Testosterone Replacement Modulates Cardiac Metabolic Remodeling after Myocardial Infarction by Upregulating PPARα by Jing Yang, Fengyue Wang, Weiju Sun, Yanli Dong, Mingyu Li, Lu Fu

“…Myocardial ischemia leads to metabolic remodeling, ultimately resulting in ATP deficiency and cardiac dysfunction. In the present study, the effects of testosterone replacement on the ischemic heart were assessed in a castrated rat myocardial infarction model established by ligating the left anterior descending coronary artery 2 weeks after castration. …”
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Forsythia suspensa leaf fermented tea extracts attenuated oxidative stress in mice via the Ref-1/HIF-1α signal pathway and modulation of gut microbiota by Lijuan Li, Yating zhao, Yuxin Ding, Lanze Guo, Ruiyao Dai, Aixiang Chen, Guofeng Duan

“…The main active components of FSLFT include forsythiaside, forsythia ester glycoside, rutin, and forsythia flavonoids, which have antibacterial, antioxidant, liver-protective, and immune-regulatory effects. Oxidative stress can trigger excessive apoptosis in intestinal epithelial cells, leading to dysfunction of the small intestinal mucosa and impaired intestinal absorption. …”
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The Anti-Inflammatory Potential of Levosimendan in Sepsis: An Experimental Study Using a LPS-Induced Rat Model by Elif Dedeler Ertanıdır, Ipek Duman, Duygu Onmaz Eryavuz, Ali Ünlü, Mehmet Ertanıdır, Ateş Duman

“…Sepsis is a life-threatening condition driven by a dysregulated host immune response to infection, with cytokine overproduction contributing to organ dysfunction and high mortality. Levosimendan, a calcium sensitizer used in acute heart failure, has been proposed to exert anti-inflammatory effects, but information on its immunomodulatory effects in early sepsis remains scarce. …”
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Disruption of the caspase-1/IL-1β axis alleviates myocardial Ischemia/Reperfusion injury via improvement of mitochondrial homeostasis and reduction of Pyroptosis by ChenKai Hu, FengXia Yuan, YingXing Wu, Shan Xiao, Yuan Xu, Xiang Peng, Lei He

“…The current study aims to elucidate the molecular mechanism affecting cardiomyocyte pyroptosis in myocardial ischemia/reperfusion (I/R) injury, both in vivo and in vitro.Methods A murine model of myocardial I/R injury was established and then treated with lentivirus-mediated shRNA targeting Caspase-1 to evaluate the effect of Caspase-1 on myocardial I/R injury. Further, Caspase-1 was silenced in the cardiomyocytes following hypoxia-reoxygenation (H/R) to detect the function of Caspase-1 in mitochondrial homeostasis and cardiomyocyte pyroptosis.Results Knockdown of Caspase-1 inhibited the secretion of interleukin-1 beta (IL-1β), improved cardiac dysfunction and decreased pyroptosis in vivo. …”
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Postbiotic Intervention in Sarcopenia: The Role of <i>Lactiplantibacillus plantarum</i> HY7715 and Its Extracellular Vesicles by Kippeum Lee, Soo Dong Park, Joo Yun Kim, Jae Jung Shim, Jae Hwan Lee

“…Sarcopenia, the age-related loss of skeletal muscle mass and function, is associated with inflammation, mitochondrial dysfunction, and gut barrier impairment. This study investigates the postbiotic effects of heat-killed <i>Lactiplantibacillus plantarum</i> HY7715 (HY7715) and its extracellular vesicles (EVs) on muscle health and intestinal integrity. …”
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Chronic Treatment with Ang-(1-7) Reverses Abnormal Reactivity in the Corpus Cavernosum and Normalizes Diabetes-Induced Changes in the Protein Levels of ACE, ACE2, ROCK1, ROCK2 and... by Mariam H. M. Yousif, Batoul Makki, Ahmed Z. El-Hashim, Saghir Akhtar, Ibrahim F. Benter

“…Angiotensin-(1-7) [Ang-(1-7)] may have beneficial effects in diabetes mellitus-induced erectile dysfunction (DMIED) but its molecular actions in the diabetic corpus cavernosum (CC) are not known. …”
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Do Statins Affect Viral Infections Encountered by International Travelers? by Chinmay T. Jani, Christian Mouchati, Nour Abdallah, Ruchi Jani, Loukas Kakoullis, Lin H. Chen

“…Given the common use of statins, we sought to evaluate the effect of statins on some viral infections encountered by residents in tropical areas or by international travelers. …”
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PLATELETS AND PLATELET-DERIVED MICROVESICLES: PHENOTYPE, CONTENT, IMPACT ON ENDOTHELIAL CELLS by Olga I. Stepanova, Marina A. Pereviazkina, Markova L. Kseniia, Sergey A. Selkov, Dmitriy I. Sokolov

“…Under the influence of microenvironment signals, the composition, phenotype of platelet microvesicles, as well as their functional abilities towards the endothelium may vary depending on the stimulus. The effect they have on angiogenesis and regeneration has not been sufficiently elucidated, experimental data demonstrate controversial effects. …”
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Trajectory of bodyweight and skeletal muscle mass in patients treated with nintedanib for idiopathic pulmonary fibrosis by Hiromi Tomioka, Takashi Fujikawa

“…Weight loss is a common complication of IPF and a side effect of nintedanib, inducing loss of skeletal muscle mass and musculoskeletal dysfunction. …”
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Vitamin D and health - The missing vitamin in humans by Szu-Wen Chang, Hung-Chang Lee

“…Furthermore, since vitamin D receptors are present all over the body, insufficient vitamin D status may correlate with several extra-skeletal effects, such as pregnancy-related complications and immune dysfunction. …”
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Self-navigating the “Island of Reil”: a systematic review of real-time fMRI neurofeedback training of insula activity by Yuan Zhang, Benjamin Becker, Keith M. Kendrick, Qiong Zhang, Shuxia Yao

“…Furthermore, we also observed a maintenance effect of self-regulation ability and sustained symptom improvement, which is of importance for clinical application. …”
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Application and mechanism of percutaneous puncture disc platelet-rich plasma injection for lumbar disc herniation: a systematic review and meta-analysis by Xingyang Xie, Yalin Peng, Guoping Liu, Qi Cao

“…Abstract Background Although platelet-rich plasma (PRP) has been increasingly used for the treatment of lumbar disc herniation (LDH), its effect on patient outcomes lacks systematic assessment. …”
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Exosomes: Emerging Therapy Delivery Tools and Biomarkers for Kidney Diseases by Can Jin, Peipei Wu, Linli Li, Wenrong Xu, Hui Qian

“…The utilization of exosomes in diagnosis and their positive effects in the repair of kidney dysfunction are discussed, along with the specific mechanisms. …”
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Muscular factor in the development of musculoskeletal pain. Treatment options by A. I. Isaikin, T. I. Nasonova

“…The effectiveness of aceclofenac (Aertal®) and the muscle relaxant tolperisone (Mydocalm®) in the of MSP treatment is discussed. …”
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Muramyl peptide blend ameliorates intestinal inflammation and barrier integrity in cell culture model by D.M. Masiuk, V.S. Nedzvetsky

“…However, molecular mechanisms of MP effect on intestinal cells remain unknown. The study of MP application to maintain viability of Caco-2 cells was aimed to explore the cytoprotective effect of MP-based probiotic on gut inflammation and intestinal barrier integrity. …”
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Lysosomal targeting of liposomes with acidic pH and Cathepsin B induces protein aggregate clearance by Minsol Jeon, Da-Eun Kim, So Young Choi, Seoyoung Kim, Seongchan Kim, Hyojin Lee, Hyunkyung Kim

“…Some of these protein aggregates may cause additional lysosomal dysfunction and create a vicious cycle leading to a gradual increase in protein aggregation. …”
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Brain natriuretic peptide: diagnostic and prognostic value in chronic heart failure (a literature review) by O. O. Sakovych, Ya. O. Antoniuk, A. F. Humeniuk, V. M. Zhebel

“…For many years, chronic heart failure (CHF) has occupied one of the leading positions in the structure of cardiac and all-cause mortality worldwide, resulting in not only negative social, but also economic effects. To optimize the timely detection of this pathological condition, laboratory biomarker-based diagnostics of heart dysfunction is widely used along with echocardiographic examination. …”
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Medium-chain triglycerides tricaprin TC10 and tricaprylin TC8 attenuated HFD-induced cognitive decline in a manner dependent on or independent of GLP-1 by Maiko Shobako, Kohei Kawano, Eriko Taniguchi, Kousaku Ohinata

“…Cognitive improvements by MCTs are widely attributed to the ketogenic effect. In the present study, TC8 significantly increased blood ketone concentrations, whereas TC10 did not. …”
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Sex differences in the mediation of the MASLD - Depression association by fat distribution in U.S. adults by Changhuai He, Liuxin Zhou, Tianming Gao, Runmin Cao, Chuanqi Cai, Guoqing Jiang

“…Purpose: This study investigates the intricate relationship between metabolic dysfunction-associated steatotic liver disease (MASLD) and depression, emphasizing the mediating role of body fat distribution, particularly in female. …”
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African walnut (Plukenetia conophora) oil improves glucose uptake and metabolic activities in erythrocytes by Ochuko L. Erukainure, Chika I. Chukwuma

“…BackgroundAfrican walnut (Plukenetia conophora) oil (AWO) has been employed in the management of glucose dysmetabolic-mediated ailments, with emerging evidence suggesting that its modulatory effects on erythrocyte glucose dysmetabolism may mitigate dysfunctions implicated in the pathophysiology of metabolic diseases.ObjectiveThe present study investigated the effect of AWO on glucose uptake and its effect on glucose metabolism, purinergic and antioxidant activities and surface morphology in isolated rats’ erythrocytes ex vivo.MethodsIsolated erythrocytes were incubated with AWO (30–240 μg/mL) and glucose (11.1 mM) for 2 h at 37°C. …”
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