5-methoxytryptophan ameliorates renal ischemia/reperfusion injury by alleviating endoplasmic reticulum stress-mediated apoptosis through the Nrf2/HO-1 pathway by Shaona Li, Hongjuan Yang, Bing Zhang, Lingyu Li, Xiangkun Li

“…The administration of 5-MTP improved renal tissue damage and kidney dysfunction impairment and reduced inflammation and oxidative stress. …”
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A novel myocarditis detection combining deep reinforcement learning and an improved differential evolution algorithm by Jing Yang, Touseef Sadiq, Jiale Xiong, Muhammad Awais, Uzair Aslam Bhatti, Roohallah Alizadehsani, Juan Manuel Gorriz

“…It is triggered by viral infections and presents symptoms such as chest pain and heart dysfunction. Early detection is crucial for successful treatment, and cardiac magnetic resonance imaging (CMR) is a valuable tool for identifying this condition. …”
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A mutation in transthyretin gene in a Mexican patient leading to hereditary amyloidosis: a case report by Muhammad Reebal Malik, Tarun Dalia, Zubair Shah

“…He was also given vitamin A supplementation to prevent vutrisiran-associated vitamin A deficiency, which is a known side effect. Conclusions A high index of suspicion is required for diagnosing transthyretin amyloidosis. …”
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Structural Defects Associated with Craniectomy Induce Neuroinflammation and Blood–Brain Barrier Permeability by Aria W. Tarudji, Brandon Z. McDonald, Evan Curtis, Connor Gee, Forrest M. Kievit

“…Thus, there is a critical need to evaluate the effect of craniectomy on neurological outcomes to develop robust experimental controls and improve pre-clinical TBI research. …”
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Intermittent hypoxia and maxillary growth restriction: evidence from a neonatal rat model by Kochakorn Lekvijittada, Chidsanu Changsiripun, Jun Hosomichi, Takashi Ono

“…IH has been implicated in various neonatal complications: neurodevelopmental impairments, cardiovascular dysfunction, and growth restriction. However, its effects on craniofacial development remain underexplored. …”
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Features of heart remodeling in patients with obstructive sleep apnea syndrome and its comorbid association with obesity in the context of the senilism concept by T. O. Brodovskaya, O. O. Grishchenko, I. F. Grishina, T. F. Peretolchina

“…At the same time, the association of OSA with obesity has an additive adverse effect on the remodeling processes and the biological age of patients.…”
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The capsaicin receptor TRPV1 reduces sepsis-associated brain injury in mice by inhibiting pyroptosis by Menghong Long, Zhenyu Hu, Feiyu Long, Yingxu Chen, Li Liu, Maohua Wang

“…Abstract Purpose Sepsis is a life-threatening disorder marked by organ dysfunction due to infection. Transient receptor potential vanilloid 1 (TRPV1) is a non-selective, ligand-gated cation channel activated by multiple stimuli. …”
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Targeting Trichloroethylene-Induced Renal Endothelial Cell Injuries: A Role of Poly I:C in Amplification of HMGB1 Acetylation by Feng Wang, Yiting Hong, Jihong Gao, Ruixuan Cheng, Muyue Chen, Dandan Zang, Jiaxiang Zhang, Qixing Zhu

“…In the current study, we focus on renal endothelial cell (EC) dysfunction after poly I:C treatment using a TCE-sensitized mouse model. …”
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Changes in granule mobility and age contribute to changes in insulin secretion after desensitization or rest by Bastian Gaus, Dennis Brüning, Kathrin Hatlapatka, Ingo Rustenbeck

“…It is known that prolonged stimulation desensitizes the secretion of insulin and thus contributes to beta cell dysfunction. Beta cell rest, in contrast, was shown to enhance the secretory response. …”
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Therapeutic Targeting of the Proinflammatory IL-6-JAK/STAT Signalling Pathways Responsible for Vascular Restenosis in Type 2 Diabetes Mellitus by Florah Tshepo Moshapa, Kirsten Riches-Suman, Timothy Martin Palmer

“…SVGF is characterised by neointimal hyperplasia (NIH) arising from endothelial cell (EC) dysfunction and uncontrolled migration and proliferation of vascular smooth muscle cells (SMCs). …”
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Burnout and sleep problems among nurses working in a tertiary hospital in Kathmandu, Nepal. by Manoj Panthi Kanak, Smriti Pant

“…Similarly, establishment of interventions like psychological help desk and support groups for the nurses could be beneficial to mitigate the effects of burnout and sleep problems among the nurses.…”
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Activation of serotonergic system with fluoxetine or 5-HTP restores blunted hypercapnic ventilatory response in Parkinson’s disease model by Kryspin Andrzejewski, Magdalena E. Orłowska, Małgorzata Zaremba, Ilona Joniec-Maciejak, Katarzyna Kaczyńska

“…Of these, respiratory muscle weakness, decreased air passage resulting in restrictive breathing changes, respiratory rhythm abnormalities, and upper airway dysfunction are usually indicated. To study respiratory impairment in PD, we used a rat model of PD induced by bilateral injection of 6-hydroxydopamine (6-OHDA) into the striatum. …”
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Comparison of Del Nido and histidine-tryptophan-ketoglutarate cardioplegia solutions: an animal study with prolonged ischaemia by Alexandro Hoyer, Maja-Theresa Dieterlen, Jagdip Kang, Hanna Oetzel, Karoline Wiesner, Kristin Klaeske, Philipp Kiefer, Susann Oßmann, André Ginther, Martin Kostelka, Suzanne de Waha, Michael A. Borger

“…Expression of ICAM-1 as a marker of endothelial dysfunction was lower in the DN group compared to the HTK group (p = 0.02). …”
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Septohippocampal acetylcholine and theta oscillations can modulate memory encoding and retrieval: Insights from a neural masses network by Gabriele Pirazzini, Mauro Ursino

“…Finally, sensitive analysis of model parameters may elucidate the pathophysiology of mnemonic disorders characterized by cholinergic dysfunction, like dementia and amnesia.…”
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A comparison between virus- versus patients-centred therapeutic attempts to reduce COVID-19 mortality by Serge Camelo, Mathilde Latil, Sam Agus, Waly Dioh, Stanislas Veillet, René Lafont, Pierre J. Dilda

“…Here, we compare the effectiveness of virus- and patients-centred strategies to reduce COVID-19 mortality. …”
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Study of Cardio-Metabolic Risk in Overweight and Obese People with Impaired Vitamin D Status by Maria Nikolova, Adriana Agovska

“…Background: Vitamin D deficiency increases cardio-metabolic risk through different mechanisms: activation of proinflammatory cytokines and mediation of endothelial dysfunction, insulin resistance, accelerated atherosclerosis, etc. …”
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Association between menstrual disorders and anti-Müllerian hormone with COVID-19: A prospective cohort study by Ziba Haghipour, Shahideh Jahanian Sadatmahalleh, Fatemeh Razavinia, Malihe Nasiri

“…Conclusion: Endocrine dysfunction in the form of low AMH and high TSH were common among COVID-19 patients. …”
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Ferroptosis and mitochondrial ROS are central to SARS-CoV-2-induced hepatocyte death by Cintia Cevallos, Patricio Jarmoluk, Franco Sviercz, Rosa Nicole Freiberger, Cynthia Alicia Marcela López, M. Victoria Delpino, Jorge Quarleri

“…Given the role of mitochondrial dysfunction, oxidative stress, and regulated cell death in COVID-19 pathogenesis, we investigated the impact of SARS-CoV-2 infection on hepatocytes using the Huh7.5 cell model.MethodsHuh7.5 hepatocytes were infected with either the ancestral Wuhan (Wh) or Omicron (BA.5) variant of SARS-CoV-2. …”
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Investigating the Impact of Organizational Bullying on Employee’s Mental Health by Hosein Faraji, Hamed KHorasaniToroghi, Vahid Mirzaei

“…This study investigated the impact of organizational bullying on the mental health of Bojnourd Municipality employees in Bojnourd City, Iran, focusing on its effects on anxiety, depression, sleep disorders, and social functioning. …”
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FIRST CLINICAL EXPERIENCE OF USING COLUMN FOR LPS-ADSORPTION OF TOXIPAK IN TREATMENT OF SEPSIS PATIENTS by L. L. Gendel, A. A. Sokolov, S. N. Gubanova, I. Yu. Adamova, P. A. Levashov

“…Endotoxicosis is one of the main factors of the pathogenesis of multiple organic dysfunctions in gram-negative sepsis, induced by the accumulation of lipopolysaccharides - wall components of gram-negative bacteria. …”
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