Involvement of Visceral Adipose Tissue in Immunological Modulation of Inflammatory Cascade in Preeclampsia by Katsuhiko Naruse, Juria Akasaka, Aiko Shigemitsu, Taihei Tsunemi, Natsuki Koike, Chiharu Yoshimoto, Hiroshi Kobayashi

“…The pathophysiology of preeclampsia is characterized by abnormal placentation, an exaggerated inflammatory response, and generalized dysfunction of the maternal endothelium. We investigated the effects of preeclampsia serum on the expression of inflammation-related genes by adipose tissue. …”
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The role of PPAR in fungal keratitis by Hongyan Zhou, Hong Zhang, Miaomiao Bi, Wensong Zhang

“…PPARa agonists inhibit early immature angiogenesis in corneal alkali burns and have potential therapeutic effects on inflammatory corneal angiogenesis. PPARs can control the progression of dry eye disease and improve the condition of meibomian gland dysfunction. …”
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Causal relationship between hyperthyroidism and cataracts: a two-sample bi-directional mendelian randomization study by Helin Ding, Taige Chen, Hao Peng, Lu Wang, Jun Gu

“…Abstract Clinical studies and meta-analyses have suggested a link between thyroid dysfunction and lens opacification. The objective of this study is to investigate the causal relationship between hyperthyroidism and the development of cataracts using the Mendelian randomization approach, with the aim of filling the gap in knowledge about the systemic effects of hyperthyroidism on ocular health. …”
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Comparative Analysis of Some Structural Equation Model Estimation Methods with Application to Coronary Heart Disease Risk by David Adedia, Atinuke O. Adebanji, Simon Kojo Appiah

“…Uncontrolled hypertension has been shown to be a leading cause of coronary heart disease, kidney dysfunction, and other negative health outcomes. It poses equal danger when asymptomatic and undetected. …”
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Auditory evoked-potential abnormalities in a mouse model of 22q11.2 Deletion Syndrome and their interactions with hearing impairment by Chen Lu, Jennifer F. Linden

“…We exploited large inter-individual variation in hearing ability among Df1/+ mice to distinguish effects of genetic background from effects of hearing impairment. …”
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Unravelling Shared Pathways Linking Metabolic Syndrome, Mild Cognitive Impairment, Dementia, and Sarcopenia by Daniela Ceccarelli Ceccarelli, Sebastiano Bruno Solerte

“…Pharmacological interventions, including GLP-1 receptor agonists, metformin, and SIRT 1 inducers, demonstrated neuroprotective effects in animals and some preliminary clinical models. …”
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Postprandial hyperlipidemia as a coronary atherosclerosis factor in patients with metabolic syndrome; corrective potential of rosuvastatin therapy by T. V. Krovyakova, P. A. Lebedev

“…To investigate the atherogenic role of postprandial hyperlipidemia (PPH) and endothelial dysfunction (ED) in the development of coronary angiosclerosis in patients with coronary heart disease (CHD) and metabolic syndrome (MS); to study the effectiveness of rosuvastatin in the correction of these factors. …”
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Antiviral Abidol is Associated with the Reduction of In-Hospital Mortality in COVID-19 Patients by Hesong Zeng, Xingwei He, Wanjun Liu, Jing Kan, Liqun He, Jinhe Zhao, Cynthia Chen, Junjie Zhang, Shaoliang Chen, Tianyu Xu, Xiaoxia Fu.

“…Information regarding the effect of Abidol on in-hospital mortality is scarce. …”
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Irisin Attenuates Neuroinflammation and Prevents the Memory and Cognitive Deterioration in Streptozotocin-Induced Diabetic Mice by Kexin Wang, Feng Song, Kai Xu, Zhi Liu, Shuhong Han, Fangna Li, Yu Sun

“…Our findings revealed the mechanism of irisin’s anti-inflammatory effect in the CNS.…”
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TLR4 deficiency does not alter glaucomatous progression in a mouse model of chronic glaucoma by Chi Zhang, Marina Simón, Jeffrey M. Harder, Haeyn Lim, Christa Montgomery, Qing Wang, Simon W.M. John

“…TLR4 activation can lead to mitochondrial dysfunction and metabolic deficits in inflammatory disorders. …”
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Home cage-based insights into motor learning and strategy adaptation in a Huntington disease mouse model. by Daniel Ramandi, Marja D Sepers, Zefang Wang, Brian Han, Cameron L Woodard, Timothy H Murphy, Lynn A Raymond

“…Huntington disease (HD) is a genetic neurodegenerative disorder characterized by progressive motor dysfunction, cognitive decline, and neuropsychiatric symptoms. …”
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Ranolazine as a therapeutic agent for diabetic cardiomyopathy: reducing endoplasmic reticulum stress and inflammation in type 2 diabetic rat model by Matin Mohyadini, Aghele Fahimi, S. Zahra Bathaie, Hamid Yaghooti

“…Ranolazine, primarily used for angina, has demonstrated potential cardioprotective effects. This study investigates the effects of ranolazine on oxidative stress, ER stress, and inflammation in the heart tissue of type 2 diabetic rats. …”
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Blue Light Emitting Diode Suppresses Sarcoma Cell Proliferation via the Endogenous Apoptotic Pathway Without Damaging Normal Cells by Shinji Kawaguchi, Toshihiko Nishisho, Shunichi Toki, Makoto Takeuchi, Shunsuke Tamaki, Koichi Sairyo

“…In this study, we examined the antitumor effects of BL on several kinds of bone and soft tissue sarcomas. …”
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PINK1 is necessary for long term survival and mitochondrial function in human dopaminergic neurons. by Alison Wood-Kaczmar, Sonia Gandhi, Zhi Yao, Andrey Y Abramov, Erik A Miljan, Gregory Keen, Lee Stanyer, Iain Hargreaves, Kristina Klupsch, Emma Deas, Julian Downward, Louise Mansfield, Parmjit Jat, Joanne Taylor, Simon Heales, Michael R Duchen, David Latchman, Sarah J Tabrizi, Nicholas W Wood

“…Parkinson's disease (PD) is a common age-related neurodegenerative disease and it is critical to develop models which recapitulate the pathogenic process including the effect of the ageing process. Although the pathogenesis of sporadic PD is unknown, the identification of the mendelian genetic factor PINK1 has provided new mechanistic insights. …”
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Transanal Rectal Resection by Circular Stapler for Rectal Prolapse: A Prospective Cohort Study by Ashwin Porwal, Paresh Gandhi, Deepak Kulkarni

“…Current treatments have issues, but the author developed TRRPCS, an innovative approach to effectively address rectal prolapse and associated functional issues. …”
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C9ORF72 poly-PR disrupts expression of ALS/FTD-implicated STMN2 through SRSF7 by Karen S. Wang, Julie Smeyers, Kevin Eggan, Bogdan Budnik, Daniel A. Mordes

“…The repeat is transcribed in the sense and the antisense directions to produce several dipeptide repeat proteins (DPRs) that have toxic gain-of-function effects; however, the mechanisms by which DPRs lead to neural dysfunction remain unresolved. …”
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The pathogenetic mechanisms of acute kidney injury and chronic kidney disease (a literature review) by T. M. Boychuk, A. I. Gozhenko, N. D. Filipets, V. M. Khodorovskyy

“…Defined nephroprotective effects of flocalin on tubular and glomerular parts indicate the pathogenetic role of KATP channels and importance of their pharmacological activation during acute and chronic kidney injury. …”
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Involvement of a battery of investigated genes in lipid droplet pathophysiology and associated comorbidities by Sami N. Al Harake, Yasamin Abedin, Fatema Hatoum, Nour Zahraa Nassar, Ali Ali, Aline Nassar, Amjad Kanaan, Samer Bazzi, Sami Azar, Frederic Harb, Hilda E. Ghadieh

“…In this review, we delineate the effects of mutations and deficiencies in genes — CIDEC, PPARG, BSCL2, AGPAT2, PLIN1, LIPE, LMNA, CAV1, CEACAM1, and INSR — involved in lipid droplet metabolism and their associated pathophysiological impairments, highlighting their roles in the development of lipodystrophies and metabolic dysfunction.…”
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A clinical case of late diagnosis of a chronic type I tyrosinemia by Natalia V. Chebotareva, Elvira D. Stafeeva, Olga А. Li, Agunda M. Kuchieva, Svetlana I. Polyakova, Jamal T. Abdurakhmanov, Sergey V. Moiseev

“…Tyrosinemia type 1 is a genetic disease mainly of the first months and years of life caused by a violation of normal tyrosine catabolism with the formation of final toxic metabolites that have a direct damaging effect on the liver and kidneys with the development of a characteristic clinical picture, represented mainly by functional and morphological disorders on a part of the liver that forms a cirrhosis clinic with a high probability of the latter's degeneration into hepatocellular carcinoma. …”
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The immunological pathogenesis of vitiligo and the potential role of mesenchymal stromal/stem cells in its treatment by Rui-Lin Yang, De-Zhi Zhao, Yi-Bing Yang, Han-Xiao Wei, Kang Yang, Yu-Jie Zhao, Wei-Hong Wan, Zu-Lin Liu, Yuan Feng, Qian Zhang, Tao Zhang

“…Currently, Mesenchymal Stromal Cells (MSCs) have gained prominence as a therapeutic modality in the research of numerous diseases, owing to their remarkable paracrine effects, making them a promising strategy for immunomodulation and tissue repair. …”
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