Safety Assessment of Neoadjuvant Pertuzumab Combined with Trastuzumab in Nonmetastatic HER2-Positive Breast Cancer in Postmenopausal Elderly Women of South Asia by Nadia Hussain, Amira S. A. Said, Zainab Khan

“…To evaluate the safety issues and adverse effects of using TCHP regimen (docetaxel, carboplatin, trastuzumab, and pertuzumab) versus TCP regimen (docetaxel, carboplatin, and trastuzumab) in older postmenopausal women with nonmetastatic HER2-positive breast cancer. …”
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Sugar Addiction: Neural Mechanisms and Health Implications by Di Qin, Jiayu Qi, Fuqiang Shi, Zhihua Guo, Hongwu Li

“…Appetite is regulated by complex neural pathways, including those in the prefrontal cortex, amygdala, and hypothalamus. Therefore, dysfunction of these areas may lead to excessive sugar intake and impulsivity. …”
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The Alteration of Proteomic Profiles in Hippocampus of Type 2 Diabetic Mice Associated With Cognitive Impairment by Yoottana Janthakhin, Sirikran Juntapremjit, Karin Hummel, Ebrahim Razzazi-Fazeli, Sutin Kingtong

“…In this study, we aimed to investigate the effects of T2DM on behavior, the proteome profile in the hippocampus, and the potential molecular pathways involved in the development of cognitive dysfunction in T2DM mice. …”
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Cardio-vascular risk in patients with non-valvular persisting atrial fibrillation by Kalashnykova O.S.

“…With regard to co-morbidity characteristics, patients in our study had higher BMI (31,9 ± 5,7 vs 28,5 ± 5,2; p<0,001), hypercholesterolaemia (72,9% vs 46,1%; p<0,001), moderate renal dysfunction (GFR 30-59 mL/min) (36,8% vs 12,1%; p<0,001) and alcohol abuse (6,8% vs 1,1%). …”
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Omentin—General Overview of Its Role in Obesity, Metabolic Syndrome and Other Diseases; Problem of Current Research State by Hubert Mateusz Biegański, Krzysztof Maksymilian Dąbrowski, Anna Różańska-Walędziak

“…It was proven to participate in the development of asthma and atopic dermatitis and to have different concentration dynamics in various types of tumors. All of omentin’s effects and properties make it an attractive subject of research, considering still unexplored inflammation mechanisms, in which it may play an important role. …”
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Daily activity limitations and fall risk among older Chinese adults with arthritis: Exploring contributing factors by Yifan Hu, Qiang Ren

“…Objective: Chronic pain and joint dysfunction caused by arthritis are significantly association with the daily living abilities of the elderly. …”
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Eucommia ulmoides Oliver polysaccharide alleviates glucocorticoid-induced osteoporosis by stimulating bone formation via ERK/BMP-2/SMAD signaling by Jiyu Song, Yongfeng Zhang, Xinghui Jin, Yanfeng Zhu, Yutong Li, Min Hu

“…Abstract Osteoporosis (OP) is a metabolic disease characterized by low bone mineral mass owing to osteoblast dysfunction. Eucommia ulmoides Oliver (EuO) is a Chinese herbal medicine traditionally used to treat OP. …”
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Cranial irradiation alters the brain's microenvironment and permits CCR2+ macrophage infiltration. by Josh M Morganti, Timothy D Jopson, Sharon Liu, Nalin Gupta, Susanna Rosi

“…It is believed that activation of neuroinflammatory signaling pathways contributes to the development of common adverse effects, which may ultimately contribute to cognitive dysfunction. …”
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Prenatal Exposure to Respiratory Syncytial Virus Alters Postnatal Immunity and Airway Smooth Muscle Contractility during Early-Life Reinfections. by Paul M Brown, Terri J Harford, Vandana Agrawal, Belinda Yen-Lieberman, Fariba Rezaee, Giovanni Piedimonte

“…Maternal viral infections can have pathological effects on the developing fetus which last long after birth. …”
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Gut microbiota and atrial cardiomyopathy by Tingting Sun, Beibei Song, Bo Li

“…The aim of this work is to bridge the knowledge gap regarding the interactions between the gut microbiota and atrial cardiomyopathy, with a particular focus on elucidating the mechanisms by which gut dysbiosis may induce atrial remodeling and dysfunction. This article provides an overview of the role of the gut microbiota in the pathogenesis of atrial cardiomyopathy, including changes in the composition of the gut microbiota and the effects of its metabolites. …”
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Severe Rhabdomyolysis due to Presumed Drug Interactions between Atorvastatin with Amlodipine and Ticagrelor by Iouri Banakh, Kavi Haji, Ross Kung, Sachin Gupta, Ravindranath Tiruvoipati

“…However, rhabdomyolysis is a well-known rare side effect of statins which should be considered when treatments are combined with cytochrome P450 3A4 enzyme inhibitors. …”
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APOE genotype and brain amyloid are associated with changes in the plasma proteome in elderly subjects without dementia by Sarah M. Philippi, Kailash BP, Towfique Raj, Joseph M. Castellano

“…While age‐associated blood‐borne proteins have been targeted to restore function to the aged brain, it remains unclear whether other dysfunctional systemic states can be exploited for similar benefits. …”
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Neuroprotective mitochondria targeted small molecule restores synapses and the distribution of synaptic mitochondria in the hippocampus of APP/PS1 mice by Noah Keller, Trace A. Christensen, Erik J. Wanberg, Jeffrey L. Salisbury, Eugenia Trushina

“…Using serial block-face scanning electron microscopy and three-dimensional electron microscopy reconstruction, we examined the effect of CP2 treatment on synapses, and the distribution and morphology of synaptic mitochondria in the hippocampus of APP/PS1 mice. …”
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Changes of the eye during long-term spaceflight. Review by I. A. Makarov, Y. I. Voronkov

“…The role of trigger such mechanisms in the development of the intracranial hypertension in the microgravity environment as anatomical predisposition of the body, race, metabolic changes under the influence of high carbon dioxide content in the different compartments of the station, high sodium intake, the enzyme dysfunction, weight exercises of the astronauts was discussed. …”
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Accelerated peripheral nerve repair using surface-modified biomaterials for targeted capture of glial-derived growth factors post-neurorrhaphy. by Shiu-Jau Chen, Chih-Ming Lin, Chiung-Hui Liu, Yin-Hsiu Chen, Yu-Lin Hsieh, You-Cheng Lin, Yin-Hung Chu, Chung-Yao Ku, Wei-Li Liao, Wen-Chieh Liao

“…Peripheral nerve injury (PNI) commonly leads to motor or sensory dysfunction, with nerve grafts being the standard treatment for neurorrhaphy. …”
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Clinical significance of platelet-to-white blood cell ratio in patients with Wilson disease: a retrospective cohort study by Hao-Jie Zhong, Jun-Yi Chen, Wei-Ming Wu, Xing-Xiang He, Yong-Qiang Zhan

“…Objective To assess the correlation between the platelet-to-white blood cell ratio (PWR) and the severity of liver dysfunction, hepatic complications, and prognosis in Wilson disease (WD) patients. …”
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Asymptomatic Leukocytospermia and Assisted Reproductive Technology Outcomes: Reason for concern? by Marie-Christin Reich, Natalie Heide, Peter Humaidan, Sandro C. Esteves

“…However, when excessively activated, they may generate high levels of reactive oxygen species (ROS), contributing to oxidative stress, sperm dysfunction, and DNA damage. This narrative review critically examines whether asymptomatic leukocytospermia adversely affects ART outcomes, including fertilization, embryo development, clinical pregnancy, and live birth rates. …”
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Immune cell aberrations in Systemic Lupus Erythematosus: navigating the targeted therapies toward precision management by YuXian Wu, Wangzheqi Zhang, Yan Liao, Ting Sun, Yang Liu, Yaoyang Liu

“…Abstract Systemic lupus erythematosus (SLE) is a complex autoimmune disease characterized by multilayered dysregulation of immune cell homeostasis, spanning B cell effector dysfunction, T follicular helper (Tfh) cell hyperactivity, and plasmacytoid dendritic cell (pDC) tolerance breakdown. …”
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Kencur Supplementation Modulates Interleukin-6 (IL-6) and C-Reactive Protein (CRP) in Response to Muscle Damage Following Eccentric Exercise by Roy Januardi Irawan, Joesoef Roepajadi, Heri Wahyudi, Noortje Anita Kumaat, Abdul Rohim Tualeka, Nanda Rimawati, Adi Wijayanto

“…Intense or unaccustomed exercise can cause muscle damage and tissue injury, leading to temporary muscle dysfunction and the release of pro-inflammatory cytokines and free radicals. …”
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“It's all my fault”: a qualitative study of how heterosexual couples experience living with vulvodynia by Linn Myrtveit‐Stensrud, Gro Killi Haugstad, Silje Endresen Rème, Sidsel Louise Schaller, Karen Synne Groven

“…This sustains avoidance and endurance behavior, increasing pain and dysfunction over time and giving rise to feelings of powerlessness and loneliness. …”
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