Chemokine Receptor and Ligand Upregulation in the Diaphragm during Endotoxemia and Pseudomonas Lung Infection by Alexandre Demoule, Maziar Divangahi, Linda Yahiaoui, Gawiyou Danialou, Dusanka Gvozdic, Basil J. Petrof

“…Manipulation of the NF-kB pathway and other regulators of chemokine expression in the diaphragm could represent a novel method for mitigating the skeletal muscle inflammatory response associated with sepsis-induced diaphragmatic dysfunction.…”
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Hepatic stereological analysis in obese Zucker rats (Leprfa) with dyslipidemia by Silvio Pires Gomes, Gabriela Salim de Castro, Vinicius Pedro Silva de Oliveira, Bruno Cogliati, Andressa Galvão da Silva Iacopino, Ivanir Santana de Oliveira Pires, Bruno Cesar Schimming, Fernanda Gosuen Gonçalves Dias, José Roberto Kfoury Junior, Tais Harumi de Castro Sasahara

“…This study reinforces the utility of the obese Zucker rat model to investigate the effects of obesity on liver health and suggests hepatic steatosis requires therapeutic strategies focused on modulating these parameters.…”
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Exploring proinsulin proteostasis: insights into beta cell health and diabetes by Parisima Ghaffarian Zavarzadeh, Kathigna Panchal, Dylan Bishop, Elizabeth Gilbert, Mahi Trivedi, Tovaria Kee, Srivastav Ranganathan, Anoop Arunagiri

“…Disruptions in these systems, due to genetic mutations, ER stress, or impaired ER-to-Golgi trafficking, lead to proinsulin accumulation and β-cell dysfunction. The unfolded protein response (UPR), especially the PERK and IRE1α-XBP1 pathways, emerges as a central regulator of protein synthesis and ER stress management. …”
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Leucine‐Rich Repeat‐Containing G Protein‐Coupled Receptor 6 Ameliorates Pressure Overload‐Induced Cardiac Hypertrophy by Regulating Cardiomyocyte Metabolic Reprogramming by Mengmeng Zhao, Jianfang Liu, Shanshan Peng, Zihui Zheng, Siqi Liu, Jun Wan, Yao Xu, Menglong Wang

“…Adeno‐associated virus 9 and adenovirus vectors are utilized to knock down and overexpress Lgr6 in cardiomyocytes, respectively. The effects of Lgr6 and its downstream molecules are subsequently determined using RNA sequencing and chromatin immunoprecipitation. …”
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Autism Spectrum Disorder in a Girl with a De Novo X;19 Balanced Translocation by Marcelo Razera Baruffi, Deise Helena de Souza, Rosana Aparecida Bicudo da Silva, Ester Silveira Ramos, Danilo Moretti-Ferreira

“…Balanced X-autosome translocations are rare, and female carriers are a clinically heterogeneous group of patients, with phenotypically normal women, history of recurrent miscarriage, gonadal dysfunction, X-linked disorders or congenital abnormalities, and/or developmental delay. …”
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Selection of Comprehensive Assessment Categories Based on the International Classification of Functioning, Disability, and Health for Elderly Patients with Heart Failure: A Delphi... by Shigehito Shiota, Makiko Naka, Toshiro Kitagawa, Takayuki Hidaka, Naoki Mio, Kana Kanai, Mariko Mochizuki, Hiroaki Kimura, Yasuki Kihara

“…This result seems to be influenced by the increasing interest in cognitive dysfunction in elderly patients with heart failure. …”
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Toll-Like Receptor-Mediated Cardiac Injury during Experimental Sepsis by Ina Lackner, Birte Weber, Shinjini Chakraborty, Sonja Braumüller, Markus Huber-Lang, Florian Gebhard, Miriam Kalbitz

“…The aim of this study was to define the effects of sepsis on cardiac structure, gap junction, and tight junction (TJ) proteins. …”
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Altered glucose metabolism in default mode network and prefrontal circuit in patients with Kallmann syndrome by Chunqing Zhou, Xueying Wang, Meichao Men, Xiaoping Yi, Ke Cao, Weidan Pu, Marcus Hacker, Xiang Li, Min Zhao

“…Subsequently, correlation and mediation analyses were performed to investigate the interrelationships and mediating effect among brain metabolic patterns, sex hormone levels, and psychosocial factors. …”
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Exploring the experiences of cognitive symptoms in Long COVID: a mixed-methods study in the UK by Ning Song, Manoj Sivan, Amy Miller, Rumana Chowdhury, Melanie Rose Burke

“…Strategies used for symptom management varied in effectiveness.Conclusion Cognitive dysfunction in LC appears to be exacerbated by vicious cycle of withdrawal from daily life including loss of employment, physical inactivity and social isolation driving low mood, anxiety and poor cognitive functioning. …”
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Disease burden and trends in gout for adolescents from 1990 to 2021, with projections to 2050 globally, in East Asia and China: results from the Global Burden of Disease study 2021 by Lu Yang, Zhenyu Wang, Ligang Cui

“…China saw 17.1–25.1% ASR increases, driven by metabolic risks (36.8%), obesity (31.4%), and kidney dysfunction (7.6%). Females consistently bore higher burdens than males across regions. …”
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A Kinematic Study on the Use of Overhead Squat Exercise with Elastic Resistance on the Shoulder Kinetic Chain Approach by Fagner Luiz Pacheco Salles, Augusto Gil Pascoal

“…Trunk flexion/extension showed a significant effect on resistance during the LOAD phase (<i>p</i> = 0.008, η²ₚ = 0.24). …”
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Identifying common factors of functioning, participation and environment amongst adults requiring specialist oral health care using the International Classification of Functioning,... by Alison Dougall, Francisca Martinez Pereira, Gustavo Molina, Caroline Eschevins, Blánaid Daly, Denise Faulks

“…<h4>Results</h4>Participants presented with oral disease (92%) and dysfunction (66% impaired chewing). 33 ICF items were affected in over 50% of participants in both groups. …”
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Ovine tricuspid annular dynamics and three-dimensional geometry during acute atrial fibrillation. by Paulina Kania-Olejnik, Marcin Malinowski, Manuel K Rausch, Tomasz A Timek

“…<h4>Objectives</h4>Long-standing atrial fibrillation (AF) may lead to tricuspid regurgitation (TR) and right ventricular dysfunction. However, the effect of acute AF on tricuspid annular (TA) dynamics and three-dimensional geometry is unknown.…”
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Patient Reported Outcomes and Treatment-Associated Complications as a Consideration in Selecting Localized Prostate Cancer Management by Nguyen T, Lightfoot C, May D, Greenberg JW, Krane LS

“…Each treatment modality presents distinct risks, notably urinary incontinence, erectile dysfunction, bowel issues, and cancer recurrence. Understanding these adverse effects in terms of PROs is critical for patients and healthcare providers to engage in shared decision-making, enabling personalized treatment plans based on clinical outcomes and patient values. …”
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Radiation diagnostics of the state of ventilation and pulmonary circulation in patients with COPD by O. S. Sementsov, S. V. Stepanenko

“…However, given the lack of unifying works on the study of this method, further studies of the capabilities of computed tomography in the diagnosis of signs of dysfunction of external respiration in patients with COPD are required. …”
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Evaluating Heart Rate Variability as a Biomarker for Autonomic Function in Parkinson’s Disease Rehabilitation: A Clustering-Based Analysis of Exercise-Induced Changes by Ahmed M. Basri, Ahmad F. Turki

“…This study investigates the effects of aerobic exercise on HRV in patients with PD and evaluates autonomic adaptations to rehabilitation. …”
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Exploring Angiopoietin-2: Clinical Insights and Experimental Perspectives in Kidney Diseases by An-Jie Luo, Fan-Chi Chang, Shuei-Liong Lin

“…Traditionally seen as an antagonist of the Tie-2, which is a receptor tyrosine kinase of endothelial cells and some hematopoietic stem cells, angiopoietin-2 exerts both proangiogenic and antiangiogenic effects, making it a versatile and context-dependent player in kidney pathophysiology. …”
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Deciphering the angiogenic potential of Zhishi Xiebai Guizhi decoction in coronary heart disease: an in-depth network pharmacology and experimental investigation by Yingli Mo, Yuping Xu, Bei Lu, Xiaojuan Fan, Qingshuang Zhang, Shaowu Cheng, Qinghua Peng

“…Its selection was rooted in documented therapeutic benefits for blood stasis and endothelial dysfunction, with modern pharmacology identifying active compounds (e.g., luteolin, quercetin) targeting inflammation and oxidative stress pathways. …”
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Viral Impact on Male Fertility: Current Insights and Implications for SARS-CoV-2 by Falah Hasan Obayes Al-Khikani

“…Additionally, the role of vaccination in preventing viral-induced reproductive dysfunction is highlighted, underscoring the need for widespread immunization against viruses such as mumps and human papillomavirus. …”
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Quantifying Impairments in the Subacute Phase of Whiplash Associated Disorders—A Cross-Sectional Study by Harpa Ragnarsdóttir, Guðný Lilja Oddsdóttir, Magnús Kjartan Gíslason, Kristín Briem

“…A key concern is cervical range of motion (cROM) impairment and sensorimotor dysfunction, which contribute to prolonged disability. …”
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