Sildenafil citrate increases fetal weight in a mouse model of fetal growth restriction with a normal vascular phenotype. by Mark Robert Dilworth, Irene Andersson, Lewis James Renshall, Elizabeth Cowley, Philip Baker, Susan Greenwood, Colin Peter Sibley, Mark Wareing

“…Sildenafil citrate (SC, Viagra™), a potent and selective phosphodiesterase-5 inhibitor, corrects ex vivo placental vascular dysfunction in FGR, demonstrating potential as a therapy for this condition. …”
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Mitochondria-Targeting Type-I Photodynamic Therapy Based on Phenothiazine for Realizing Enhanced Immunogenic Cancer Cell Death via Mitochondrial Oxidative Stress by Duan Z, Li L, Zhan Q, Chen J, Li Q, Liu R, Tu Y

“…The type-I ROS generation ability, mitochondrial targeting capacity, and ICD triggering effect mediated by Rh-PTZ NPs under LED light irradiation were investigated. …”
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Consistency and reliability of ultrasound-derived fat fraction in hepatic steatosis assessment: influence of posture and breathing variations by Tingjing You, Shengmin Zhang, Shuai Cheng, Zhenyu Shen

“…Abstract Background Given the recent redefinition of metabolic dysfunction-associated steatotic liver disease (MASLD) and the clinical demand for non-invasive tools, this study evaluated the effect of body position (e.g., supine, left lateral recumbent) and respiratory status (e.g., deep inspiration, expiration) on ultrasound-derived fat fraction (UDFF) measurements., assessed their reliability and consistency, and determined the optimal conditions for obtaining UDFF. …”
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<i>Lactobacillus murinus</i> Reduces Susceptibility to Secondary MRSA Infection in IAV-Infected Mice Through Promoting a T Cell-Independent IgA Response by Qichao Chen, Yanfeng Lin, Kaiying Wang, Jinhui Li, Peng Li, Hongbin Song

“…The 16S rRNA gene sequencing results showed that <i>L. murinus</i> supplementation ameliorated microbiota composition disorder and regulated metabolic dysfunction in the gut of IAV-infected mice. The correlation analysis and antibiotic cocktail treatment experiment showed that the TI IgA response in lungs is dependent on gut microbiota. …”
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Roles of Non-Coding RNA in Anthracycline Cardiotoxicity: A Narrative Review by Xiao S, Li Y, Li B, Wang H, Wang K, Yang S

“…Nonetheless, anthracyclines predominantly account for the cardiotoxic effects, both acute and chronic, experienced by individuals undergoing cancer treatment. …”
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Impaired interhemispheric synchrony in patients with iridocyclitis and classification using machine learning: an fMRI study by Yan Tong, Zhi Wen, Xin Huang

“…Furthermore, the extracted resting-state zVMHC features effectively classified patients with iridocyclitis and HCs, achieving an area under the receiver operating characteristic curve (AUC) of 0.74 and an overall accuracy of 0.673 (P &lt; 0.001, non-parametric permutation test).ConclusionOur findings reveal disrupted interhemispheric functional organization in patients with iridocyclitis, offering insight into the pathophysiological mechanisms associated with vision loss and cognitive dysfunction in this patient population. …”
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Giardia duodenalis stabilizes HIF-1α and induces glycolytic alterations in intestinal epithelial cells by Emily DeMichele, Olivia Sosnowski, Darragh Flood, Cormac T. Taylor, Ian A. Lewis, Thibault Allain, Andre G. Buret

“…While many pathogens can activate HIF, the effects of enteric protozoa on HIF activation in gastrointestinal epithelial cells remain unclear. …”
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Mechanisms of Development of Hemostatic Disorders after Liver Resection by S. A. Shaposhnikov, S. V. Sinkov, K. F. Ivanov, I. B. Zabolotskikh

“…To correct the existing Адрес для к°рреспонденции (Correspondence to): energy deficiency is the key condition to determine the effectiveness of performed hemostasis-modulating therapy. …”
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Bifidobacterium depletion promotes goiter via gut-thyroid axis: evidence from Mendelian randomization and experimental validation by Wenyong Liao, Yang Jiang, Jiwen Zhang, Yinghao Wu, Xue Yu, Shaohong Chen, Haiyan Liu, Linlin Xiu, Gansheng Zhong

“…Experimental validation included: (1) establishing a propylthiouracil (PTU)-induced goiter rat model with 16S rRNA sequencing of fecal samples, (2) targeted SCFAs quantification, (3) thyroid/serum iodine measurement, (4) thyroid hormone assays, and (5) sodium-iodide symporter (NIS) protein expression analysis.ResultsMR analysis identified 10 gut microbial taxa causally associated with goiter risk (all p &lt; 0.05), with Bifidobacterium bifidum showing protective effects (OR = 0.861, 95% CI: 0.764–0.971, p = 0.014). …”
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Bromodomain-containing protein 4 knockdown promotes neuronal ferroptosis in a mouse model of subarachnoid hemorrhage by Peng Lu, Fan Zhang, Lei Yang, Yijing He, Xi Kong, Kecheng Guo, Yuke Xie, Huangfan Xie, Bingqing Xie, Yong Jiang, Jianhua Peng

“…Neuronal cell death is a common outcome of multiple pathophysiological processes and a key factor in neurological dysfunction after subarachnoid hemorrhage. Neuronal ferroptosis in particular plays an important role in early brain injury. …”
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Attitudes and knowledge of pain specialists in Israel regarding sexual health in chronic pain patients by Haggai Sharon, Roy Cohen, Silviu Brill, Morsi Khashan, Uri Hochberg

“…Chronic pain can significantly impair sexual functioning through complex and multimodal effects spanning physical, psychological, and social domains. …”
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Repetitive transcranial magnetic stimulation (rTMS) using different TMS instruments for major depressive disorder at a suburban tertiary clinic by Maria Cristina Davila, Brianna Ely, Ann M. Manzardo

“…Repetitive transcranial magnetic stimulation (rTMS) is a neurostimulatory technique used to modulate orbital frontal corticostriatal (OFC) activity and clinical symptomatology for psychiatric disorders involving OFC dysfunction. We examined the effectiveness of rTMS in the treatment of major depressive disorder in an applied clinical setting (Awakening KC CNI) to assess efficacy and optimize rTMS parameters within clinical practice. …”
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Evaluating the impact of anti-CGRP monoclonal antibodies on retinal features in migraine patients: a retrospective optical coherence tomography study by Massimo Cesareo, Alessio Martucci, Roberta Bovenzi, Marco Lombardo, Francesca Pistoia, Vittoria Carla D’Agostino, Alessandro Stefani, Carlo Nucci, Nicola Biagio Mercuri, Maria Albanese

“…Short-term treatment with anti-CGRP mAbs may exert neuroprotective effects, potentially preventing permanent ocular damage. …”
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Development and validation of derivative UV spectroscopic methods for simultaneous estimation of duloxetine and tadalafil in their binary mixtures: greenness-blueness evaluation by Dalia M. Nagy, Sayed M. Derayea, Al Amir S. Zaafan, Mohamed Oraby

“…Abstract Antidepressant drugs, particularly selective serotonin reuptake inhibitors (SSRIs) and serotonin-norepinephrine reuptake inhibitors (SNRIs) are known to induce sexual dysfunction as a side effect. Duloxetine (DLX) and Tadalafil (TDL) are simultaneously determined in their pure state and laboratory-prepared mixtures by two novel, environmentally friendly, and accurate spectrophotometric methods. …”
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The Role of the IL-33/ST2 Axis in CpG-Induced Macrophage Activation Syndrome by Yuanji Dong, Rongfen Gao, Kailin He, Jixin Zhong, Lingli Dong

“…Thus, the IL-33/ST2 axis has little effect on the prognosis of CpG-induced MAS.…”
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Embolisation of Type I Endolic after the Endoprosthesis Replacement of the Infrarenal Aorta. Case Report by M. O. Loginov, A. A. Khamitov, N. R. Chernaya

“…The clinical case example demonstrates the effectiveness of embolisation of the endoleak area in a patient with severe cardiac pathology as an alternative to open surgery.Results and discussion. …”
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Carpolobia lutea methanol root extract reinstates androgenesis and testicular function in cadmium- challenged rats by Ejike, Daniel Eze, Okpa, Precious Nwaka, Igbokwe, Ugochukwu Vincent, Moses, Dele Adams, Karimah, Mohammed Rabiu, Ayikobua, Emmanuel Tiyo

“…Cadmium produces a wide range of biological dysfunctions in human and laboratory animals where it chiefly affects the testes, whereas, Carpolobia lutea has been known to have antioxidant benefits. …”
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Respiratory Pathology and Cardiovascular Diseases: A Scoping Review by Francisco Campos-Rodríguez, Eusebi Chiner, David de la Rosa-Carrillo, Borja G. Cosío, Jesús R. Hernádez-Hernández, David Jiménez, Raúl Méndez, María Molina-Molina, José-Gregorio Soto-Campos, José-Manuel Vaquero, Francisco-Javier Gonzalez-Barcala

“…With this in mind, our objective was to provide information that may be helpful to better understand the relationship between respiratory pathology and CVDs.There are different reasons for this relationship, such as shared risk factors, common pathophysiological mechanisms, side effects of treatment and the direct effect in the heart and great vessels of respiratory diseases.Indeed, aging and smoking are risk factors for CVDs and also for respiratory diseases such as obstructive sleep apnea (OSA), COPD and interstitial lung diseases (ILD).Furthermore, there are common pathophysiological mechanisms that affect both respiratory diseases and CVDs, such as accelerated atherosclerosis, microvascular dysfunction, endothelial dysfunction, inflammation, hypoxemia and oxidative stress.Besides that, it is well known that lung cancer, sarcoidosis and amyloidosis may directly affect the heart and great vessels.Finally, side effects of drugs for respiratory diseases and the discontinuation of treatments that are necessary for CVDs, such as β-blockers and aspirin, may have a deleterious impact on the cardiovascular system.In conclusion, the coexistence of respiratory diseases and CVDs is very common. …”
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Suppression of Spry1 reduces HIF1α-dependent glycolysis and impairs angiogenesis in BRAF-mutant cutaneous melanoma by Barbara Montico, Giorgio Giurato, Roberto Guerrieri, Francesca Colizzi, Annamaria Salvati, Giovanni Nassa, Jessica Lamberti, Domenico Memoli, Patrizia Sabatelli, Marina Comelli, Arianna Bellazzo, Albina Fejza, Lucrezia Camicia, Lorena Baboci, Michele Dal Bo, Alessia Covre, Tuula A. Nyman, Alessandro Weisz, Agostino Steffan, Michele Maio, Luca Sigalotti, Maurizio Mongiat, Eva Andreuzzi, Elisabetta Fratta

“…Abstract Background About 50% of cutaneous melanoma (CM) harbors the activating BRAFV600 mutation which exerts most of the oncogenic effects through the MAPK signaling pathway. In the last years, a number of MAPK modulators have been identified, including Spry1. …”
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Expression of protein disulfide isomerase A3Q481K variant associated with amyotrophic lateral sclerosis triggers disease features in mice by Martin Sepulveda, Francisca Martínez Traub, Patricia Ojeda, Viviana Perez, Jorge Ojeda, Jessica Mella, Rodrigo Diaz, Pablo Rozas, Matías Mansilla-Jaramillo, Amparo Zuleta, Guillermo Diaz, Bredford Kerr, Ute Woehlbier, Juan Pablo Henríquez, Danilo B. Medinas, Claudio Hetz

“…Amyotrophic lateral sclerosis (ALS) is a fatal neurodegenerative disease characterized by loss of motoneurons and compromised proteostasis. Dysfunction of the endoplasmic reticulum (ER) has been identified as a transversal pathogenic mechanism associated with motoneurons vulnerability in ALS. …”
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