Association between weight-adjusted-waist index and retinopathy among American adults: a cross-sectional study and mediation analysis by Junmeng Li, Qianshuo Yin, Jianchen Hao, Ruilin Zhu, Jing Zhang, Yadi Zhang, Xiaopeng Gu, Zihui Wu, Liu Yang

“…BackgroundRetinopathy, a microvascular complication linked to obesity and metabolic dysfunction, is characterized by the absence of reliable anthropometric predictors. …”
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Postoperative hypoxia and length of intensive care unit stay after cardiac surgery: the underweight paradox? by Marco Ranucci, Andrea Ballotta, Maria Teresa La Rovere, Serenella Castelvecchio, Surgical and Clinical Outcome Research (SCORE) Group

“…Obese patients are partially protected against the deleterious effects of hemodilution and transfusions. Underweight patients present the "paradox" of a better lung gas exchange but a longer intensive care unit stay. …”
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Using virtual patient cohorts to uncover immune response differences in cancer and immunosuppressed COVID-19 patients. by Sonia T Gazeau, Xiaoyan Deng, Elsa Brunet-Ratnasingham, Daniel E Kaufmann, Catherine Larochelle, Penelope A Morel, Jane M Heffernan, Courtney L Davis, Amber M Smith, Adrianne L Jenner, Morgan Craig

“…It is difficult to conduct clinical studies in these populations, resulting in a restricted amount of data that can be used to relate mechanisms of immune dysfunction to COVID-19 outcomes in these vulnerable groups. …”
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Epigenetic influence of long non-coding RNAs on the development of insulin resistance in metabolically associated fatty liver disease (part 2) by O.E. Abaturov, A.O. Nikulina

“…Understanding the mechanisms of action of long non-coding RNAs (lncR) and their significance in the development of insulin resistance (IR) in patients with metabolically associated fatty liver disease will allow modifying and increasing the effectiveness of methods for diagnosing and treating metabolic disorders. …”
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Cl-amidine confers organ protection and improves survival in hemorrhagic shock rats via the PAD4-CitH3-NETs axis. by Huiting Yun, Yunfei Chi, Bin Wei, Hailiang Bai, Weihua Cao, Zheng Zhang, Yufang Zhang, Quanxi Zhang, Hongjie Duan

“…<h4>Background</h4>The occurrence of multi-organ dysfunction following hemorrhagic shock (HS) remains a critical clinical challenge. …”
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In vivo mitochondrial ATP production is improved in older adult skeletal muscle after a single dose of elamipretide in a randomized trial. by Baback Roshanravan, Sophia Z Liu, Amir S Ali, Eric G Shankland, Chessa Goss, John K Amory, H Thomas Robertson, David J Marcinek, Kevin E Conley

“…Despite the increase in ATPmax there was no significant effect of treatment on fatigue resistance in the FDI.…”
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Sympathetic cholinergic nerve fibres promote BMSC differentiation into osteoblasts via NRTN secretion: a potential treatment for osteoporosis by Yuechun Chen, Zhenyu Zhang, Huibo Ti, Junjie Wu, Feng-lai Yuan, Xia Li

“…Abstract Background Peripheral nerves within the bone actively participate in bone remodelling by secreting various bioactive molecules, and dysfunction or changes in their abundance greatly contribute to the onset of osteoporosis. …”
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SARS-CoV-2 Envelope (E) protein interacts with PDZ-domain-2 of host tight junction protein ZO1. by Ariel Shepley-McTaggart, Cari A Sagum, Isabela Oliva, Elizabeth Rybakovsky, Katie DiGuilio, Jingjing Liang, Mark T Bedford, Joel Cassel, Marius Sudol, James M Mullin, Ronald N Harty

“…We postulate that SARS-CoV-2 E interacts with ZO1 in infected epithelial cells, and this interaction may contribute, in part, to tight junction damage and epithelial barrier compromise in these cell layers leading to enhanced virus spread and severe dysfunction that leads to morbidity. Prophylactic/therapeutic intervention targeting this virus-host interaction may effectively reduce airway and/or gastrointestinal barrier damage and mitigate virus spread.…”
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Cluster analysis of hotspots and research trends of epirubicin-induced cardiotoxicity: a bibliometric study by Dongning He, Wenjuan Wang, Xigang Luo, Yadi Wang, Yadi Wang

“…BackgroundEpirubicin, a widely used anthracycline, effectively treats various cancers but poses a high risk of cardiotoxicity, leading to heart failure and myocardial dysfunction. …”
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Microglial progranulin differently regulates hypothalamic lysosomal function in lean and obese conditions via cleavage-dependent mechanisms by Chae Beom Park, Chan Hee Lee, Gil Myoung Kang, Se Hee Min, Min-Seon Kim

“…In cultured hypothalamic neurons and microglia, PGRN treatment enhanced lysosomal function, an effect inhibited by PGRN cleavage but restored when its cleavage was blocked. …”
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Neuraxial biomechanics, fluid dynamics, and myodural regulation: rethinking management of hypermobility and CNS disorders by Nicole Frost, Nicole Frost, S. Jade Barclay, S. Jade Barclay

“…Altered mechanical loading or vascular supply of neural structures can adversely impact neural health and conductivity, with local and remote effects on inflammation, venous congestion, and muscle control. …”
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Feasibility of Early Definitive Internal Fixation of Pelvic Bone Fractures in Therapeutic Open Abdomen by Kyunghak Choi, Kwang-Hwan Jung, Min Ae Keum, Sungjeep Kim, Jihoon T Kim, Kyu-Hyouck Kyoung

“…A large part of severe abdominal injury occurs with a concomitant pelvic bone fracture. The safety and effectiveness of internal fixation of pelvic bone fracture(s) has not been established. …”
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Comparative omics analysis of the impact of Mycoplasma synoviae infection on the immune mechanisms of poultry spleen by Lemiao Zhong, Chunlin Wu, Lvyan Liao, Jian Li, Yijian Wu

“…Mycoplasma synoviae (MS) infection can cause severe inflammatory responses in avian species, evading immune recognition, leading to chronic infection and immune dysfunction. Although the pathogenic mechanisms and immune evasion strategies of MS have not been fully elucidated, the crucial role of the spleen in immune responses cannot be overlooked. …”
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Transgenerational impact of maternal adverse childhood experiences on children's mental health among families experiencing homelessness by AnnaMaria Boullion, Holly Brott, Taylor Oren, Maciel van Eckhardt, Melissa Holland, Stephen E. Brock, Gary A. Incaudo

“…Rather than using the cumulative approach to conceptualize ACEs, we analyzed a model that assessed the effect of each maternal ACE individually (i.e., specificity model) and another model that categorized them into two subtypes of maltreatment and household dysfunction (i.e., dimensional model). …”
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Heart failure in cancer patients by A. F. Khalirakhmanov, A. Z. Sharafeev, G. D. Gatiyatullina, S. V. Zinchenko, R. F. Gaifullina, A. A. Rizvanov

“…They are all based on accurate patient selection, short- and longterm follow-up, and therapies that can prevent and delay cardiac dysfunction. Conclusion. The main goal of cardio-oncology is to prevent and treat of cardiotoxic effects of chemotherapy drugs. …”
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Optimasi Kecepatan Sentrifugasi Sampel Darah untuk Pemeriksaan Diabetes Melitus Tipe 2 (T2D) Berbasis Molekuler by Miftahul Mushlih, Fitrian Desi Prameswari, Jamilatur Rohmah, Andika Aliviameita

“…Type 2 Diabetes Mellitus (T2D) is a metabolic disorder caused by dysfunction of insulin secretion by pancreatic beta cells and the inability of insulin tissue to respond appropriately to insulin. …”
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Glutathione Decreases Parkinsonism‐Induced Ferroptosis and Oxidative Stress Through the Inhibition of the TRPM2 Channel in Neuronal Cells by Elif Güzel, Ayşe Arzu Sayın Şakul, Mustafa Nazıroğlu

“…Our aim in this study was to examine the function of TRPM2 and the protective effect of GSH in the dopaminergic human SH‐SY5Y neuronal cells that had been exposed to 1‐methyl 4‐phenylpyridinium (MPP) to produce parkinsonism. …”
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Statin-induced rhabdomyolysis in a 60-year-old woman with decompensated type 2 diabetes: a case report by O. V. Tsygankova, N. E. Evdokimova, S. S. Bayramova, A. V. Susekov

“…According to the appointment of a primary care physician, three months before hospitalization, the patient was switched from therapy with European generic brand-name rosuvastatin 20 mg to the Russian generic unbranded atorvastatin in the same dose (20 mg), which is not comparable in lipid-lowering effect. In a laboratory study, an increase in creatine phosphokinase level by 348 times (50462 U/L) of upper normal limit in combination with severe hypokalemia 1б7 mmol/L in the absence of renal dysfunction was recorded. …”
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Mapping dysphagia in pediatric dystonia. by Muserrefe Nur Keles, Esra Serdaroglu

“…<h4>Conclusion</h4>Swallowing dysfunction was observed in almost all children with dystonia, with the majority presenting with severe dysphagia and an elevated risk of aspiration. …”
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miR‐373 regulates inflammatory cytokine‐mediated chondrocyte proliferation in osteoarthritis by targeting the P2X7 receptor by Wei Zhang, Biao Zhong, Chi Zhang, Congfeng Luo, Yulin Zhan

“…Furthermore, the proliferative and pro‐inflammatory effects of miR‐373 on the chondrocytes could be suppressed by a P2X7R antagonist, further suggesting that miR‐373 mediates chondrocyte proliferation and inflammation by targeting P2X7R. …”
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