A precursor of Aflatoxin B1, Versicolorin A, impairs the mitochondrial function of human intestinal Caco-2 cells by Thierry Gauthier, Sylvie Puel, Ophelie Rocher, Isabelle P. Oswald, Olivier Puel

“…The aim of the present study was to investigate the effect of VERA on mitochondrial function in intestinal Caco-2 cells. …”
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Irbesartan Ameliorates Diabetic Nephropathy by Suppressing the RANKL-RANK-NF-κB Pathway in Type 2 Diabetic db/db Mice by Xiao-Wen Chen, Xiao-Yan Du, Yu-Xian Wang, Jian-Cheng Wang, Wen-Ting Liu, Wen-Jing Chen, Hong-Yu Li, Fen-Fen Peng, Zhao-Zhong Xu, Hong-Xin Niu, Hai-Bo Long

“…Our present study investigated the effects of Irb in DN and whether the renal protective effects of Irb are mediated by RANKL/RANK and the downstream NF-κB pathway in db/db mice. …”
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The Class I Histone Deacetylase Inhibitor MS-275 Prevents Pancreatic Beta Cell Death Induced by Palmitate by Valérie Plaisance, Laure Rolland, Valéry Gmyr, Jean-Sébastien Annicotte, Julie Kerr-Conte, François Pattou, Amar Abderrahmani

“…The protective effect of MS-275 was associated with the attenuation of the expression of Atf3 and Chop. …”
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The AMPK agonist 5‐aminoimidazole‐4‐carboxamide ribonucleotide (AICAR), but not metformin, prevents inflammation‐associated cachectic muscle wasting by Derek T Hall, Takla Griss, Jennifer F Ma, Brenda Janice Sanchez, Jason Sadek, Anne Marie K Tremblay, Souad Mubaid, Amr Omer, Rebecca J Ford, Nathalie Bedard, Arnim Pause, Simon S Wing, Sergio Di Marco, Gregory R Steinberg, Russell G Jones, Imed‐Eddine Gallouzi

“…However, AMPK also has anti‐inflammatory effects, suggesting that in cachexia, a syndrome of inflammatory‐driven muscle wasting, AMPK activation could be beneficial. …”
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In Strawberries, Calcium Uptake and Water Soaking Are Negatively Related by Grecia Hurtado, Kristian Pineda, Moritz Knoche

“…Vascular import of Ca to developing strawberry fruit decreases during development as a result of progressive xylem dysfunction. Calcium sprays can raise Ca levels in late-stage strawberry fruit. …”
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Pharmacological insights and therapeutic advances of mangiferin against various pathological conditions in liver diseases by Tanvir Zaman Shoyshob, Sumaya Akter, Muhammad Ramiz Uddin, Mithila Farjana, Akhi Moni, Wonhyo Seo, Md. Golzar Hossain, Md Jamal Uddin

“…The purpose of this literature review was to delineate the hepatoprotective effects of mangiferin, a natural bioactive compound without side effects, and explain how it protects the liver via the suppression of pathological conditions involved in liver diseases. …”
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Nicotinamide mononucleotide protects ovarian function and oocyte developmental competence during chemotherapy by Lin Shen, Hemei Li, Xueqi Gong, Hanwang Zhang, Yiqing Zhao

“…Abstract Background Cyclophosphamide (CTX)-induced ovarian dysfunction and infertility represent significant concerns for reproductive-age or younger female cancer patients. …”
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Uridine treatment protects against blood–brain barrier disruption in a rat model of Li-pilocarpine-induced status epilepticus by Birnur Aydin, Busra Ocalan Esmerce, Aysen Cakir, Sueda Tuncak, Cansu Koc, Mehmet Cansev, Tulin Alkan

“…Uridine is a pyrimidine nucleoside with neuroprotective, antiepileptic and antiepileptogenic effects; however, its mechanism of action is not fully characterized. …”
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Serum uric acid, renal status, cardiovascular-kidney-metabolic syndrome and drug therapy, a wide-angled Mendelian randomization analysis by Lingyun Luo, Xuelian Luo, Zhen He

“…Regarding renal status, renal dysfunction led to a wider phenotype of CKM syndrome including hypertension, cerebrovascular disease, chronic kidney disease and renal failure. …”
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Nitazoxanide protects against heart failure with preserved ejection and metabolic syndrome induced by high-fat diet (HFD) plus L-NAME “two-hit” in mice by Jiahui Chen, Liping Zhang, Ting Xie, Xiao Zhang, Congcong Pan, Fangli Sun, Wenfeng Li, Zhijie Sun, Deli Dong

“…The in vitro experiments revealed that tizoxanide, the active metabolite of nitazoxanide, increased the basal mitochondria metabolism of cardiomyocytes, inhibited cardiomyocyte hypertrophy and collagen secretion from cardiac fibroblasts, and relaxed phenylephrine- and U46619-induced constriction of rat mesenteric arteries, indicating that the direct effect of tizoxanide might partly contribute to the protective effect of nitazoxanide against HFpEF in vivo. …”
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Influences of different sedatives on gastric antrum contraction in patients with acute brain injury by Meihua Mei, Mingli Yao, Jingchao Li, Chunfang Qiu, Yufang Wang, Yan Li, Lei Shi, Lingyan Wang, Bin Ouyang

“…All sedatives, either propofol, midazolam, or dexmedetomidine, had inhibited effects on gastric motilities. Dexmedetomidine has less inhibitory effects on ACA and MI compared with propofol and midazolam.…”
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Puerarin pretreatment provides protection against myocardial ischemia/reperfusion injury via inhibiting excessive autophagy and apoptosis by modulation of HES1 by Yong Yuan, Songqing Lai, Tie Hu, Fajia Hu, Chenchao Zou, Xiuqi Wang, Ming Fang, Jichun Liu, Huang Huang

“…In conclusion, Pue effectively ameliorated HES1-mediated MIRI-induced autophagy, apoptosis, and mitochondrial dysfunction.…”
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Salidroside Protects Dopaminergic Neurons by Preserving Complex I Activity via DJ-1/Nrf2-Mediated Antioxidant Pathway by Ruru Li, Songhai Wang, Tao Li, Leitao Wu, Yan Fang, Yang Feng, Lingling Zhang, Jianzong Chen, Xin Wang

“…However, the mechanism of Sal-induced neuroprotective effects against PD remains poorly understood. Therefore, we further investigated whether Sal plays neuroprotective effects by activating complex I via DJ-1/Nrf2-mediated antioxidant pathway. …”
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New Opportunities for Complex Therapy in Patients with Dry Eye Syndrome of Various Etiologies by V. V. Brzheskiy, S. Yu. Golubev, O. I. Lebedev, E. S. Milyudin, A. S. Apostolova, A. V. Surov, E. L. Efimova, E. V. Varlashina, I. N. Gorbachevskaya, V. O. Kirichenko

“…The purpose: to evaluate the effectiveness of the Delfanto® in the complex therapy of patients with dry eye syndrome of various etiologies and severity of the clinical course.Patients and methods. 114 patients (228 eyes) with dry eye syndrome of various etiologies were examined: 72 patients with chronic meibomian blepharitis and dysfunction of the meibomian glands (xerosis due to increased evaporation of the tear film), 33 women with perimenopause (a mixed form of xerosis with a predominant decrease in the production of components of the tear film) and 9 persons with Syegren syndrome (xerosis due to a pronounced decrease in tear production). …”
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Understanding the role of temporary epicardial pacemakers after heart transplantation in the cardiac intensive care unit by Goyal Umadat, MD, Jennifer Lee, DO, Bria Rice, MD, Shahyar Michael Gharacholou, MD, Parag Patel, Rohan Goswami, MD

“…No mode of epicardial pacing was associated with an increased ICU LOS, hospital LOS, increased readmission rates, increased short-term adverse effects, increased long-term adverse effects, or increased duration of support with vasoactive medications.Our study demonstrated no significant association between the mode of temporary pacing and LOS or adverse effects after heart transplantation.…”
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Anti-neuroinflammatory and neuroprotective potential of Cissus tuberosa ethanol extract in Parkinson's disease model through the modulation of neuroinflammatory markers. by Malik Saadullah, Amna Sehar, Zunera Chauhdary, Rida Siddique, Hafsa Tariq, Muhammad Asif, Shazia Anwer Bukhari, Aisha Sethi

“…The study seeks to determine the neuroprotective effects of C. tuberosa ethanolic extract (CTE) against Parkinson's disease by evaluating its impact on motor dysfunction, cognitive deficits, neuroinflammation, and neurodegeneration in paraquat-induced Parkinson's disease models. …”
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Notoginsenoside R1 alleviates spinal cord injury through the miR-301a/KLF7 axis to activate Wnt/β-catenin pathway by Tang Zhi, Yang Chunhua, He Zhengwen, Deng Zhiyong, Li Xiaoming

“…In this study, the effect and molecular mechanisms of NGR1 in models of SCI were further investigated. …”
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The Impact of Edentulism and Periodontitis on Cognition by Lauren Berard, Miou Zhou

“…Background Masticatory dysfunction and periodontitis are independently linked to cognitive decline. …”
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Resveratrol Suppresses Gut-Derived NLRP3 Inflammasome Partly through Stabilizing Mast Cells in a Rat Model by Weicheng Zhao, Xiaolei Huang, Xue Han, Dan Hu, Xiaohuai Hu, Yuantao Li, Pinjie Huang, Weifeng Yao

“…Inflammatory responses induced by intestinal ischemia-reperfusion (IIR) lead to serious systemic organ dysfunction and pose a challenge for current treatment. …”
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Potential role of 4-hydroxyisoleucine in enhancing fertility in male mice with diet-induced obesity by Emmanuel Osei Nkansah, Yunzhu Lan, Hui Zhang, Binbin Xu, Qiaodan Li, Mohammad Ishraq Zafar, Jian Xu

“…Therefore, therapeutic interventions to counteract the adverse effects of obesity are crucial. This study explored the therapeutic effects of 4-hydroxyisoleucine (4-HIL) on fertility in male mice with diet-induced obesity.MethodsC57BL6 male mice (n=45) were randomly divided into normal diet (ND, n=15) and high-fat diet (HFD, n=30) groups for 10 weeks. …”
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