Naringenin cationic lipid-modified nanoparticles mitigate MASLD progression by modulating lipid homeostasis and gut microbiota by Lu Dong, Wenyong Lou, Congfei Xu, Juan Wang

“…Abstract Naringenin (NAR) possesses various pharmacological activities including antioxidant, anti-inflammatory, and hepatoprotective effects. However, its therapeutic efficacy is limited by its hydrophobic and crystalline nature. …”
Get full text

Efficacy and safety of novel complement inhibitors in atypical haemolytic uremic syndrome: a protocol for systematic review and meta-analysis by Maulana Empitu, Ruthvika Jayanthi, Muhammad Nabhan Yasin, Afaf Bouqoufi

“…If inadequately managed, aHUS can lead to progressive kidney failure, cardiovascular complications and multiorgan dysfunction, resulting in high healthcare costs and a substantial impact on patients’ quality of life. …”
Get full text

Complex I superoxide anion production is necessary and sufficient for complex I inhibitor-induced dopaminergic neurodegeneration in Caenorhabditis elegans by Katherine S. Morton, Alex J. George, Joel N. Meyer

“…The lack of tools to isolate effects of CI inhibition have rendered it difficult to determine which mechanistic step is critical for CI inhibitor-induced dopaminergic neurodegeneration. …”
Get full text

Expert Opinion on the Diagnosis and Management of Male Hypogonadism in India by Sanjay Kalra, Jubbin Jacob, A. G. Unnikrishnan, Ganapathi Bantwal, Abhay Sahoo, Rakesh Sahay, Sushil Jindal, Madhu Sudan Agrawal, Nitin Kapoor, Banshi Saboo, Mangesh Tiwaskar, Kapil Kochhar

“…Untreated MH can result in long-term effects, including metabolic, musculoskeletal, mood-related, and reproductive dysfunction. …”
Get full text

Compound 4f, a novel brain-penetrant reversible monoacylglycerol inhibitor, ameliorates neuroinflammation, neuronal cell loss, and cognitive impairment in mice with kainic acid-ind... by Naoto Arimura, Chie Maeda, Kazunobu Aoyama, Namiko Yamaguchi, Ayumu Sugiura, Yasuko Takahashi, Ryouta Maeda, Tatsuya Ando, Makoto Kamata, Hideki Matsui, Maiko Tanaka

“…Neuroinflammation, a hallmark of neurodegenerative diseases, is associated with neuronal cell loss and cognitive dysfunction. Monoacylglycerol lipase (MAGL) is involved in neuroinflammation in the brain via the degradation of endocannabinoid 2-arachidonoylglycerol to arachidonic acid, a precursor of some eicosanoids; therefore, MAGL inhibitors are expected to have anti-inflammatory effects. …”
Get full text

Spermidine Enhances Mitochondrial Bioenergetics in Young and Aged Human-Induced Pluripotent Stem Cell-Derived Neurons by Leonora Szabo, Imane Lejri, Amandine Grimm, Anne Eckert

“…Previous studies have revealed that polyamine spermidine appears to exert health-protective and lifespan-promoting effects. Notably, recent findings have also described a spermidine-induced improvement in age-associated mitochondrial dysfunction, but the beneficial effects of spermidine on aged mitochondria have not been entirely examined yet. …”
Get full text

Therapies and delivery systems for diabetic wound care: current insights and future directions by Preeti Singh Yadav, Mahendra Singh, Ramachandran Vinayagam, Prashant Shukla

“…These agents exert their therapeutic effects primarily through antioxidant, antibacterial, anti-inflammatory, and pro-angiogenic mechanisms and properties, typically with minimal side effects. …”
Get full text

Coagulation Abnormalities in Lung Cancer: Diagnostic Challenges and Therapeutic Perspectives by Athena Myrou MD, MSc, PhD, Athanasios Penopoulos MD, Konstantinos Barmpagiannos MD, Styliani Ouzouni MD, Fotios Girtovitis MD, PhD

“…This hypercoagulable state arises from a multifaceted interplay between tumor-derived procoagulants, systemic inflammation, endothelial dysfunction, autoimmune mechanisms, and treatment-associated effects. …”
Get full text

Assessing Executive Abilities Following Acute Stroke with the Trail Making Test and Digit Span by Elaine Tamez, Joel Myerson, Lucy Morris, Desirée A. White, Carolyn Baum, Lisa Tabor Connor

“…Data from the Stroke and Lesion Registry maintained by the Washington University Cognitive Rehabilitation Research Group were analyzed to compare the effects of frontal versus nonfrontal strokes and to assess the effects of stroke severity. …”
Get full text

Galectin-9 and Tim-3 in gastric cancer: a checkpoint axis driving T cell exhaustion and Treg-mediated immunosuppression independently of anti-PD-1 blockade by Charlotte N. Hill, Charlotte N. Hill, Charlotte N. Hill, Charlotte N. Hill, Gabriela Maita, Gabriela Maita, Gabriela Maita, Camille Cabrolier, Camille Cabrolier, Camille Cabrolier, Constanza Aros, Constanza Aros, Ana Maria Vega-Letter, Pamela Gonzalez, Pamela Gonzalez, Alexis M. Kalergis, Alexis M. Kalergis, Patricia Luz-Crawford, Patricia Luz-Crawford, Patricia Luz-Crawford, Gareth I. Owen, Gareth I. Owen

“…LGALS9 expression strongly correlated with signatures of CD8⁺ T cell dysfunction and increased infiltration of regulatory T cells (Tregs). …”
Get full text

Protection by ozone preconditioning is mediated by the antioxidant system in cisplatin-induced nephrotoxicity in rats by Aluet Borrego, Zullyt B. Zamora, Ricardo González, Cheyla Romay, Silvia Menéndez, Frank Hernández, Teresita Montero, Enys Rojas

“…Here, we show the protective effect of ozone oxidative preconditioning against cisplatin-induced renal dysfunction in rats. …”
Get full text

Early Immunological and Inflammation Proteomic Changes in Elderly COVID-19 Patients Predict Severe Disease Progression by Shiyang Liu, Wen Xu, Bo Tu, Zhiqing Xiao, Xue Li, Lei Huang, Xin Yuan, Juanjuan Zhou, Xinxin Yang, Junlian Yang, De Chang, Weiwei Chen, Fu-Sheng Wang

“…<b>Conclusions:</b> Elderly COVID-19 patients with severe progression demonstrate early immune dysregulation, hyperinflammation, coagulation dysfunction, and multi-organ injury. The model we proposed effectively predicts disease progression in elderly COVID-19 patients, providing potential biomarkers for early clinical risk stratification in this vulnerable population.…”
Get full text

P-96 LONG-TERM PIOGLITAZONE TREATMENT AND LIVER STIFFNESS IN MASLD PATIENTS: INSIGHTS FROM A MULTICENTRIC STUDY by Mario Guimarães Pessoa, ISABEL VELOSO ALVES PEREIRA, Patricia Momoyo Yoshimura Zitelli, Mísia Joyner de Sousa Dias Monteiro, Claudia Couto, Juliana Souza de Oliveira, Ana Beatriz Souza de Oliveira, José Tadeu Stefano, Renato Altikes, Ana Luiza Gomes Reis, Ana Carolina Ferreira Netto Cardoso, Cláudio de Figueiredo Mendes, Lais Arrivabene Barbieri, Nathalie C. Leite, Cristiane A. Villela-Nogueira, Claudia P Oliveira

“…It also addresses systemic and adipose tissue insulin resistance in patients with type 2 diabetes and metabolic dysfunction-associated fatty liver disease (MASLD). …”
Get full text

C/EBPβ–VCAM1 axis in Kupffer cells promotes hepatic inflammation in MASLD by Shuang-Zhe Lin, Yang Xie, Yu-Qing Cheng, Rui Xue, Yin-Shi Su, Mingxi Liu, Yuan-Wen Chen, Jian-Gao Fan

“…Background &amp; Aims: Kupffer cells (KCs) can promote hepatic inflammation in metabolic dysfunction-associated steatotic liver disease (MASLD), but the underlying molecular mechanisms are not fully understood. …”
Get full text

Nanotechnology to Overcome Blood–Brain Barrier Permeability and Damage in Neurodegenerative Diseases by Adriana Jiménez, Enrique Estudillo, Mara A. Guzmán-Ruiz, Nieves Herrera-Mundo, Georgina Victoria-Acosta, Enoc Mariano Cortés-Malagón, Adolfo López-Ornelas

“…Nanoparticles (NPs) have been widely explored as drug carriers capable of overcoming this barrier and effectively transporting therapies to the brain. However, their potential to directly address and ameliorate BBB dysfunction has received limited attention. …”
Get full text

SARS-CoV2 and Co-Infections: A Review of Two Cases by Sumit Sohal, Guillermo Rodriguez-Nava, Ramzy Khabbaz, Sana Chaudry, Clio Musurakis, Solab Chitrakar, Vishnu V. Chundi, Harvey J. Friedman

“…Further studies are needed to study the effect of co-infections on morbidity and mortality of patients and establish the outcome of such infections.…”
Get full text

Prepregnancy Obesity Reprograms Offspring Skeletal Muscle Fibre Transition Through H3K9me3 by Yichi Wu, Sujuan Li, Jingyi Zhang, Anran Tian, Xiangyao Wang, Xi Yang, Fucheng Meng, Qing Li, Yuan Gao, Yingying Li, Furong Liang, Minglan Yao, Xiaoping Luo, Cai Zhang

“…Targeting IDH2 may represent a potential therapeutic strategy to mitigate metabolic dysfunction in offspring exposed to maternal prepregnancy obesity.…”
Get full text

Integration of active ingredients from traditional Chinese medicine with nano-delivery systems for tumor immunotherapy by Hao Zheng, Yiquan Chen, Wei Luo, Shiqi Han, Mengjuan Sun, Min Lin, Chenghan Wu, Lili Gao, Tian Xie, Na Kong

“…Abstract Tumor immune escape presents a significant challenge in cancer treatment, characterized by the upregulation of immune inhibitory molecules and dysfunction of immune cells. Tumor immunotherapy seeks to restore normal anti-tumor immune responses to control and eliminate tumors effectively. …”
Get full text

Glucans: A Therapeutic Alternative for Sepsis Treatment by Jesse P. M. Viana, Fernanda F. Costa, Tatielle G. Dias, Priscila M. Mendes, Gabriel B. Copeland, Willian S. Nascimento, Sofia S. N. Mendes, Isabella F. S. Figueiredo, Elizabeth S. Fernandes, Anamelia L. Bocca, Márcia C. G. Maciel

“…Sepsis treatment is a challenging condition due to its complexity, which involves host inflammatory responses to a severe and potentially fatal infection, associated with organ dysfunction. The aim of this study was to analyze the scientific literature on the immunomodulatory effects of glucans in a murine model of systemic infection induced by cecal ligation and puncture. …”
Get full text

Seasonal Influence on the Impact of Human Chorionic Gonadotropin (hCG) on Testicular Haemodynamics and Hormonal Responses in Canines: A Comparative Study by Behnam Nadali, Arman Abdous, Nima Karami, Mohammad Jokar, Ourang Ataie Amarloie, Mehran Farhoodi

“…ABSTRACT Human chorionic gonadotropin (hCG) is widely used to treat reproductive dysfunction by enhancing testicular blood flow and stimulating hormonal activity. …”
Get full text