Rosemary essenitial oil counters MnO2 nanoparticle-induced fertility deficits in rats via antioxidant mechanisms and upregulation of StAR signalling by Hager M. Ramadan, Nadia A. Taha, Ahmed M. Youssef, Asmaa S. Morsi

“…Abstract Manganese, an essential nutrient for male reproductive health, exerts dose-dependent effects, with excessive exposure—particularly to manganese dioxide nanoparticles (MnO 2 -NPs) from environmental or industrial sources inducing gonadal damage via oxidative stress, hormonal disruption, and impaired steroidogenesis. …”
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Sildenafil for Primary Prevention of Anthracycline-Induced Cardiac Toxicity: A Phase I/II Randomized Clinical Trial, SILDAT-TAHA6 Trial by Armin Attar, Masoumeh Heydari, Firoozeh Abtahi, Alireza Rezvani, Shirin Haghighat, Reza Vojdani, Mani Ramzi, Mehdi Dehghani, Mojtaba Karimi, Mohammad Kasaei, Shahdad Khosropanah, Mahmood Tabandeh

“…Previous animal studies have shown a protective effect of 5-phosphodiesterase inhibitors on cancer therapeutics-related cardiac dysfunction (CTRCD) of anthracyclines. …”
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Why Diabetes Worsens Patient Prognosis: A Literature Review of Cardiovascular and Renal Complications by Magdalena Rafałowicz, Adam Rafałowicz, Urszula, Justyna Wojciechowska, Jakub Mierzejewski

“…Conclusion. The multifactorial effects of hyperglycaemia on both the cardiovascular system and chronic kidney disease synergistically worsen outcomes in diabetes. …”
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Progress in research on nutrition, neuroinflammation and dopaminergic alterations in Tic disorders by Lu Bai, Mei Jin, Qi Zhang, Suzhen Sun

“…Tic disorders (TD) represent a prevalent neurodevelopmental condition in children, characterised by involuntary, sudden motor or vocal tics. Dysfunction of the dopamine system plays a pivotal role in the pathogenesis of TD. …”
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Sensitivity of mitochondrial transcription and resistance of RNA polymerase II dependent nuclear transcription to antiviral ribonucleosides. by Jamie J Arnold, Suresh D Sharma, Joy Y Feng, Adrian S Ray, Eric D Smidansky, Maria L Kireeva, Aesop Cho, Jason Perry, Jennifer E Vela, Yeojin Park, Yili Xu, Yang Tian, Darius Babusis, Ona Barauskus, Blake R Peterson, Averell Gnatt, Mikhail Kashlev, Weidong Zhong, Craig E Cameron

“…However, their clinical applications have been limited by off target effects. Development of antiviral ribonucleosides for treatment of hepatitis C virus (HCV) infection has been hampered by appearance of toxicity during clinical trials that evaded detection during preclinical studies. …”
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Spike Timing-Dependent Plasticity and Random Inputs Shape Interspike Interval Regularity of Model STN Neurons by Thoa Thieu, Roderick Melnik

“…These insights improve our understanding of how noise and plasticity contribute to neural function and dysfunction, with implications for PD symptom management.…”
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GsMTx-4 combined with exercise improves skeletal muscle structure and motor function in rats with spinal cord injury. by Xin Zhang, Xinyu Liu, Qianxi Li, Chenyu Li, Xinyan Li, Jinghua Qian, Jianjun Li, Xuemei Li

“…Motor dysfunction and muscle atrophy are typical symptoms of patients with spinal cord injury (SCI). …”
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Enhancing Ferroptosis in Lung Adenocarcinoma Cells via the Synergistic Action of Nonthermal Biocompatible Plasma and a Bioactive Phenolic Compound by Sabnaj Khanam, Young June Hong, Youngsun Kim, Eun Ha Choi, Ihn Han

“…This study aimed to investigate the combined effect of NBP and p-CA on the induction of ferroptosis in lung adenocarcinoma via the GPX4, xCT, and NRF2 pathways. …”
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In vitro and in silico neuroprotective evaluation of new biotransformation metabolites of (-)-α-bisabolol by Reham Mansour, Ramadan A. Eldomany, Amira Mira, Mohamed A. Sabry, Saleh H. El-sharkawy, Amal F. Soliman

“…Metabolites 6 and 2 demonstrated superior neuroprotective effects against H2O2 and Aβ 1-42-induced toxicity compared to α-bisabolol. …”
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Investigation of the mechanism of hypertension caused by BTKi in the treatment of hematologic diseases by Jiayi Xu, Junling Lin, Haojian Gan, Qingjian He, WenJuan Wang, Yuanhua Liu

“…Therapeutic benefits aside, the clinical use of BTKis comes with several side effects, of which hypertension (HTN) is quite common and serious and of significant clinical concern. …”
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Curcumin as a potential therapeutic agent for Parkinson’s disease: a systematic review by Yu-Hsien Chang

“…A nanomicelle formulation of curcumin significantly improved sleep quality and overall quality of life in PD patients over a three-month period, while no significant effect was observed on fatigue severity.Conclusion and Relevance:Curcumin, particularly in formulations that enhance its bioavailability, may be a beneficial add-on treatment for PD, potentially improving non-motor symptoms and slowing the advancement of motor dysfunction. …”
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The impact of induced stress on reactive and proactive control in depression by Akihiro Masuyama

“…Stress, known to exacerbate cognitive dysfunction in depression, may influence the balance between these control processes, though the specific effects remain poorly understood. …”
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Enhancing the Efficacy and Safety of Methotrexate Treatment: A Focus on Drug Interactions (Review) by S. A. Doktorova, Yu. Yu. Grabovetskaya, M. Stefanov, V. V. Rafalskiy

“…Some non-steroidal anti-inflammatory drugs (NSAIDs), theophylline, sulfasalazine, antibacterial agents, and proton pump inhibitors (PPIs) affect MTX elimination and therapeutic effects. The main ADRs associated with MTX include haematotoxicity, hepatotoxicity, lung tissue damage (interstitial pneumonitis and pulmonary fibrosis), and renal dysfunction. …”
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UQCRC1 downregulation impairs cognitive function in mice via AMPK inactivation by Jing Zhang, Zuoxi Wu, Zonghong Long, Feng Ceng, Fuhai Bai, Hong Li

“…Methods To investigate its pathophysiological effects, we developed a mouse model with downregulated UQCRC1 expression. …”
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Molecular Pathogenesis of Avian Splenic Injury Under Thermal Challenge: Integrated Mitigation Strategies for Poultry Heat Stress by Qing Liu, Lizhen Ma, Lili Liu, Ding Guan, Zhen Zhu, Xiangjun Hu

“…Heat stress (HS), an important environmental stressor for healthy poultry farming, has been shown to have a detrimental effect on production performance and induce serious diseases through immune system damage. …”
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Global, regional, and national burdens of chronic kidney disease attributable to high body mass index from 1990 to 2021, with future forecasts up to 2050: a systematic analysis for... by Jun Ying, Xiaolei Lan, Hanjing Zhou, Hongxia Li, Weixin Sheng, Jian Huang

“…With respect to the age effect, deaths from CKD attributable to high BMI increased with age. …”
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Type 2 diabetes mellitus – conventional therapies and future perspectives in innovative treatment by Barbara Gieroba, Adrianna Kryska, Anna Sroka-Bartnicka

“…Type 2 Diabetes Mellitus (T2DM) is a chronic metabolic disorder characterized by insulin resistance and dysfunction of the pancreatic beta cells, which leads to elevated blood glucose levels. …”
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Correlations of inflammatory processes caused by cerebral stroke with the outcome of the disease by A. Vaitkus, J. Valinčiūtė, S. Gylytė

“…These processes may have detrimental effects on cognitive function after stroke. Therapeutic approaches that enhance pro-inflammatory cytokines and the immune system may be useful in preventing cognitive dysfunction, particularly after stroke. …”
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New Strategies for the Treatment of Diabetic Foot Ulcers Using Nanoenzymes: Frontline Advances in Anti-Infection, Immune Regulation, and Microenvironment Improvement by Jia S, Wu S, Yi M, Jiang Z, Cai X, Chen S, Li Y

“…This condition involves pathological changes such as wound infection, hyperglycemia, hypoxia, oxidative stress, and cellular dysfunction, necessitating multifaceted interventions. …”
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Long-term stimulant treatment affects brain dopamine transporter level in patients with attention deficit hyperactive disorder. by Gene-Jack Wang, Nora D Volkow, Timothy Wigal, Scott H Kollins, Jeffrey H Newcorn, Frank Telang, Jean Logan, Millard Jayne, Christopher T Wong, Hao Han, Joanna S Fowler, Wei Zhu, James M Swanson

“…<h4>Objective</h4>Brain dopamine dysfunction in attention deficit/hyperactivity disorder (ADHD) could explain why stimulant medications, which increase dopamine signaling, are therapeutically beneficial. …”
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