Apo A1 Mimetic Rescues the Diabetic Phenotype of HO-2 Knockout Mice via an Increase in HO-1 Adiponectin and LKBI Signaling Pathway by Jian Cao, Nitin Puri, Komal Sodhi, Lars Bellner, Nader G. Abraham, Attallah Kappas

“…Insulin resistance, with adipose tissue dysfunction, is one of the hallmarks of metabolic syndrome. …”
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Women's Quality of Life After Surgical Treatment for Breast Cancer by Daniel Alejandro Arroyo Zumarraga, Ximena Elizabeth Trujillo Romero, Miguel Ramos Argilagos

“…<br /><strong>Conclusions:</strong> several factors influence the quality of life and psychosexual functioning of the women studied: the scope of the surgical intervention, the effectiveness of oncological treatment, age, number of children, educational level, economic situation and status labor.…”
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Towards personalized microbial therapies for metabolic alterations in celiac disease by Alejandro Borrego-Ruiz, Juan J. Borrego

“…Postbiotics complement these effects by reinforcing barrier integrity and counteracting gliadin-induced inflammation. …”
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Astrocytes-associated research in Parkinson’s disease: an explored trends analysis by Yan-Jun Chen, Yan-Jun Chen, Ming-Rong Xie, Sheng-Qiang Zhou, Fang Liu

“…Among the various cellular and molecular mechanisms of PD, astrocyte dysfunction is one of the causes of disease development. …”
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A randomised trial examining inflammatory signaling in acutely induced hyperinsulinemia and hyperlipidemia in normal weight women-the reprometabolic syndrome. by Andrew Tannous, Andrew P Bradford, Katherine Kuhn, Angela Fought, Irene Schauer, Nanette Santoro

“…These results imply that the endocrine disruption and adverse reproductive outcomes of obesity are not a consequence of the ambient inflammatory environment but may be mediated by direct lipotoxic effects on the hypothalamic-pituitary-ovarian (HPO) axis.…”
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When lightning strikes the heart: a rare injury with features of non‑ST elevation myocardial infarction – a case report by Muhammad Isra Rafidin Rayyan, Aulia Shakila Rahma, Nabil Athoillah, Muhammad Daffa Husniatama, Nurwahyudi Nurwahyudi

“…Although various organ systems can be involved, the effects of electric current on the cardiovascular system can manifest as electrocardiographic (ECG) changes, elevated cardiac-specific enzymes, and cardiac and respiratory arrest, although rare. …”
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Soy milk and ginger (Sulehe) increase PPAR-γ expression in a rat model of insulin resistance by Wiwik Handayani, Sri Andarini, Diana Lyrawati, Achmad Rudijanto

“…This disease leads to dysfunction of various organs including eyes, kidneys, and heart. …”
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Association Between Antioxidant Capacity and Vascular Hemodynamics in Premenopausal Women Following Exercise Training by Gordon Fisher, Aparna Tamhane, Douglas R. Moellering, Christian E. Behrens, Gary R. Hunter

“…ABSTRACT Oxidative stress plays a role in vascular dysfunction and cardiometabolic health. The purpose of this study was to assess the effects of aerobic exercise training on antioxidant capacity (ferric reducing ability of plasma/FRAP) and hemodynamic measures: systolic blood pressure (∆SBP), diastolic blood pressure (∆DBP), mean arterial blood pressure (∆MAP), large arterial elasticity index (∆LAEI), and small arterial elasticity index (∆SAEI) in a cohort of healthy women. …”
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Long-term Neurological Consequences of COVID-19 in Patients With Pre-existing Alzheimer’s and Parkinson’s Disease: A Comprehensive Review by Kelechi Wisdom Elechi, Ogundipe Oyepeju Nkem, Ndubuisi Timothy Chibueze, Ubalaeze Solomon Elechi, Kenechukwu Franklin Chimaobi

“…SARS-CoV-2, the causative agent of COVID-19, has profound systemic effects, including significant impacts on the central nervous system (CNS). …”
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Use of Immune Modulating Agents to Regulate Hyperinflammation in Severe COVID 19: Assessment of Tocilizumab Use in Combination with Steroids by Somayeh Sadeghi, Zohre Naderi, Nima Arezoomandi, Mozhdeh Saghaei, Fereshteh Tavakoli, Mahsa Hajizadeh

“…Logistic regression revealed increased risks of mortality, nosocomial infection, and adverse effects, including hepatic and renal dysfunction and gastrointestinal bleeding, in Groups B and C compared with Group A. …”
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Carnitine levels and cardiac functions in children with solid malignancies receiving doxorubicin therapy by Anant Khositseth, Suwadee Jirasakpisarn, Samart Pakakasama, Lulin Choubtuym, Duangrurdee Wattanasirichaigoon

“…Conclusions: Carnitine levels tended to decrease after doxorubicin treatment. LV global dysfunction was documented early after doxorubicin. …”
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Comparable Efficacy and Safety of Teriflunomide versus Dimethyl Fumarate for the Treatment of Relapsing-Remitting Multiple Sclerosis by Nasim Nehzat, Omid Mirmosayyeb, Mahdi Barzegar, Reza Vosoughi, Erfane Fazeli, Vahid Shaygannejad

“…The drug-associated adverse effects (AEs) were recorded. We conducted propensity matching score to compare the efficacy between TRF and DMF. …”
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Importance of early ventilation tubes insertion in chronic otitis media with effusion in children with congenital cleft palate by Šubarević Vladan, Arsović Nenad, Simić Radoje, Stanković Katarina

“…The Eustachian tube dysfunction is the main factor that leads to the presence of the middle ear effusion. …”
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Clinical study of critical patients with hemorrhagic fever with renal syndrome complicated by acute respiratory distress syndrome. by Hong Du, Jing Li, Wei Jiang, Haitao Yu, Ye Zhang, Junning Wang, Pingzhong Wang, Xuefan Bai

“…The non-survivors were found to have higher frequencies of encephalopathy, refractory shock and multiple organ dysfunction syndrome (MODS), lower incidences of acute renal failure (ARF) and secondary hypertension (P<0.05). …”
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Potassium Clearance in Optic Nerve: A Multidomain Model by Shanfeng Xiao, Huaxiong Huang, Robert Eisenberg, Zilong Song, Shixin Xu

“…Changes in AQP4 expression had limited effect on ionic homeostasis in the current model. …”
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CCL2 Inhibitor Bindarit Improve Postoperative Cognitive Function by Attenuating Pericyte Loss-Related Blood–Brain Barrier Disruption and Neuroinflammation by Hui Yuan, Bo Lu, Daofan Sun, Junping Chen, Xiangming Fang

“…This study investigates whether C–C motif chemokine ligand 2 (CCL2) in hippocampal tissues contributes to postoperative PC injury, blood–brain barrier (BBB) disruption, neuroinflammation, and cognitive dysfunction. Sixteen-month-old C57BL/6 mice underwent tibial fracture surgery to induce PND. …”
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Decoding survival in MASLD: the dominant role of metabolic factors by Zhiqiang Jin, Cheng Zeng, Yang Yang, Shan Zhong, Zhi Zhou

“…Abstract Background Metabolic factors are considered to influence disease progression in patients with Metabolic Dysfunction-Associated Steatotic Liver Disease (MASLD), but the impact of individual metabolic factors on the survival rate of patients with MASLD is still unclear. …”
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Current Application of Mineralocorticoid Antagonist (MRA) in Heart Failure and CKD: Does Non-Steroidal Drug Add Novel Insights by Irene Carlino, Filippo Pirrotta, Luigi Gennari, Alberto Palazzuoli

“…However, some categories such as patients with renal dysfunction tend to be excluded from larger randomized clinical trials. …”
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Irisin mitigates salt-sensitive hypertension via regulating renal AMPK-Rac1 pathway by Jie Mao, Xiaocui Zhang, Chunxiang Wang, Suying Peng

“…However, whether irisin attenuates salt-sensitive hypertension and the related underlying mechanisms is unknown.Methods Male Dahl salt-resistant (DSR) and Dahl salt-sensitive (DSS) (12 weeks) rats were fed a high salt diet (8% NaCl) with or without irisin treatment by intraperitoneal injection for 8 weeks.Results Compared with DSR rats, DSS rats showed higher systolic blood pressure (SBP), impaired natriuresis and diuresis and renal dysfunction. In addition, it was accompanied by downregulation of renal p-AMPKα and upregulation of renal RAC1 and nuclear mineralocorticoid receptor (MR). …”
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CD44 signaling in skin wound healing and regeneration by Annie Y. Guan, Yanlin Chen, Scheffer C. Tseng, Qing Lin

“…The development of HTS can result from dysfunction in the four overlapping phases of wound healing, particularly during the inflammatory phase. …”
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