Metformin modulates oxidative stress via activation of AMPK/NF-κB signaling in Trisomy 21 fibroblasts: an in vitro study by Angelika Buczyńska, Piotr Malinowski, Arkadiusz Żbikowski, Adam Jacek Krętowski, Adam Jacek Krętowski, Monika Zbucka-Krętowska

“…IntroductionOxidative stress and impaired antioxidant defenses are key contributors to cellular dysfunction in Trisomy 21 (T21), highlighting the need for targeted therapeutic strategies. …”
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Mesenchymal Stem Cell-Derived Small Extracellular Vesicle as A Novel Therapeutic Approach for Chemotherapy-Induced Male Infertility: A Review Article by Maryam Taher, Hanieh Jalali, Homa Mohseni Kouchesfehani, Gholamreza Kaka

“…Chemotherapy induces side effects on various organs, particularly those with high proliferative capacity, such as testicular tissue. …”
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COMPARATIVE EFFICACY OF COMBINED ANTIHYPERTENSIVE THERAPY IN PATIENTS WITH MODERATE ARTERIAL HYPERTENSION ACCOMPANIED BY TYPE 2 DIABETES by E. I. Tarlovskaya, Yu. A. Balandina, I. E. Sapozhnikova, N. S. Maksimchuk

“…The maximal antihypertensive effect was observed in group C (systolic BP (SBP) decreased in 46.6±1.3 mm Hg), followed by group A (SBP decreased in 43.1±0.8 mm Hg) and B (SBP decreased in 40.0±0.8 mm Hg). …”
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Transcranial Magneto-Acoustic Stimulation Enhances Cognitive and Working Memory in AD Rats by Regulating Theta-Gamma Oscillation Coupling and Synergistic Activity in the Hippocampa... by Jinrui Mi, Shuai Zhang, Xiaochao Lu, Yihao Xu

“…<b>Background:</b> Alzheimer’s disease (AD) is a progressive neurodegenerative disorder characterized by cognitive dysfunction and working memory impairment, with early hippocampal damage being a prominent feature. …”
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Evaluation of NAPLES Prognostic Score to Predict Long-Term Mortality in Patients with Pulmonary Embolism by Süheyla Kaya, Veysi Tekin

“…Our study aimed to examinate the effect of NPS on APE prognosis, so the relationship between NPS and APE prognosis was evaluated in our study. …”
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Integrating Rational Emotive Behavior Therapy, Compassion-Focused Therapy with Cognitive Retraining in Traumatic Brain Injury: A Case Report by Shweta Nitin Mahajan, Anuja Jain, Shreshtha Chattopadhyay, Shamli Themse

“…CASE REPORT: A 34-year-old Indian female presented signs of emotional dysfunction, cognitive impairment, social maladaptation, shamefulness, and self-deprecation following a TBI sustained 10 years prior. …”
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Exosomes as Regulators of Macrophages in Cardiovascular Diseases by Marina Soriano-Cruz, Wendy Guadalupe Vázquez-González, Paula Molina-Vargas, Alejandro Faustino-Trejo, Adriana Karina Chávez-Rueda, María Victoria Legorreta-Haquet, Sergio Roberto Aguilar-Ruíz, Luis Chávez-Sánchez

“…In this review, we provide an overview of the biological role of macrophages in atherosclerosis and myocardial infarction and the effects of exosomes on these cells as therapeutic agents in the disease.…”
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Application of biomarkers in the assessment and treatment of cancer-related fatigue by Hui-Hui Hu, Huan Zhao, Yong-Jing Ren, Sai-Qi Wang, Zhe-Sheng Chen, Hong Guo, Yu-Hua He, Xiao-Hui Gao, Xiaobing Chen

“…Abstract Cancer-related fatigue (CRF) is a common side effect experienced by cancer patients and disease-free survivors, significantly impacting their quality of life. …”
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The Role of Coenzyme Q10 Supplementation as a Potential Adjunct in the Treatment of Autoimmune Diseases by Martyna Bukała, Karolina Ochyra, Kornelia Pudło, Jowita Frydrych, Gabriela Prucnal, Karolina Ryba, Katarzyna Znamirowska, Klaudia Zacher, Patrycja Walkiewicz, Anna Rakoczy

“…There is a great need to search for new treatment methods because of the difficulty of treatment, the numerous side effects of pharmacotherapy and the life-threatening complications associated with these diseases. …”
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Necroptosis in vascular cognitive impairment: mechanisms and therapeutic potential by Shufei Wei, Shufei Wei, Lin Cheng, Lin Cheng, Chunxiao Shen, Chunxiao Shen, Zefen Li, Zefen Li, Jiahui Teng, Jiahui Teng, Liangliang Wang, Liangliang Wang, Xiaorong Zhang, Xiaorong Zhang

“…Necroptosis is important in neuroinflammation, neuronal loss, blood–brain barrier dysfunction, and demyelination. Cerebral ischemia activates the necroptotic pathway, and necroptosis inhibitors have a significant inhibitory effect on brain injury. …”
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Mitoregulin, a tiny protein at the crossroads of mitochondrial functioning, stress, and disease by Petr Sergiev, Petr Sergiev, Petr Sergiev, Olga Averina, Julia Golubeva, Julia Golubeva, Mikhail Vyssokikh, Mikhail Vyssokikh, Olga Dontsova, Olga Dontsova, Olga Dontsova, Olga Dontsova

“…While controversies remain, we seek to offer a unified view of its functions, spanning molecular mechanisms to organism-level effects.…”
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Oesophageal adenocarcinoma, obesity, and cancer: the role of nutrition in prevention and management by Claudia Reytor-González, Daniel Simancas-Racines, Emilia Jiménez-Flores, Martín Campuzano-Donoso, Angelo Michele Carella, Luigi Coppola, Marco Marchetti, Raynier Zambrano-Villacres, Gerardo Sarno

“…Oesophageal adenocarcinoma (EAC) is increasingly associated with obesity, metabolic dysfunction, and genetic predispositions. This review explores how nutritional factors interact with these risk elements, emphasizing the potential of dietary strategies in EAC prevention and management. …”
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Marine natural products as an important source of bioactive substances for non-alcoholic fatty liver disease management by Menglei Shi, Menglei Shi, Sisi Chen, Sisi Chen, Yutong Feng, Yutong Feng, Shiyuan Wang, Yuyu Xia, Jianlin He

“…Marine bioactive substances from natural products, such as polysaccharides, polyphenols, polyunsaturated fatty acids, and peptides, have been shown to benefit liver health by alleviating metabolic dysfunction through multiple mechanisms. This paper reviews the effects of marine bioactive substances from various marine entities, including marine fauna, flora, and microorganisms, on the regulation of NAFLD. …”
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CURRENT PRINCIPLES OF COMPLEX REHABILITATION OF CHILDREN WITH STROKE CONSEQUENCES by S. A. Nemkova, N. N. Zavadenko, O. I. Maslova, G. A. Karkashadze, A. M. Mamedyarov, V. E. Popov, I. O. Chshederkina, I. E. Koltunov, Y. E. Nesterovskiy

“…The article demonstrates that diagnosis and treatment of stroke consequences in children is a difficult problem, which requires a differential complex approach in order to improve effectiveness of both drug therapy and rehabilitation and quality of life of the patients.…”
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PPAR-Alpha Agonist Used at the Acute Phase of Experimental Ischemic Stroke Reduces Occurrence of Thrombolysis-Induced Hemorrhage in Rats by Sophie Gautier, Thavarak Ouk, Maud Pétrault, Olivier Pétrault, Vincent Bérézowski, Régis Bordet

“…The PPAR-alpha agonist significantly reduced the risk of hemorrhage after thrombolysis in parallel with a decrease in the infarct volume and in the stroke-induced vascular endothelial dysfunction. These effects are concomitant with a reduction in microglial activation and neutrophil infiltration in infarct area. …”
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TRPC3 inhibition induces myofibroblast differentiation in diabetic dermal fibroblasts by Gemma Toogood, Robin Evans, Liping Zhang, Rima Patel, Songmei Meng, Vijay K. Boda, Wei Li, Junwang Xu

“…This study investigates the role of transient receptor potential canonical-3 (TRPC3) in the dysfunction of diabetic fibroblasts and explores the therapeutic potential of TRPC3 inhibition. …”
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Peripheral substance P induces deficits in hippocampal synaptic plasticity and memory by Sun Yong Kim, Kyeong-No Yoon, Jungeun Ji, Min-Gyun Kim, Seung Ah Choi, Gunhyuk Park, Won-Woo Lee, Jin Ho Chung, Sang Jeong Kim, Joon-Yong An, Dong Hun Lee, Yong-Seok Lee

“…Targeting peripheral SP or its receptor may provide a therapeutic avenue for cognitive dysfunction associated with peripheral inflammation.…”
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From Headache to Heart Health: Investigating the Migraine–Cardiovascular Disease Connection by Claudio Tana, Dilara Onan, Roberta Messina, Marta Waliszewska-Prosół, David Garcia-Azorin, Luis Leal-Vega, Maria Begoña Coco-Martin, Raffaele Ornello, Bianca Raffaelli, Marcio Nattan Portes Souza, William Wells-Gatnik, Paolo Martelletti

“…Moreover, preliminary evidence suggests these agents may have a positive effect on mood symptoms in patients with comorbid depression and anxiety. …”
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Valvular Heart Disease In Antiphospholipid Syndrome (Review) by G. A. Ignatenko, G. G. Taradin, L. V. Kononenko, I. V. Rakitskaya, Y. S. Kagitina, B. D. Prendergast

“…In addition to epidemiological data and classification criteria for APS, information is provided on the prevalence, pathogenetic mechanisms, and pathomorphological features of VHD, which is characterized by verrucous endocarditis (or Libman-Sacks endocarditis), thickening of the leaflets and valve dysfunction. The main pathogenetic events of VHD are caused by the effects of antiphospholipid antibodies, local platelet aggregation, migration of inflammatory cells and deposition of immune complexes. …”
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Insights into Alkaline Phosphatase Anti-Inflammatory Mechanisms by Larissa Balabanova, Georgii Bondarev, Aleksandra Seitkalieva, Oksana Son, Liudmila Tekutyeva

“…This review outlines the established effects of ALP on lipopolysaccharide (LPS)-induced inflammation, including the neutralization of LPS and the modulation of purinergic signaling. …”
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