Zhihui Huang, Jun Tan

“…BackgroundKuntai capsules, a traditional Chinese medicine, are speculated to improve the treatment outcomes of patients with ovarian reserve dysfunction (DOR), but existing evidence is limited.ObjectiveTo investigate the effects of Kuntai capsule pretreatment on the IVF/ICSI treatment outcomes of DOR patients with different ovarian stimulation regimens (PPOS, antagonists, and microstimulation).MethodA retrospective cohort study design was used to include 7271 DOR patients who underwent IVF/ICSI between January 2015 and February 2025. …”
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Bariatric Surgery Impact on Women with Polycystic Ovary Syndrome: A Prospective Cohort Study by Shumin Li, Xin Huang, Han Zhao, Shaozhuang Liu, Shigang Zhao

“…These findings suggest that while bariatric surgery effectively improves metabolic health and ovulation in PCOS, its long-term hormonal and ovarian effects remain unclear and require further investigation. …”
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