BMAL1 in Astrocytes: A Protective Role in Alzheimer’s and Parkinson’s Disease by David Brash-Arias, Luis I. García, Gonzalo Aranda-Abreu, Rebeca Toledo-Cárdenas, César Pérez-Estudillo, Donaji Chi-Castañeda

“…This review explores the relationship between circadian dysfunction and the development/progression of AD and PD. …”
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Choline and contribution to normal liver function of the foetus and exclusively breastfed infants: evaluation of a health claim pursuant to Article 14 of Regulation (EC) No 1924/20... by EFSA Panel on Nutrition, Novel Foods and Food allergens (NDA), Dominique Turck, Torsten Bohn, Jacqueline Castenmiller, Stefaan De Henauw, Karen Ildico Hirsch‐Ernst, Helle Katrine Knutsen, Alexandre Maciuk, Inge Mangelsdorf, Harry J McArdle, Androniki Naska, Kristina Pentieva, Frank Thies, Sophia Tsabouri, Marco Vinceti, Jean‐Louis Bresson, Thibault Fiolet, Alfonso Siani

“…No human studies have addressed the effect of low maternal dietary choline intake on liver function in the fetus or exclusively breastfed infants. …”
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An unexpected cause of severe metabolic acidosis by Suzanne K. Veneman, Stephanie E. Veneman, Hardjit Kharagjitsing, Thiemo F. Veneman

“…In addition to the indirect effect of dehydration resulting from the gastrointestinal side effects of hydroxyurea, another known but rarely reported adverse effect is (tubular) renal dysfunction, which may have contributed to the progression of metabolic acidosis. …”
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Cardiovascular Risk Factors at Different Stages of Menopause: A Study among Bengali-Speaking Hindu Ethnic Group, India by Debasmita Kar, Subho Roy

“… A reduction in the estrogen and progesterone levels during midlife leads to adverse changes in body fat distribution, insulin and lipid metabolism, and endothelial dysfunction; all of these increase the risk of cardiovascular disease (CVD). …”
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The role of HDAC11 in age-related hearing loss: Mechanisms and therapeutic implications by Guan Lina, Chen Jing, Jiang Hongqun

“…In addition, the overexpression of HDAC11 inhibited the Pink1/Parkin signaling pathway, which impeded the mitochondrial autophagy process and ultimately led to mitochondrial dysfunction. In animal experiments, we further verified the ameliorative effect of HDAC11 overexpression on hearing loss in aged mice. …”
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Psychiatric Disorders in Complex Regional Pain Syndrome (CRPS): The Role of the Consultation-Liaison Psychiatrist by Michael Brinkers, Paulina Rumpelt, Anke Lux, Moritz Kretzschmar, Giselher Pfau

“…The medical treatment of psychiatric dysfunction leads to an analgesic effect. Only every second CRPS patient had an additional psychiatric diagnosis, and 15.6% were diagnosed with depressive mood disorders and show a higher prevalence of depressive symptoms than the general population and exceed the mean for all patients treated in our pain clinic. …”
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Neuroserpin alleviates cerebral ischemia-reperfusion injury by suppressing ischemia-induced endoplasmic reticulum stress by Yumei Liao, Qinghua Zhang, Qiaoyun Shi, Peng Liu, Peiyun Zhong, Lingling Guo, Zijian Huang, Yinghui Peng, Wei Liu, Shiqing Zhang, István Adorján, Yumi Fukuzaki, Eri Kawashita, Xiao-Qi Zhang, Nan Ma, Xiaoshen Zhang, Zoltán Molnár, Lei Shi

“…Our findings demonstrate that neuroserpin exerts neuroprotective effects on ischemic stroke by suppressing endoplasmic reticulum stress.…”
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Empagliflozin Plays Vasoprotective Role in Spontaneously Hypertensive Rats via Activation of the SIRT1/AMPK Pathway by Monika Kloza, Anna Krzyżewska, Hanna Kozłowska, Sandra Budziak, Marta Baranowska-Kuczko

“…Empagliflozin (EMPA), a sodium-glucose co-transporter 2 (SGLT2) inhibitor, prevents endothelial dysfunction, but its effects on vascular tone in hypertension remain unclear. …”
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Venous Thromboembolism in Spinal Fusion Surgery: A Literature Review of Economic Impact, Risk Factors, and Preoperative Management by Sai Suraj Kollapaneni, Malek Moumne, Henry Twibell, John DeVine

“…Spinal level and multilevel fusion are risk factors for postoperative VTE. The effect of the surgical approach on VTE risk is unclear. …”
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Indicators of pain sensitivity threshold in experimental osteoarthritis and hypothyroidism. by D. S. Nosivets

“…Diseases of the thyroid gland are an urgent problem of modern society due to a wide, constant spread of this pathology and with somatic, reproductive and mental disorders associated with these diseases. The negative effect of thyroid hormone dysfunction on the functional state of organs and systems is due to the key role of thyroid hormones in metabolic processes. …”
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Coptisine-induced cell cycle arrest at G2/M phase and reactive oxygen species–dependent mitochondria-mediated apoptosis in non-small-cell lung cancer A549 cells by Poorna Chandra Rao, Sajeli Begum, Mahendra Sahai, D Saketh Sriram

“…Besides, treatment with a reactive oxygen species inhibitor (N-acetyl cysteine) abrogated coptisine-induced growth inhibition, apoptosis, reactive oxygen species generation, and mitochondrial dysfunction. Thus, the mediation of reactive oxygen species in the apoptosis-induced effect of coptisine in A549 cells was corroborated. …”
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From deficiency to excess: the impact of iodine excess on reproductive health by Aiman Khudair, Ahmed Khudair, Sara Anjum Niinuma, Haniya Habib, Alexandra E. Butler

“…In view of rising global infertility rates, excess iodine has been linked to significant reproductive health effects. These include decreased sperm count, motility and morphology in males, as well as adverse pregnancy outcomes in females, such as maternal thyroid dysfunction and congenital hypothyroidism. …”
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Social isolation increases impulsive choice with minor changes on metabolic function in middle‐aged rats by Jassmyn J. Venegas, Jacob M. Weisz, Chan Young Choi, Ren E. Herringshaw, Omar A. Nabelsi, Nu‐Chu Liang

“…Abstract The effects of social isolation (SI) during middle age remain unclear, so we tested the hypothesis that SI would lead to an increase in impulsive choice (IC), anxiety‐like behavior, and metabolic dysfunction in middle‐aged rats. …”
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Omentin-1 ameliorates pulmonary arterial hypertension by inhibiting endoplasmic reticulum stress through AMPKα signaling by Xinyu Deng, Hao Luo, Jing He, Wang Deng, Daoxin Wang

“…Background Endothelial dysfunction of the pulmonary artery contributes to hypoxia-induced pulmonary arterial hypertension (PAH). …”
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Voice disorder in cystic fibrosis patients. by Bruna Mendes Lourenço, Kauê Machado Costa, Manoel da Silva Filho

“…While most of cystic fibrosis treatment is dedicated to mitigating the effects of respiratory dysfunction, the potential effects of this disease on vocal parameters have not been systematically studied. …”
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Pretreatment with Chrysin Reduces Ifosfamide-Induced Acute Nephrotoxicity in Male Rats through Mitochondrial Protection by Ahmad Salimi, Zhaleh Jamali, Mohammad Shabani, Deniz Bayrami, Amin Ashena Moghadam

“…Histopathological results showed that chrysin had protective effects and reduced histopathological abnormalities caused by ifosfamide. …”
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Electronic Cigarettes and Cardiovascular Risk: Caution Waiting for Evidence by Domenico D’Amario, Stefano Migliaro, Josip Andjelo Borovac, Rocco Vergallo, Mattia Galli, Attilio Restivo, Matteo Bonini, Enrico Romagnoli, Antonio Maria Leone, Filippo Crea

“…Some preclinical studies demonstrated the toxic and detrimental effects of electronic cigarettes liquid components. …”
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Alterations in brain connectivity underlying beta oscillations in Parkinsonism. by Rosalyn J Moran, Nicolas Mallet, Vladimir Litvak, Raymond J Dolan, Peter J Magill, Karl J Friston, Peter Brown

“…Here, we used dynamic causal modelling (DCM) and the 6-hydroxydopamine-lesioned rat model of PD to examine the effective connectivity underlying these spectral abnormalities. …”
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Lipidomics-based plasma signature of alcohol-related hepatitis linked to short-term mortality by Florent Artru, Stephen Atkinson, Francesca Trovato, Luke D. Tyson, Vishal C. Patel, Nikhil Vergis, Noora Kano, Robert Goldin, Alberto Quaglia, Alexandros Pechlivanis, Phillip Morgan, Salma Mujib, Anna Cavazza, Ellen Jerome, Marc Zentar, Roosey Sheth, Maura Morrison, Evangelos Triantafyllou, Elaine Holmes, María Gómez-Romero, Mark J. McPhail, Mark Thursz

“…Hypothesis-driven approaches have failed to identify effective treatments. Given the role of lipids as inflammatory mediators, this study aimed to identify lipidomic changes and lipid species associated with sAH and mortality risk. …”
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Canagliflozin‐induced renal glutathione distribution mapping in non‐diabetic male rat kidneys by Guy Watanabe, Shoichiro Horita, Reika Flora Moriya, Yusuke Masuishi, Shingen Misaka, Shu Taira, Kenju Shimomura, Michio Shimabukuro, Junichiro James Kazama

“…To clarify the pharmacological mechanism of SGLT2 inhibitor, we investigated the effects of canagliflozin on oxidative stress in the kidneys of normal, non‐diabetic Sprague–Dawley rats. …”
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