Ticam2 ablation facilitates monocyte exhaustion recovery after sepsis by Blake A. Caldwell, Susanti Ie, Amy Lucas, Liwu Li

“…This is due in part to immune dysfunction resulting from monocyte exhaustion, a phenotype of reduced antigen presentation, altered CD14/CD16 inflammatory subtypes, and disrupted cytokine production. …”
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Tamarixetin: A Promising Bioflavonoid Against Acetaminophen-Induced Liver Injury by Mehmet Ali Telafarlı, Ejder Saylav Bora, Firdes Topal, Oytun Erbaş

“…Oxidative stress, mitochondrial dysfunction, and inflammatory responses cause acute liver failure in most cases of acetaminophen (APAP) overdose. …”
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The association between melatonin hormone and reproductive hormones in polycystic ovary syndrome: A case–control study by Ban Jabir Edan, Zahid Mohammed-Ali Kadhim

“…Conclusions: Although PCOS women had higher serum melatonin concentrations, their effect on ovarian hormones is diminished. Melatonin had a connection with androgen, and melatonin supplements may improve metabolic dysfunction in PCOS patients.…”
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Monitoring and early warning of ovarian cancer using high-dimensional non-parametric EWMA control chart based on sliding window by Bin Wu, Wen Zhong, Yixing Ren, Zhongli Zhou, Liu Liu

“…In addition, we further validated the effectiveness of this method through analysis of a tumor resection data example.…”
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Metabolic and Phenotypic Differences between Mice Producing a Werner Syndrome Helicase Mutant Protein and Wrn Null Mice. by Lucie Aumailley, Chantal Garand, Marie Julie Dubois, F Brad Johnson, André Marette, Michel Lebel

“…These results indicate that the deleterious effects of the helicase-deficient Wrn protein are mediated by the dysfunction of several cellular organelles.…”
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Construction of a 12-gene prognostic model for colorectal cancer based on heat shock protein-related genes by Qin Tong, Junchao Zhou

“…Combined, our study successfully crafted a novel CRC prognostic model that can effectively predict patient survival, immune landscape, and treatment response, providing important support and guidance for CRC patient prognosis.…”
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Metabolically associated fatty liver disease. What is the danger of a "safe" disease? Pathogenesis of cardiovascular complications by M. A. Isaikina, O. Yu. Isaykina, O. Yu. Trushina

“…The epidemiological burden of hepatic steatosis associated with metabolic dysfunction is constantly increasing worldwide and in all age groups. …”
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Evaluation of the impact of continuous nursing and cluster nursing on carpal tunnel syndrome release surgery by Yang Chen, Ruihua Li, Yongqiang Zhu, Ran Chen

“…However, the study group demonstrated lower scores in symptom and dysfunction, as well as lower VAS and NRS scores compared to the control group (P < 0.05). …”
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Modern approaches to transvenous lead extraction by D. G. Podolyak, A. Yu. Kiprensky, S. A. Mironovich

“…Aim. To show the effectiveness and safety of modern transvenous lead extraction (TLE) techniques used in cardiac surgery.Material and methods. …”
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Evaluation of thrombomodulin (THBD) plasma levels in sickle cell disease and correlation with disease severity by Yasmeen M.M. Selim, Amina Abdelsalam, Eman A. Youssef, Abdelkarem Bahy, Dalia El-Sayed

“…Abstract Background Endothelial dysfunction is a hallmark of sickle vasculopathy. Thrombomodulin (THBD) is a transmembrane protein expressed on vascular endothelial cells suppressing blood coagulation and exerting anti-inflammatory effects. …”
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Identifying colorectal cancer subtypes and establishing a prognostic model using metabolic plasticity and ferroptosis genes by Jingwen Guan, Simin Min, Yan Xia, Zhiguo Guo, Xiaolan Zhou

“…Abstract Metabolic plasticity and ferroptosis are essential for colorectal cancer (CRC) progression. The effects and prognostic value of metabolic plasticity- and ferroptosis-related genes (MPFRGs) in CRC remain unclear. …”
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Striatal dopamine transmission is subtly modified in human A53Tα-synuclein overexpressing mice. by Nicola J Platt, Suzana Gispert, Georg Auburger, Stephanie J Cragg

“…While modest, these modifications may indicate or contribute to striatal dysfunction.…”
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Treatment challenges and survival analysis of human epidermal growth factor receptor 2-positive breast cancer in real world by Praveen Adusumilli, Meher Lakshmi Konatam, Sadashivudu Gundeti, Stalin Bala, Lakshmi Srinivas Maddali

“…Seven patients (9.45%) developed Grade II reversible diastolic dysfunction. Grade II/III peripheral neuropathy due to paclitaxel is the main adverse effect seen in 21 patients. …”
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PK2/PKR1 Signaling Regulates Bladder Function and Sensation in Rats with Cyclophosphamide-Induced Cystitis by Biao Chen, Huiping Zhang, Lili Liu, Jiaojiao Wang, Zhangqun Ye

“…Blocking PKRs with PKRA showed no effect on micturition reflex activity and bladder sensation in control rats while it increased the voiding volume, prolonged voiding interval, and ameliorated visceral hyperalgesia in rats suffering from CYP-induced cystitis. …”
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Meriones unguiculatus serves as a spontaneous primary aldosteronism rodent model. by Mei You, Zongshi Lu, Bowen Wang, Min Liu, Qing Zhou, Li Li, Dan Tong, Yu Zhao, Hexuan Zhang, Zhongping Bai, Lijuan Wang, Tingbing Cao, Peng Gao, Zhencheng Yan, Zhiming Zhu

“…Compared with control groups, the inhibitory effect of a high-sodium diet on the RAAS was milder in MU, accompanied by significant cardiac dysfunction. …”
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Physiological roles and therapeutic implications of USP6 by Suaad Syed, Muhammad Yasir Khan Painda, Dawood Ghafoor, Dongjin Gu, Feng Wang

“…Dysregulation of USP6 has been implicated in a spectrum of diseases, including bone tumors, breast and colorectal cancers, cranial fasciitis, and neurological disorders such as memory dysfunction. Furthermore, USP6 is involved in emerging therapeutic strategies highlighting its implications for drug development. …”
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Fluoxetine Attenuated Anxiety-Like Behaviors in Streptozotocin-Induced Diabetic Mice by Mitigating the Inflammation by Peng Yuan, Jian Zhang, Liang Li, Zhendi Song

“…We found that fluoxetine could effectively mitigate the level of anxiety and attenuate the cognitive dysfunction in diabetic mice. …”
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Targeting the NLRP3 inflammasome for calcium oxalate stones: pathophysiology and emerging pharmacological interventions by Andrew M. Boldt, Francesca Di Sole

“…Future studies should focus on optimizing NLRP3-targeted therapies, assessing their long-term effects on kidney stone prevention and CKD progression. …”
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Mitochondrial superclusters influence age of onset of Parkinson's disease in a gender specific manner in the Cypriot population: A case-control study. by Andrea Georgiou, Christiana A Demetriou, Alexandros Heraclides, Yiolanda P Christou, Eleni Leonidou, Panayiotis Loukaides, Elena Yiasoumi, Dimitris Panagiotou, Panayiotis Manoli, Pippa Thomson, Maria A Loizidou, Andreas Hadjisavvas, Eleni Zamba-Papanicolaou

“…<h4>Background</h4>Despite evidence supporting an involvement of mitochondrial dysfunction in the pathogenesis of some neurodegenerative disorders, there are inconsistent findings concerning mitochondrial haplogroups and their association to neurodegenerative disorders, including idiopathic Parkinson's disease (PD).…”
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Association between cardiometabolic index and self-reported symptoms of obstructive sleep apnea: a cross-sectional study by Mingyue Cui, Xianchao Xiao, Xue Zhao, Xiaokun Gang, Guixia Wang

“…Abstract The Cardiometabolic Index (CMI) is a new indicator of visceral fat distribution and dysfunction that can be calculated using lipid parameters, waist circumference, and height. …”
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