Dysregulated monocyte compartment in PACS patients by Romy Kronstein-Wiedemann, Romy Kronstein-Wiedemann, Madeleine Teichert, Elisa Michel, Janina Berg, George Robinson, Kristin Tausche, Kristin Tausche, Martin Kolditz, Martin Kolditz, Johannes Bergleiter, Jessica Thiel, Jessica Thiel, Dirk Koschel, Dirk Koschel, Dirk Koschel, Stephan R. Künzel, Stephan R. Künzel, Kristina Hölig, Kristina Hölig, Kristina Hölig, Torsten Tonn, Torsten Tonn, Torsten Tonn, Manuela Rossol, Manuela Rossol

“…Symptoms associated with the post-acute sequelae of COVID-19 (PACS) include, among others, fatigue, shortness of breath, cough, and cognitive dysfunction. Since the dysregulated immune response appears to be caused by the sustained activation of certain immune cells, including monocytes, and the release of specific cytokines, the aim of our study was to investigate the effect of PACS disease on monocyte subpopulations.MethodsTwenty-two healthy and thirty-two patients with PACS were included into this study. …”
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Host Response Protein Biomarkers Indicative of Persistent Acute Kidney Injury in Critically Ill COVID-19 Patients by Thei S. Steenvoorden, MD, Koen C. de Kruijf, BSc, Brent Appelman, MD, Bas Moggre, MD, Lieuwe D. J. Bos, MD, PhD, Alexander P. J. Vlaar, MD, PhD, Reneé A. Douma, MD, PhD, Fabrice Uhel, MD, PhD, Jesper Kers, MD, PhD, Jetta J. Oppelaar, MD, Lonneke A. van Vught, MD, PhD, Martijn Beudel, MD, PhD, Paul W. G. Elbers, MD, PhD, W. Joost Wiersinga, MD, PhD, Tom van der Poll, MD, PhD, Liffert Vogt, MD, PhD, Hessel Peters-Sengers, PhD, on behalf of the Amsterdam UMC COVID-19 Biobank Study Group and the CovidPredict Study Group, Diederik van de Beek, Sanne de Bruin, Daisy Rusch, Suat Simsek, Kees Brinkman, Niels Gritters van den Oever, Joop van den Bergh, Hamza Moeniralam, N. Bokhizzou, Martijn de Kruif, Helen Leavis

“…These were related to inflammation (triggering receptor expressed on myeloid cells 1, p < 0.001; tumor necrosis factor receptor 1, p < 0.001; procalcitonin, p = 0.001), complement activation (mannan-binding lectin serine protease-2, p = 0.001), kidney dysfunction (cystatin C, p < 0.001; neutrophil gelatinase-associated lipocalin, p < 0.001), and lung dysfunction (Clara cell secretory protein 16, p < 0.001). …”
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FGF21 and its underlying adipose tissue-liver axis inform cardiometabolic burden and improvement in obesity after metabolic surgeryResearch in context by Marie Patt, Isabel Karkossa, Laura Krieg, Lucas Massier, Kassem Makki, Shirin Tabei, Thomas Karlas, Arne Dietrich, Martin Gericke, Michael Stumvoll, Matthias Blüher, Martin von Bergen, Kristin Schubert, Peter Kovacs, Rima M. Chakaroun

“…Higher FGF21 were linked with AT dysfunction reflected in fibro-inflammatory and lipid dysmetabolism pathways. …”
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Understanding Ciguatoxin-Induced CNS Depression and Evaluating Piperine as a Therapeutic Strategy by Vishesh Kumar Maurya

“…Introduction: Ciguatoxin (CTX) is a potent marine toxin known for its detrimental effects on the Central Nervous System (CNS), inducing symptoms of depression and neurological dysfunction. …”
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The levels of inflammatory, angiogenic, and stress biomarkers in plasma of donors depending on anti-SARS-CoV-2 IgG titers by D.I. Krenytska, V.L. Karbovskyy, Ludovico Abenavoli, T.M. Falalyeyeva, Giuseppe Guido Maria Scarlata, N.G. Raksha, T.B. Vovk, L.I. Kot, O.M. Savchuk, Maria Luisa Gambardella, O.I. Kovalchuk, V.I. Pankiv, L.I. Ostapchenko

“…While the acute phase of the infection has been extensively studied, the long-term effects, particularly in individuals who have recovered, remain unclear. …”
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MASLD and liver fibrosis in patients with psoriasis receiving IL-17 or IL-23 inhibitors: a systematic review by José González Fernández, Lucía Prieto-Torres, Mariano Ara Martín, Samuel J. Martínez-Domínguez

“…Background: Metabolic dysfunction-associated steatotic liver disease (MASLD) is more prevalent in patients with psoriasis compared to healthy individuals. …”
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Modern Views on the Neuropeptide Oxytocin. Part II. Oxytocin in the Process of Evolution. The Role of Oxytocin in the Behavioural, Somatic and Autonomic Functions of Humans and Ani... by Elena A. Leonova, Albina A. Bakhova, Irina L. Cherednik, Yulia V. Kashina, Aleksandr N. Ardelyan

“…The anti-stress and anxiolytic effects of this neuropeptide blocking the effects of the main stress hormone, cortisol, have been detected. …”
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Therapeutic potential of a drug based on avocado and soy unsaponifiable compounds in the treatment of osteoarthritis: data from Russian and international studies (descriptive revie... by A. E. Karateev, A. M. Lila

“…According to the results of the presented studies, ASACs have proven efficacy in reducing the intensity of pain and dysfunction in knee OA. There are data confirming the structure-modifying effect of ASACs in OA of the hip joint (HJ). …”
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Bifidobacterium bifidum CCFM1389 Regulates Intestinal Motility Disorder by Repairing the Enteric Nervous System and Intestinal Barrier by HUANG Yin, LI Jiazhen, LIU Wenxu, XUE Yifan, ZHU Shengnan, WANG Linlin, WANG Gang

“…Bifidobacterium bifidum CCFM1167 was used as a positive strain, and another four B. bifidum strains were screened and evaluated for their regulatory effects on intestinal dysfunction and the ENS. 16S rDNA gene sequencing was used to detect changes in the gut microbiota, and hematoxylin-eosin (H&E) staining and real-time polymerase chain reaction (PCR) were employed to characterize the damage of the ENS and the intestinal barrier. …”
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Systematic mediation and interaction analyses of kidney function genetic loci in a general population study. by Dariush Ghasemi-Semeskandeh, David Emmert, Eva König, Luisa Foco, Martin Gögele, Mohamed S Sarhan, Laura Barin, Ryosuke Fujii, Christian Fuchsberger, Dorien J M Peters, Peter P Pramstaller, Cristian Pattaro

“…To assess whether a study sample from a specific population could extend existing knowledge on kidney function genetics, we selected 147 kidney function relevant loci identified by a large GWAMA, assessing their association with the glomerular filtration rate estimated from serum creatinine (eGFRcrea) in 10,146 participants to the Cooperative Health Research In South Tyrol (CHRIS) study, conducted in an Alpine region where thyroid dysfunction is common. We identified associations with single nucleotide polymorphisms (SNPs) at 11 loci, showing up-to-5.4 times larger effect sizes than in the corresponding GWAMA, not explainable by allele frequency differences. …”
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Heparins: Mechanism of Action and Application in Acute Pancreatitis by Chooklin S., Pidhirnyy B., Chuklin S.

“…Its major anticoagulant effect is attributed to a unique pentasaccharide structure. …”
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Valacyclovir-induced neurotoxicity and nephrotoxicity in an elderly patient with a history of nephrectomy: a case report by Sondos Badran, Sylvia Li, Sabrina Nguyen, Johnny S. Randhawa, Abdulrahman Badran, Farbod Farmand

“…Common adverse effects include headache, nausea, and vomiting. A rare adverse effect of valacyclovir is acute kidney injury (AKI) due to obstructive crystal-induced nephropathy, tubular dysfunction, or tubulointerstitial nephritis. …”
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The future of critical care: AI-powered mortality prediction for acute variceal gastrointestinal bleeding and acute non-variceal gastrointestinal bleeding patients by Zhou Liu, Guijun Jiang, Liang Zhang, Palpasa Shrestha, Yugang Hu, Yi Zhu, Guang Li, Yuanguo Xiong, Liying Zhan

“…AUGIB characterized by hemorrhagic shock, hypotension, multiple organ dysfunction (MODS), and even circulatory failure is life-threatening. …”
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Improved CAR internalization and recycling through transmembrane domain optimization reduces CAR-T cytokine release and exhaustion by Shufeng Xie, Shufeng Xie, Jinlan Long, Ruiheng Wang, Ruiheng Wang, Rufang Xiang, Rufang Xiang, Huajian Xian, Yixin Wang, Weiyu Dou, Wenjie Zhang, Dan Li, Ting Kang, Zhihong Chen, Zhihong Chen, Chunjun Zhao, Zhenshu Xu, Han Liu

“…BackgroundAnti-CD19 chimeric antigen receptor T (CAR-T) cell therapy has proven effective for treating relapsed or refractory acute B cell leukemia. …”
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5-Oxoproline prevents doxorubicin-induced cardiotoxicity and tumor growth by Xinning Guo, Meng Jiang, Zhengyu Tao, Huijuan Dai, Chen Wu, Yinan Wang, Zi Wang, Xiaoning Wang, Zhixuan Zhang, Kun Qian, Shanshan Zeng, Yihua Bei, Jun Pu

“…Exogenous 5-oxoproline supplementation effectively restored myocardial 5-oxoproline levels, subsequently mitigating DOX-induced cardiac dysfunction. …”
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The potential of exogenous specialized pro-resolving mediators in protecting against sepsis-associated lung injury: a review by Jiwei Shen, Jiwei Shen, Jiwei Shen, Huiqin Shen, Huiqin Shen, Huiqin Shen, Shujun Sun, Shujun Sun, Shujun Sun, Shiwen Fan, Shiwen Fan, Shiwen Fan, Tianhao Zhang, Tianhao Zhang, Tianhao Zhang, Guobin Song, Guobin Song, Guobin Song, Ning An, Ning An, Ning An, Xiangdong Chen, Xiangdong Chen, Xiangdong Chen, Yafen Gao, Yafen Gao, Yafen Gao

“…SPMs, derived from polyunsaturated fatty acids, exert protective effects through multiple mechanisms: enhancing alveolar fluid clearance by upregulating ENaC, Na,K-ATPase, CFTR, and AQP5; reducing alveolar epithelial cell apoptosis and epithelial-mesenchymal transition; preserving endothelial glycocalyx integrity via modulating heparanase and exostosin-1 expression; alleviating oxidative stress and mitochondrial dysfunction by scavenging ROS and activating Nrf2; and immunomodulation by limiting neutrophil infiltration, promoting macrophage efferocytosis and M2 polarization, and dampening pro-inflammatory cytokine production. …”
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Multivariate genome-wide analysis of sarcopenia reveals genetic comorbidity with urological diseases by Feixiang Yang, Xiangyu Zhang, Wei Dai, Ke Xu, Yunyun Mei, Tianrui Liu, Kun Wang, Qianjun Liang, Peng Guo, Chaozhao Liang, Jialin Meng

“…Conclusion: These findings unveil a shared genetic architecture between sarcopenia and urological diseases, especially BPH, with heritability enrichment in fibroblast tissue and metabolic dysfunction emerging as the significant overlapping pathway.…”
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ACE Inhibitors and Angiotensin Receptor Blockers for the Primary and Secondary Prevention of Cardiovascular Outcomes: Recommendations from the 2024 Egyptian Cardiology Expert Conse... by Mohamed Sobhy, Adel Eletriby, Hany Ragy, Hossam Kandil, Mohamed Ayman Saleh, Nabil Farag, Ramez Guindy, Ahmed Bendary, Ahmed Mohamed Elmahmoudy Nayel, Ahmed Shawky, Ayman Khairy, Ayman Mortada, Bassem Zarif, Haitham Badran, Hazem Khorshid, Kareem Mahmoud, Karim Said, Khaled Leon, Mahmoud Abdelsabour, Mazen Tawfik, Mohamed Aboel-Kassem F. Abdelmegid, Mohamed Koriem, Mohamed Loutfi, Moheb Wadie, Mohamed Elnoamany, Mohamed Sadaka, Mohamed Seleem, Mohamed Zahran, Osama A. Amin, Sameh Elkaffas, Sherif Ayad, Wael El Kilany, Walid Ammar, Waleed Elawady, Walid Elhammady, Yasser Abdelhady

“…Results The consensus statements highlight the importance of effective BP control and the role of RAAS blockade for prevention and management of various cardiovascular diseases. …”
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Vascular Endothelial Over-Expression of Human Soluble Epoxide Hydrolase (Tie2-sEH Tr) Attenuates Coronary Reactive Hyperemia in Mice: Role of Oxylipins and ω-Hydroxylases. by Ahmad Hanif, Matthew L Edin, Darryl C Zeldin, Christophe Morisseau, John R Falck, Mohammed A Nayeem

“…EETs have numerous beneficial physiological effects, including vasodilation and protection against ischemia/reperfusion injury, whereas ω-terminal HETEs induce vasoconstriction and vascular dysfunction. …”
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The role of genetic and epigenetic factors on the development of cognitive deficits in patients with severe trauma after repeated anesthesia (literature review) by S. N. Kuchina, I. M. Spivak, A. V. Shchegolev, A. I. Levshankov

“…To determine the prospects of studying the effect of polymorphic alleles of various genes on the development of a pathological condition in a certain cohort, namely the development of cognitive dysfunction in patients with severe trauma after repeated anesthesia.Materials and methods. …”
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