Compound 48/80 increases bladder compliance by activating MMP-2 and inhibiting TIMP-2 by Pragya Saxena, Ashika Goel, Eli Broemer, Emma Darios Flood, Osvaldo Jose Vega-Rodriguez, Gerald Mingin, Sara Roccabianca, Nathan R. Tykocki

“…While the effects on detrusor excitability depended on urothelial prostaglandin production, the mechanisms by which compound 48/80 altered mechanical compliance remained unclear. …”
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A triterpene-enriched natural extract from Eucalyptus tereticornis modulates the expression of genes involved in adipogenesis, lipolysis, and extracellular matrix remodeling in a p... by Sergio Acin, Alejandro Mejia-Garcia, Geysson Javier Fernandez, Norman Balcazar

“…(Myrtaceae), with ursolic acid, oleanolic acid, and ursolic acid lactone mixed with minor metabolites, provided a superior antiobesity effect than reconstituted triterpenoid mixtures in adipocyte cell lines and a pre-diabetic mouse model. …”
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Improved detection of air trapping on expiratory computed tomography using deep learning. by Sundaresh Ram, Benjamin A Hoff, Alexander J Bell, Stefanie Galban, Aleksa B Fortuna, Oliver Weinheimer, Mark O Wielpütz, Terry E Robinson, Beverley Newman, Dharshan Vummidi, Aamer Chughtai, Ella A Kazerooni, Timothy D Johnson, MeiLan K Han, Charles R Hatt, Craig J Galban

“…<h4>Objective</h4>To investigate the effectiveness of a convolutional neural network (CNN) model for quantifying and monitoring AT, and to compare it with other quantitative AT measures obtained from threshold-based techniques.…”
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Towards novel liver injury therapies based on design, synthesis and therapeutic efficacy of novel sulfone bis-compound on liver necrosis by Huda R. M. Rashdan, Sarah Hassan, Sara Maher, Hend Okasha

“…Abstract Liver necrosis is the irreversible loss of hepatocytes through toxin-induced injury, ischemia, or infection to produce organ dysfunction. It is a significant pathological marker in many liver disorders, including cirrhosis, and hepatitis, and contributes to organ failure and general systemic effects. …”
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The Intake of Sucrose but Not of the Intense Sweetener Sucralose Is Associated with Postprandial Endotoxemia in Healthy Young Adults by Raphaela Staltner, Anja Baumann, Ina Bergheim

“…Background and objectives: Similar to saturated fat, a diet rich in sugar may contribute to the development of overweight and obesity and associated metabolic diseases, like type 2 diabetes and metabolic dysfunction associated steatotic liver disease (MASLD). …”
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FLOT chemotherapy treatment affects adipocyte’s lipid metabolism: an in vitro study by Lisa Guerrier, Ruddy Richard, Jean Brac de la Perrière, Ophélie Bacoeur-Ouzillou, Julianne Touron, Johan Gagnière, Alexandre Pinel, Corinne Malpuech-Brugère

“…These findings elucidate previously unrecognized mechanisms underlying adipose tissue dysfunction in cancer cachexia.…”
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New Algorithm for Conservative Treatment of Patients with Keratoconus by E. S. Milyudin, O. Yu. Smorodinova, K. E. Kuchuk

“…The purpose of our study was to substantiate and evaluate the effectiveness of the conservative method of treating keratoconus in the early stages of the development of the disease. …”
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Noble Metal Complexes in Cancer Therapy: Unlocking Redox Potential for Next-Gen Treatments by Alina Stefanache, Alina Monica Miftode, Marcu Constantin, Roxana Elena Bogdan Goroftei, Iulia Olaru, Cristian Gutu, Alexandra Vornicu, Ionut Iulian Lungu

“…<b>(1) Context</b>: Cancer is still a major problem worldwide, and traditional therapies like radiation and chemotherapy often fail to alleviate symptoms because of side effects, systemic toxicity, and mechanisms of resistance. …”
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Somatosensory Plasticity in Pediatric Cerebral Palsy following Constraint-Induced Movement Therapy by Pawel J. Matusz, Alexandra P. Key, Shirley Gogliotti, Jennifer Pearson, Megan L. Auld, Micah M. Murray, Nathalie L. Maitre

“…However, effects of CIMT on somatosensory processing remain unclear. …”
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TIMP1 promotes microglia M2 polarization through MAPK pathway to ameliorate early brain injury after ischemia by Kangkang Zhao, Zizhao Huang

“…Additionally, the effects of TIMP1 overexpression on MAPK pathway in BV2 cells were also detected by Western blot. …”
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FABP7 in Hepatic Macrophages Promotes Fibroblast Activation and CD4+ T-Cell Migration by Regulating M2 Polarization During Liver Fibrosis by Hirofumi Miyazaki, Tunyanat Wannakul, Shuhan Yang, Dandan Yang, Ayano Karasawa, Ai Shishido, Ruizhu Cao, Yui Yamamoto, Yoshiteru Kagawa, Shuhei Kobayashi, Masaki Ogata, Motoko Maekawa, Yuji Owada

“…Therefore, we aimed to elucidate the mechanisms underlying the effects of FABP7 on the functions of hepatic macrophages in metabolic dysfunction-associated steatohepatitis (MASH) and liver fibrosis models. …”
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Comparison of cilomilast, tadalafil, and both drug combinations in the treatment of monocrotaline-induced pulmonary arterial hypertension in rats by Necip Ermis, Onural Ozhan, Azibe Yıldız, Zeynep Ulutas, Hakan Parlakpinar, Ahmet Ulu, Burhan Ates, Nigar Vardi, Zeynep Kucukakcali, Ahmet Acet

“…Abstract Background Pulmonary arterial hypertension (PAH) is a progressive disease characterized by endothelial dysfunction and inflammation. This study aimed to evaluate the effects of cilomilast (CIL), a phosphodiesterase-4 inhibitor, and tadalafil (TAD), a phosphodiesterase-5 inhibitor, on PAH induced by monocrotaline (MCT) in rats. …”
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Modulating depressive-like behaviors, memory impairment, and oxidative stress in chronic stress rat model using visible light therapy by Elham Zahedi, Rasoul Kavyannejad, Pooria Salami, Seyed Shahabeddin Sadr

“…This study investigates the therapeutic effects of different visible light wavelengths (white, red, green, and blue) on cognitive dysfunction and oxidative stress in a chronic unpredictable mild stress (CUMS)-induced rat model using stressors such as cold-water swimming, tail pinching, food and water deprivation, cage tilting, shaking, continuous illumination, wet cages, heat stress, and restraint. …”
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TIM-3 teams up with PD-1 in cancer immunotherapy: mechanisms and perspectives by Zhuohong Yan, Chunmao Wang, Jinghong Wu, Jinghui Wang, Teng Ma

“…TIM-3 exhibits multiple immunosuppressive effects on various types of immune cells. Given its differential expression levels at distinct stages of T cell dysfunction in the tumor microenvironment (TME), TIM-3, along with programmed cell death protein 1 (PD-1), serves as indicators of T cell exhaustion. …”
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Identification of BDNF sensitive electrophysiological markers of synaptic activity and their structural correlates in healthy subjects using a genetic approach utilizing the functi... by Fruzsina Soltész, John Suckling, Phil Lawrence, Roger Tait, Cinly Ooi, Graham Bentley, Chris M Dodds, Sam R Miller, David R Wille, Misha Byrne, Simon M McHugh, Mark A Bellgrove, Rodney J Croft, Bai Lu, Edward T Bullmore, Pradeep J Nathan

“…Increasing evidence suggests that synaptic dysfunction is a core pathophysiological hallmark of neurodegenerative disorders. …”
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Ergocalciferol and microcirculatory function in chronic kidney disease and concomitant vitamin d deficiency: an exploratory, double blind, randomised controlled trial. by Gavin Dreyer, Arthur T Tucker, Steven M Harwood, Rupert M Pearse, Martin J Raftery, Muhammad M Yaqoob

“…<h4>Background and objectives</h4>Vitamin D deficiency and endothelial dysfunction are non-traditional risk factors for cardiovascular events in chronic kidney disease. …”
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Robust Metformin Nanosystem Promotes Hair Growth in Androgenetic Alopecia by Qiuying Mai, Weisen Lin, Xiaoyu Qin, Guowang Cheng, Chen Wang, Guangtao Yu, Tongkai Chen

“…However, both drugs have serious side effects, including hypersensitivity and sexual dysfunction. …”
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Reduced L-carnitine transport in aortic endothelial cells from spontaneously hypertensive rats. by Rocío Salsoso, Enrique Guzmán-Gutiérrez, Pablo Arroyo, Carlos Salomón, Sonia Zambrano, María Victoria Ruiz-Armenta, Antonio Jesús Blanca, Fabián Pardo, Andrea Leiva, Alfonso Mate, Luis Sobrevia, Carmen María Vázquez

“…Impaired L-carnitine uptake correlates with higher blood pressure in adult men, and L-carnitine restores endothelial function in aortic rings from spontaneously hypertensive rat (SHR). Thus, endothelial dysfunction in hypertension could result from lower L-carnitine transport in this cell type. …”
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Multi-Omics Joint Analysis of Molecular Mechanisms of Compound Essential Oils Inhibiting Spoilage Yeast in Paocai by Xinyi Wu, Zhiyan Zhu, Hao Tian, Li Liu, Xuerui Li, Jun Pan, Yifan Hu, Zhirui Niu, Hanmo Wang, Xiuwei Liu

“…The results showed that the minimum inhibitory concentration (MIC) of <i>P. manshurica</i> was 2 µL/mL, and the combined multi omics analyses indicated that the treatment of the CEO disrupted the ABC transporters, glycophospholipid metabolism, and nucleotide metabolism of <i>P. manshurica</i>, leading to the disruption of the integrity of <i>P. manshurica</i> cell wall and cell membrane, resulting in energy and metabolic dysfunction, and ultimately achieving the effect of inhibiting <i>P. manshurica</i>. …”
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Multi‐omic network analysis identified betacellulin as a novel target of omega‐3 fatty acid attenuation of western diet‐induced nonalcoholic steatohepatitis by Jyothi Padiadpu, Manuel Garcia‐Jaramillo, Nolan K Newman, Jacob W Pederson, Richard Rodrigues, Zhipeng Li, Sehajvir Singh, Philip Monnier, Giorgio Trinchieri, Kevin Brown, Amiran K Dzutsev, Natalia Shulzhenko, Donald B Jump, Andrey Morgun

“…Herein, we used multi‐omic network analysis that unveiled critical molecular pathways involved in ω3 PUFA effects in a preclinical mouse model of western diet induced NASH. …”
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