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6461
European Society of Cardiology Guidelines on the Management of Stable Coronary Artery Disease (2013)
Published 2014-06-01“…Recommendations for application, interaction and side effects of the main drugs are considered, evaluation of possible complications in patients with ischemic (coronary) heart disease in accordance with the Recommendations of the European Association of Cardiologists regarding the management of patients with stable coronary heart disease (2013) has been made. …”
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6462
Major Ozonated Autoheamotherapy Alleviates Skeletal Muscle Ischemia/Reperfusion Injury by Regulating Nrf2/HO‐1 Pathway
Published 2025-08-01“…In oxygen–glucose deprivation/reoxygenation (OGD/R)‐treated L6 myoblast models, ozone pretreatment enhanced cellular proliferation capacity while attenuating apoptosis and mitochondrial dysfunction. Subsequent analyzes revealed ozone's regulatory effects on oxidative stress markers (MDA content, SOD and CAT activity) and inflammatory factors (TNF‐α and IL‐1β) across both in vivo and in vitro models. …”
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6463
Energy-structural status in perioperative sedoanalgesia
Published 2018-08-01“…According to the initial level of energy-structural activity, all patients were divided into three groups: with dysfunction of the energy-structural status, with damage and insufficiency. …”
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6464
The Role of Physical Activity and Exercise in Cystic Fibrosis – A Literature Review
Published 2025-05-01“…Physical activity is recommended not only for the general population but is also increasingly recognized for its beneficial effects in patients with various chronic diseases. …”
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6465
Tetrahedral Framework Nucleic Acids Inhibit Oxidative Stress and Cardiomyocyte Apoptosis in Doxorubicin-Induced Cardiotoxicity
Published 2025-07-01“…In vivo studies confirmed functional improvement in cardiac tissue, validated by reduced biomarkers of cardiotoxicity and enhanced histological integrity.Conclusion: tFNAs effectively mitigated DIC pathogenesis through dual mechanisms of mitochondrial protection and apoptosis inhibition. …”
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6466
Association between active cooling and lower mortality among patients with heat stroke and heat exhaustion.
Published 2021-01-01“…The best available evidence supporting active cooling is based on a case series without comparison groups; thus, the effectiveness of this method in improving patient prognoses cannot be appropriately quantified. …”
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6467
Decreased Insulin Secretion but Unchanged Glucose Homeostasis in Cadmium-Exposed Male C57BL/6 Mice
Published 2019-01-01“…The aim of this study is to evaluate the possible effects of chronic Cd exposure on glucose metabolism in male C57BL/6 mice. …”
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6468
IRGM Deficiency Exacerbates Sepsis-Induced Acute Lung Injury by Inhibiting Autophagy Through the AKT/mTOR Signaling Pathway
Published 2024-12-01“…Further investigation revealed that treatment with the AKT inhibitor MK2206 effectively reversed the autophagy inhibition caused by IRGM knockdown and reduced apoptosis. …”
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6469
Genetics of Inflammatory Bowel Disease: Current Understanding and Future Directions
Published 2024-12-01“…Aim: to present literature data on the genetic underpinnings of inflammatory bowel disease (IBD), focusing on key genetic variants such as NOD2, ATG16L1, and IL23R; The objective of this was to understand how these genetic factors contribute to immune dysregulation, epithelial barrier dysfunction, and mucosal homeostasis in IBD.Key points. …”
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6470
Inhibition of miR-20a promotes neural stem cell survival under oxidative stress conditions
Published 2025-06-01“…IntroductionOxidative stress (OS) is a key contributor to secondary damage following spinal cord injury (SCI), leading to neural stem cell (NSC) dysfunction and apoptosis. MicroRNA-20a (miR-20a) is upregulated after SCI and plays a role in regulating apoptosis and survival pathways. …”
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6471
The choice of blood transfusion strategy in severe traumatic brain injury
Published 2024-07-01“…One of the main directions of treatment for patients with TBI is to prevent the development of secondary brain damage due to systemic dysfunction. Anemia occupies an important place among them. …”
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6472
Acute Coronary Syndrome (ACS) during Corona Virus Disease-19 (COVID-19) Pandemic: A Single-Center Comparative Study
Published 2021-07-01“…However, patients with STEMI had more left ventricular (LV) dysfunction, LV thrombus, and a significantly higher incidence of mitral regurgitation (13.3% vs. 8.8%, P < 0.05). …”
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6473
Eicosapentaenoic Acid Improves Endothelial Nitric Oxide Bioavailability Via Changes in Protein Expression During Inflammation
Published 2024-07-01“…Background Endothelial cell (EC) dysfunction involves reduced nitric oxide (NO) bioavailability due to NO synthase uncoupling linked to increased oxidation and reduced cofactor availability. …”
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6474
Short-Term Incubation of H9c2 Cardiomyocytes with Cannabigerol Attenuates Diacylglycerol Accumulation in Lipid Overload Conditions
Published 2025-06-01“…Therefore, in the current study, we evaluated a concentration-dependent effect of CBG (2.5 µM, 5 µM, and 10 µM) on H9c2 cardiomyocytes in lipid overload conditions. …”
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6475
Positive feedback loop between MAPK and aquaporin 7 regulates autophagy and apoptosis induced by palmitate in RIN‐m5f cells
Published 2025-06-01“…Type 2 diabetes mellitus (T2DM) is characterized by peripheral blood insulin resistance and progressive pancreatic β‐cell dysfunction which is closely related to apoptosis of β‐cells. …”
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6476
α-Lipoic acid alleviate myocardial infarction by suppressing age-independent macrophage senescence
Published 2025-04-01“…Macrophage SASP was induced by ROS and mitochondrial dysfunction. ALA alleviated SASP by decreasing ROS generation and autophagy flux while increasing SIRT1 levels, and Nrf2 nuclear translocation. …”
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6477
IL-33 and ST2 levels in chronic kidney disease: Associations with inflammation, vascular abnormalities, cardiovascular events, and survival.
Published 2017-01-01“…In this study, we aimed to investigate the levels of IL-33 and ST2 in the different stages of CKD and to determine their effect on vascular damage and cardiovascular events (CVE).…”
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6478
Therapeutic efficacy of mobilization with movement in early postoperative rehabilitation after unicompartmental knee arthroplasty: a double-blind, randomized controlled trial
Published 2025-07-01“…Mobilization with movement (MWM), a manual therapy technique targeting joint kinematics and neuromuscular control, may synergize with rapid rehabilitation to address postoperative dysfunction. Purpose To evaluate the adjunctive effects of MWM on early postoperative functional recovery, pain control, and knee joint stability in patients receiving a standardized rapid rehabilitation protocol for UKA. …”
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6479
Neonatal brain injury influences structural connectivity and childhood functional outcomes.
Published 2022-01-01“…DMRI of 35 subjects with CHD and 62 subjects with HIE were compared to understand differences in the effects of HIE and CHD on the development of network topological parameters and functional outcomes. …”
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6480
Case Report: Simultaneous hepatic and renal echinococcosis in a child: a multidisciplinary approach
Published 2025-07-01“…Postoperatively, transient hypernatremia and hepatic dysfunction occurred but were effectively managed. The patient was discharged on postoperative day 7 and showed no recurrence at the 1-month follow-up.DiscussionThis case underscores the complexity and rarity of simultaneous hepatic and renal echinococcosis in children. …”
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