Psychological Disturbances and Quality of Life in Obese and Infertile Women and Men by Piotr Kocełak, Jerzy Chudek, Beata Naworska, Monika Bąk-Sosnowska, Barbara Kotlarz, Monika Mazurek, Paweł Madej, Violetta Skrzypulec-Plinta, Piotr Skałba, Magdalena Olszanecka-Glinianowicz

“…Obesity is also associated with male infertility related to erectile dysfunction, hormonal disturbances and lower semen quality. …”
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Hemin regulates platelet clearance in hemolytic disease by binding to GPIbα by Man Zhao, Dongxin Peng, Yuxuan Li, Minwei He, Yulong Zhang, Qianqian Zhou, Sujing Sun, Ping Ma, Liping Lv, Xiaohui Wang, Linsheng Zhan

“…Hemolysis is associated with thrombosis and vascular dysfunction, which are the pathological components of many diseases. …”
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Muscle‐directed gene therapy corrects Pompe disease and uncovers species‐specific GAA immunogenicity by Michelle Eggers, Charles H Vannoy, Jianyong Huang, Pravinkumar Purushothaman, Jacqueline Brassard, Carlos Fonck, Hui Meng, Mariah J Prom, Michael W Lawlor, Justine Cunningham, Chanchal Sadhu, Fulvio Mavilio

“…Abstract Pompe disease is a severe disorder caused by loss of acid α‐glucosidase (GAA), leading to glycogen accumulation in tissues and neuromuscular and cardiac dysfunction. Enzyme replacement therapy is the only available treatment. …”
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A case report and literature review on giant tumefactive perivascular spaces by Chang Cheng, Yiqi Pan, Ke Ma, Shuhan Liu, Xiaoli Mai, Xiaoli Mai, Xiaoli Mai

“…Literature review suggests PVS dilation reflects glymphatic dysfunction, providing new pathophysiological insights. …”
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Krüppel like factor 7 regulates mitochondrial dynamics balance in myocardial infarction by Cao Wang, Fuxing Zhu, Lan Zhou, Situo Zhang, Ruiqi Wang, Hui Tian, Bosong Zhang, Jiahui Wu, Xiang Xu, Ruixian Jiang, Xiaolu Hou, Jian Liu, Weiming Tian

“…Abstract Targeting the balance of mitochondrial fission and fusion can effectively alleviate the cardiac energy supply efficiency, to restore cardiac systolic dysfunction and reduce mortality. …”
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The risk factors, pathogenesis and treatment of premature ovarian insufficiency by Yanjing Huang, Zhuo Liu, Yuli Geng, Fan Li, Runan Hu, Yufan Song, Mingmin Zhang, Kunkun Song

“…It is characterized by ovarian dysfunction, estrogen deficiency, and increased gonadotropin levels in women under 40 years old. …”
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The Role of Neuroglia in the Development and Progression of Schizophrenia by Neha S. Rawani, Allen W. Chan, Kathryn G. Todd, Glen B. Baker, Serdar M. Dursun

“…We also review crosstalk between microglia, astrocytes and oligodendrocytes and the effects of antipsychotics on neuroglia. Problems associated with studies on specific biomarkers for glia in schizophrenia are discussed.…”
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Quantitative PET imaging and modeling of molecular blood-brain barrier permeability by Kevin J. Chung, Yasser G. Abdelhafez, Benjamin A. Spencer, Terry Jones, Quyen Tran, Lorenzo Nardo, Moon S. Chen, Souvik Sarkar, Valentina Medici, Victoria Lyo, Ramsey D. Badawi, Simon R. Cherry, Guobao Wang

“…Our method opens new directions to effectively study the molecular permeability of the human blood-brain barrier in vivo using the large catalogue of available molecular positron emission tomography tracers.…”
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Role of Chemokine (C–X–C Motif) Ligand 10 (CXCL10) in Renal Diseases by Jie Gao, Lingling Wu, Siyang Wang, Xiangmei Chen

“…In the last few years, strong experimental and clinical evidence has indicated that CXCL10 is involved in the development of renal diseases through the chemoattraction of inflammatory cells and facilitation of cell growth and angiostatic effects. In addition, CXCL10 has been shown to be a significant biomarker of disease severity, and it can be used as a prognostic indicator for a variety of renal diseases, such as renal allograft dysfunction and lupus nephritis. …”
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Low-Density Lipoprotein Modified by Myeloperoxidase in Inflammatory Pathways and Clinical Studies by Cédric Delporte, Pierre Van Antwerpen, Luc Vanhamme, Thierry Roumeguère, Karim Zouaoui Boudjeltia

“…Furthermore, Mox-LDL seems to have specific effects and triggers inflammation. Indeed, those oxidized lipoproteins activate endothelial cells and monocytes/macrophages and induce proinflammatory molecules such as TNFα and IL-8. …”
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A dataset of hidden small non-coding RNA in the testis of heat-stressed models revealed by Pandora-seq by Mailin Gan, Yuhang Lei, Kai Wang, Yan Wang, Tianci Liao, Jianfeng Ma, Li Zhu, Linyuan Shen

“…Male infertility, stemming from spermatogenic dysfunction and reduced sperm quality, stands as a primary factor contributing to infertility. …”
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Comparison of Instantaneous Wave-Free Ratio (iFR) and Fractional Flow Reserve (FFR) with respect to Their Sensitivities to Cardiovascular Factors: A Computational Model-Based Study by Xinyang Ge, Youjun Liu, Zhaofang Yin, Shengxian Tu, Yuqi Fan, Yuri Vassilevski, Sergey Simakov, Fuyou Liang

“…In this study, a computational method was used to systemically investigate the respective effects of various cardiovascular factors on FFR and iFR. …”
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Treatment of Acute Tacrolimus Toxicity with Phenytoin in Solid Organ Transplant Recipients by Arin S. Jantz, Samir J. Patel, Wadi N. Suki, Richard J. Knight, Arvind Bhimaraj, A. Osama Gaber

“…The pharmacokinetics of tacrolimus are influenced by many factors, including genetic variability, acute infections, liver dysfunction, and interacting medications, which can result in elevated concentrations. …”
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Obstructive sleep apnea-associated hypertensive disorders in pregnancy: a literature review and clinical management strategies by Wei-Zhen Tang, Kang-Jin Huang, Hong-Yu Xu, Qin-Yu Cai, Ying-Ping Song, Tian-Qi Fan, Yao Zhang, Tai-Hang Liu, Ying-Bo Li

“…This literature review explores potential pathways, including intermittent hypoxia, oxidative stress, systemic inflammation, dysregulation of the sympathetic nervous system, endothelial dysfunction, and atherosclerosis. It also examines current treatments, especially CPAP therapy, and its variable effectiveness in managing HDP symptoms, as well as potential alternatives such as throat strengthening exercises and external hypoglossal stimulation. …”
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Continuous Renal Replacement Therapy Using Membranes with Increased Adsorption Capacity in Patients with Septic Shock after Neurosurgical Interventions by А. I. Burov, T. А. Аbramov, N. V. Kurdyumova, А. V. Oshorov, D. S. Korotkov, N. S. Kostritsa, G. V. Danilov, Yu. V. Strunina, I. А. Savin

“…Changes in neurological status can be considered as an additional parameter for the effectiveness of therapy for septic shock in patients with primary brain injury.…”
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Correlation of non-alcoholic fatty liver disease and neurodegenerative disorders by Pranali A. Jadhav, Asha B. Thomas, Vinay M. Chopada, Prajay V. Bokaria, Shivam B. Deokate, Pankaj S. Chougule, Pruthviraj N. Chavan, Sohan S. Chitlange

“…A broad understanding of the complex linking between NAFLD and neurodegenerative disorders is essential for the advancement of future therapeutic strategies that can effectively lessen the load of these devastating conditions. …”
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Overexpression of Tn antigen induces chronic pancreatitis in mice by Baris Mercanoglu, Nina Schraps, Anastasios D. Giannou, Elena Neuburg, Jan Kempski, Christoph Wagener, Nathaniel Melling, Maximilian Bockhorn, Thilo Hackert, Gerrit Wolters-Eisfeld

“…Notably, the expression of the Tn antigen is primarily attributed to dysfunction of the chaperone Cosmc, while the overexpression of polypeptide N-acetylgalactosaminyltransferases (GalNAc-Ts) has also been implicated in numerous diseases. …”
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Cuproptosis and its potential role in musculoskeletal disease by Ziyang Xiang, Huiling Mei, Honglin Wang, Xiaoyue Yao, Ji Rao, Wentao Zhang, Aoshuang Xu, Lin Lu

“…However, excessive copper exerts cytotoxic effects through multiple pathways, including increased reactive oxygen species (ROS) production, apoptotic cascade activation, necrotic membrane rupture, inflammatory responses, and mitochondrial dysfunction. …”
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Potential of Quercetin as a Promising Therapeutic Agent Against Type 2 Diabetes by Przemysław Niziński, Anna Hawrył, Paweł Polak, Adrianna Kondracka, Tomasz Oniszczuk, Jakub Soja, Mirosław Hawrył, Anna Oniszczuk

“…Furthermore, QE mitigates the progression of diabetic complications such as nephropathy, retinopathy, and vascular dysfunction, reducing lipid peroxidation and protecting endothelial function. …”
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Fanconi Syndrome: Genetic and Acquired Determinants by Rafał Rejmak, Kornelia Karamus, Jan Biłogras, Wojciech Urban, Martyna Borowska-Łygan, Konrad Strużek, Jakub Tomaszewski

“… Fanconi syndrome is a condition characterized by proximal tubular dysfunction of the nephron, leading to urinary loss of glucose, amino acids, and electrolytes such as phosphate, sodium, potassium, calcium, and magnesium. …”
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