PSMA2 promotes chemo- and radioresistance of oral squamous cell carcinoma by modulating mitophagy pathway by Chun-I Wang, Cheng-Yi Chen, Ting-Wen Chen, Chun-Chia Cheng, Shu-Wen Hong, Tsung-You Tsai, Kai-Ping Chang

“…Notably, mitophagy inducer exhibit antitumor effects in PSMA2-overexpressing OSCC xenograft mouse model. …”
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A possible important regulatory role of estrogen in obstructive sleep apnea hypoventilation syndrome by Pinyi Zhou, Hongmei Li, Hongyan Li, Yan Chen, Yunhui Lv

“…If left untreated, OSAHS can induce or aggravate systemic dysfunction across multiple organ systems, with a particularly pronounced impact on cardiovascular health, thereby posing a substantial threat to overall human well-being. …”
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Stress-Induced Sleep Dysregulation: The Roles of Astrocytes and Microglia in Neurodegenerative and Psychiatric Disorders by Ángel R. Rábago-Monzón, Juan F. Osuna-Ramos, David A. Armienta-Rojas, Josué Camberos-Barraza, Alejandro Camacho-Zamora, Javier A. Magaña-Gómez, Alberto K. De la Herrán-Arita

“…Many of these effects converge on the disruption of synaptic processes, such as neurotransmitter balance, synaptic plasticity, and pruning, which in turn contribute to the pathophysiology of neurodegenerative and psychiatric disorders. …”
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Inhibition of VDAC1 oligomerization blocks cysteine deprivation-induced ferroptosis via mitochondrial ROS suppression by Se-Kyeong Jang, Se Hee Ahn, Gyeongmi Kim, Selim Kim, Jungil Hong, Ki Soo Park, In-Chul Park, Hyeon-Ok Jin

“…Our results demonstrate that the mitochondria-targeted antioxidants MitoQ and MitoT effectively block ferroptosis induction and that dysfunction of complex III of the mitochondrial electron transport chain contributes to ferroptosis induction. …”
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NLRP3: A Novel Mediator in Cardiovascular Disease by Wenyi Zhou, Chunyuan Chen, Zhiheng Chen, Lin Liu, Jie Jiang, Zhixiang Wu, Mingyi Zhao, Yanfang Chen

“…Piling evidence has revealed that the NLRP3 inflammasome could exert an inflammatory effect by inducing the secretion of proinflammatory cytokines (i.e., IL-1β, IL-18) or could cause pyroptosis, a novel programmed cell death process, in a caspase-1-dependent manner. …”
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Enhancement of Dopaminergic Differentiation in Proliferating Midbrain Neuroblasts by Sonic Hedgehog and Ascorbic Acid by Floriana Volpicelli, Claudia Consales, Massimiliano Caiazzo, Luca Colucci-D'Amato, Carla Perrone-Capano, Umberto di Porzio

“…Our strategy provides an enriched source of MES DA neurons that are useful for analyzing molecular mechanisms controlling their function and for experimental regenerative approaches in DA dysfunction.…”
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Targeting synergetic endothelial inflammation by inhibiting NFKB and JAK-STAT pathways by Stijn A. Groten, Pieter Langerhorst, Georgios Malamas, Alastair Barraclough, Arie J. Hoogendijk, Maartje van den Biggelaar

“…Summary: Multiple systemic vascular inflammatory disorders are associated with endothelial dysfunction and elevated levels of TNFα and IFNγ. Combined TNFα and IFNγ stimulation induces synergetic hyperinflammation in endothelial cells (ECs) through the activation of the NFKB and JAK/STAT pathways. …”
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High-resolution lifestyle profiling and metabolic subphenotypes of type 2 diabetes by Heyjun Park, Ahmed A. Metwally, Alireza Delfarah, Yue Wu, Dalia Perelman, Caleb Mayer, Curtis McGinity, Majid Rodgar, Alessandra Celli, Tracey McLaughlin, Emmanuel Mignot, Michael Snyder

“…Abstract Distinct metabolic susceptibilities (beta-cell dysfunction, insulin resistance (IR), and impaired incretin response) underlie type 2 diabetes (T2D). …”
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Infectious agents as a risk factor for Alzheimer’s disease by S. V. Vorobyev, K. V. Shalepo, E. V. Spasibova, A. M. Savicheva, A. N. Grigor’ev

“…This is due to both their high frequency of occurrence and significant negative impact, which has a violation of higher cortical functions on the quality of life of patients due to the deterioration of their social communication, as well as reducing the effectiveness of professional and household functions. …”
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Association of glymphatic system function with peripheral inflammation and motor symptoms in Parkinson’s disease by Ruolan Lin, Guoen Cai, Ying Chen, Jinmei Zheng, Shu Wang, Huinan Xiao, Qinyong Ye, Yunjing Xue, Rifeng Jiang

“…Overall, glymphatic dysfunction correlates with peripheral inflammation and may mediate effects of inflammation on motor symptoms in PD, with distinct inflammation profiles between TD and PIGD.…”
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SARS-CoV-2 Nsp6-Omicron causes less damage to the Drosophila heart and mouse cardiomyocytes than ancestral Nsp6 by Jun-yi Zhu, Jin-Gu Lee, Guanglei Wang, Jianli Duan, Joyce van de Leemput, Hangnoh Lee, Wendy Wenqiao Yang, Zhe Han

“…Through validation in mouse primary cardiomyocytes, we find that Nsp6-induced dysregulated glycolysis underlies the cardiac dysfunction. Together, the results indicate that the amino acid changes in Omicron might hinder its interaction with host proteins thereby minimizing its pathogenicity.…”
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Stepwise targeting hyaluronic acid-based polymeric prodrug for acute kidney injury and prevents its progression to chronic kidney disease by Li-Bin Zhou, Xuan-Ze Peng, Hui-Min Long, Jing-Bo Hu, Jian-Ting Xu

“…A key factor in AKI development is mitochondrial dysfunction, which disrupts energy and oxygen supply, increases ROS generation, and triggers inflammation. …”
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Sleep Quality in Head and Neck Cancer by Giancarlo Pecorari, Simone Moglio, Dario Gamba, Marco Briguglio, Ester Cravero, Eugenio Sportoletti Baduel, Giuseppe Riva

“…Given the effect of sleep on overall well-being, addressing sleep disorders should be a priority in the care of HNC patients.…”
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Nanomedicine Approaches for Intervertebral Disc Regeneration: From Bench to Bedside by Yifan Ding, Fan Li, Yunyun Wang, Weizhen Pan, Xiangning Fu, Songwei Tan

“…Intervertebral disc degeneration (IDD) is a leading cause of low back pain (LBP) and neurological dysfunction, contributing significantly to disability-adjusted life years globally. …”
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FBXL4 deficiency increases mitochondrial removal by autophagy by David Alsina, Oleksandr Lytovchenko, Aleksandra Schab, Ilian Atanassov, Florian A Schober, Min Jiang, Camilla Koolmeister, Anna Wedell, Robert W Taylor, Anna Wredenberg, Nils‐Göran Larsson

“…Surprisingly, the few surviving animals are apparently normal until the age of 8–12 months when they gradually develop signs of mitochondrial dysfunction and weight loss. One‐year‐old Fbxl4 knockouts show a global reduction in a variety of mitochondrial proteins and mtDNA depletion, whereas lysosomal proteins are upregulated. …”
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Transcatheter repair for papillary muscle rupture Post-AMI by Fei Guo, Guanghui Zhu, Dongmei Yang, Jing Zhu, Jianfeng Luo, Jian Xu

“…Case presentation This case report aims to explore the feasibility and effectiveness of the DragonFly™ system in patients with papillary muscle rupture following AMI. …”
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IVABRADINE INFLUENCE ON SYSTOLIC AND DIASTOLIC FUNCTION OF HEART VENTRICLES IN PATIENTS WITH ISCHEMIC HEART DISEASE AFTER PRIMARY REVASCULARIZATION by N. V. Drobotya, A. A. Dyuzhikov, E. A. Kudryashova, D. V. Vasilikhina, V. V. Kaltykova

“…Aim. To compare effects of different medication therapy schedules on parameters of systolic and diastolic function of the left (LV) and right (RV) ventricles in patients with ischemic heart disease (CHD) after primary revascularization of myocardium (PPCI).Material and metods. …”
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Esophageal Diameter on High-Resolution Computed Tomography – a Potential Useful Marker for Interstitial Lung Disease Severity in Patients with Systemic Sclerosis by Anja Ljilja Posavec, Lea Šalamon, Renata Huzjan Korunić, Nevenka Piskač Živković, Joško Mitrović

“…Patients with systemic sclerosis (SSc) are at an increased risk of developing interstitial lung disease (ILD) and esophageal dysfunction, with frequently present esophageal dilatation. …”
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Deep phenotyping of patients with MASLD upon high-intensity interval training by Veera Houttu, Ulrika Boulund, Marian Troelstra, Susanne Csader, Daniela Stols-Gonçalves, Anne Linde Mak, Anne-Marieke van Dijk, Julia Bouts, Maaike Winkelmeijer, Xanthe Verdoes, Sandra van den Berg-Faay, Donne Lek, Ted Ronteltap, Ferdinand de Haan, Harald Jorstad, Ville Männistö, Kai Savonen, Heikki Pentikäinen, Kati Hanhineva, Ambrin Farizah Babu, Gianni Panagiotou, Otto van Delden, Joanne Verheij, Michial Doukas, Aart Nederveen, Ursula Schwab, Aldo Grefhorst, Max Nieuwdorp, Adriaan Georgius Holleboom

“…Background & Aims: Exercise is a key component of lifestyle management in patients with metabolic dysfunction-associated steatotic liver disease (MASLD), but neither its therapeutic effect on the active stage of the disease, that is metabolic dysfunction-associated steatohepatitis (MASH) nor the mediating mechanisms have been characterized. …”
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The role of cytokines in wound healing: from mechanistic insights to therapeutic applications by Rachel Si-Yin Wong, Timothy Tan, Alexander Shao-Rong Pang, Dinesh Kumar Srinivasan

“…Cytokines are a promising therapeutic target, as they regulate all stages of wound healing, and dysfunction in cytokine production can cause inflammatory non-healing wounds. …”
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