Cardiomyocyte-specific NHE1 overexpression confers protection against myocardial infarction during hyperglycemia by Kai Jiang, Fanghua Su, Ruhua Deng, Yue Xu, Anqi Qin, Xun Yuan, Dongmei Xing, Yang Chen, Dandan Wang, Lan Shen, John Hwa, Lei Hou, Yaozu Xiang

“…However, the precise role of NHE1 in the pathophysiology of MI with acute hyperglycemia remains to be elucidated, and there are no effective strategies for its prevention or treatment. …”
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Sarsasapogenin protects hair cells from cisplatin-induced ototoxicity by attenuating apoptosis and ferroptosis via alleviating oxidative stress by Zhifeng Chen, Zhifeng Chen, Zhifeng Chen, Ting Xie, Chenyu Chen, Chenyu Chen, Chenyu Chen, Tingting Lin, Xiaobo Wu, Xiaobo Wu, Yuqing Chen, Yuqing Chen, Yanchun Lin, Yanchun Lin, Xiaoyang Luo, Xiaoyang Luo, Chaojun Zeng, Chaojun Zeng, Chaojun Zeng, Chang Lin, Chang Lin, Chang Lin

“…Furthermore, sarsasapogenin effectively protected against cisplatin-induced sensorineural hearing loss and hair cell degeneration in vivo. …”
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Advances in Minimally Invasive Treatments for Prostate Cancer: A review of the Role of Ultrasound Therapy and Laser therapy by Corneliu-Dan Blendea, Mohammad Tazim Khan, Marius Stoian, Teodor Claudiu Ion Gligore, Ștefan Cuculici, Ion Lucian Stanciu, Mirela Gabriela-Irina Protosevici, Marius Iordache, Anca Buliman, Carmen Costea-Firan, Ioana Simona Cazacu, Liviu-Constantin Iordache, Doroteea Teoibaș-Șerban

“…While conventional treatments like radical prostatectomy and radiation therapy are effective, they are often associated with significant adverse effects, including sexual dysfunction and urinary incontinence. …”
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Nuclear receptor corepressor 1 represses cardiac hypertrophy by Chao Li, Xue‐Nan Sun, Bo‐Yan Chen, Meng‐Ru Zeng, Lin‐Juan Du, Ting Liu, Hui‐Hui Gu, Yuan Liu, Yu‐Lin Li, Lu‐Jun Zhou, Xiao‐Jun Zheng, Yu‐Yao Zhang, Wu‐Chang Zhang, Yan Liu, Chaoji Shi, Shuai Shao, Xue‐Rui Shi, Yi Yi, Xu Liu, Jun Wang, Johan Auwerx, Zhao V Wang, Feng Jia, Ruo‐Gu Li, Sheng‐Zhong Duan

“…Finally, overexpression of RIDs of NCoR1 in the heart attenuated cardiac hypertrophy and dysfunction induced by pressure overload. In conclusion, NCoR1 cooperates with MEF2 and HDACs to repress cardiac hypertrophy. …”
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Schaftoside improves HFpEF through regulation the autophagy-lysosome pathway by allosterically targeting CaMKII-δ by Haiying Zhang, Yanan Gao, Min Zhang, Zhexin Yuan, Yu Chen, Aiping Wang, Xinxing Liu, Shunchang Ji, Jianfeng Jin, Jingwei Liang, Yan Liu

“…HFpEF presents with a normal or near-normal left ventricular ejection fraction, cardiac diastolic dysfunction, and a metabolic profile characterized by impaired inflammation and oxidative stress. …”
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Arrhythmias, conduction disorders and sudden cardiac death in cancer patients and survivors: expert opinion of the working groups on cardio-oncology and on electrophysiology of the... by Kalliopi Keramida, Ourania Kariki, Eleni Angelopoulou, Ioannis Kalafatis, Christos Lafaras, Konstantinos P. Letsas, Helena Michalopoulou, Athanasios Saplaouras, Konstantinos Tampakis, Dorothea Tsekoura, George Andrikopoulos

“…Abstract Advances in cancer therapeutics have significantly improved patient survival; however, cardiotoxic effects—including arrhythmias—have emerged as a growing clinical concern. …”
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Structural resilience of climate regime in the global conflicts by Chuanjing Guan, Jialian Meng, Qinyi Xu

“…In the era of global conflicts, the effectiveness of current climate regime has been questioned. …”
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Systematic analysis of molecules regulating nitric oxide (NO) metabolism and vascular endothelium condition by I. Yu. Torshin, A. G. Chuchalin, O. A. Gromova

“…An array of all currently available publications on fundamental and clinical studies of the effects of various molecules on NO levels was studied. …”
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Development of a spontaneous model of renal interstitial fibrosis in NOD/SCID mice: Aging-induced pathogenesis. by Lihua Qiu, Zhaoxia Ma, Jinyan Li, Zhen Wu, Longmei Dai, Ruimin Long, Linlin Hu, Jianxiu Sun, Min Hu, Yanjiao Li

“…This study effectively developed a model of spontaneous renal interstitial fibrosis linked to natural aging in 43-week-old NOD/SCID mice. …”
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Draining Fluids through a Peritoneal Catheter in Newborns after Cardiac Surgery Helps to Control Fluid Balance by Elisa Ruano Cea, Philippe Jouvet, Suzanne Vobecky, Aicha Merouani

“…In order to determine the effect of peritoneal drainage, we selected a period of one week before and one week after the removal of the drain to compare daily clinical data, urine electrolytes and renal function and found a positive effect on fluid balance control. …”
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FASN promotes the stemness of cancer stem cells and protects colorectal cancer cells from ferroptosis by inhibiting the activation of SREBP2 by Ming Wang, Fulin Ge, Cheng Wu, Binbin Su, Xiaoyu Dong, Shiping Xu, Hui Shi

“…Mechanistically, FASN knockdown decreased cholesterol, activated SREBP2, and induced ferroptosis (elevated ferrous ions, ROS, lipid peroxidation, mitochondrial dysfunction); these effects were reversed by fatostatin. …”
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Diuretic Therapy: Mechanisms, Clinical Applications, and Management by Nicoleta-Mirela Blebea, Ciprian Pușcașu, Emil Ștefănescu, Alina Mihaela Stăniguț

“…Given the potential for adverse effects such as electrolyte disturbances and renal dysfunction, diuretic therapy should be individualized, with the careful monitoring of the dosage, patient response, and comorbid conditions. …”
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Understanding the impacts of extreme heat on the mental well-being of older adults: a systematic review by Jifei Chen, Laurence L Delina

“…Our analysis encompassed 22 articles, revealing several detrimental effects of extreme heat on mental well-being, including social isolation, cognitive dysfunction, affective disorders, and sleep disturbances. …”
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Research Progress on the Mechanisms of Action of Food-Derived Aryl Hydrocarbon Receptor Ligands in Ulcerative Colitis by MA Xuan, CHEN Qin, HE Yi, ZHAO Chenrui, YAN Wenjie, GUO Qingbin, WANG Feng

“…The paper also explains the reasons for the unstable effects of certain AHR ligands, providing a scientific basis for exploring diet-based intervention strategies for UC.…”
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Signaling Mechanisms of Selective PPARγ Modulators in Alzheimer’s Disease by Manoj Govindarajulu, Priyanka D. Pinky, Jenna Bloemer, Nila Ghanei, Vishnu Suppiramaniam, Rajesh Amin

“…Furthermore, these dosing levels are associated with several adverse effects including increased incidence of weight gain, liver abnormalities, and heart failure. …”
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Evaluating the association of adverse childhood experiences, mood and anxiety disorders, and suicidal ideation among behavioral health patients at a large federally qualified healt... by April Joy Damian, May Oo, Daniel Bryant, Joseph J Gallo

“…Although numerous studies have examined the relationship between adverse childhood experiences (ACEs) and suicide, research is needed that studies the effects of specific ACEs, including subclasses of ACEs, independent of the effect of other ACEs. …”
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Anthocyanin attenuates pulmonary arterial hypertension and associated heart failure via improving mitochondrial function through Nrf2-dependent mechanism by Xiao Liu, Xiaoli Tan, Yidan Su, Luohao Zou, Wenhui Yuan, Changqing Yu

“…Background Mitochondrial dysfunction of pulmonary vascular endothelial cells is one of the important pathogenesis of pulmonary arterial hypertension (PAH). …”
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CHD8 adulthood microglial knockdown in C57BL6 mice induces behavioral, morphological, and transcriptional changes in a sex-dependent manner by Orly Weissberg, Ram Harari, Chizim Dogun, Dmitriy Getselter, Evan Elliott

“…In contrast, adulthood neuron knockdown had more subtle effects on behavior, mainly on depression-like behavior in males. …”
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A POSSIBILITY TO USE ANTIARRHYTHMIC MEDICATIONS FROM II CLASS AND MODULATED KINESITHERAPY AS PRIMARY PREVENTION OF ATRIAL FIBRILLATION IN METABOLIC SYNDROME PATIENTS by A. I. Olesin, V. A. Litvinenko, I. V. Konstantinova, A. V. Shlapakova

“…All patients, as primary prevention of AF, used antiarrhythmics of the 2nd class, and in side effects development or in contraindications they underwent MK; polyunsaturated fatty acids also used (PUFA).Results. …”
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Multiple myeloma and cardiovascular risk (a literature review) by B. B. Samura, M. O. Panasenko, S. Ya. Dotsenko

“…Side effects of chemotherapy include hypotension, hypertension, arrhythmias, conduction disturbances, pericarditis, thromboembolic events, heart failure, death. …”
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