ROS-responsive nanoparticles for bioimaging and treating acute lung injury by releasing dexamethasone and improving alveolar macrophage homeostasis by Wenna Fan, Yongyao Tang, Yamin Liu, Ya Ran, Guangrui Pan, Xin Song, Li Mai, Xue Jiang, Dan Chen, Fangzhou Song, Haiyu Li

“…Conclusions This protective effect is mediated through the regulation of intracellular Ca2+ levels and mitochondrial respiratory chain complexes, suggesting RCMNs as a therapeutic strategy for mitochondrial dysfunction in ALI. …”
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Curcumin alleviates visceral adiposity via inhibiting GIP release from hypoxic intestinal damage in MASH rats by Yingyi Liao, Xingyu Xie, Zixin Lin, Ning Huang, Guilan Wei, Jiazhen Wu, Yucui Li, Jiannan Chen, Ziren Su, Xiuting Yu, Liping Chen, Yuhong Liu

“…Abstract Visceral adiposity is an important characteristic of metabolic dysfunction-associated steatohepatitis (MASH) that affects its development. …”
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Knowledge domains and hotspots in corticosteroid use for cardiac surgery: a 23-Year bibliometric and visualized analysis by Wan-wan Zou, Qi-kun Zhu, Song Yang, En-ze Bian, Wei-zhong Zhuang, Jian-zheng Cen, Qiang Gao

“…Keyword co-occurrence analysis revealed four primary clusters: cardiopulmonary bypass, systemic inflammatory response, methylprednisolone, and dysfunction. Over recent decades, research focus has shifted from examining how prophylactic corticosteroid use attenuates postoperative inflammation to investigating its potential effects on clinical complications following cardiac surgery. …”
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Hyaluronic acid-tailored prodrug nanoplatforms for efficiently overcoming colorectal cancer chemoresistance and recurrence by synergistic inhibition of cancer cell stemness by Xirui Duan, Hailong Tian, Peilan Peng, Ping Zhou, Ning Ding, Guowen Liu, Gary T. Bentley, Canhua Huang, Jun Yang, Ke Xie

“…Simultaneously, HCQ effectively inhibited autophagy to disrupt the self-protection mechanism of CRC cells. …”
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C(60) fullerene restores gastrocnemius contractile activity in a rat model of neurogenic muscle atrophy by M. S. Anhelov, T. Yu. Matviienko, O. V. Lynchak, O. V. Korzhyk, Yu. M. Valetskyi, K. I. Bogutska, Yu. I. Prylutskyy

“…In our opinion, C60 fullerene prevented significant dysfunction of the gastrocnemius muscle after neurogenic atrophy by exerting an antioxidant effect and improving its contractile activity.…”
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BPA and low-Se exacerbate apoptosis and mitophagy in chicken pancreatic cells by regulating the PTEN/PI3K/AKT/mTOR pathway by Wenying Sun, Yutian Lei, Zhihui Jiang, Kun Wang, Huanyi Liu, Tong Xu

“…Objectives: An in vivo model was established to investigate the effects of BPA and low-Se on chicken pancreatic tissue, and identify the possible potential molecular mechanism. …”
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Bacterial microcompartments and energy metabolism drive gut colonization by Bilophila wadsworthia by Lizbeth Sayavedra, Muhammad Yasir, Andrew Goldson, Arlaine Brion, Gwenaelle Le Gall, Mar Moreno-Gonzalez, Annalisa Altera, Michael D. Paxhia, Martin Warren, George M. Savva, A. Keith Turner, Naiara Beraza, Arjan Narbad

“…Abstract High-fat diets reshape gut microbiota composition and promote the expansion of Bilophila wadsworthia, a sulfidogenic bacterium linked to inflammation and gut barrier dysfunction. The genetic basis for its colonisation and physiological effects remain poorly understood. …”
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Urinary and serum biomarkers of renal injury in coronary artery bypass grafting: a prospective evaluation with new biomarkers’ by Antônio Felipe Leite Simão, Gdayllon Cavalcante Meneses, Lia Cavalcante Cezar, Letícia Machado de Araújo, Alice Maria Costa Martins, Heraldo Guedis Lobo Filho, Bruna Viana Barroso Martins, Geraldo Bezerra da Silva Júnior, Elizabeth De Francesco Daher, José Glauco Lobo Filho

“…Abstract Introduction: Cardiopulmonary bypass (CPB) for coronary artery bypass grafting (CABG) often causes kidney dysfunction and increases morbidity and mortality. …”
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Selenium mitigated cadmium-induced ovarian retardation in female Procambarus clarkii by regulating vitellogenin synthesis and transfer in the hepatopancreas by Huijun Yang, Yifan Yang, Aijie Mo, Yongchao Yuan

“…Selenium (Se) is recognized for mitigating heavy metal toxicity, though its protective effects against Cd in aquatic crustaceans remain underexplored. …”
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New Insights into the Role of Cellular Senescence and Its Therapeutic Implications in Ocular Diseases by Junying Wu, Xiuxing Liu, Yidan Liu, Wenru Su, Yehong Zhuo

“…The process of aging exerts profound effects on various physiological systems, leading to the progression of chronic degenerative disorders and pathologies associated with advancing age. …”
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Systemic DNA damage in Brazilian farmers exposed to pesticides by Melissa Mancini, Maria Eduarda Vieira Cerny, Natali Silva Cardoso, Gabriela Batista Cordeiro Deckmann, Sharbel Weidner Maluf

“… The chronic health effects of pesticides exposure include reproductive damage, neurological damage, hormonal dysfunction, and cancer; the genotoxic effects of pesticides are the primary factor contributing to carcinogenesis. …”
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Cortical Gyrification and Cognitive Decline in the Human Brain With Type 2 Diabetes Mellitus by Weiye Lu, Yuna Chen, Zidong Cao, Zhizhong Sun, Wenbin Qiu, Limin Ge, Xin Tan, Yi Liang, Shijun Qiu

“…The aim of this cross‐sectional study was to assess the potential negative effects of glucose metabolism levels on cognition and cortical gyrification in T2DM. …”
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IMMEDIATE AND LONG-TERM RESULTS OF VARIOUS TREATMENT STRATEGIES FOR PATIENTS WITH MACROFOCAL RECURRENT MYOCARDIAL INFARCTION by G. A. Gazaryan, Y. V. Taraseyeva, M. A. Sagirov, L. G. Tyurina, M. N. Zhizhina, E. A. Nefedova, Kh. G. Alidzhanova

“…Aim of study: to assess the effectiveness of invasive treatment strategies in patients with repeated myocardial infarction (rMI). …”
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Chromium picolinate prevents the development of oxidative-nitrosative stress and restores endogenous H(2)S production in the rat brain under rotenone-induced toxicity by A. O. Mykytenko, I. S. Hrytsenko, A. Y. Semenchuk, M. V. Voroniuk, V. V. Kovpak, O. Y. Akimov, K. S. Neporada

“…Energy deficit, mitochondrial dysfunction and oxidative stress induced by rotenone may play a decisive role in the pathogenesis of neurodegenerative disorders. …”
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Selenium-enriched and ordinary green tea extracts prevent high blood pressure and alter gut microbiota composition of hypertensive rats caused by high-salt diet by Meirong Wu, Xiaobin Wu, Jiangxiong Zhu, Fanglan Li, Xinlin Wei, Yuanfeng Wang

“…Besides, the key parameters associated with oxidative stress, inflammation and endothelial dysfunction were also altered by GT and Se-GT treatments. …”
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Dapagliflozin in Chronic Kidney Disease: Insights from Network Pharmacology and Molecular Docking Simulation by Atthaphong Phongphithakchai, Aman Tedasen, Ratana Netphakdee, Rattana Leelawattana, Thatsaphan Srithongkul, Sukit Raksasuk, Jason C. Huang, Moragot Chatatikun

“…Chronic kidney disease (CKD) involves inflammation, oxidative stress, and fibrosis, leading to renal dysfunction. Dapagliflozin, an SGLT2 inhibitor, shows renoprotective effects beyond glucose control, but its precise molecular mechanisms remain unclear. …”
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Cymbopogon citratus Essential Oil Protects Tubular Renal Cells against Ischemia/Reoxygenation Injury - Involvement Nrf2/Keap1 Pathway by Duaran Lopes de Sousa, Mary Anne Medeiros Bandeira, Igor Lima Soares, Bruna Ribeiro Duque, Mac Dionys Rodrigues da Costa, Glautemberg de Almeida Viana, Emanuel Paula Magalhães, Ramon Róseo Paula Pessoa Bezerra de Menezes, Tiago Lima Sampaio, Márcia Machado Marinho, Alice Maria Costa Martins

“…Abstract Ischemia and reoxygenation (I/R) cause acute kidney injury with progression related to oxidative damage, mitochondrial dysfunction and cell death. Nrf2-Keap1 pathway is involved in this process. …”
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Pulmonary Involvement Caused by Primary Sjogren’s Syndrome: The Pilot phase of Iran Primary Sjogren’s Syndrome Registry by Asghar Hajiabbasi, Hoorvash Ebrahimi, Irandokht Shenavar Masouleh, Samira Forouzan, Amirmohammad Ghanbari, Azita Tangestaninejad, Pooneh Ghavidel Parsa

“…This disease can be associated with systemic complications such as polyarthritis, autonomic dysfunction, pancreatitis, vasculitis, and kidney and lung complications. …”
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Noninvasive ventilation in critically ill very old patients with pneumonia: A multicenter retrospective cohort study. by Bruno A M P Besen, Marcelo Park, Otávio T Ranzani

“…IMV) and hospital mortality adjusting for confounding factors. We evaluated effect modification with interaction terms in pre-specified sub-groups.…”
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A Real-World Experience With Resmetirom: Tolerability and Access by Sameera Shuaibi, Ian Tobal, James Gore, Ruona Ebiai, Claire Ozoral, George Therapondos

“…Background and Aims: Metabolic dysfunction–associated steatohepatitis (MASH) is a progressive liver disease often leading to cirrhosis. …”
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