Terminal differentiation of T cells is strongly associated with CMV infection and increased in HIV-positive individuals on ART and lifestyle matched controls. by Thijs Booiman, Ferdinand W Wit, Arginell F Girigorie, Irma Maurer, Davide De Francesco, Caroline A Sabin, Agnes M Harskamp, Maria Prins, Claudio Franceschi, Steven G Deeks, Alan Winston, Peter Reiss, Neeltje A Kootstra, Co-morBidity in Relation to Aids (COBRA) Collaboration

“…HIV-associated immune dysfunction has been suggested to contribute to increased AANCC risk. …”
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Low-intensity sciatic nerve-stretch injury increases nociception, anxiety-like behaviors, and astrocyte activity in male Wistar rats by G.K. Silva-Cardoso, P.E. Bello-Junior, W. Lazarini-Lopes, A.A. Ferrarese-Tiballi, C.R.A. Leite-Panissi

“…The incidence of chronic pain in the general population is highly correlated to anxiety disorders, which promote negative effects on the quality of life. Stretch injury is the primary cause of nerve dysfunction and injury in the civilian population. …”
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Metallothionein II treatment mitigates rotenone-induced neurodegeneration in zebrafish models of Parkinson’s disease by Yong Hui Nies, Wei Ling Lim, Norwahidah Abd Karim, Mohamad Fairuz Yahaya, Seong Lin Teoh

“…Additionally, PD model zebrafish exhibited reduced dopamine levels, decreased dopaminergic neuron population, elevated oxidative stress, heightened inflammatory response and mitochondrial dysfunction. Treatment with hMT2, especially in the co-treatment group, ameliorated these deficits by restoring locomotor activity, dopamine levels, and dopaminergic neuron counts while reducing oxidative stress and inflammation, and improving mitochondrial function.DiscussionThese results suggest that hMT2 exhibited neuroprotective effect in the PD model zebrafish. …”
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The Mechanism of Relieving Diarrheal Irritable Bowel Syndrome Using Polyphenols from <i>Ribes nigrum</i> L. Based on a Network Pharmacology Analysis and 16S rRNA Sequencing by Xi Yu, Xiaotian Wang, Xintong Liu, Fangfei Li, Yihong Bao, Yangyang Chai

“…Diarrheal irritable bowel syndrome (IBS-D) is a chronic bowel condition that leads to intestinal dysfunction and is typically accompanied by diarrhea, stomach pain, and abdominal distension. …”
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Therapeutic Potential of Ellagic Acid in Liver Diseases by Karolina Wojtunik-Kulesza, Przemysław Niziński, Anna Krajewska, Tomasz Oniszczuk, Maciej Combrzyński, Anna Oniszczuk

“…This review highlights the therapeutic potential of EA in the treatment of liver diseases, particularly metabolic-dysfunction-associated steatotic liver disease (MASLD).…”
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Oral State and Salivary Cortisol in Multiple Sclerosis Patients by Aleksandra Kapel-Reguła, Justyna Chojdak-Łukasiewicz, Anna Rybińska, Irena Duś-Ilnicka, Małgorzata Radwan-Oczko

“…<b>Background:</b> MS patients experience gradual and progressive functional limitation, bulbar symptoms, cognitive dysfunction, and psychiatric disorders that can impinge on oral status. …”
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Recent Advances in Nanozymes for the Treatment of Atherosclerosis by Zou Z, Bi X, Ma H, Chen L, Jin H, Gong S, Li X, Liu X

“…Zheng Zou,1,&amp;ast; Xiaojun Bi,2,&amp;ast; Huan Ma,3 Ligang Chen,1 Hai Jin,1 Shun Gong,1 Xinning Li,1 Xiyu Liu1 1Department of Neurosurgery, General Hospital of Northern Theater Command, Liaoning, 110016, People’s Republic of China; 2Department of Urology, General Hospital of Northern Theater Command, Liaoning, 110016, People’s Republic of China; 3The Fourth Affiliated Hospital, China Medical University, Liaoning, 110031, People’s Republic of China&amp;ast;These authors contributed equally to this workCorrespondence: Xiyu Liu, Email lilsha0108@163.comAbstract: Atherosclerosis (AS) is a complex, multifactorial cardiovascular disease characterized by lipid accumulation, chronic inflammation, oxidative stress, and endothelial dysfunction. Conventional therapies, including lipid-lowering and anti-inflammatory agents, offer limited efficacy due to inadequate lesion targeting, low bioavailability, and systemic side effects. …”
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Novel targets for treating neurodegenerative diseases: The PKM2-STAT3-hnRNPA1 feedback loop by Ping Ye, Zhen Li, Hong Jiang

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Integrated multi-omics analysis and predictive modeling of heart failure using sepsis-related gene signature. by Yiping Lang, Tianyu Liang, Fei Li

“…<h4>Background</h4>Heart failure (HF) is characterized by complex molecular alterations, and recent studies suggest a potential role for sepsis-related genes in cardiovascular dysfunction. This study aimed to develop a predictive model for HF based on sepsis-related gene signatures.…”
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Asymptomatic renal damages in persons with chronic professional exposure to elementary mercury low concentrations by Đurić Stevan, Jovanović Dragan, Hrvačević Rajko, Kovačević Zoran, Konjević Marija

“…The frequency of asymptomatic renal tubular lesions and dysfunction of moderate extent were found to be higher in the exposed group than in the control one.…”
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High risk oral contraceptive hormones do not directly enhance endothelial cell procoagulant activity in vitro. by Emma G Bouck, Marios Arvanitis, William O Osburn, Yaqiu Sang, Paula Reventun, Homa K Ahmadzia, Nicholas L Smith, Charles J Lowenstein, Alisa S Wolberg

“…Endothelial cell (EC) dysfunction is thought to initiate venous thromboembolism. …”
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Group physiotherapy with survivors of torture in urban and camp settings in Jordan and Kenya by Laura Janet Pizer Gueron, Arobogust Amoyi, Winnie Chao, Justine Chepngetich, Jepkemoi Joanne Kibet, Stephen Nyambok, Joseph Wesonga

“…In addition, some survivors report having pelvic floor dysfunction and data will be offered about a subset of survivors looking at prevalence of these issues. …”
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A homolog of FHM2 is involved in modulation of excitatory neurotransmission by serotonin in C. elegans. by Elena G Govorunova, Mustapha Moussaif, Andrey Kullyev, Ken C Q Nguyen, Thomas V McDonald, David H Hall, Ji Y Sze

“…Migraine is the most common neurological disorder linked to serotonergic dysfunction. We sought to study the pathophysiological mechanisms of migraine and their relation to serotonin (5-HT) signaling using C. elegans as a genetic model. …”
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Sex Differences in Atrial Fibrillation: Evidence from Circulating Metabolites by Ningjing Qian, Junyan Jin, Ying Gao, Jiayi Liu, Yaping Wang

“…Transcriptomics data of the left atrium were used to investigate the molecular alteration of the left atrium responding to identified sex-specific circulating metabolites. The effect of selected sex-specific metabolites on cardiomyocytes was further investigated. …”
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Results of correction of aortic valve defects using small‑diameter «BioLAB» xenopericardial prosthesis in old patients by S. I. Babenko, R. M. Muratov, T. A. Chabaidze, N. N. Soboleva, M. N. Sorkomov

“…There were no reoperations due to early prosthetic endocarditis or prosthetic dysfunction in hospital. Hospital mortality was 6% (4 patients). …”
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Recombinant interleukin-7 treatment of refractory complex lung disease (IMPULSE-7): a pilot phase II, single-center, randomized, clinical trial by Carlos Mejia-Chew, Andrej Spec, Andrew H. Walton, Alina Ulezko Antonova, Alexandra Dram, Sanjeev Bhalla, Marco Colonna, Michel Morre, Richard Hotchkiss

“…Interleukin 7 (IL-7) is a pleiotropic cytokine with broad-ranging effects that enhance immunity and augment monocyte/macrophage anti- Mycobacterium avium killing in vitro. …”
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Prognostic value of left atrioventricular coupling index assessed by 3D echocardiography in patients with chronic kidney disease and heart failure with preserved ejection fraction by Weiyi Zhang, Xin Liu

“…The optimal cutoff value of 0.26 (AUC = 0.843, P < 0.001) effectively stratified high-risk patients (log-rank P < 0.001). …”
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Unraveling the role of NOG gene in hereditary sensory neuropathy type 1F through CRISPR/Cas9-mediated ATL3 knockout by Mahsa Saffar, Mahintaj Dara, Maryam Fazelzadeh Haghighi, Maryam Baneshi, Seyed Mohammad Bagher Tabei

“…Abstract Background ATL3 pathogenic variations cause hereditary sensory neuropathy type 1F (HSN1F), an autosomal dominant disorder characterized by distal sensory dysfunction manifesting as numbness, tingling, or discomfort. …”
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SHLP6: a novel NLRP3 and Cav1 modulating agent in Cu-induced oxidative stress and neurodegeneration by H. Thamarai Kannan, Suganiya Umapathy, Ieshita Pan

“…IntroductionCopper sulfate exposure induces oxidative stress by triggering excessive reactive oxygen species (ROS) production, leading to inflammatory responses, neuroinflammation, and cellular dysfunction. Small humanin-like peptide-6 (SHLP-6), a mitochondria-derived peptide with anti-aging and anti-cancer properties, has not been explored for its protective effects against copper sulfate toxicity. …”
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Diagnostic potential of soluble TNF alpha receptor 1 in diabetic and hypertensive patients with renal impairment and UTI. by Fatin Ayoob Hameed, Ali Mansoor Al Ameri, Israa Hashim Saadoon

“…In addition, investigating the effect of the immunological causes of renal impairment on the level of TNFR, both in urine and serum. …”
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