Challenges of anticoagulant treatment in atrial fibrillation with liver disease by Alina Doina Nicoara, Andra Iulia Suceveanu, Ionut Eduard Iordache, Iulia Tania Andronache, Andreea Nelson Twakor, Andreea Georgiana Sunda, Ioan Cristian Nichita, Anca Pantea Stoian, Felix Voinea, Adrian Paul Suceveanu

“…The debate over the safety and effectiveness of direct oral anticoagulants compared to traditional drugs like warfarin in cirrhotic patients with atrial fibrillation is still ongoing. …”
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Biomineralize Mitochondria in Metal‐Organic Frameworks to Promote Mitochondria Transplantation From Non‐Tumorigenic Cells Into Cancer Cells by Jun‐Nian Zhou, Chang Liu, Yonghui Wang, Yong Guo, Xiao‐Yu Xu, Elina Vuorimaa‐Laukkanen, Oliver Koivisto, Anne M. Filppula, Jiangbin Ye, Hongbo Zhang

“…ABSTRACT Mitochondria are crucial to cellular physiology, and growing evidence highlights the significant impact of mitochondrial dysfunction in diabetes, aging, neurodegenerative disorders, and cancers. …”
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Breakthrough Infection and Death after COVID-19 Vaccination: A Physics Perspective by Seyed Ali Reza Mortazavi, Abdollah Jafarzadeh, Abdolkarim Ghadimi-Moghadam, Seyed Mohammad Javad Mortazavi, Masoud Haghani, Ali Ghadimi-Moghadam, Lembit Sihver

“…There are reports indicating unfavorable health effects, ranging from transient thyroid dysfunction to death following vaccination. …”
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Role of NR1D1 in Bisphenol A-Induced Anxiety-like Behavior and Inflammation in Zebrafish Larvae by Mingjun Wu, Pinyi Chen, Yuting Wang, Xinwei Wang, Yuqianrui Bao, Liqiao Fan, Yuxiao Rao, Xiaoyao Song, Jie Zhang

“…These findings highlight NR1D1 as a critical regulator linking circadian rhythm disruption, neuroinflammation, and dopaminergic dysfunction to anxiety-like behavior. This study provides novel insights into the mechanisms underlying BPA-induced neurotoxicity and identifies NR1D1 as a potential therapeutic target for mitigating the adverse effects of early-life BPA exposure.…”
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IL-10 Treatment Is Associated with Prohibitin Expression in the Crohn’s Disease Intestinal Fibrosis Mouse Model by C. Yuan, W.-X. Chen, J.-S. Zhu, N.-W. Chen, Y.-M. Lu, Y.-X. Ou, H.-Q. Chen

“…Prohibitin, which can inhibit oxidative stress and mitochondrial dysfunction, has been shown to have significant anti-inflammatory activities. …”
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c-Abl/TFEB Pathway Activation as a Common Pathogenic Mechanism in Lysosomal Storage Diseases: Therapeutic Potential of c-Abl Inhibitors by Miguel V. Guerra, Juan Castro, Antonio Moreno, Elisa Balboa, Juan J. Marugan, Alejandra R. Alvarez, Silvana Zanlungo

“…Additionally, we explore the effects of c-Abl inhibitors in cholesterol accumulation in LSDs neuronal models. …”
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Rejuvenated Circulating Endothelial Progenitor Cells and Nitric Oxide in Premenopausal Women with Hyperhomocysteinemia by Long Peng, Qianlin Gu, Zhenhua Huang, Lijin Zeng, Chang Chu, Xiaoan Yang

“…Hyperhomocysteinemia (HHcy) induced endothelial dysfunction is associated with disturbance in circulating endothelial progenitor cells (EPCs). …”
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The use of oxygenated saline enteral solution in the complex intensive care of severe community-acquired pneumonia caused by COVID-19 by M. V. Bykov, D. V. Chernyshev, Yu. A. Loptev, S. V. Krasnova, N. A. Tsvetkova, Zh. B. Ponezheva, V. G. Akimkin

“…In most cases, COVID-19 has a mild course without complications, but 14–20% of patients develop a severe course that requires hospitalization and oxygen support.The effect of oxygenated saline enteral solution (OSES) in complex intensive care on the possibility of correcting gastrointestinal dysfunction and systemic oxygenation in severe community-acquired pneumonia caused by COVID-19 was determined. …”
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N-Acetyl Cysteine Protects against Methamphetamine-Induced Dopaminergic Neurodegeneration via Modulation of Redox Status and Autophagy in Dopaminergic Cells by Prashanth Chandramani Shivalingappa, Huajun Jin, Vellareddy Anantharam, Anumantha Kanthasamy, Arthi Kanthasamy

“…Methamphetamine- (MA-) induced neurotoxicity is associated with mitochondrial dysfunction and enhanced oxidative stress. Our previous study demonstrated that MA induces autophagy in a dopaminergic neuronal cell model (N27 cells). …”
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The emerging role of miRNAs in biological aging and age-related diseases by Rawad Turko, Amro Hajja, Ahmad M. Magableh, Mohammed H. Omer, Areez Shafqat, Mohammad Imran Khan, Ahmed Yaqinuddin

“…Despite data showing that lifestyle modifications, such as caloric restriction and exercise, can lead to healthy ageing and greatly reduce the incidence of chronic disorders, no medical therapies exist to delay or prevent these conditions effectively. We also lack tools to effectively track the ageing process in a manner that predicts an individual's risk of chronic disease and assess response to lifestyle or medical interventions. …”
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Short-term microplastic exposure: A double whammy to lung metabolism and fecal microflora in diabetic SD rats by Minghui Li, Guozhu Ye, Yuhang Liu, Tao Yang, Baoshan Zhao, Ru Jiang, Guoyou Chen

“…This study investigates the effects of short-term PS exposure on diabetic SD rats, using histological, apoptotic, and omics techniques, including metabolomics, lipidomics, and 16S rDNA sequencing. …”
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Phosphodiesterase Type 5 Inhibitors in Male Reproduction: Molecular Mechanisms and Clinical Implications for Fertility Management by Aris Kaltsas, Fotios Dimitriadis, Athanasios Zachariou, Nikolaos Sofikitis, Michael Chrisofos

“…Over the past several decades, investigations have expanded beyond the original therapeutic intent of PDE5 inhibitors for erectile dysfunction, exploring their broader reproductive implications. …”
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A Pneumatic Soft Glove System Based on Bidirectional Bending Functionality for Rehabilitation by Xiaohui Wang, Qinkun Cheng, Zhifeng Wang, Yongxu Lu, Zhaowei Zhang, Xingang Zhao

“…Stroke-related hand dysfunction significantly limits the ability to perform daily activities. …”
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Gentiopicroside improves DSS-induced ulcerative colitis and secondary liver injury in mice by enhancing the intestinal barrier and regulating the gut microbiome by Liu Cao, Mengyuan Niu, Xiaoqing Tang, Yiting Wang, Xianjing Hu, Weibo Dai

“…This study aimed to evaluate the protective effects and underlying mechanisms of GPS in a dextran sulfate sodium (DSS)-induced mouse model of UC and associated SLI. …”
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G6PD deficiency might offer protection against fatal poisoning caused by Aluminum phosphide: A Case Series in North Iran by Navid khosravi, Homa Talabaki, Hosna Zohdi

“…Its toxicity is primarily mediated through the generation of phosphine gas, leading to severe oxidative stress, mitochondrial dysfunction, and multi-organ failure. Recent studies suggest that glucose-6-phosphate dehydrogenase (G6PD) deficiency may offer a protective effect by modulating oxidative stress pathways.Case Reports: We report three cases of patients with confirmed AlP poisoning who were also diagnosed with G6PD deficiency. …”
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Heart function enhancement by an Nrf2-activating antioxidant in acute Y-strain Chagas disease, but not in chronic Colombian or Y-strain. by Hilton Antônio Mata-Santos, Camila Victória Sousa Oliveira, Daniel F Feijo, Daniel Figueiredo Vanzan, Glaucia Vilar-Pereira, Isalira P Ramos, Vitor Coutinho Carneiro, Oscar Moreno-Loaiza, Jaline Coutinho Silverio, Joseli Lannes-Vieira, Emiliano Medei, Marcelo T Bozza, Claudia N Paiva

“…Oxidative stress promotes T. cruzi growth and development of chronic Chagas heart dysfunction. However, the literature contains gaps that must be fulfilled, largely due to variations in parasite DTU sources, cell types, mouse strains, and tools to manipulate redox status. …”
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Assessment of Nanosilymarin's Therapeutic Efficacy in Mitigating CCl4-Induced Hepatotoxicity in Rats by Nisreen Jasim

“…Drug and chemical substances are common causes of liver dysfunction, including acute hepatitis and liver failure. …”
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Cognitive impairments in schizophrenia and their impact on oxidative stress by A. S. Piatoikina, T. V. Zhilyaeva, G. E. Mazo

“…Two hypotheses about the dynamics of neurocognitive impairments in schizophrenia are also considered: the theory of «static encephalopathy» and progressive impairment of cognitive functions.This review evaluates the results of a comparative analysis of the effectiveness of first and second generation antipsychotics in the treatment of cognitive dysfunction. …”
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Psoriatic arthritis (literature review) by N. S. Asfandiyarova, R. R. Shilin

“…In the absence of an effect from previously conducted treatment and contraindications, genetically engineered biological drugs are used.…”
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Pancreatic Solid Pseudopapillary Tumor Associated with Elevated DHEA and Testosterone by Elias Estifan, Yana Cavanagh, Ashima Kapoor, Matthew Grossman

“…Symptoms of tumor mass effect were the second most common. To our knowledge, this is the first reported presentation of elevated DHEA and testosterone levels associated with a solid pseudopapillary tumor in the absence of an underlying adrenal lesion or dysfunction. …”
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