Determinants of quality of life in patients with fibromyalgia: A structural equation modeling approach. by Jeong-Won Lee, Kyung-Eun Lee, Dong-Jin Park, Seong-Ho Kim, Seong-Su Nah, Ji Hyun Lee, Seong-Kyu Kim, Yeon-Ah Lee, Seung-Jae Hong, Hyun-Sook Kim, Hye-Soon Lee, Hyoun Ah Kim, Chung-Il Joung, Sang-Hyon Kim, Shin-Seok Lee

“…The present study assessed relationships among physical function, social factors, psychological factors, and HRQOL, and the effects of these variables on HRQOL in a hypothesized model using structural equation modeling (SEM).…”
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A single main-chain hydrogen bond required to keep GABAA receptors closed by Cecilia M. Borghese, Jason D. Galpin, Samuel Eriksson Lidbrink, Yuxuan Zhuang, Netrang G. Desai, Rebecca J. Howard, Erik Lindahl, Christopher A. Ahern, Marcel P. Goldschen-Ohm

“…Genetic mutations causing their dysfunction are related to a broad spectrum of human disorders such as epilepsy, neurodevelopment and intellectual disability, autism spectrum disorder, schizophrenia, and depression. …”
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miR-1275 Delivered via Mesenchymal Stem Cell-Derived Extracellular Vesicles Regulates ER-Phagy Through AXIN2 in Nucleus Pulposus Cells by Zhiwu Dong, Hailong Zhang, Wenwei Yang, Keliang Huang, Xin Zhang, Lianxiang Xing, Ying Zhang, Kewen Zhao

“…Nucleus pulposus (NP) cells are essential for maintaining disc homeostasis, and their dysfunction plays a crucial role in IDD development. …”
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Deletion of Metabotropic Glutamate Receptors 2 and 3 (mGlu2 & mGlu3) in Mice Disrupts Sleep and Wheel-Running Activity, and Increases the Sensitivity of the Circadian System to... by David Pritchett, Aarti Jagannath, Laurence A Brown, Shu K E Tam, Sibah Hasan, Silvia Gatti, Paul J Harrison, David M Bannerman, Russell G Foster, Stuart N Peirson

“…The co-morbidity of schizophrenia and SCRD may in part stem from dysfunction in common brain mechanisms, which include the glutamate system, and in particular, the group II metabotropic glutamate receptors mGlu2 and mGlu3 (encoded by the genes Grm2 and Grm3). …”
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Bisphenol A Exposure Induces Small Intestine Damage Through Oxidative Stress, Inflammation, and Microbiota Alteration in Rats by Kai Wang, Juan Tang, Dan Shen, Yansen Li, Kentaro Nagaoka, Chunmei Li

“…This study explored the toxicological effects of BPA on the small intestine of rats, focusing on the duodenum, jejunum, and ileum. …”
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A nomogram to predict the risk of insulin resistance in Chinese women with polycystic ovary syndrome by Benjie Guo, Yuting Shen, Ziying Dai, Kalibinuer Yimamu, Jianhua Sun, Lixia Pei

“…BackgroundInsulin resistance (IR) is considered a major driver of the pathophysiology of polycystic ovary syndrome (PCOS), mediating the progression of hyperandrogenism and metabolic and reproductive dysfunction in patients with PCOS. Early detection of the risk of concurrent IR is essential for women with PCOS. …”
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The Impact of Sleep Disorders on Cardiovascular Risk by Anna Blazhkova, Dominka Rehan, Katarzyna Rzym, Sven Solisch, Anna Susłow, Ewa Szczęsna, Adam Szwed

“…Further research is needed to understand better the association of sleep disorders with cardiovascular risk, to assess long-term treatment effects, and to guide evidence-based integration of sleep medicine with strategies for the prevention and treatment of cardiovascular disease. …”
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lncRNA IL-17RA-1 Attenuates LPS-Induced Sepsis via miR-7847-3p/PRKCG-Mediated MAPK Signaling Pathway by Yuanxiu Gan, Jie Long, Yan Zeng, Yan Zhang, Yang Tao

“…And pathway IL-17RA-1/miR-7847-3p/protein kinase C gamma (PRKCG) coexpression network was successfully sorted out. The effect of this network on LPS-induced sepsis model in THP-1 cells was also verified by CCK-8, scratch, ELISA, Western blot, and qRT-PCR assays. …”
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Longitudinal assessment of cortical motor function in amyotrophic lateral sclerosis by Dhayalen Krishnan, Dayna-Lee Talbot, Jasmine F. Ashhurst, Susanna B. Park, Steve Vucic, Hannah C. Timmins, Matthew C. Kiernan

“…There was no significant main effect of site of onset on averaged SICI (p = 0.78). …”
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Three-Dimensional Echocardiography in Evaluating LA Volumes and Functions in Diabetic Normotensive Patients without Symptomatic Cardiovascular Disease by Mohamed Hamza, Ahmed Mamdouh, Dina Ezzeldin, Adnan Tawfik, Ahmed Nayel

“…Objectives. To evaluate the effect of diabetes mellitus on left atrial volumes and functions by using real-time 3-dimensional echocardiography in normotensive patients free from cardiovascular disease. …”
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Corneal Neurotization, Recent Progress, and Future Perspectives by Ovidiu Samoilă, Lăcrămioara Samoilă, Lorina Petrescu

“…This review evaluates the outcomes of corneal neurotization in patients with NK and compares the effectiveness of direct (DNT) and indirect (INT) techniques. …”
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Association Between Perceived Noise Pollution and Sleep Quality: Findings from the 2018 Community Health Survey by Sujin Lee, Jae Ho Chung

“…Perceived noise annoyance could be used as a signal of health effects in the public community.…”
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Hyperfunctional Neutrophils in Aged Mice Are Linked to Enhanced Bone Loss in Ligature-Induced Periodontitis by Antoine Magne, Chunxiang Sun, Sina Zargaran, Jeffrey W. Chadwick, Abdelahhad Barbour, Michael Glogauer

“…This study examined age-related neutrophil dysfunction and its impact on periodontal bone loss. …”
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Cerebellar Purkinje Cells and GABA Neurotransmission in the Diabetic Rodent Models: A Systematic Review by Viskasari P Kalanjati, Rayhan B Mahdi, Dwi Martha Nur Aditya

“…Taken altogether, these results in motor impairment and cognitive dysfunction.…”
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Hearts from mice fed a non-obesogenic high-fat diet exhibit changes in their oxidative state, calcium and mitochondria in parallel with increased susceptibility to reperfusion inju... by Ben Littlejohns, Philippe Pasdois, Simon Duggan, Andrew R Bond, Kate Heesom, Christopher L Jackson, Gianni D Angelini, Andrew P Halestrap, M-Saadeh Suleiman

“…<h4>Rationale</h4>High-fat diet with obesity-associated co-morbidities triggers cardiac remodeling and renders the heart more vulnerable to ischemia/reperfusion injury. However, the effect of high-fat diet without obesity and associated co-morbidities is presently unknown.…”
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Evaluation of the Efficacy of Treatment of Newborns with Transient Myocardial Ischemia by Yulia N. Dovnar, Alla A. Tarasova, Ivan F. Ostreykov, Vladimir N. Podkopaev

“…Various correlative links between parameters of left ventricular systolic function and blood biochemistry before and during the treatment reflecting the myocardial dysfunction with a gradual reverse development have been found.Conclusion. …”
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α-linolenic acid-induced facilitation of GABAergic synaptic transmission is mediated via acid-sensing ion channel (ASIC1a) activity in the basolateral amygdala by Volodymyr I. Pidoplichko, Taiza H. Figueiredo, Maria F. M. Braga, Ann M. Marini

“…Temporal lobe epilepsy is a highly pharmacoresistant form of epilepsy that involves the amygdala, hippocampus with or without hippocampal sclerosis as well as other limbic structures. Loss and/or dysfunction of GABAergic inhibitory neurons play a critical role in tipping the balance toward excitation. …”
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Feasibility and Safety of Endoscopic Balloon-Assisted Laser Treatment (EBLT) for Gastroesophageal Reflux Disease: Functional, Structural, and Gene Expression Analysis in Preclinica... by Boram Cha, Hyejin Kim, Van Gia Truong, Sun-Ju Oh, Seok Jeong, Hyun Wook Kang

“…Gastroesophageal reflux disease (GERD) is a prevalent disorder caused by lower esophageal sphincter (LES) dysfunction, often requiring long-term treatment. This study assessed the feasibility of endoscopic balloon-assisted laser treatment (EBLT) using a porcine GERD model. …”
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SPECIFIC FEATURES OF HEART RATE VARIABILITY IN CHILDREN WITH ENT PATHOLOGY IN NEED OF SURGICAL TREATMENT by YU. S. АLEKSАNDROVICH, V. V. RYBIANOV, K. V. PSHENISNOV, I. V. АLEKSАNDROVICH

“…Pre-operative assessment of heart rate variability in children with ENT pathology allows identifying risk factors of hemodynamic disorders during anesthesia and preventing the use of drugs providing an undesirable effect on the vegetative nervous system.…”
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Differentially Expressed Genes Analysis in the Human Small Airway Epithelium of Healthy Smokers Shows Potential Risks of Disease Caused by Oxidative Stress and Inflammation and the... by Irandi Putra Pratomo, Aryo Tedjo, Dimas R. Noor, null Rosmalena

“…Cigarette smoke (CS) was known for its effect of increasing oxidative stress that could trigger tissue injury and endothelial dysfunction mediated by free radicals and reactive oxygen species (ROS). …”
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