Treadmill exercise promotes neuroprotection against cerebral ischemia–reperfusion injury via downregulation of pro-inflammatory mediators by Zhang Y, Cao RY, Jia X, Li Q, Qiao L, Yan G, Yang J

“…Both clinical and experimental data suggest that early physical training after ischemic brain injury may reduce the extent of motor dysfunction. However, the exact mechanisms have not been fully elucidated. …”
Get full text

Demyelinating Neurological Adverse Events following the Use of Anti-TNF-α Agents: A Double-Edged Sword by Miral H. Gharib, Mohamed Awni AlKahlout, Beatriz Garcia Canibano, Dirk Theophiel Deleu, Hani Malallah AlEssa, Samar AlEmadi

“…The clinical examination showed signs of cerebellar dysfunction. MRI findings were consistent with multiple sclerosis. …”
Get full text

Kidney pathology in COVID-19 patients by A. V. Kiseleva, A. V. Leskova, V. V. Skvortsov

“…Various clinical forms of kidney damage in COVID-19 are due to numerous pathogenetic mechanisms, such as the direct cytopathic effect of the virus on kidney structures, endothelial dysfunction, cytokine storm, hemodynamic and water metabolism disorders, and damage to the renin-angiotensin-aldosterone system. …”
Get full text

Dexmedetomidine administration is associated with reduced mortality in patients with sepsis-induced acute respiratory distress syndrome: a retrospective study by Jianguo Zhang, Zhaoyuan Jia, Yu Zhang, Zhimin Tao

“…However, the multiple organ dysfunction syndrome (MODS) incidence and actual mortality rate were significantly lower in the DEX group compared to the control group. …”
Get full text

Monitoring of the lateral spread response combined with brainstem auditory evoked potentials in microvascular decompression for hemifacial spasm by Dejing Cheng, Chengfang Liu, Youjia Qiu, Chengyuan Ji

“…ObjectiveDespite high cure rates, symptom persistence and auditory dysfunction occur sometimes after microvascular decompression (MVD) surgery for hemifacial spasm (HFS). …”
Get full text

Prevalence of the use of medications requiring renal adjustment in critical care units of a public hospital by Dandara BINDEMANN, Lorena FRANQUETO, Antonio Matoso MENDES, Inajara ROTTA

“…It was noted that dose adjustment is necessary not only to reduce adverse reactions or nephrotoxicity but also to ensure therapeutic effectiveness. Conclusion: This study emphasized the importance of adjusting medication doses in critically ill patients with renal dysfunction. …”
Get full text

Progress and Frontiers of Research on Dexmedetomidine in Perioperative Medicine: A Bibliometric Analysis by Zheng T, Pei Z, Huang X

“…Dexmedetomidine research is thriving and expanding rapidly around the world. The effect of dexmedetomidine on cognitive function has been the latest research hotspot. …”
Get full text

Umbilical Cord-Derived Mesenchymal Stem Cells Attenuate S100-Induced Autoimmune Hepatitis via Modulating Th1 and Th17 Cell Responses in Mice by Xiaofeng Wei, Xinhong Cheng, Yang Luo, Xun Li

“…However, hormone and immunosuppressive therapy can cause serious side effects, such as Cushing syndrome and bone marrow suppression. …”
Get full text

<i>Tribulus terrestris</i> fruit’s potential for synthesizing gold nanoparticles with remarkable biological prospects by Nighat Nawaz, Irshad Ahmad, Simon G. Patching, Iqbal Hussain

“…The plant has been used traditionally as an analgesic and to relieve rheumatic pain, eye problems, sexual dysfunction and edema. The aim of this work was to test the use of T. terrestris fruit extract as a reducing agent in synthesizing gold nanoparticles (AuNPs), test their biological activities, and assess their suitability as a therapeutic agent by testing them for potential adverse effects on human cells. …”
Get full text

20-HETE mediates Ang II-induced cardiac hypertrophy via ROS and Ca2+ signaling in H9c2 cells by Jingyi Han, Jiaojiao Li, Lianlian Liu, Kaiyuan Li, Chun Zhang, Yong Han

“…However, the role of 20-HETE in Ang II-induced cardiac dysfunction had yet to be fully elucidated. This study investigated the effects of Ang II on CYP4A expression and 20-HETE production in H9c2 cells using RT-qPCR, Western blot, and ELISA. …”
Get full text

Oral Sulforaphane Intervention Protects Against Diabetic Cardiomyopathy in db/db Mice: Focus on Cardiac Lipotoxicity and Substrate Metabolism by Pan Wang, Ziling Wang, Xinyuan Jin, Mengdi Zhang, Mengfan Shen, Dan Li

“…Furthermore, SFN-I improved the lipotoxicity-related phenotype of T2DM cardiomyopathy, manifested as attenuation of diastolic dysfunction, cardiac injury, fibrosis, lipid accumulation and peroxidation, ROS generation, and decreased mitochondrial complex I and II activities and ATP content, despite having no effect on ceramide abnormalities. …”
Get full text

A High Phosphorus Diet Affects Lipid Metabolism in Rat Liver: A DNA Microarray Analysis. by Sunwoo Chun, Takeshi Bamba, Tatsuya Suyama, Tomoko Ishijima, Eiichiro Fukusaki, Keiko Abe, Yuji Nakai

“…We previously demonstrated that DNA microarray analysis is an appropriate method to comprehensively evaluate the effects of a HP diet on kidney dysfunction such as calcification, fibrillization, and inflammation. …”
Get full text

Placental Ras Regulates Inflammation Associated with Maternal Obesity by Stella Liong, Gillian Barker, Martha Lappas

“…Heightened placental inflammation and dysfunction are commonly associated in pregnant obese women compared to their pregnant lean counterparts. …”
Get full text

Efficacy and safety of nafamostat mesilate for sepsis (EASNMS): study protocol for a multicenter randomized controlled trial by Hongyu Yang, Jianshuang Feng, Yuteng Ma, Xiaochun Ma, Xu Li, on behalf of the EASNMS investigators

“…Both preclinical experiments and clinical studies have evaluated the protective effect of nafamostat mesilate (NM) in sepsis. However, there is still a lack of randomized controlled trials (RCTs) to further confirm the therapeutic effect and safety of NM in sepsis patients. …”
Get full text

Crosstalk between hypertension and diabetes: focusing on pregnancy and offspring. A systematic review by Medina-Hernández Alejandra, Espinosa-Tanguma Ricardo, Donjuán-Loredo Guadalupe

“…IntroductionThe coexistence of diabetes mellitus (DM) and hypertension (HT) is very common; both pathologies seem to share different mechanisms such as insulin resistance (IR), endothelial dysfunction, increase in reactive oxygen species (ROS), among others. …”
Get full text

Non-ischaemic preservation of the donor heart in heart transplantation: protocol design and rationale for a randomised, controlled, multicentre clinical trial across eight European... by Göran Dellgren, Filip Rega, Janne Brouckaert, Andreas Wallinder

“…The patients are followed for 12 months after transplantation.The primary objective is to evaluate the effect of NIHP on survival, allograft function and rejection episodes within the first 30 days after transplantation. …”
Get full text

Metabolic Syndrome: the Influence of Adipokines on the L-Arginine-NO Synthase-Nitric Oxide Signaling Pathway by L. A. Kuznetsova

“…Others have the negative inflammatory effect in the development ofmetabolic syndrome: visfatin, vaspin, apelin. …”
Get full text

Influence of Thyroid Hormones on the Body’s Adaptive Capabilities (Review) by Yuliya A. Shatyr, Galina A. Sroslova, Ruslan I. Glushakov

“…According to the results of this theoretical study, thyroid hormones are involved in almost all physiological processes, exerting a metabolic effect on a number of tissues and systems as well as influencing pro- and antioxidant mechanisms. …”
Get full text

Current Approaches to the Treatment of Traumatic Shock (Review) by D. A. Ostapchenko, A. I. Gutnikov, L. A. Davydova

“…Replacement of circulating blood volume is aimed both at achieving hemodynamic effect and restoring the concentration of sources of oxygen carriers and plasma pro- and anticoagulant factors. …”
Get full text

MOLECULAR MECHANISMS DEFINING APPLICATION OF GLYCINE AND ZINC COMBINATIONIN CORRECTION OF STRESS AND ANXIETY MAIN MANIFESTATIONS by V. N. Shishkova, Y. R. Nartsissov, V. Y. Titova, E. V. Sheshegova

“…The replenishment of the glycine and zinc combined deficiency is an important element in the correction of a post-stress dysfunction of the central nervous system. A balanced intake of zinc and glycine is essential for most people who experience daily effects of multiple stresses and anxiety. …”
Get full text