IL-17 Mildly Rescued the Impaired Proliferation of Alveolar Epithelial Cells Induced by LCN2 Overexpression by Tingting Lv, Ziliang Hou, Kaiyuan Yang, Jinxiang Wang

“…The impaired proliferative capacity of alveolar epithelial cells after injury is an important factor causing epithelial repair dysfunction, leading to the occurrence of idiopathic pulmonary fibrosis (IPF). …”
Get full text

Biomechanical Evaluation of the Flexor Digitorum Longus and Flexor Hallucis Longus Transfer Used for the Treatment of Adult Acquired Flatfoot Deformity: A Finite Element Study by Chandra Pasapula, Nicolas Yanguma, Brayan David Solorzano, Tamas Kobezda, Christian Cifuentes-De la Portilla, Md Abdul Aziz

“…<b>Introduction:</b> Management strategies for stage II tibialis posterior tendon dysfunction are centered on tendon transfers and osteotomies. …”
Get full text

Transfer of preclinical study data on the influence of cimicifuga racemosaon functional changes in the hippocampus during menopause by Petra Stute, Hans-Heinrich Henneicke-von Zepelin, Petra Nicken

“…Menopausal transition in women involves complex neurobiochemical changes linked to ovarian dysfunction, resulting in symptoms like vasomotor symptoms (VMS), sleep disturbances, anxiety, and cognitive impairments. …”
Get full text

The role of lycopene in alleviating soybean meal-induced intestinal injury in an early-weaned piglet model by Shugui Zheng, Mingbo Li, Xinhong Luan, Chuan Tong, Jiguang Li, Zhiying Zhang

“…IntroductionSoybean meal (SBM), widely used in pig farming, can induce intestinal damage and dysfunction in newly-weaned piglets due to the presence of soybean antigen proteins. …”
Get full text

Causal associations between circulating metabolites and chronic kidney disease: a Mendelian randomization study by Jie He, Lin Li, Hongjie Hu

“…To assess potential adverse effects of metabolite modulation, we conducted a phenome-wide Mendelian randomization analysis, followed by multivariate Mendelian randomization to adjust for confounders.Results We identified glycine and N-acetylornithine as potential causal mediators of CKD and renal dysfunction. …”
Get full text

Regulation of Blood–Brain Barrier Permeability via JNK Signaling Pathway: Mechanisms and Potential Therapeutic Strategies for Ischemic Stroke, Alzheimer’s Disease and Brain Tumors... by Mark B. Plotnikov, Anna M. Anishchenko, Andrei I. Khlebnikov, Igor A. Schepetkin

“…Certain compounds mitigate BBB dysfunction, being promising candidates for neuroprotective therapies. …”
Get full text

Cholic acid as a treatment for cerebrotendinous xanthomatosis: a comprehensive review of safety and efficacy by Gary Pasternack, Jeff Courtney, Gurdyal Kalsi

“…Importantly, outcomes with CA therapy are indistinguishable from those mediated by CDCA therapy and are associated with significantly fewer adverse effects. CA is used as an alternative therapy in patients who cannot tolerate CDCA due to its negative effects. …”
Get full text

Inhibition of miR-17~92 Cluster Ameliorates High Glucose-Induced Podocyte Damage by Xiaobao Fan, Zhiming Hao, Zhenjiang Li, Xiaoming Wang, Jing Wang

“…The downregulation of the miR-17∼92 cluster effectively suppressed the cell apoptosis, inflammation, fibrosis, and podocyte dysfunction in HG-stimulated MPC5 cells. …”
Get full text

Exposure to Batrachochytrium dendrobatidis metabolites altered ghost shrimp behavior and reduced mortality by Ellisa Carla Parker-Athill, Liam C. Muldro, Aiza J. Malinias, Taegan A. McMahon

“…We examined the effects of Bd metabolites on the freshwater species, Palaemonetes paludosus, or ghost shrimp, focusing specifically on the effects on behavior, cardiac function, and mortality. …”
Get full text

Noradrenergic and Dopaminergic modulation of meta-cognition and meta-control. by Sara Ershadmanesh, Sahar Rajabi, Reza Rostami, Rani Moran, Peter Dayan

“…We first administered a simple perceptual task to examine the effects of the manipulations on meta-cognitive ability. …”
Get full text

Identification of Anticancer Target Combinations to Treat Pancreatic Cancer and Its Associated Cachexia Using Constraint-Based Modeling by Feng-Sheng Wang, Ching-Kai Wu, Kuang-Tse Huang

“…A fuzzy multi-objective optimization framework was employed within the anticancer target discovery platform to evaluate cell viability and metabolic deviation as dual criteria for assessing therapeutic efficacy and potential side effects. While single-enzyme targets were found to be context-specific and medium-dependent, eight combinatorial targets demonstrated robust, medium-independent effects in both PDAC and PDAC-CX cells. …”
Get full text

Microglia-derived CXCL2 induced neuronal ferroptosis via CXCR2/Jun axis in sepsis-associated encephalopathy by Yu-Shen Yang, Jin-Wei Liang, Meng-Qin Pei, Yu-Ming Fang, Zhen-Dong Sun, He-Fan He

“…The following experiments further demonstrated that microglia-secreted CXCL2 induced the neuronal ferroptosis, but siRNA-Jun in neuron can abolish this effect. In addition, siRNA-CXCL2 of microglia mitigated the neuronal ferroptosis induced by sepsis, while Jun agonist reversed this protective effect.ConclusionIn conclusion, microglia-derived CXCL2 could induce the occurrence of neuronal ferroptosis by targeting Jun. …”
Get full text

Prophylactic Antioxidant Potential of Gallic Acid in Murine Model of Sepsis by Harikesh Maurya, Vaishali Mangal, Sanjay Gandhi, Kathiresan Prabhu, Kathiresan Ponnudurai

“…Present study is to investigate the effect of Gallic acid pretreatment on survival of septic animals and oxidative stress in different organs like lungs, liver, kidney, spleen, and vascular dysfunction of mice. …”
Get full text

Therapeutic Potential of Mesenchymal Stem Cell-Derived Extracellular Vesicles in the Treatment of Parkinson’s Disease by Ana Volarevic, Carl Randall Harrell, Aleksandar Arsenijevic, Valentin Djonov, Vladislav Volarevic

Get full text

Acne Vulgaris in Adolescents: Scientific Evidence for Optimizing Treatment Regimens via Dermatocosmetics by Elena R. Araviyskaya, Nikolay N. Murashkin, Roman A. Ivanov

“…Though, the comprehensive analysis of the available core care products, their composition and the effect of their ingredients on the structural and functional integrity of the skin, is required to ensure such effect.…”
Get full text

Pharmacological activation of BK channels protects against LPS-induced pneumonia by Tatiana Zyrianova, Benjamin Lopez, Janelle SooHoo, Christian Boehmer, Annie Ye, Hailey Kang, Nairrita Majumder, Andreas Schwingshackl

“…These protective effects were replicated with a structurally different BK channel activator, NS19504. …”
Get full text

Proanthocyanidin offers protection against diabetic nephropathy: elucidation of its mechanism of action using animal models by Dengpiao Xie, Huan Wang, Qing Ji, Jianting Wang

“…The protective mechanism of PA was associated with anti-inflammatory, antioxidant, antifibrotic, and antiapoptotic effects; inhibition of endoplasmic reticulum stress; and alleviation of mitochondrial dysfunction and dyslipidemia.Conclusion These findings suggest that PA alleviates DN by mediating multiple targets and pathways.…”
Get full text

Single‐Cell Transcriptomics Reveals a Pivotal Role of DOCK2 in Sjögren Disease by Yiran Shen, Alexandria Voigt, Indraneel Bhattacharyya, Cuong Q. Nguyen

“…We further determined the therapeutic effect of inhibiting dedicator of cytokinesis 2 (DOCK2) shared by novel clusters of CD8+ T cells in an SjD mouse model. …”
Get full text

Magnolia kobus DC. Alleviates adenine-induced chronic kidney disease by regulating ferroptosis in C57BL/6 mice by Jong Min Kim, Yiseul Kim, Hyun-Jin Na, Haeng Jeon Hur, Sang-Hee Lee, Mi Jeong Sung

“…(MO) is a medicinal plant that reportedly possesses various bioactive properties, including anti-hyperplastic, anti-inflammatory, and anti-cancer effects. Chronic kidney disease (CKD) is a progressive disorder characterized by inflammation, fibrosis, and oxidative stress, which leads to renal dysfunction. …”
Get full text

An Overview of Paraquat Poisoning: A Review by Arkaketan Chatterjee, Mariam Ansar, Atanu Chandra, Uddalak Chakraborty, Sugata Dasgupta

“…Paraquat (PQ) is a toxic bipyridyl compound commonly used in agriculture and it has potential ill-effects with high fatality if ingested even in very small amounts. …”
Get full text