Mitochondrial deoxyguanosine kinase depletion induced ROS causes melanocyte stem cell exhaustion and hair greying by Kaiyao Zhou, Gangyun Wu, Rui Dong, Changhao Kan, Lin Xie, Lijuan Gao, Hua Li, Jianwei Sun, Wenxiu Ning

“…Abstract Hair pigmentation is regulated by melanocyte stem cells (MeSCs) within the hair follicle. Mitochondrial dysfunction is associated with hair depigmentation, primarily due to defects in melanogenesis. …”
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Gallic and Hesperidin Ameliorate Electrolyte Imbalances in AlCl3-Induced Nephrotoxicity in Wistar Rats by Tajudeen Olabisi Obafemi

“…This study aimed to evaluate the effect of hesperidin and gallic acid on serum electrolytes and ion pumps in Wistar rats subjected to aluminum chloride (AlCl3)-induced nephrotoxicity. …”
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Progress in rheumatology in the early 21st century by E. L. Nasonov

“…The main treatment goal is to improve quality of life, by controlling the symptoms of the disease, by preventing joint destruction and dysfunction, and by maintaining social possibilities. …”
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Structured Self-Rated Response to Iontophoresis with Verapamil and Dexamethasone in Peyronie’s Disease by Abas Kokab, Kevan Wylie, Patricia Allen, Abhijeeth Shetty, Debbie Davies-South

“…The data was collected from December 2004 to November 2009 and analysed to evaluate the effectiveness of the treatment. Results. Median age of patients was 59 (range 39–71). …”
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Recovering Voiding and Sex Function in a Patient with Chronic Complete Spinal Cord Injury by Olfactory Ensheathing Cell Transplantation by Di Chen, Haitao Xi, Ke Tan, Hongyun Huang

“…Transplantation of olfactory ensheathing cells has demonstrated neurorestoration effects for many neurological conditions, including SCI. …”
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The therapeutic potential of RNA m(6)A in lung cancer by Jingran Yu, Wei Sun, Xiangxuan Zhao, Yingying Chen

“…Intriguingly, an increasing number of studies have also shown that eliminating RNA m(6)A dysfunction can exert significant anti-cancer effects on LC such as suppression of cell proliferation and viability, induction of cell death, and reversal of treatment insensitivity. …”
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Altered drug metabolism and increased susceptibility to fatty liver disease in a mouse model of myotonic dystrophy by Zachary Dewald, Oluwafolajimi Adesanya, Haneui Bae, Andrew Gupta, Jessica M. Derham, Ullas V. Chembazhi, Auinash Kalsotra

“…Much of DM1 research has focused on the effects within the muscle and neurological tissues; however, DM1 patients also suffer from various metabolic and liver dysfunctions such as increased susceptibility to metabolic dysfunction-associated fatty liver disease (MAFLD) and heightened sensitivity to certain drugs. …”
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Enhancement of the HIF-1α/15-LO/15-HETE axis promotes hypoxia-induced endothelial proliferation in preeclamptic pregnancy. by Dandan Yuan, Yajuan Ran, Qian Liu, Yanhua Zhang, Huiying Li, Peiling Li, Daling Zhu

“…Mounting evidence shows that PE is associated with placental hypoxia, impaired placental angiogenesis, and endothelial dysfunction. In this study, we confirmed the upregulated expression of hypoxia-inducible factor 1α (HIF-1α) and 15-lipoxygenase-1/2 (15-LO-1/2) in patients with PE. …”
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Bioenergetics of the calf muscle in Friedreich ataxia patients measured by 31P-MRS before and after treatment with recombinant human erythropoietin. by Wolfgang Nachbauer, Sylvia Boesch, Rainer Schneider, Andreas Eigentler, Julia Wanschitz, Werner Poewe, Michael Schocke

“…Our results confirm mitochondrial dysfunction and exercise intolerance due to impaired oxidative phosphorylation in skeletal muscle tissue of FRDA patients. …”
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Neuro-immune Interactions in Metabolic Regulation: Brain and Adipose Tissue Crosstalk by Chan Hee Lee

“…This review discusses the detrimental effects of hypothalamic microgliosis on energy metabolism and highlights emerging evidence suggesting paradoxically beneficial roles of hypothalamic microgliosis in metabolic regulation. …”
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Targeting Senescence: A Review of Senolytics and Senomorphics in Anti-Aging Interventions by Timur Saliev, Prim B. Singh

“…While transient senescence contributes to beneficial processes such as tissue repair and tumor suppression, the persistent accumulation of senescent cells is implicated in tissue dysfunction, chronic inflammation, and age-related diseases. …”
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Targeting oxidized phosphatidylcholines in SOD1-associated ALS: therapeutic potential of PC-OxPL-VecTab® by Andreia Gomes-Duarte, Sofia Pascoal, Rob Haselberg, Marina Sogorb-Gonzalez, Sander van Deventer

“…Collectively, the present study underscores the significance of PC-OxPL dysfunction in the context of SOD1 genotypes and sheds light on the potential of PC-OxPL-VecTab® for therapeutically targeting ALS.…”
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Oligodendroglial Lineage Cells in Thyroid Hormone-Deprived Conditions by Min Joung Kim, Steven Petratos

“…Based on the therapeutic effects exhibited by TH in various preclinical studies, particularly related to its remyelinating potential, TH has now entered the initial stages of a clinical trial to test the therapeutic efficacy in relapsing-remitting MS patients (NCT02506751). …”
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Ocular-cerebral immune dialogue: a new perspective and therapeutic potential of regional lymphatic systems by Yiran Wang, Pei Guo, Weihong Li, Weihong Li, Tong Li

“…The Central Nervous System (CNS), due to its unique structure and function, possesses immune privilege, which is primarily maintained through mechanisms such as the blood-brain barrier, immune cell exclusion, and neuroglial cell regulation, effectively protecting the CNS from external insults. …”
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Acute Kidney Injury Secondary to Trauma Brain Injury (TBI) and the Role of Angiotensin-1-7 by Mehdi Jahantigh, Abolfazl Parsi-Moud, Hamede Damani, Mohammad Ali Mirshekar, Ilia Mirzaei, Hossein Bagheri, Elham Shoghi, Tahereh Safari

“…Therapeutic administration of Ang-1-7 post-TBI attenuated these effects in TBI+Ang-1-7 group, reducing Cr levels P<0.05. …”
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Modulation of microglia activation and Alzheimer's disease: CX3 chemokine ligand 1/CX3CR and P2X7R signaling by Pavithra Suresh, Sarayut Phasuk, Ingrid Y Liu

“…Two hallmarks of AD that cause chronic inflammation and lead to neuronal dysfunction and damage are tau tangles and amyloid plaques. …”
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Vitamin D3 Supplementation Attenuates Surgery-Induced Neuroinflammation and Cognitive Impairment by Regulating NLRP3 Inflammasome in Mice by Jingyan Jiang, Xin Huang, Xiang Gao, Shenghui Yu

“…Neuroinflammation plays a dominant role in the progression of postoperative cognitive dysfunction (POCD). Vitamin D has been known to have important regulatory functions in inflammation and immune response. …”
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Mycobacterium Avium Paratuberculosis and the Etiology of Crohn’s Disease: A Review of the Controversy from the Clinician’s Perspective by Greg Rosenfeld, Brian Bressler

“…The first is that MAP is a principal cause of CD, while the second is that MAP is more prevalent because of the immune dysfunction seen in CD but does not play a causative role. …”
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Distinct mechanisms of inadequate erythropoiesis induced by tumor necrosis factor alpha or malarial pigment. by Abigail A Lamikanra, Alison T Merryweather-Clarke, Alex J Tipping, David J Roberts

“…The role of infection in erythropoietic dysfunction is poorly understood. In children with P. falciparum malaria, the by-product of hemoglobin digestion in infected red cells (hemozoin) is associated with the severity of anemia which is independent of circulating levels of the inflammatory cytokine tumor necrosis alpha (TNF-α). …”
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Current Concepts of Molecular Mechanisms of Age-Related Changes in Eye Lens by T. N. Kiseleva, M. S. Zaitsev

“…This review provides information on results of experimental and clinical studies which demonstrate the anti-cataract effect of Pirenoxine 0, 005 %.…”
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