Chitosan attenuates titanium dioxide nanoparticles induced hepatic and renal toxicities by Amal Abdelmonem Halawa, Gehad Elshopakey, Mohamed El-Adl, Samah Lashen, Nancy Shalaby, Shaymaa Rezk, Omar Elmetwally, Ehab Eldomany, Ahmed Farghali, Mohamed Elmetwally

“…Carboxymethyl chitosan (5 mg/kg BW) significantly improved the harmful effects of nano-titanium particles highlighting its relevance in reducing TiO2 NPs – induced hepatic and renal dysfunction.…”
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Role of the endothelial cell glycocalyx in sepsis-induced acute kidney injury by Yixun Wang, Yixun Wang, Yixun Wang, Zhaohui Zhang, Zhaohui Zhang, Zhaohui Zhang, Xingguang Qu, Xingguang Qu, Xingguang Qu, Gaosheng Zhou, Gaosheng Zhou, Gaosheng Zhou

“…The pathophysiologic mechanisms underlying S-AKI are complex, and include renal vascular endothelial cell dysfunction. The endothelial glycocalyx (EG) is a polysaccharide/protein complex located on the cell membrane at the luminal surface of vascular endothelial cells that has anti-inflammatory, anti-thrombotic, and endothelial protective effects. …”
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Identification of novel therapeutic targets for cognitive performance and associations with brain health by Lu-Yang Zhang, Yu-Xin Liu, Yun-Hui Chu, Yun-Fan You, Luo-Qi Zhou, Sheng Yang, Ming-Hao Dong, Hang Zhang, Xiao-Wei Pang, Lian Chen, Li-Fang Zhu, Jun Xiao, Ke Shang, Wei Wang, Chuan Qin, Dai-Shi Tian

“…Abstract Cognitive dysfunction poses a significant challenge in clinical practice, but currently available drugs mainly address symptoms and have limited effectiveness in treating cognitive dysfunction associated with various neurological disorders. …”
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Transient Azoospermia Induced by Valganciclovir Treatment for Cytomegalovirus Infection in a Reproductive Male After Kidney Transplant: A Case Report by Kosuke Mieda, Shunta Hori, Mitsuru Tomizawa, Kuniaki Inoue, Tatsuo Yoneda, Yuji Nitta, Yasushi Nakai, Makito Miyake, Nobumichi Tanaka, Kiyohide Fujimoto

“…ABSTRACT Introduction Spermatogenic dysfunction is a side effect of valganciclovir, which is commonly used to treat cytomegalovirus infections. …”
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ESTERASE ACTIVITY AMONG PATIENTS WITH GASTROINTESTINAL DISEASES WORKING AT THE PLANTS PROVIDING STORAGE AND DISPOSAL OF ORGANOPHOSPHORUS COMPOUNDS by A. V. Fomichev, V. V. Miroshnikova, U. S. Chalimov, V. U. Golofeevskiy, A. V. Yazenok, V. G. Kuzmich, K. V. Muzurov, E. V. Malysheva, S. N. Pchelina

“…In order to evaluate the effect of dysfunction of detoxification system on the development of gastrointestinal pathology, we studied «esterase status» (activity of acetylcholinesterase, butyrylcholinesterase and paraoxonase 1 (PON1)) among workers at the plants providing storage and disposal of OPs. …”
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Cisplatin-Induced Hearing Loss, Oxidative Stress, and Antioxidants as a Therapeutic Strategy—A State-of-the-Art Review by Olaf Rose, Tim Croonenberg, Stephanie Clemens, Tobias Hinteregger, Stefanie Eppacher, Petra Huber-Cantonati, Marta Garcia-Miralles, Raffaella Liuni, Silvia Dossena

“…Cisplatin is an established component of treatment protocols for various solid malignancies but carries a significant potential for serious adverse effects. Ototoxicity from cisplatin treatment is an important dose-limiting toxicity that manifests as bilateral, progressive, irreversible, dose-dependent sensorineural hearing loss, ear pain, tinnitus, and vestibular dysfunction. …”
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Insulin Sensitivity, Serum Lipids, and Systemic Inflammatory Markers in School-Aged Obese and Nonobese Children by Jinkwan Kim, Rakesh Bhattacharjee, Leila Kheirandish-Gozal, Abdelnaby Khalyfa, Oscar Sans Capdevila, Riva Tauman, David Gozal

“…The impact of obesity as a systemic low-grade inflammatory process has only partially been explored. To this effect, 704 community-based school-aged children (354 obese children and 350 age-, gender-, and ethnicity-matched controls) were recruited and underwent assessment of plasma levels of fasting insulin and glucose, lipids, and a variety of proinflammatory mediators that are associated with cardiometabolic dysfunction. …”
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Integrative approaches in Alzheimer’s disease: evaluating the potential of traditional, complementary, and integrative medicine (TCIM) by R. Sneha Sri, T. Pavithra, T. Vinciya, V. Santhosh Kumar, N. Harikrishnan, Rukaiah Fatma Begum, S. Ankul Singh

“…Unlike pharmaceutical treatments that primarily offer symptomatic relief, TCIM encompasses holistic approaches that target multiple pathophysiological pathways involved in AD, including tau pathology, oxidative stress, mitochondrial dysfunction, and neuroinflammation. Herbal therapies such as Withania somnifera, Ginkgo biloba, and Curcuma longa have shown promising neuroprotective effects in preclinical and limited clinical studies. …”
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The Role of Epigenetic Mechanisms in the Development of PM_2.5-Induced Cognitive Impairment by Lishan Jiang, Mingxia Shao, Chao Song, Li Zhou, Wenke Nie, Hang Yu, Siqi Wang, Yongping Liu, Li Yu

“…The underlying mechanisms of epigenetic alterations are related to inflammation, synaptic dysfunction, cardiovascular factors, and alterations in neuronal structure and function. …”
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Enhancement of gut barrier integrity by a Bacillus subtilis secreted metabolite through the GADD45A‐Wnt/β‐catenin pathway by Shiqi Liu, Peiran Cai, Wenjing You, Mingshun Yang, Yuang Tu, Yanbing Zhou, Teresa G. Valencak, Yingping Xiao, Yizhen Wang, Tizhong Shan

“…In this study, we isolated a novel strain of Bacillus subtilis (B. subtilis) and observed promising effects in protecting against disruption of the gut barrier. …”
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Magnetic mesoporous silica loaded with CGRP antagonist and curcumin coated with cerium oxide for the treatment of neuropathic pain by Yue Tian, Lei Wei, Liangliang Gao, Yi Zhu, Zhuoliang Zhang, Xinyu Lu, Yinhong Jiang, Chengyong Gu, Chenghuan Shi, Huibin Su

“…Abstract Neuropathic pain is chronic pain caused by damage or dysfunction of the nervous system. Pro-inflammatory factors and abnormal reactive oxygen species (ROS) production in the spinal cord play a key role in the occurrence and development of neuropathic pain. …”
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Complement factor H in molecular regulation of angiogenesis by Li Jiang, Wang Kaili, Starodubtseva Maria N., Nadyrov Eldar, Kapron Carolyn M., Hoh Josephine, Liu Ju

“…In this review, we summarize the molecular mechanisms of the anti-angiogenic effects of CFH and the regulatory mechanisms of CFH expression. …”
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Capsaicin‐mediated repair of circadian disruption‐induced Intestinal barrier damage via the gut microbiota by Yupei Deng, Bolin Lin, Chi‐Tang Ho, Jie Xiao, Yong Cao, Jun‐qing Huang, Muwen Lu

“…This study investigated the effectiveness of capsaicin (CAP) in mitigating intestinal barrier dysfunction induced by circadian disruption in male SPF C57BL/6J mice. …”
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A single systemic inflammatory insult causes acute motor deficits and accelerates disease progression in a mouse model of human tauopathy by Megan Torvell, David W. Hampton, Peter Connick, Alasdair M.J. MacLullich, Colm Cunningham, Siddharthan Chandran

“…Methods The ability of systemically administered lipopolysaccharide (LPS ‐ 500 μg/kg) to effect acute and chronic behavioural changes in C57BL/6 and P301S tauopathy mice was assessed. …”
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miRNA mediated mitochondrial function and gene regulation associated with Alzheimer’s disease by Kumudu Subasinghe, Robert Barber, Robert Barber, Robert Barber, Nicole Phillips, Nicole Phillips

“…Dysregulation of miRNA activity has been implicated in the pathology of Alzheimer’s disease (AD), offering insights into potential biomarkers for early diagnosis and therapeutic targets. Mitochondrial dysfunction and its associated effects (such as oxidative stress) can be seen in early-onset AD. …”
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Long-term electroacupuncture for low anterior resection syndrome in postoperative rectal cancer patients: case reports by Wenna Li, Wenna Li, Ming Yang, Ming Yang, Jinchang Huang, Jinchang Huang, Qiaoli Zhang, Qiaoli Zhang

“…Both patients presented with significant bowel dysfunction, including frequent defecation, urgency, fecal incontinence, and incomplete evacuation. …”
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L- and D-Lactate: unveiling their hidden functions in disease and health by Jianting Li, Peng Ma, Zhizhen Liu, Jun Xie

“…Recent studies have shown that disruptions in these two lactate stereoisomers have distinct effects on health and disease. L-lactate is central to glycolysis and energy transfer through the Cori cycle but also acts as the dominant lactylation isomer induced by glycolysis, influencing metabolism and cell survival. …”
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Pexophagy and Oxidative Stress: Focus on Peroxisomal Proteins and Reactive Oxygen Species (ROS) Signaling Pathways by Xiaofan Wei, Laxman Manandhar, Hyunsoo Kim, Arun Chhetri, Jaetaek Hwang, Gyuho Jang, Channy Park, Raekil Park

“…Peroxisomes generate reactive oxygen species (ROS) and also play a role in protecting cells from the damaging effects of such radicals. Dysfunctional peroxisomes are recognized by receptors and degraded by a selective type of macroautophagy called pexophagy. …”
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The Role of Gut Microbiota in the Prevention or Development of Atherosclerosis – A Review by Marcin Początek, Michał Piotrowski, Piotr Serwicki, Szczepan Pośpiech, Jakub Prosowski

“…Main results: The findings reveal that gut microbiota exerts a dual influence on atherosclerosis development through its metabolites, with SCFAs offering anti-inflammatory and cardioprotective effects, while TMAO promotes endothelial dysfunction and pro-thrombotic states. …”
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Autoimmune encephalitis associated with antibodies against α-enolase sequestrated from degenerating retina in retinitis pigmentosa by Qun Zeng, Jin Ming Lin, Androniki Syrrou, Onur İnam, Sarah Flanagan Wesley, Tongalp H. Tezel

“…This unique case demonstrates the remote effects of retinitis pigmentosa and an autoimmune pathogenetic pathway that triggered autoimmune encephalitis. …”
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