An Isolated Hypogonadotropic Hypogonadism due to a L102P Inactivating Mutation of KISS1R/GPR54 in a Large Family by Ahmad J. Alzahrani, Azzam Ahmad, Tariq Alhazmi, Lujin Ahmad

“…We showed that a loss-of-function mutation (p.Tyr305C) in the KISS1R gene can cause (L102P) KISS1 receptor dysfunction and familial nIHH, revealing the crucial role of this amino acid in KISS1R function. …”
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Freezing Promotes Postmortem Proteolysis in Beef by Accelerating the Activation of Endogenous Proteolytic Systems by Chandler D. Stafford, David S. Dang, Kara Thornton-Kurth, Mackenzie J. Taylor, Mohammed A. Alruzzi, Sulaiman K. Matarneh

“…This study investigated the effect of freezing and subsequent aging on beef quality, particularly focusing on the extent of postmortem proteolysis and tenderization. …”
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Microsurgical encapsulated resection of brachial plexus schwannoma with intraoperative neuromonitoring to preserve neurological function: 36 cases report and literature review by Jingsen Chen, Xiao Dong, Shenglong Cao, Hanghuang Jin, Haiying Hu, Taizhou

“…Abstract Objective To investigate the effect of protecting neural function of microsurgical encapsulated resection of brachial plexus schwannoma with intraoperative neuromonitoring. …”
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CASE OF ACQUIRED COAGULOPATHY by M. T. Vatutin, E. S. Gasendich, E. I. Iofe

“…This clinical case presents a case of the development of severe acquired (warfarin-induced) coagulopathy in a patient with cognitive dysfunction.…”
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Development and Evaluation of a Predictive Tool for Second-Pregnancy Preterm Birth and Cervical Insufficiency in Patients With a History of Cervical Insufficiency by Xin Liu, Junhong Jiang, Yan Wang

“…The risk model derived from multi-model analysis can effectively identify high-risk pregnancies.…”
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Spastic Paraplegia Type 78 Associated With ATP13A2 Gene Variants in Compound Heterozygosity by R. Bermejo Ramírez, N. Villena Gascó, L. Ruiz Palmero, G. A. Ribes Bueno, E. Seiti Yamanaka, J. D. Arroyo Andújar

“…ABSTRACT Background Spastic Paraplegia Type 78 (SPG78) is a rare form of hereditary spastic paraplegia (HSP), mainly characterized by late‐onset lower‐limb spasticity, muscle weakness, and in some cases cerebellar dysfunction and cognitive impairment. Understanding its genetic background is essential to distinguish it from other autosomal recessive types of HSP. …”
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Selected forms of therapy of a child with DiGeorge syndrome. A case study by Edyta Ewelina Osękowska, Natalia Malik, Malwina Dąbek, Magdalena Maria Skalny

“…Among the most characteristic symptoms are features of facial dysmorphia, abnormalities of intellectual development and speech, as well as dysfunction of many organ systems. Despite the relatively high incidence of DiGeorge syndrome, still little is known about the therapeutic management of children burdened with this genetic defect. …”
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A case of non-occlusive mesenteric ischaemia caused by pelvic fracture due to fall trauma by Yuichiro Furutani, Kaname Ishiguro, Masato Tokuraku, Hitoshi Moritomo

“…Over time, the patient developed liver and renal dysfunction and died 16 days after surgery. Conclusions We experienced a case of NOMI caused by bleeding from a pelvic fracture. …”
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T Cell Aging: An Important Target for Perioperative Immunomodulation by Lan H, Xu S, Li H, Guo R, Feng Z, Wang Y

“…For example, elderly cancer patients with multiple chronic diseases may be the most affected by T cell aging. We also discuss the effects of T cell aging on postoperative phenomena such as neurological dysfunction and recovery quality. …”
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Gut Microbe-Generated Metabolite Trimethylamine-N-Oxide and Ischemic Stroke by Zhen Li, Xinyi He, Qi Fang, Xulong Yin

“…Although the pathogenic mechanisms underlying TMAO’s aggravation of disease severity and its effects on post-stroke neurological recovery and recurrence risk remain unclear, they may involve inflammation, astrocyte function, and pro-inflammatory monocytes. …”
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Whole-genome analysis of Bacillus paranthracis YC06 isolated from healthy individual feces for biodegrading inosine and guanosine by Xiaoyu Cao, Yu Zhang, Qianqian Xu, Hai Yan

“…B. paranthracis YC06 resting cells (live but suspended in PBS buffer) and its cell-free extracts could effectively biodegrade inosine and guanosine in vitro. …”
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Hypertensive crisis in children and adolescents: aspects of intensive therapy by Yu. V. Bykov, A. N. Obedin, A. A. Muravyeva, V. V. Fischer, E. V. Volkov, I. V. Yatsuk, O. N. Zinchenko

“…HC is subdivided into uncomplicated (acute), in which no signs of organ damage are present, and complicated (urgent), with acute organ damage (neurological, renal or cardiac dysfunction). The main triggers of HC are concomitant endocrine disorders, renal impairment, and use of certain medications. …”
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P72 | A SWAB NEGATIVE PATIENT AFTER SARS-COV-2 INFECTION DISPLAYS INCREASE OF VEGF AND FIBRONECTIN ASSOCIATED WITH ALTERATIONS OF INTERCELLULAR JUNCTIONS

“…The ultrastructural analysis gave insights on the morpho-functional effects of SARS-Cov-2 infection on the gut epithelium, indicating that the damage is not limited to vascular structures. …”
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Comparison of Changes in Cortisol Values Before and After Administration of a Combination of Continuous Fentanyl and Paracetamol Drip in Post-Craniotomy Patients in ICU of Haji Ada... by Cassandra Etania, Rr Sinta Irina, Muhammad Ihsan

“…Prolonged stress response to pain can increase cortisol secretion which will eventually be resulted in cortisol dysfunction and widespread inflammation. Opioids have been shown to provide pain management after craniotomy. …”
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The role of cardiac troponin T in detection of cardiac damage and long term mortality in children with chronic renal disease by Ulaş Karadaş, Nihal Özdemir Karadaş, Mustafa Bak, Erkin Serdaroğlu, Murat Muhtar Yılmazer, Timur Meşe

“…In this study, it was shown that it is possible to obtain information about cardiac effects by examining the serum cTnT level before clinical symptoms occur in children with CKD, and that cTnT can be used for screening purposes. …”
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Autophagy: a double-edged sword in ischemia–reperfusion injury by Lingxuan Tang, Wangzheqi Zhang, Yan Liao, Weijie Wang, Xiaoming Deng, Changli Wang, Wenwen Shi

“…Subsequent reperfusion exacerbates mitochondrial dysfunction, leading to increased oxidative stress and the accumulation of reactive oxygen species (ROS). …”
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Review of rhythm disturbances in patient after fontan completion: epidemiology, management, and surveillance by Kevin Wall, Camden Hebson, Roshan D’Souza, Seshadri Balaji

“…However, ventricular pacing seems to often lead to deleterious effects. Current guidelines recommend surveillance with Holter monitor every 2–3 years in adolescents and every 1–2 years in adults. …”
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The landscape of renal protein S-acylation in mice with lipid-induced nephrotoxicity by Fangrui Xiu, Zhibo Gai, Peter Gehrig, Witold E. Wolski, Museer A. Lone, Michele Visentin

“…Abstract Excess fat intake is associated with kidney toxicity and dysfunction. Because fatty acids can also be reversibly attached onto cysteine residues and modulate the function of several membrane-bound proteins, we studied the effect of high-fat diet (HFD) on the S-acylated proteome of mouse kidneys to uncover novel biochemical changes that might contribute to lipid-induced nephrotoxicity. …”
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Case Report: Dual immunomodulatory and hematologic benefits of rituximab in refractory anemia of ANCA-associated vasculitis by Ningjun Shao, Lingxiong Chai, Xu Bai, Qun Luo

“…Anemia, affecting 73–92% of AAV patients, arises from multifactorial mechanisms including renal dysfunction, chronic inflammation, and iron dysregulation. …”
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TIPE2 suppresses ferroptosis and pro-inflammatory polarization in macrophages triggered by SARS-CoV-2 spike protein by Simin Zhu, Wei Li, Yuqiu Hao, Lin Zhang, Peng Gao

“…Given the emerging evidence that macrophage polarization and dysfunction play pivotal roles in COVID-19 progression, we established a THP-1-derived macrophage model stimulated with the SARS-CoV-2 spike (S) protein to mimic the host immune response. …”
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