Sirtuin 4 accelerates heart failure development by enhancing reactive oxygen species-mediated profibrotic transcriptional signaling by Nikole J. Byrne, Christoph Koentges, Elisabeth Khan, Katharina Pfeil, Robert Sandulescu, Sayan Bakshi, Carolin Költgen, Ivan Vosko, Johannes Gollmer, Thomas Rathner, Günter Roth, Michael M. Hoffmann, Katja E. Odening, Hauke Horstmann, Luke A. Potter, Christoph Bode, Dennis Wolf, Harald Sourij, Senka Ljubojevic-Holzer, Markus Wallner, Peter P. Rainer, Simon Sedej, Daniel Scherr, Dirk von Lewinski, Adam R. Wende, Andreas Zirlik, Heiko Bugger

“…To current study was designed to explore mechanisms underlying adverse effects of increased SIRT4 levels in the heart following pressure overload. …”
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Current approaches to therapy for complications of bone metastases from breast cancer by L. G. Zhukova

“…Denosumab is an effective, well-tolerated drug that can increase a chance of preventing BMRCs in breast cancer.…”
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Osteoimmunology: an interdisciplinary approach to studying the relationships between immune and bone cells by V. S. Shirinsky, I. V. Shirinsky

“…These effects promote accumulation and maintenance of the bone mass. …”
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Rutaecarpine alleviates hepatic ischemia‒reperfusion injury in liver transplantation by inhibiting inflammatory response and oxidative stress by Yan Liu, Yan Liu, Feng Qi, Lun-Jian Xiang, Zhu-Jun Yi, Sheng-Wei Li

“…The key molecules involved in the hepatoprotective effects of Rut were identified through joint analysis of data from LT patients and drug targets. …”
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Escherichia coli Nissle 1917 Protects Intestinal Barrier Function by Inhibiting NF-κB-Mediated Activation of the MLCK-P-MLC Signaling Pathway by Shihao Guo, Shanwen Chen, Ju Ma, Yongchen Ma, Jing Zhu, Yuanyuan Ma, Yucun Liu, Pengyuan Wang, Yisheng Pan

“…Then, Caco-2 monolayers were utilized to further investigate the protective effect of the EcN supernatant (EcNsup) on the barrier dysfunction induced by TNF-α and IFN-γ in vitro; the plasma level of both the cytokines increased significantly during sepsis. …”
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Trailblazer Tepezza for thyroid by Aamna Khatoon, Fatima Kaleem Ahmed, Amna Kaleem Ahmed

“…Unfortunately, this drug has not reached Pakistan yet and we still resort to using conventional treatments namely lubricants and steroids despite their worrying side effects and contraindications in patients having other comorbid conditions which majority of the people of Pakistan suffer from such as diabetes, hypertension, osteoporosis and hepatic dysfunction. [5] The government should subsidize the use of this novel drug in TED patients by incentivizing its availability and training physicians to monitor the patients taking the infusions. …”
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Epidemiological status, development trends, and risk factors of disability-adjusted life years due to diabetic kidney disease: A systematic analysis of Global Burden of Disease Stu... by Jiaqi Li, Keyu Guo, Junlin Qiu, Song Xue, Linhua Pi, Xia Li, Gan Huang, Zhiguo Xie, Zhiguang Zhou, Jinjiao Li

“…Interestingly, the most pronounced effect of positive DALYs change from 1990 to 2021 was presented in high-SDI quintile, while in low-SDI quintile, DALYs for DKD-T1DM and DKD-T2DM presented a decreasing trend over the past years. …”
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Charcteristics of the Autonomic Nervous System in Patients with Liver Cirrhosis and its Dependence on the Severity of Portal Hypertension due to the Values of the Heart Rate Variab... by Abrahamovych M., Ferko M.

“…Despite the high prevalence of the autonomic nervous system dysfunction in patients with liver cirrhosis, the condition of the autonomic nervous system in patients with liver cirrhosis and its dependence on the severity of portal hypertension is insufficiently studied, because clinicians often do not pay attention to it, focusing on the deviations of laboratory parameters and severity of liver disease. …”
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Andrias davidianus bone peptides alleviates hyperuricemia-induced kidney damage in vitro and in vivo by Wei Li, Haihong Chen, Hongliang Chen, Ziyin Li, Wei Hu, Qinxuan Zhou, Bing Xu, Yi Wang, Xinhui Xing

“…Metabolomic analysis highlighted 14 metabolites that could be selected as potential biomarkers and attributed to the amelioration effects of ADBP on CKD mice kidney dysfunction. Intriguingly, ADBP restored the gut microbiome homeostasis in CKD mice, especially with respect to the elevated helpful microbial abundance, and the decreased harmful bacterial abundance. …”
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PATHOGENESIS OF OSTEOARTHRITIS AND SUBSTANTIATION OF THE USE OF STRONTIUM RANELATE by Elena Mikhailovna Zaitseva, L I Alekseeva, E L Nasonov

“…Osteoarthritis (OA) is one of the most common diseases, pain and joint dysfunction being its main symptoms. Although OA is a progressive disease causing disability, rapid progression is observed only in some patients. …”
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The Use of β-blockers in Patients with Ventricular Ectopic Heartbeat in the Early and Distant Postinfarction Period by N. M. Kulayets

“…Aim: to increase the effectiveness of patients after Q-, QS- myocardial infarction rehabilitation, based on the study of clinical, instrumental and biochemical changes in cases of cardiac arrhythmias, and development on this basis of new approaches to treatment. …”
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Honokiol protects against diabetic retinal microvascular injury via sirtuin 3-mediated mitochondrial fusion by Jiemei Shi, Jiemei Shi, Min Liu, Min Liu, Jiajie Zhao, Jiajie Zhao, Ye Tan, Chunhui Jiang, Chunhui Jiang

“…IntroductionMitochondrial dysfunction and oxidative stress play important roles in diabetic retinal vascular injuries. …”
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The role of PKM2-mediated metabolic reprogramming in the osteogenic differentiation of BMSCs under diabetic periodontitis conditions by Yanlin Zhu, Yuhan Yang, Yuyan Lan, Zun Yang, Xiang Gao, Jie Zhou

“…Shikonin effectively reversed these adverse effects by inhibiting PKM2 tetramerization, rescuing the loss of osteogenic function in BMSCs. …”
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Neuroprotective role of traditional Chinese plant extracts on Parkinson's disease; a comprehensive preclinical review by Rabia Anjum

“…The studied compounds demonstrated effects on essential signaling pathways related to oxidative and inflammatory stress in neurons. …”
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Astragaloside IV Alleviates Brain Injury Induced by Hypoxia via the Calpain-1 Signaling Pathway by Yan Meng, Shengxue Yu, Fang Zhao, Yu Liu, Yue Wang, Siqi Fan, Yuhong Su, Meili Lu, Hongxin Wang

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Ways to optimize infusion therapy for diabetic ketoacidosis by M. I. Neimark, E. A. Kloster, A. A. Bulganin, A. E. Zavyalov

“…The effectiveness of infusion therapy in the treatment of diabetic ketoacidosis is determined by the functional state of the endothelium.The objective was to evaluate the effectiveness of meglumine sodium succinate used in the infusion therapy of diabetic ketoacidosis for correction of endothelial glycocalyx dysfunction Materials and methods. …”
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SMND-309 activates Nrf2 signaling to alleviate acetaminophen-induced hepatotoxicity and oxidative stress. by Yao Dong, Ru Jia, Yujie Jiang, Qing Li, Lei Wang, Wensi Ding, Rui Yan, Yujie Qiu, Zhengjie Shi, Wenying Liu, Jing Wang, Sen Xu, Na Li

“…<h4>Objective</h4>To explore the protective effect of the natural compound SMND-309 against AILI and the potential mechanism.…”
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Photobiomodulation therapy at 650 nm enhances osteogenic differentiation of osteoporotic bone marrow mesenchymal stem cells through modulating autophagy by Haotian Li, Wenwen Yang, Biao Zhu, Miao Li, Xinran Zhang

“…Background: Photobiomodulatiom therapy (PBMT) has biostimulatory effects on bone marrow mesenchymal stem cells (BMSCs), which takes a pivotal role in maintaining bone mass and avoiding osteoporosis (OP). …”
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Pentraxin-3 as a Biomarker in Diabetes Mellitus: Insights into Inflammation, Vascular Complications, and Modulation by Antidiabetic Medications by Roxana-Cristina Dobriceanu, Andreea Daniela Meca, Ianis Kevyn Stefan Boboc, Liliana Mititelu-Tartau, Mihaela Simona Naidin, Adina Turcu-Stiolica, Maria Bogdan

“…Pentraxin-3 (PTX3) has emerged as a key biomarker of inflammation and endothelial dysfunction in DM. We aimed to examine the role of PTX3 in DM and assesses the impact of pharmacological interventions on its expression. …”
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Functional feed ingredients modulate the immune response of RTgutGC cells to LPS-induced inflammation by Malene Malchus Fosse, Laura Rivera Méndez, Tania Rodríguez-Ramos, Brian Dixon, Henrik Sundh, Rolf Erik Olsen

“…LPS induced inflammation, barrier dysfunction and reduced proliferation. These effects were modulated by high-dose β-glucan and both laminarin concentrations, which significantly reduced il6 expression (p &lt; 0.05). …”
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