Brain Oxygenation During Exercise in Different Types of Chronic Lung Disease: A Narrative Review by Stella Kritikou, Andreas Zafeiridis, Georgia Pitsiou, Ioannis Gkalgkouranas, Leonidas Kastritseas, Afroditi Boutou, Konstantina Dipla

“…While pulmonary, cardiovascular, respiratory, and peripheral muscle dysfunction contribute to exercise limitations, recent evidence suggests that hypoxia and impairments in cerebral oxygenation may also play a role in exercise intolerance. …”
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Selection of Target Mean Arterial Pressure in Severely Burned Patients with Septic Shock by A. A. Kleuzovich, V. V. Kazyonnov, A. N. Kudryavtsev, A. V. Geyze, G. P. Plotnikov, А. A. Alekseyev

“…Monitoring methods providing early diagnosis of organ dysfunction development are of great importance. Assessment of the glomerular filtration rate with central hemodynamic parameters can be considered as a component of comprehensive monitoring of effectiveness of septic shock therapy.Aim: to determine the relationship between the target mean arterial pressure and glomerular filtration rate parameters in the treatment of severely burned patients with septic shock.Material and methods. 158 severely burned patients with septic shock were included in the study, of them 121 patients represented a retrospective historical group, and 37 patients constituted a prospective group. …”
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Vascular Remodeling, Oxidative Stress, and Disrupted PPARγ Expression in Rats of Long-Term Hyperhomocysteinemia with Metabolic Disturbance by Yajing Huo, Xuqing Wu, Jing Ding, Yang Geng, Weiwei Qiao, Anyan Ge, Cen Guo, Jianing Lv, Haifeng Bao, Wei Fan

“…Our study was aimed at exploring the effect of long-term hyperhomocysteinemia with metabolic disturbances on vascular remodeling. …”
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Advancing The Cardiovascular Care in Cancer Patients on Chemotherapy by Muhammad Yamin, Simon Salim, Muhammad Syahrir Azizi, Lusiani Rusdi, Aru Wisaksono Sudoyo, Anneira Amanda Putri

“… Cardiotoxicity associated with chemotherapy, also known as Cancer Therapy-Related Cardiac Dysfunction (CTRCD), affects 10% of patients undergoing chemotherapy and is the most undesirable side effect of chemotherapy. …”
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Plasma proteomic signatures of dual cognitive and mobility decline in older adultsResearch in context by Qu Tian, Erin E. Greig, Michael R. Duggan, Keenan A. Walker, Luigi Ferrucci

“…Interpretation: Older adults experiencing dual decline exhibit longitudinal protein changes, indicating mitochondrial dysfunction, proteostasis, neuroinflammation, and immune responses. …”
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Exercise Attenuates Skeletal Muscle Atrophy in Senescent SAMP8 Mice: Metabolic Insights from NMR-Based Metabolomics by Wenfang Wu, Linglin Zhang, Yifen Chen, Caihua Huang, Longhe Yang, Donghai Lin

“…This study used the SAMP8 model to evaluate the effects of exercise on muscle atrophy and associated metabolic changes. …”
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Association between thyroid function and osteopenia or osteoporosis: a cross-sectional study in China by Ling Zhang, Chao Ma, Xin Yin, Fenglian Zhang, Xiuyan Fang, Chen Zhang, Lei Shang, Li Ma

“…Abstract Thyroid dysfunction is associated with bone health, but the relationship with osteopenia remains unclear. …”
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SIRT5 regulates granulosa cell proliferation and apoptosis in polycystic ovarian syndrome via desuccinylation of GLI1 by Yiwen Zhang, Fangfang He, Ning Cai, Guanmei Chen, Yinyin Wang, Weiwei Bai, Peng Guo

“…This study aimed to analyze the effect of desuccinylase SIRT5 on granulosa cell phenotype and the molecular mechanism. …”
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Overdiagnosis and Overtreatment in Prostate Cancer by Zaure Dushimova, Yerbolat Iztleuov, Gulnar Chingayeva, Abay Shepetov, Nagima Mustapayeva, Oxana Shatkovskaya, Marat Pashimov, Timur Saliev

“…Overdiagnosis involves identifying indolent tumors unlikely to affect a patient’s lifespan, while overtreatment refers to unnecessary interventions that can cause adverse effects such as urinary incontinence, erectile dysfunction, and a reduced quality of life. …”
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Hybrid pelvic floor reconstruction using a vaginal flap with unilateral apical fixation in the management of post-hysterectomy prolapse: A retrospective study by Dmitry D. Shkarupa, Rustam A. Shakhaliev, Nikita D. Kubin, Andrei S. Shulgin, Zaynulabid I. Muldarov, Firdavskhuja P. Sultonov

“…To evaluate the anatomical effectiveness and safety of hybrid pelvic floor reconstruction using a vaginal flap with unilateral apical fixation in women with post-hysterectomy prolapse. …”
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THE GENETIC SUSCEPTIBILITY TO ATHEROSCLEROSIS by T. V. Kozhanova, E. V. Neudakhin, S. S. Zhilina, T. I. Mescheryakova, A. A. Abramov, E. N. Lukash, A. G. Prityko

“…Multiple factors, including endothelial dysfunction, lipid metabolism defects, inflammation and immune responses, oxidative stress, cell proliferation, tissue remodeling and hemostatic defects are involved in the pathogenesis of atherosclerosis. …”
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Predictors of the development of non-cardiogenic syncopal conditions at a young age by D. A. Napalkov, A. A. Sokolova, M. R. Kondratyuk, A. A. Kudryavtseva, P. M. Krupenin, G. E. Savkov, O. D. Savkova, S. Yu. Yagofarova, A. V. Buchneva, J. M. Kwedhi

“…A significant correlation was found between the onset of reflex syncope and the presence of anemia and autonomic dysfunction syndrome. We proved the absence of a correlation between the level of daily load and the frequency of syncope conditions.…”
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Multiple pathways through which the gut microbiota regulates neuronal mitochondria constitute another possible direction for depression by Hongyi Zhao, Xiongfeng Qiu, Shuyu Wang, Yi Wang, Li Xie, Xiuwen Xia, Weihong Li, Weihong Li

“…As a significant mental health disorder worldwide, the treatment of depression has long faced the challenges of a low treatment rate, significant drug side effects and a high relapse rate. Recent studies have revealed that the gut microbiota and neuronal mitochondrial dysfunction play central roles in the pathogenesis of depression: the gut microbiota influences the course of depression through multiple pathways, including immune regulation, HPA axis modulation and neurotransmitter metabolism. …”
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The role of Mitofusin-1 and Mitofusin-2 in periodontal disease: a comprehensive review by Sudhir R. Varma, Sudhir R. Varma, Omar H. A. A. Ani, Jayaraj K. Narayanan, Jayaraj K. Narayanan, Asok Mathew, Asok Mathew

“…The aim of the current study is to comprehensively review including evaluate the roles of MFN2 and MFN1 in the pathogenesis as well as the progression of periodontal disease, foregrounding their effect on mitochondrial integrity, inflammatory pathways, and oxidative stress. …”
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PPARα Agonist Fenofibrate Reduced the Secreting Load of β-Cells in Hypertriglyceridemia Patients with Normal Glucose Tolerance by Jia Liu, Rui Lu, Ying Wang, Yanjin Hu, Yumei Jia, Ning Yang, Jing Fu, Guang Wang

“…Hypertriglyceridemia is an important risk factor associated with insulin resistance and β-cell dysfunction. This study investigated the effects of hypertriglyceridemia and fenofibrate treatment on insulin sensitivity and β-cell function in subjects with normal glucose tolerance. …”
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Exploring the application of dietary antioxidant index for disease risk assessment: a comprehensive review by Hossein Pourmontaseri, Sina Bazmi, Matin Sepehrinia, Matin Sepehrinia, Ayda Mostafavi, Reza Arefnezhad, Reza Arefnezhad, Reza Homayounfar, Farhad Vahid

“…Numerous studies have highlighted the adverse effects of high reactive oxygen species (ROS) levels in the progression of chronic noncommunicable diseases and also during infections. …”
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Significance of the pulsatility index in the evaluation of hemodynamic changes in peripheral arterial circulation in the obese treated with orlistat by Hajduković Zoran, Dragović Tamara, Rađen Slavica, Marinković Dejan M., Ratković Nenad, Kiković Saša

“…Prolonged hyperinsulinemia accelerates the process of endothelial dysfunction and arteriosclerotic changes affecting the development of cardiovascular and cerebrovascular diseases. …”
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Determinants and Regression Equations for the Calculation of z Scores of Left Ventricular Tissue Doppler Longitudinal Indexes in a Healthy Italian Pediatric Population by Veronica Fibbi, Piercarlo Ballo, Silvia Favilli, Gaia Spaziani, Giovanni B. Calabri, Iva Pollini, Alfredo Zuppiroli, Enrico Chiappa

“…Male gender showed no effects except for a weak association with lateral s', suggesting no need of gender-specific reference ranges. …”
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An adverse outcome pathway for cigarette smoke-mediated oxidative stress in plaque formation by Patrudu Makena, Linsey E. Haswell, Michael McEwan, Brian M. Keyser, David E. Smart, Robert Leverette, Kristen Jordan, Damien Breheny, Sarah Baxter-Wright

“…In the absence of epidemiological evidence, assessment of the health effects of a product, chemical or therapy on the progression of atherosclerosis would necessitate long-term animal exposure studies such as the use of the Apolipoprotein E deficient mouse. …”
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Slc25a21 in cisplatin-induced acute kidney injury: a new target for renal tubular epithelial protection by regulating mitochondrial metabolic homeostasis by Xin Su, Mi Bai, Yaqiong Shang, Yang Du, Shuang Xu, Xiuli Lin, Yunzhi Xiao, Yue Zhang, Huimei Chen, Aihua Zhang

“…Abstract Acute kidney injury (AKI) is a significant global health issue, which is often caused by cisplatin therapy and characterized by mitochondrial dysfunction. Restoring mitochondrial homeostasis in tubular cells could exert therapeutic effects. …”
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