Vaspin Alleviates Sepsis-Induced Cardiac Injury and Cardiac Inflammation by Inhibiting Kallikrein 7 in Mice by Na Yin, Fuze Pan, Lingyue Qiu, Zicong Yang, Rixin Xiong, Lei Shi, Ying Shi, Ning Wu, Kui Wu, Qingkuan Li, Daojun Wen, Qili Huang, Yuyan Zhang, Yuhong Mi, Qingwei Ji

“…The protective effects of vaspin on CLP mice were masked by the deletion of KLK7, which was demonstrated to be a downstream signal of vaspin. …”
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Protein modifications in hepatic ischemia-reperfusion injury: molecular mechanisms and targeted therapy by Xiaohong Zhao, Qinyi Li, Xiaolong Zhu, Yuanyuan Jiao, Huan Yang, Jiao Feng

“…Among these, hepatic ischemia-reperfusion injury is a prevalent complication in liver transplantation, significantly impacting the functional recovery of the transplanted liver and potentially leading to primary graft dysfunction. With the growing demand for organ transplants and the limited availability of donor organs, effectively addressing hepatic ischemia-reperfusion injury is essential for enhancing transplantation success rates, minimizing complications, and improving graft survival. …”
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Preliminary Exploration of Potential Active Ingredients and Molecular Mechanisms of Yanggan Yishui Granules for Treating Hypertensive Nephropathy Using UPLC-Q-TOF/MS Coupled with N... by Fan Yang, Kailun Zhang, Xiaohua Dai, Weimin Jiang

“…Research in clinical settings has revealed that Yanggan Yishui Granule (YGYSG) has significant therapeutic effects on HN. However, the material basis and action mechanisms of YGYSG against HN remain unclear. …”
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Hypoxia-inducible factor prolyl hydroxylase domain (PHD) inhibition after contusive spinal cord injury does not improve locomotor recovery. by George Z Wei, Sujata Saraswat Ohri, Nicolas K Khattar, Adam W Listerman, Catherine H Doyle, Kariena R Andres, Saravanan S Karuppagounder, Rajiv R Ratan, Scott R Whittemore, Michal Hetman

“…As the ATF4-CHOP (CCAAT-enhancer-binding protein homologous protein) pathway plays a role in the pathogenesis of contusive SCI, we examined the effects of PHD inhibition in a mouse model of moderate T9 contusive SCI in which white matter damage is the primary driver of locomotor dysfunction. …”
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Coxa Vara of Unknown Etiology: A Unique Case Report by M Vignesh Velavan, J K Giriraj Harshavardhan

“…Introduction: Coxa vara is a rare pediatric hip disorder characterized by a reduced femoral neck shaft angle (NSA) (<120°), resulting in limb length discrepancy, gait abnormalities, and hip dysfunction. While developmental coxa vara has characteristic radiological features, atypical presentations with unknown etiologies are infrequently reported. …”
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Diagnosis and Treatment of Adolescent Polycystic Ovary syndrome:A Review by Zhang Y, Yang K, Fan T, Zheng D, Liu H

“…The diagnosis of adolescent PCOS should meet two primary criteria—ovulatory dysfunction and biochemical or clinical hyperandrogenism—after excluding other causes. …”
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Liver gene expression and its rewiring in hepatic steatosis are controlled by PI3Kα-dependent hepatocyte signaling. by Marion Régnier, Arnaud Polizzi, Tiffany Fougeray, Anne Fougerat, Prunelle Perrier, Karen Anderson, Yannick Lippi, Sarra Smati, Céline Lukowicz, Frédéric Lasserre, Edwin Fouche, Marine Huillet, Clémence Rives, Blandine Tramunt, Claire Naylies, Géraldine Garcia, Elodie Rousseau-Bacquié, Justine Bertrand-Michel, Cécile Canlet, Sylvie Chevolleau-Mege, Laurent Debrauwer, Christophe Heymes, Rémy Burcelin, Thierry Levade, Pierre Gourdy, Walter Wahli, Yuna Blum, Laurence Gamet-Payrastre, Sandrine Ellero-Simatos, Julie Guillermet-Guibert, Phillip Hawkins, Len Stephens, Catherine Postic, Alexandra Montagner, Nicolas Loiseau, Hervé Guillou

“…We used mice lacking p110α, the catalytic subunit of PI3Kα, to investigate its role in the regulation of liver gene expression in health and in metabolic dysfunction-associated steatotic liver disease (MASLD). …”
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Pre‐clinical validation of a selective anti‐cancer stem cell therapy for Numb‐deficient human breast cancers by Daniela Tosoni, Sarah Pambianco, Blanche Ekalle Soppo, Silvia Zecchini, Giovanni Bertalot, Giancarlo Pruneri, Giuseppe Viale, Pier Paolo Di Fiore, Salvatore Pece

“…Thus, targeting Numb/p53 dysfunction in Numb‐deficient human BCs could represent a novel anti‐CSC therapy. …”
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Bradykinesia-akinesia incoordination test: validating an online keyboard test of upper limb function. by Alastair J Noyce, Anna Nagy, Shami Acharya, Shahrzad Hadavi, Jonathan P Bestwick, Julian Fearnley, Andrew J Lees, Gavin Giovannoni

“…<h4>Background</h4>The Bradykinesia Akinesia Incoordination (BRAIN) test is a computer keyboard-tapping task that was developed for use in assessing the effect of symptomatic treatment on motor function in Parkinson's disease (PD). …”
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Noradrenergic deficits contribute to apathy in Parkinson's disease through the precision of expected outcomes. by Frank H Hezemans, Noham Wolpe, Claire O'Callaghan, Rong Ye, Catarina Rua, P Simon Jones, Alexander G Murley, Negin Holland, Ralf Regenthal, Kamen A Tsvetanov, Roger A Barker, Caroline H Williams-Gray, Trevor W Robbins, Luca Passamonti, James B Rowe

“…Locus coeruleus integrity was assessed in vivo using magnetisation transfer imaging at ultra-high field 7T. The effect of atomoxetine depended on locus coeruleus integrity: participants with a more degenerate locus coeruleus showed a greater increase in prior weighting on atomoxetine versus placebo. …”
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Reciprocal interaction between IK1 and If in biological pacemakers: A simulation study. by Yacong Li, Kuanquan Wang, Qince Li, Jules C Hancox, Henggui Zhang

“…Pacemaking dysfunction (PD) may result in heart rhythm disorders, syncope or even death. …”
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Evaluation of a caudal midline glossectomy on tongue volume and upper airway cross-sectional areas in brachycephalic dogs: a cadaveric study by Valeria T. Colberg, Raymond K. Kudej, Nicole Moyer, Joshua A. Peters, William M. Karlin

“…The objective of this study was to evaluate the effects of a caudal midline glossectomy (CMG) on tongue volume and upper airway cross-sectional areas.MethodsCadaveric brachycephalic dogs (n = 6) were positioned with the tongue retracted and jaw nearly closed. …”
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Seroprevalence of scrub typhus among patients with acute febrile illness: A study from northern districts of West Bengal by Santanu Hazra, Arpita P. Dutta, Sumana Moitra, Shampa Das, Sanjoy K. Mallick, Arunabha Sarkar, Binita Pradhan, Ayan Chakraborty, Debapriya Bhowmick, Arnab Saha

“…Surveillance and vector control strategies can effectively control the disease burden.…”
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Nanoengineered hydrogels disrupt tumor antioxidant defense via photothermal-chemodynamic synergy and oxidative stress boosts by Leiguang Ye, Yang Qiao, Peisan Wang, Wei Li, Xianwen Wang, Yiqun Zhang, Zhennan Yuan

“…Mechanistic studies revealed that combination therapy induced mitochondrial dysfunction and activated the apoptosis/ferroptosis pathways. …”
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Therapeutic Potential of Flavonoids and Flavonoid-Rich Compounds in Irritable Bowel Syndrome by Xia Y, Liang C, Luo H, Zhang Y

“…Although individuals with IBS are commonly treated with medications and lifestyle modifications, the side effects of various treatments and their inconsistent efficacy often leads to a recurrence that poses a significant burden for patients. …”
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Neglect and Neurodevelopment: A Narrative Review Understanding the Link Between Child Neglect and Executive Function Deficits by Silvia Herrero-Roldán, Alexandra Martín-Rodríguez

“…<b>Background</b>: Childhood neglect is a pervasive yet often overlooked form of maltreatment that exerts profound and lasting effects on neurodevelopment. Unlike other types of abuse, neglect is characterized by the absence of essential stimuli and caregiving, which are critical for normal brain maturation, particularly in regions involved in executive function. …”
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Finetuning Type I Interferon Signaling to Enhance T Cell Immunity in HIV Infection by Wenli Mu, Nandita Kedia, Anjie Zhen

“…Type I interferons (IFN-Is) play a dual role in the immune response to HIV-1, providing early antiviral defense while driving immune dysfunction in the chronic phase. During acute infection, robust IFN signaling is critical in controlling viral replication, activating innate immunity, and limiting reservoir establishment. …”
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Exploring fatty acid metabolism in Alzheimer’s disease: the key role of CPT1A by Yanxiu Ju, Songtao Li, Xiangyi Kong, Qing Zhao

“…Accumulating evidence has highlighted the effects of fatty acid metabolism on AD. In this study, fatty acid metabolism was used as an entry point to understand the pathogenesis of AD and identify new targets. …”
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The Impact of a Comprehensive Intervention on Sensorimotor Recovery in Cerebro Vascular Accident (CVA) Patients in Selected Hospitals, Coimbatore, Tamil Nadu by Deepa Ramaswamy, Arockiamary Ignasimuthu, S. Parimala, Lingaraj Chitra, Sasikala Gunasekaran, Panneerselvam Periasamy

“…Introduction: A cerebrovascular accident (CVA) occurs when a blood clot blocks oxygen and blood flow to the brain, causing physical limitations, sensory dysfunction, headaches, and incontinence in patients. …”
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Clinical and paraclinical assessment of the efficacy of calcium carbonate, vitamin d3 and chitosan in the management of chronic renal failure in dogs by Florin Dan SIMIZ, Elena Daniela BRĂSLAȘU, Cristina VĂDUVA

“…Concurrently, marked decreases were observed in key renal dysfunction markers: phosphorus (-53.7%), creatinine (-75.54%), SDMA (-48.1%), and urea (-71.7%). …”
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